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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-hydroxy-TEMPO
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Accession:CHEBI:180664 term browser browse the term
Definition:A member of the class of aminoxyls that is TEMPO carrying a hydroxy substituent at position 4. It is a radical scavenger which exhibits anti-inflammatory and analgesic properties.
Synonyms:exact_synonym: (4-hydroxy-2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl
 related_synonym: 2,2,6,6-tetramethyl-1-oxy-4-hydroxypiperidine;   2,2,6,6-tetramethyl-4-hydroxypiperidin-1-oxyl;   2,2,6,6-tetramethyl-4-hydroxypiperidine 1-oxide radical;   2,2,6,6-tetramethyl-4-hydroxypiperidine-1-oxyl;   2,2,6,6-tetramethyl-4-hydroxypiperidinooxy;   2,2,6,6-tetramethyl-4-hydroxypiperidinooxy radical;   2,2,6,6-tetramethyl-4-hydroxypiperidyl 1-oxyl;   2,2,6,6-tetramethyl-4-oxypiperidine-1-oxyl;   2,2,6,6-tetramethyl-4-piperidinol 1-oxide;   2,2,6,6-tetramethyl-4-piperidinol 1-oxyl;   2,2,6,6-tetramethyl-4-piperidinol N-oxyl;   2,2,6,6-tetramethyl-4-piperidinol nitroxide;   2,2,6,6-tetramethyl-4-piperidinol-1-oxy;   2,2,6,6-tetramethyl-4-piperidinol-1-oxyl radical;   2,2,6,6-tetramethylpiperidine-N-oxyl-4-ol;   4-Hydroxy-2,2,6,6-tetramethylpiperidinyloxyl;   4-OH-TEMPO;   4-hydroxy-2,2,6,6-tetramethyl-1-piperidinoxyl;   4-hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy;   4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl;   4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl;   4-hydroxy-2,2,6,6-tetramethylpiperidine N-oxide;   4-hydroxy-2,2,6,6-tetramethylpiperidinooxy;   4-hydroxy-2,2,6,6-tetramethylpiperidinooxy radical;   4-hydroxy-TEMPO free radical;   Formula=C9H18NO2;   HyTEMPO;   InChI=1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3;   InChIKey=UZFMOKQJFYMBGY-UHFFFAOYSA-N;   SMILES=CC1(C)CC(O)CC(C)(C)N1[O];   TEMPOL;   TMPN;   Tanol
 xref: CAS:2226-96-2;   Chemspider:121639;   DrugBank:DB12449
 xref_mesh: MESH:C001803
 xref: PMID:24769526;   PMID:2610866;   PMID:27044831;   PMID:28320189;   PMID:28714295;   PMID:30549080;   PMID:30924375;   PMID:31504248;   PMID:31825758;   PMID:32366855;   PMID:32573229;   PMID:32726580;   PMID:33061560;   PMID:33078650;   PMID:33098599;   PMID:33467068;   PMID:33669093;   PMID:34248639;   PMID:34290305;   PMID:34425240;   PMID:34522067;   PMID:34630119;   PMID:34632934;   Reaxys:11328213;   Wikipedia:4-Hydroxy-TEMPO



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4-hydroxy-TEMPO term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP tempol inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
JBrowse link
G XDH xanthine dehydrogenase multiple interactions EXP tempol inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; tempol results in decreased activity of [Hypoxanthine co-treated with XDH protein] CTD PMID:21984542 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5148
    role 5115
      chemical role 866
        catalyst 41
          4-hydroxy-TEMPO 2
            4-hydroxy-TEMPO benzoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 5148
    subatomic particle 5139
      composite particle 5139
        hadron 5139
          baryon 5139
            nucleon 5139
              atomic nucleus 5139
                atom 5139
                  main group element atom 5112
                    p-block element atom 5109
                      carbon group element atom 5027
                        carbon atom 5026
                          organic molecular entity 5026
                            organic molecule 4975
                              organic cyclic compound 4916
                                organic heterocyclic compound 4706
                                  organic heteromonocyclic compound 4467
                                    piperidines 22
                                      TEMPO 2
                                        4-hydroxy-TEMPO 2
                                          4-hydroxy-TEMPO benzoate 0
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