CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: Destruxin B
Accession: CHEBI:181259
browse the term
Synonyms: exact_synonym: (3R,10S,13S,16S,19S)-16-[(2S)-butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone; 16-butan-2-yl-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone
related_synonym: Formula=C30H51N5O7; InChI=1S/C30H51N5O7/c1-10-19(6)24-29(40)34(9)25(18(4)5)30(41)33(8)20(7)26(37)31-14-13-23(36)42-22(16-17(2)3)28(39)35-15-11-12-21(35)27(38)32-24/h17-22,24-25H,10-16H2,1-9H3,(H,31,37)(H,32,38); InChIKey=GNBHVMBELHWUIF-UHFFFAOYSA-N; SMILES=O1C(C(=O)N2C(CCC2)C(=O)NC(C(CC)C)C(=O)N(C(C(C)C)C(=O)N(C(C(=O)NCCC1=O)C)C)C)CC(C)C
xref: Chemspider:378942; Chemspider:9299946
xref_mesh: MESH:C040424
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Anxa5
annexin A5
increases expression
ISO
destruxin B results in increased expression of ANXA5 protein
CTD
PMID:22465936
NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
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Bak1
BCL2-antagonist/killer 1
increases expression multiple interactions
ISO
destruxin B results in increased expression of BAK1 protein Sorafenib promotes the reaction [destruxin B results in increased expression of BAK1 protein]
CTD
PMID:24434019
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
destruxin B results in increased expression of BAX; destruxin B results in increased expression of BAX protein
CTD
PMID:22465936 PMID:23751424
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression
ISO
Sorafenib promotes the reaction [destruxin B results in decreased expression of BCL2 protein] destruxin B results in decreased expression of BCL2; destruxin B results in decreased expression of BCL2 protein
CTD
PMID:22465936 PMID:23751424 PMID:24434019
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
multiple interactions decreases expression
ISO
Sorafenib promotes the reaction [destruxin B results in decreased expression of BCL2L1 protein]
CTD
PMID:22465936 PMID:24434019
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bid
BH3 interacting domain death agonist
increases expression increases cleavage
ISO
destruxin B results in increased expression of BID protein alternative form destruxin B results in increased cleavage of BID protein
CTD
PMID:23751424
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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Birc5
baculoviral IAP repeat-containing 5
decreases expression
ISO
destruxin B results in decreased expression of BIRC5 protein
CTD
PMID:22465936 PMID:24434019
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Casp3
caspase 3
increases expression increases cleavage multiple interactions
ISO
destruxin B results in increased expression of CASP3 protein destruxin B results in increased cleavage of CASP3 protein destruxin B results in increased cleavage of and results in increased activity of CASP3 protein
CTD
PMID:22465936 PMID:23751424 PMID:24434019
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
increases activity decreases expression
ISO
destruxin B results in increased activity of CASP8 protein destruxin B results in decreased expression of CASP8 protein
CTD
PMID:23751424
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases cleavage multiple interactions
ISO
destruxin B results in increased cleavage of CASP9 protein destruxin B results in increased cleavage of and results in increased activity of CASP9 protein
CTD
PMID:23751424 PMID:24434019
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Ccnd1
cyclin D1
decreases expression
ISO
destruxin B results in decreased expression of CCND1 protein
CTD
PMID:22465936 PMID:24434019
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cdh1
cadherin 1
multiple interactions increases expression
ISO
Sorafenib promotes the reaction [destruxin B results in increased expression of CDH1 protein]
CTD
PMID:24434019
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdh2
cadherin 2
decreases expression multiple interactions
ISO
destruxin B results in decreased expression of CDH2 protein Sorafenib promotes the reaction [destruxin B results in decreased expression of CDH2 protein]
CTD
PMID:24434019
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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Chuk
component of inhibitor of nuclear factor kappa B kinase complex
decreases expression
ISO
destruxin B results in decreased expression of CHUK protein
CTD
PMID:22465936
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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Ctnnb1
catenin beta 1
multiple interactions decreases expression affects localization
ISO
destruxin B results in decreased activity of [TCF4 protein co-treated with CTNNB1 protein]; Sorafenib promotes the reaction [destruxin B results in decreased expression of CTNNB1 protein] destruxin B results in decreased expression of CTNNB1 protein; destruxin B results in decreased expression of CTNNB1 protein modified form destruxin B affects the localization of CTNNB1 protein
CTD
PMID:22465936 PMID:24434019
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Fadd
Fas associated via death domain
increases activity
ISO
destruxin B results in increased activity of FADD protein
CTD
PMID:23751424
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
decreases expression
ISO
destruxin B results in decreased expression of FOS protein
CTD
PMID:22465936
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
decreases expression
ISO
destruxin B results in decreased expression of JUN protein
CTD
PMID:22465936
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Mmp2
matrix metallopeptidase 2
decreases expression
ISO
destruxin B results in decreased expression of MMP2 mRNA
CTD
PMID:22465936
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp9
matrix metallopeptidase 9
decreases expression
ISO
destruxin B results in decreased expression of MMP9 mRNA
CTD
PMID:22465936
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression
ISO
destruxin B results in decreased expression of MYC protein
CTD
PMID:22465936 PMID:24434019
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Nfkbia
NFKB inhibitor alpha
increases expression
ISO
destruxin B results in increased expression of NFKBIA protein
CTD
PMID:22465936
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
destruxin B results in increased cleavage of PARP1 protein
CTD
PMID:22465936
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pecam1
platelet and endothelial cell adhesion molecule 1
decreases expression
ISO
destruxin B results in decreased expression of PECAM1 protein
CTD
PMID:22465936
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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Rela
RELA proto-oncogene, NF-kB subunit
decreases expression
ISO
destruxin B results in decreased expression of RELA protein
CTD
PMID:22465936
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Snai2
snail family transcriptional repressor 2
multiple interactions decreases expression
ISO
destruxin B promotes the reaction [Sorafenib results in decreased expression of SNAI2 protein]; Sorafenib promotes the reaction [destruxin B results in decreased expression of SNAI2 protein]
CTD
PMID:24434019
NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
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Tcf4
transcription factor 4
decreases expression multiple interactions
ISO
destruxin B results in decreased expression of TCF4 protein destruxin B affects the localization of and results in decreased expression of TCF4 protein; destruxin B results in decreased activity of [TCF4 protein co-treated with CTNNB1 protein]
CTD
PMID:22465936 PMID:24434019
NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425
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Vim
vimentin
multiple interactions decreases expression
ISO
destruxin B promotes the reaction [Sorafenib results in decreased expression of VIM protein]; Sorafenib promotes the reaction [destruxin B results in decreased expression of VIM protein]
CTD
PMID:24434019
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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