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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-hydroxy-TEMPO
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Accession:CHEBI:180664 term browser browse the term
Definition:A member of the class of aminoxyls that is TEMPO carrying a hydroxy substituent at position 4. It is a radical scavenger which exhibits anti-inflammatory and analgesic properties.
Synonyms:exact_synonym: (4-hydroxy-2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl
 related_synonym: 2,2,6,6-tetramethyl-1-oxy-4-hydroxypiperidine;   2,2,6,6-tetramethyl-4-hydroxypiperidin-1-oxyl;   2,2,6,6-tetramethyl-4-hydroxypiperidine 1-oxide radical;   2,2,6,6-tetramethyl-4-hydroxypiperidine-1-oxyl;   2,2,6,6-tetramethyl-4-hydroxypiperidinooxy;   2,2,6,6-tetramethyl-4-hydroxypiperidinooxy radical;   2,2,6,6-tetramethyl-4-hydroxypiperidyl 1-oxyl;   2,2,6,6-tetramethyl-4-oxypiperidine-1-oxyl;   2,2,6,6-tetramethyl-4-piperidinol 1-oxide;   2,2,6,6-tetramethyl-4-piperidinol 1-oxyl;   2,2,6,6-tetramethyl-4-piperidinol N-oxyl;   2,2,6,6-tetramethyl-4-piperidinol nitroxide;   2,2,6,6-tetramethyl-4-piperidinol-1-oxy;   2,2,6,6-tetramethyl-4-piperidinol-1-oxyl radical;   2,2,6,6-tetramethylpiperidine-N-oxyl-4-ol;   4-Hydroxy-2,2,6,6-tetramethylpiperidinyloxyl;   4-OH-TEMPO;   4-hydroxy-2,2,6,6-tetramethyl-1-piperidinoxyl;   4-hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy;   4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl;   4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl;   4-hydroxy-2,2,6,6-tetramethylpiperidine N-oxide;   4-hydroxy-2,2,6,6-tetramethylpiperidinooxy;   4-hydroxy-2,2,6,6-tetramethylpiperidinooxy radical;   4-hydroxy-TEMPO free radical;   Formula=C9H18NO2;   HyTEMPO;   InChI=1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3;   InChIKey=UZFMOKQJFYMBGY-UHFFFAOYSA-N;   SMILES=CC1(C)CC(O)CC(C)(C)N1[O];   TEMPOL;   TMPN;   Tanol
 xref: CAS:2226-96-2;   Chemspider:121639;   DrugBank:DB12449
 xref_mesh: MESH:C001803
 xref: PMID:24769526;   PMID:2610866;   PMID:27044831;   PMID:28320189;   PMID:28714295;   PMID:30549080;   PMID:30924375;   PMID:31504248;   PMID:31825758;   PMID:32366855;   PMID:32573229;   PMID:32726580;   PMID:33061560;   PMID:33078650;   PMID:33098599;   PMID:33467068;   PMID:33669093;   PMID:34248639;   PMID:34290305;   PMID:34425240;   PMID:34522067;   PMID:34630119;   PMID:34632934;   Reaxys:11328213;   Wikipedia:4-Hydroxy-TEMPO



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4-hydroxy-TEMPO term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP tempol inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein] CTD PMID:25204689 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503
JBrowse link
G Agt angiotensinogen multiple interactions EXP
ISO
tempol inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 mRNA]; tempol inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 protein]; tempol inhibits the reaction [AGT protein results in decreased export of Sodium]; tempol inhibits the reaction [AGT protein results in increased abundance of Oxygen]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]
tempol inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]; tempol inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; tempol inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]; tempol inhibits the reaction [ATP7A mutant form inhibits the reaction [AGT protein results in increased susceptibility to Acetylcholine]]; tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]]; tempol promotes the reaction [ATOX1 protein inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]]
CTD PMID:14597645 PMID:17391658 PMID:17620961 PMID:18250367 PMID:18768397 More... NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO tempol inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA] CTD PMID:17620961 NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,381,467...34,435,660
JBrowse link
G Agtr1b angiotensin II receptor, type 1b multiple interactions ISO tempol inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA] CTD PMID:17620961 NCBI chr 2:104,774,005...104,849,262
Ensembl chr 2:104,773,930...104,849,310
JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation ISO tempol affects the phosphorylation of AKT1 protein CTD PMID:24550650 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO tempol inhibits the reaction [APOE gene mutant form results in decreased susceptibility to Arachidonic Acid]
tempol inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]
CTD PMID:20530721 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855
JBrowse link
G Atox1 antioxidant 1 copper chaperone multiple interactions ISO tempol promotes the reaction [ATOX1 protein inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]] CTD PMID:22753205 NCBI chr10:40,065,525...40,080,627
Ensembl chr10:40,065,527...40,080,585
JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO tempol inhibits the reaction [ATP7A mutant form inhibits the reaction [AGT protein results in increased susceptibility to Acetylcholine]]; tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]] CTD PMID:18768397 NCBI chr  X:75,159,635...75,267,094
Ensembl chr  X:75,159,782...75,267,093
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression
decreases expression
ISO
EXP
