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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-methoxy-TEMPO
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Accession:CHEBI:180670 term browser browse the term
Definition:A member of the class of aminoxyls that is TEMPO carrying a methoxy substituent at position 4.
Synonyms:exact_synonym: (4-methoxy-2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl
 related_synonym: 2,2,6,6-Tetramethyl-4-methoxypiperidine-1-oxyl;   2,2,6,6-tetramethyl-4-methoxypiperidine 1-oxide;   2,2,6,6-tetramethylpiperidine-4-methoxy-1-oxyl;   4-Methoxy-2,2,6,6-tetramethylpiperidinyloxyl;   4-methoxy-2,2,6,6-tetramethyl-1-piperidinyloxy;   4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxy;   4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxyl;   4-methoxy-2,2,6,6-tetramethylpiperidine 1-oxide;   4-methoxy-2,2,6,6-tetramethylpiperidine-1-oxy;   4-methoxy-2,2,6,6-tetramethylpiperidine-N-oxyl;   4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy;   4-methoxy-2,2,6,6-tetramethylpiperidinyloxy;   4-methoxy-TEMPO free radical;   Formula=C10H20NO2;   InChI=1S/C10H20NO2/c1-9(2)6-8(13-5)7-10(3,4)11(9)12/h8H,6-7H2,1-5H3;   InChIKey=SFXHWRCRQNGVLJ-UHFFFAOYSA-N;   MeO-TEMPO;   Metexyl;   SMILES=COC1CC(C)(C)N([O])C(C)(C)C1
 xref: CAS:95407-69-5;   Chemspider:8488900
 xref_mesh: MESH:C062073
 xref: PMID:10697546;   PMID:18728872;   PMID:18972469;   PMID:2610866;   PMID:27001507;   PMID:28688768;   PMID:28993908;   PMID:30878645;   PMID:31142008;   PMID:31593888;   PMID:31638966;   PMID:33382248;   Reaxys:4740399


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4-methoxy-TEMPO term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chek1 checkpoint kinase 1 increases phosphorylation ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of CHEK1 protein CTD PMID:28993908 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of CHEK2 protein CTD PMID:28993908 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions		 ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of H2AX protein
Acetylcysteine inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of H2AX protein]; pyrazolanthrone inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of H2AX protein]		 CTD PMID:28993908 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases metabolic processing ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased metabolism of MAP1LC3B protein CTD PMID:28993908 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO U 0126 inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of MAPK1 protein] CTD PMID:28993908 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of MAPK3 protein
U 0126 inhibits the reaction [4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in increased phosphorylation of MAPK3 protein]		 CTD PMID:28993908 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO 4-methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxy results in decreased expression of SQSTM1 protein CTD PMID:28993908 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      biological role 19788
        biochemical role 19501
          autophagy inducer 1361
            4-methoxy-TEMPO 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic molecule 19656
                              organic cyclic compound 19461
                                organic heterocyclic compound 18817
                                  organic heteromonocyclic compound 17582
                                    piperidines 7711
                                      TEMPO 101
                                        4-methoxy-TEMPO 7
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