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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Destruxin B
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Accession:CHEBI:181259 term browser browse the term
Synonyms:exact_synonym: (3R,10S,13S,16S,19S)-16-[(2S)-butan-2-yl]-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone;   16-butan-2-yl-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone
 related_synonym: Formula=C30H51N5O7;   InChI=1S/C30H51N5O7/c1-10-19(6)24-29(40)34(9)25(18(4)5)30(41)33(8)20(7)26(37)31-14-13-23(36)42-22(16-17(2)3)28(39)35-15-11-12-21(35)27(38)32-24/h17-22,24-25H,10-16H2,1-9H3,(H,31,37)(H,32,38);   InChIKey=GNBHVMBELHWUIF-UHFFFAOYSA-N;   SMILES=O1C(C(=O)N2C(CCC2)C(=O)NC(C(CC)C)C(=O)N(C(C(C)C)C(=O)N(C(C(=O)NCCC1=O)C)C)C)CC(C)C
 xref: Chemspider:378942;   Chemspider:9299946
 xref_mesh: MESH:C040424


show annotations for term's descendants           Sort by:
Destruxin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa5 annexin A5 increases expression ISO destruxin B results in increased expression of ANXA5 protein CTD PMID:22465936 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression
multiple interactions		 ISO destruxin B results in increased expression of BAK1 protein
Sorafenib promotes the reaction [destruxin B results in increased expression of BAK1 protein]		 CTD PMID:24434019 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO destruxin B results in increased expression of BAX; destruxin B results in increased expression of BAX protein CTD PMID:22465936 PMID:23751424 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO Sorafenib promotes the reaction [destruxin B results in decreased expression of BCL2 protein]
destruxin B results in decreased expression of BCL2; destruxin B results in decreased expression of BCL2 protein		 CTD PMID:22465936 PMID:23751424 PMID:24434019 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO Sorafenib promotes the reaction [destruxin B results in decreased expression of BCL2L1 protein] CTD PMID:22465936 PMID:24434019 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression
increases cleavage		 ISO destruxin B results in increased expression of BID protein alternative form
destruxin B results in increased cleavage of BID protein		 CTD PMID:23751424 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO destruxin B results in decreased expression of BIRC5 protein CTD PMID:22465936 PMID:24434019 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage
multiple interactions		 ISO destruxin B results in increased expression of CASP3 protein
destruxin B results in increased cleavage of CASP3 protein
destruxin B results in increased cleavage of and results in increased activity of CASP3 protein		 CTD PMID:22465936 PMID:23751424 PMID:24434019 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity
decreases expression		 ISO destruxin B results in increased activity of CASP8 protein
destruxin B results in decreased expression of CASP8 protein		 CTD PMID:23751424 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions		 ISO destruxin B results in increased cleavage of CASP9 protein
destruxin B results in increased cleavage of and results in increased activity of CASP9 protein		 CTD PMID:23751424 PMID:24434019 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO destruxin B results in decreased expression of CCND1 protein CTD PMID:22465936 PMID:24434019 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdh1 cadherin 1 multiple interactions
increases expression		 ISO Sorafenib promotes the reaction [destruxin B results in increased expression of CDH1 protein] CTD PMID:24434019 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdh2 cadherin 2 decreases expression
multiple interactions		 ISO destruxin B results in decreased expression of CDH2 protein
Sorafenib promotes the reaction [destruxin B results in decreased expression of CDH2 protein]		 CTD PMID:24434019 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases expression ISO destruxin B results in decreased expression of CHUK protein CTD PMID:22465936 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
affects localization		 ISO destruxin B results in decreased activity of [TCF4 protein co-treated with CTNNB1 protein]; Sorafenib promotes the reaction [destruxin B results in decreased expression of CTNNB1 protein]
destruxin B results in decreased expression of CTNNB1 protein; destruxin B results in decreased expression of CTNNB1 protein modified form
destruxin B affects the localization of CTNNB1 protein		 CTD PMID:22465936 PMID:24434019 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Fadd Fas associated via death domain increases activity ISO destruxin B results in increased activity of FADD protein CTD PMID:23751424 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO destruxin B results in decreased expression of FOS protein CTD PMID:22465936 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO destruxin B results in decreased expression of JUN protein CTD PMID:22465936 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO destruxin B results in decreased expression of MMP2 mRNA CTD PMID:22465936 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO destruxin B results in decreased expression of MMP9 mRNA CTD PMID:22465936 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO destruxin B results in decreased expression of MYC protein CTD PMID:22465936 PMID:24434019 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO destruxin B results in increased expression of NFKBIA protein CTD PMID:22465936 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO destruxin B results in increased cleavage of PARP1 protein CTD PMID:22465936 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO destruxin B results in decreased expression of PECAM1 protein CTD PMID:22465936 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO destruxin B results in decreased expression of RELA protein CTD PMID:22465936 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Snai2 snail family transcriptional repressor 2 multiple interactions
decreases expression		 ISO destruxin B promotes the reaction [Sorafenib results in decreased expression of SNAI2 protein]; Sorafenib promotes the reaction [destruxin B results in decreased expression of SNAI2 protein] CTD PMID:24434019 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Tcf4 transcription factor 4 decreases expression
multiple interactions		 ISO destruxin B results in decreased expression of TCF4 protein
destruxin B affects the localization of and results in decreased expression of TCF4 protein; destruxin B results in decreased activity of [TCF4 protein co-treated with CTNNB1 protein]		 CTD PMID:22465936 PMID:24434019 NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425 		JBrowse link
G Vim vimentin multiple interactions
decreases expression		 ISO destruxin B promotes the reaction [Sorafenib results in decreased expression of VIM protein]; Sorafenib promotes the reaction [destruxin B results in decreased expression of VIM protein] CTD PMID:24434019 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    chemical entity 19829
      group 19788
        organic group 18944
          amino-acid residue 11125
            peptide 11125
              depsipeptide 4571
                cyclodepsipeptide 4559
                  Destruxin B 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  carbon oxoacid 18613
                                    carboxylic acid 18610
                                      carboacyl group 17699
                                        univalent carboacyl group 17699
                                          carbamoyl group 17549
                                            carboxamide 17549
                                              peptide 11125
                                                depsipeptide 4571
                                                  cyclodepsipeptide 4559
                                                    Destruxin B 28
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