tempol affects the expression of BAX protein
tempol results in decreased expression of BAX protein
CTD PMID:18714161 PMID:24550650 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO tempol affects the expression of BCL2 protein CTD PMID:24550650 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G C1qa complement C1q A chain decreases expression ISO tempol results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:154,417,087...154,427,732
JBrowse link
G C4b complement C4B decreases expression ISO tempol results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,201,961...4,216,289
JBrowse link
G Casp1 caspase 1 multiple interactions ISO tempol inhibits the reaction [7-ketocholesterol results in increased activity of CASP1 protein]; tempol inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein] CTD PMID:28633109 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO
EXP
[tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein]
tempol results in decreased expression of CASP3 protein
CTD PMID:18714161 PMID:20153346 PMID:20371263 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Casp7 caspase 7 multiple interactions ISO tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein]; tempol results in increased cleavage of and results in increased activity of CASP7 protein CTD PMID:20371263 PMID:26177467 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512
JBrowse link
G Casp9 caspase 9 decreases expression EXP tempol results in decreased expression of CASP9 protein CTD PMID:18714161 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions EXP CAT protein results in increased susceptibility to [tert-Butylhydroperoxide co-treated with Desoxycorticosterone co-treated with tempol] CTD PMID:12646410 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP tempol results in decreased expression of CCN2 mRNA CTD PMID:16685210 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO tempol results in decreased expression of CCND1 protein CTD PMID:26177467 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
JBrowse link
G Cd38 CD38 molecule multiple interactions ISO tempol inhibits the reaction [Superoxides affects the localization of CD38 protein] CTD PMID:23940720 NCBI chr14:71,384,532...71,424,794
Ensembl chr14:71,384,532...71,424,505
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO tempol promotes the reaction [CDKN1A protein results in increased susceptibility to Doxorubicin]
tempol results in increased expression of CDKN1A protein
CTD PMID:15601469 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
JBrowse link
G Ctss cathepsin S decreases expression ISO tempol results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 2:185,775,316...185,803,440
Ensembl chr 2:185,775,296...185,803,440
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO tempol results in decreased expression of CXCL14 mRNA CTD PMID:19555370 NCBI chr17:8,323,150...8,331,176
Ensembl chr17:8,323,143...8,331,172
JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression EXP tempol results in decreased expression of CYBA mRNA CTD PMID:16685210 NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214
JBrowse link
G Cybb cytochrome b-245 beta chain decreases expression EXP tempol results in decreased expression of CYBB; tempol results in decreased expression of CYBB mRNA CTD PMID:16685210 PMID:20943769 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP tempol inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine] CTD PMID:7710944 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP tempol inhibits the reaction [Streptozocin results in increased phosphorylation of DRD1 protein] CTD PMID:16478977 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166
JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions
EXP
ISO
tempol results in decreased expression of EDN1 mRNA; tempol results in decreased expression of EDN1 protein
tempol inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]
CTD PMID:17391658 PMID:28039404 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,660,799...22,666,687
JBrowse link
G Epas1 endothelial PAS domain protein 1 affects localization ISO tempol affects the localization of EPAS1 protein CTD PMID:24755467 NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:13,544,389...13,624,729
JBrowse link
G Epo erythropoietin multiple interactions ISO tempol inhibits the reaction [sodium arsenate results in increased expression of EPO mRNA]; tempol inhibits the reaction [sodium arsenate results in increased expression of EPO protein] CTD PMID:36513130 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:24,841,285...24,844,725
JBrowse link
G Fancd2 FA complementation group D2 decreases response to substance ISO tempol results in decreased susceptibility to FANCD2 gene mutant form CTD PMID:22628295 NCBI chr 4:148,234,633...148,299,035
Ensembl chr 4:148,234,708...148,299,035
JBrowse link
G Foxo3 forkhead box O3 affects phosphorylation ISO tempol affects the phosphorylation of FOXO3 protein CTD PMID:24550650 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO NFE2L2 protein affects the reaction [tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of FTH1 protein]]; tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of FTH1 protein] CTD PMID:38454815 NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP
ISO
