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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-methoxy-TEMPO
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Accession:CHEBI:180670 term browser browse the term
Definition:A member of the class of aminoxyls that is TEMPO carrying a methoxy substituent at position 4.
Synonyms:exact_synonym: (4-methoxy-2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl
 related_synonym: 2,2,6,6-Tetramethyl-4-methoxypiperidine-1-oxyl;   2,2,6,6-tetramethyl-4-methoxypiperidine 1-oxide;   2,2,6,6-tetramethylpiperidine-4-methoxy-1-oxyl;   4-Methoxy-2,2,6,6-tetramethylpiperidinyloxyl;   4-methoxy-2,2,6,6-tetramethyl-1-piperidinyloxy;   4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxy;   4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxyl;   4-methoxy-2,2,6,6-tetramethylpiperidine 1-oxide;   4-methoxy-2,2,6,6-tetramethylpiperidine-1-oxy;   4-methoxy-2,2,6,6-tetramethylpiperidine-N-oxyl;   4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy;   4-methoxy-2,2,6,6-tetramethylpiperidinyloxy;   4-methoxy-TEMPO free radical;   Formula=C10H20NO2;   InChI=1S/C10H20NO2/c1-9(2)6-8(13-5)7-10(3,4)11(9)12/h8H,6-7H2,1-5H3;   InChIKey=SFXHWRCRQNGVLJ-UHFFFAOYSA-N;   MeO-TEMPO;   Metexyl;   SMILES=COC1CC(C)(C)N([O])C(C)(C)C1
 xref: CAS:95407-69-5;   Chemspider:8488900
 xref_mesh: MESH:C062073
 xref: PMID:10697546;   PMID:18728872;   PMID:18972469;   PMID:2610866;   PMID:27001507;   PMID:28688768;   PMID:28993908;   PMID:30878645;   PMID:31142008;   PMID:31593888;   PMID:31638966;   PMID:33382248;   Reaxys:4740399



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4-methoxy-TEMPO term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chek1 checkpoint kinase 1 increases phosphorylation ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of CHEK1 protein CTD PMID:28993908 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of CHEK2 protein CTD PMID:28993908 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions
ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of H2AX protein
Acetylcysteine inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of H2AX protein]; pyrazolanthrone inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of H2AX protein]
CTD PMID:28993908 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases metabolic processing ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased metabolism of MAP1LC3B protein CTD PMID:28993908 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO U 0126 inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of MAPK1 protein] CTD PMID:28993908 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of MAPK3 protein
U 0126 inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of MAPK3 protein]
CTD PMID:28993908 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in decreased expression of SQSTM1 protein CTD PMID:28993908 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link

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  CHEBI ontology 20056
    role 20008
      biological role 20007
        biochemical role 19640
          autophagy inducer 1345
            4-methoxy-TEMPO 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic molecule 19822
                              organic cyclic compound 19575
                                organic heterocyclic compound 18798
                                  organic heteromonocyclic compound 17145
                                    piperidines 7687
                                      TEMPO 101
                                        4-methoxy-TEMPO 7
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