CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 4-hydroxy-TEMPO
Accession: CHEBI:180664
browse the term
Definition: A member of the class of aminoxyls that is TEMPO carrying a hydroxy substituent at position 4. It is a radical scavenger which exhibits anti-inflammatory and analgesic properties.
Synonyms: exact_synonym: (4-hydroxy-2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl
related_synonym: 2,2,6,6-tetramethyl-1-oxy-4-hydroxypiperidine; 2,2,6,6-tetramethyl-4-hydroxypiperidin-1-oxyl; 2,2,6,6-tetramethyl-4-hydroxypiperidine 1-oxide radical; 2,2,6,6-tetramethyl-4-hydroxypiperidine-1-oxyl; 2,2,6,6-tetramethyl-4-hydroxypiperidinooxy; 2,2,6,6-tetramethyl-4-hydroxypiperidinooxy radical; 2,2,6,6-tetramethyl-4-hydroxypiperidyl 1-oxyl; 2,2,6,6-tetramethyl-4-oxypiperidine-1-oxyl; 2,2,6,6-tetramethyl-4-piperidinol 1-oxide; 2,2,6,6-tetramethyl-4-piperidinol 1-oxyl; 2,2,6,6-tetramethyl-4-piperidinol N-oxyl; 2,2,6,6-tetramethyl-4-piperidinol nitroxide; 2,2,6,6-tetramethyl-4-piperidinol-1-oxy; 2,2,6,6-tetramethyl-4-piperidinol-1-oxyl radical; 2,2,6,6-tetramethylpiperidine-N-oxyl-4-ol; 4-Hydroxy-2,2,6,6-tetramethylpiperidinyloxyl; 4-OH-TEMPO; 4-hydroxy-2,2,6,6-tetramethyl-1-piperidinoxyl; 4-hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy; 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl; 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl; 4-hydroxy-2,2,6,6-tetramethylpiperidine N-oxide; 4-hydroxy-2,2,6,6-tetramethylpiperidinooxy; 4-hydroxy-2,2,6,6-tetramethylpiperidinooxy radical; 4-hydroxy-TEMPO free radical; Formula=C9H18NO2; HyTEMPO; InChI=1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3; InChIKey=UZFMOKQJFYMBGY-UHFFFAOYSA-N; SMILES=CC1(C)CC(O)CC(C)(C)N1[O]; TEMPOL; TMPN; Tanol
xref: CAS:2226-96-2; Chemspider:121639; DrugBank:DB12449
xref_mesh: MESH:C001803
xref: PMID:24769526; PMID:2610866; PMID:27044831; PMID:28320189; PMID:28714295; PMID:30549080; PMID:30924375; PMID:31504248; PMID:31825758; PMID:32366855; PMID:32573229; PMID:32726580; PMID:33061560; PMID:33078650; PMID:33098599; PMID:33467068; PMID:33669093; PMID:34248639; PMID:34290305; PMID:34425240; PMID:34522067; PMID:34630119; PMID:34632934; Reaxys:11328213; Wikipedia:4-Hydroxy-TEMPO
G
NFE2L2
NFE2 like bZIP transcription factor 2
multiple interactions
EXP
tempol inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]
CTD
PMID:24512358
NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
G
XDH
xanthine dehydrogenase
multiple interactions
EXP
tempol inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; tempol results in decreased activity of [Hypoxanthine co-treated with XDH protein]
CTD
PMID:21984542
NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all