tempol inhibits the reaction [Aldosterone results in increased expression of GCLC protein]
NFE2L2 protein affects the reaction [tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of GCLC protein]]; tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of GCLC protein]; tempol promotes the reaction [NFE2L2 protein inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of GCLC protein]]
CTD PMID:24512358 PMID:25204689 PMID:38454815 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO NFE2L2 protein affects the reaction [tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of GCLM protein]]; tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of GCLM protein]; tempol promotes the reaction [NFE2L2 protein inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of GCLM protein]] CTD PMID:38454815 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [tempol co-treated with Tobacco Smoke Pollution] results in increased expression of GPX2 mRNA; tempol promotes the reaction [Tobacco Smoke Pollution results in increased expression of GPX2 protein] CTD PMID:32726580 NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862
JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression
multiple interactions
ISO tempol results in increased expression of GPX4 mRNA
NFE2L2 protein affects the reaction [tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of GPX4 protein]]; tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of GPX4 protein]
CTD PMID:22221582 PMID:38454815 NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 multiple interactions EXP tempol inhibits the reaction [Streptozocin results in increased localization of GRK2 protein] CTD PMID:16478977 NCBI chr 1:211,010,259...211,031,013
Ensembl chr 1:211,009,978...211,031,015
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP tempol inhibits the reaction [Nitric Oxide deficiency results in increased expression of GSR protein] CTD PMID:15925750 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
EXP tempol inhibits the reaction [Sodium Chloride results in increased expression of HIF1A protein]
tempol results in increased expression of HIF1A protein
CTD PMID:12595275 PMID:20232302 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO tempol inhibits the reaction [Asbestos, Crocidolite results in decreased activity of HMGCR protein]; tempol inhibits the reaction [Vitamin K 3 results in decreased activity of HMGCR protein] CTD PMID:21257924 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
tempol results in increased expression of HMOX1 mRNA
[tempol co-treated with Tobacco Smoke Pollution] results in increased expression of HMOX1 mRNA; tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]
NFE2L2 protein affects the reaction [tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]]; tempol promotes the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of HMOX1 protein]
CTD PMID:12595275 PMID:32726580 PMID:38454815 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO tempol inhibits the reaction [PRKAA2 protein affects the expression of HSPA5 protein] CTD PMID:21145922 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
JBrowse link
G Htra2 HtrA serine peptidase 2 multiple interactions ISO [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione affects the localization of HTRA2 protein] CTD PMID:20153346 NCBI chr 4:117,114,631...117,117,793
Ensembl chr 4:117,114,633...117,117,793
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon decreases expression ISO tempol results in decreased expression of IKBKE protein CTD PMID:26177467 NCBI chr13:45,264,404...45,290,737
Ensembl chr13:45,264,412...45,289,396
JBrowse link
G Il10 interleukin 10 multiple interactions ISO tempol inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of IL10 mRNA] CTD PMID:32726580 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Il17a interleukin 17A multiple interactions ISO tempol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL17A mRNA] CTD PMID:32726580 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO
tempol inhibits the reaction [Phenol results in decreased expression of IL1B mRNA]
tempol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL1B mRNA]
CTD PMID:16785328 PMID:32726580 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 multiple interactions ISO tempol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA]
tempol inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of and results in increased secretion of IL6 protein]
CTD PMID:24296301 PMID:32726580 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Ireb2 iron responsive element binding protein 2 increases expression ISO tempol results in increased expression of IREB2 protein CTD PMID:18073202 NCBI chr 8:64,124,152...64,207,702
Ensembl chr 8:64,154,945...64,205,520
JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO tempol inhibits the reaction [Benzene results in decreased phosphorylation of IRS2 protein] CTD PMID:30346588 NCBI chr16:85,190,310...85,214,543
Ensembl chr16:85,190,111...85,214,543
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO tempol inhibits the reaction [Paraquat results in increased expression of JUN mRNA] CTD PMID:7662713 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO tempol inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]] CTD PMID:20530721 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675
