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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-methoxy-TEMPO
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Accession:CHEBI:180670 term browser browse the term
Definition:A member of the class of aminoxyls that is TEMPO carrying a methoxy substituent at position 4.
Synonyms:exact_synonym: (4-methoxy-2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl
 related_synonym: 2,2,6,6-Tetramethyl-4-methoxypiperidine-1-oxyl;   2,2,6,6-tetramethyl-4-methoxypiperidine 1-oxide;   2,2,6,6-tetramethylpiperidine-4-methoxy-1-oxyl;   4-Methoxy-2,2,6,6-tetramethylpiperidinyloxyl;   4-methoxy-2,2,6,6-tetramethyl-1-piperidinyloxy;   4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxy;   4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxyl;   4-methoxy-2,2,6,6-tetramethylpiperidine 1-oxide;   4-methoxy-2,2,6,6-tetramethylpiperidine-1-oxy;   4-methoxy-2,2,6,6-tetramethylpiperidine-N-oxyl;   4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy;   4-methoxy-2,2,6,6-tetramethylpiperidinyloxy;   4-methoxy-TEMPO free radical;   Formula=C10H20NO2;   InChI=1S/C10H20NO2/c1-9(2)6-8(13-5)7-10(3,4)11(9)12/h8H,6-7H2,1-5H3;   InChIKey=SFXHWRCRQNGVLJ-UHFFFAOYSA-N;   MeO-TEMPO;   Metexyl;   SMILES=COC1CC(C)(C)N([O])C(C)(C)C1
 xref: CAS:95407-69-5;   Chemspider:8488900
 xref_mesh: MESH:C062073
 xref: PMID:10697546;   PMID:18728872;   PMID:18972469;   PMID:2610866;   PMID:27001507;   PMID:28688768;   PMID:28993908;   PMID:30878645;   PMID:31142008;   PMID:31593888;   PMID:31638966;   PMID:33382248;   Reaxys:4740399



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4-methoxy-TEMPO term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chek1 checkpoint kinase 1 increases phosphorylation ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of CHEK1 protein CTD PMID:28993908 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of CHEK2 protein CTD PMID:28993908 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions
ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of H2AX protein
Acetylcysteine inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of H2AX protein]; pyrazolanthrone inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of H2AX protein]
CTD PMID:28993908 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases metabolic processing ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased metabolism of MAP1LC3B protein CTD PMID:28993908 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO U 0126 inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of MAPK1 protein] CTD PMID:28993908 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of MAPK3 protein
U 0126 inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of MAPK3 protein]
CTD PMID:28993908 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in decreased expression of SQSTM1 protein CTD PMID:28993908 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        biochemical role 19515
          autophagy inducer 2013
            4-methoxy-TEMPO 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                organic heterocyclic compound 18852
                                  organic heteromonocyclic compound 17794
                                    piperidines 7739
                                      TEMPO 102
                                        4-methoxy-TEMPO 7
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