CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 2-aminophenol
Accession: CHEBI:18112
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Definition: The aminophenol which has the single amino substituent located ortho to the phenolic -OH group.
Synonyms: related_synonym: 2-Aminobenzenol; 2-Hydroxyaniline; Formula=C6H7NO; InChI=1S/C6H7NO/c7-5-3-1-2-4-6(5)8/h1-4,8H,7H2; InChIKey=CDAWCLOXVUBKRW-UHFFFAOYSA-N; SMILES=Nc1ccccc1O; o-Aminophenol; o-hydroxyaniline
alt_id: CHEBI:1023; CHEBI:11527; CHEBI:19476; CHEBI:39779
xref: CAS:95-55-6; DrugBank:DB01726; Gmelin:26978; Gmelin:606075; KEGG:C01987; KNApSAcK:C00007533
xref_mesh: MESH:C027667
xref: PDBeChem:2AF; PMID:11304127; PMID:1395635; PMID:24124510; PMID:24571346; PMID:9683650; Reaxys:606075; UM-BBD_compID:c0316; Wikipedia:2-Aminophenol
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Akr1c2
aldo-keto reductase family 1, member C2
increases expression
ISO
2-aminophenol results in increased expression of AKR1C2 mRNA
CTD
PMID:20491607
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
2-aminophenol results in increased expression of CYP1A1 mRNA
CTD
PMID:20491607
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Hmox1
heme oxygenase 1
increases expression
ISO
2-aminophenol results in increased expression of HMOX1 mRNA
CTD
PMID:20491607
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression affects response to substance
ISO
2-aminophenol results in increased expression of NQO1 mRNA NQO1 gene SNP affects the susceptibility to 2-aminophenol
CTD
PMID:20491607 PMID:25622337
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
affects response to substance
ISO
NR3C1 gene SNP affects the susceptibility to 2-aminophenol
CTD
PMID:25622337
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Rnf115
ring finger protein 115
affects response to substance
ISO
RNF115 gene SNP affects the susceptibility to 2-aminophenol
CTD
PMID:25622337
NCBI chr 2:184,262,087...184,329,839
Ensembl chr 2:184,262,371...184,329,823
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