JBrowse link
G Lep leptin multiple interactions EXP tempol inhibits the reaction [LEP protein results in decreased activity of PON1 protein] CTD PMID:15829432 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
JBrowse link
G Lepr leptin receptor multiple interactions ISO tempol inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine] CTD PMID:19478208 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tempol results in increased phosphorylation of MAPK1 protein] CTD PMID:20056918 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tempol results in increased phosphorylation of MAPK3 protein] CTD PMID:20056918 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mir322 microRNA 322 multiple interactions ISO tempol inhibits the reaction [Glucose results in decreased expression of MIR322] CTD PMID:25516495 NCBI chr  X:137,726,147...137,726,241 JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity EXP tempol results in increased activity of MMP2 protein CTD PMID:17196988 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity EXP tempol results in increased activity of MMP9 protein CTD PMID:17196988 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO tempol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased activity of MPO protein] CTD PMID:32726580 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases ubiquitination
EXP
ISO
tempol inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]
NFE2L2 protein affects the reaction [tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of FTH1 protein]]; NFE2L2 protein affects the reaction [tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of GPX4 protein]]; NFE2L2 protein affects the reaction [tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NFE2L2 protein]]; NFE2L2 protein affects the reaction [tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SLC7A11 protein]]; NFE2L2 protein affects the reaction [tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of GCLC protein]]; NFE2L2 protein affects the reaction [tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of GCLM protein]]; tempol promotes the reaction [NFE2L2 protein inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of NFE2L2 protein]]; tempol promotes the reaction [NFE2L2 protein inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SLC7A11 protein]]; tempol promotes the reaction [NFE2L2 protein inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of GCLC protein]]; tempol promotes the reaction [NFE2L2 protein inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of GCLM protein]]
tempol results in decreased ubiquitination of NFE2L2 protein
CTD PMID:25204689 PMID:38454815 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP tempol inhibits the reaction [copper histidine results in increased activity of NFKB1 protein]; tempol inhibits the reaction [Copper results in increased activity of NFKB1 protein] CTD PMID:16987042 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO tempol inhibits the reaction [Particulate Matter results in decreased expression of NFKBIA protein] CTD PMID:27128347 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tempol results in increased phosphorylation of NOS1 protein]; tempol inhibits the reaction [lead acetate results in increased expression of NOS1 protein]; tempol inhibits the reaction [Phenol results in decreased expression of NOS1 mRNA] CTD PMID:11454931 PMID:16785328 PMID:20056918 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP tempol inhibits the reaction [copper histidine results in increased expression of NOS2 protein]; tempol inhibits the reaction [Copper results in increased expression of NOS2 protein]; tempol inhibits the reaction [lead acetate results in increased expression of NOS2 protein] CTD PMID:11454931 PMID:16987042 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP
ISO
tempol inhibits the reaction [lead acetate results in increased expression of NOS3 protein]; tempol inhibits the reaction [Sodium Chloride results in decreased expression of NOS3 protein] CTD PMID:11230275 PMID:11454931 PMID:20232302 NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO tempol inhibits the reaction [Paraquat results in increased activity of ODC1 protein] CTD PMID:7662713 NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146
JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO tempol results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr 7:23,793,096...23,885,631
Ensembl chr 7:23,792,781...23,885,627
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO tempol inhibits the reaction [sodium arsenite results in increased expression of PECAM1 protein] CTD PMID:19033667 NCBI chr10:92,090,263...92,152,002
Ensembl chr10:92,090,235...92,151,839
JBrowse link
G Pon1 paraoxonase 1 multiple interactions EXP tempol inhibits the reaction [LEP protein results in decreased activity of PON1 protein] CTD PMID:15829432 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions ISO tempol inhibits the reaction [PRKAA2 protein affects the expression of HSPA5 protein] CTD PMID:21145922 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324
JBrowse link
G Prkcb protein kinase C, beta multiple interactions EXP tempol inhibits the reaction [Streptozocin results in increased expression of and results in increased activity of PRKCB protein] CTD PMID:16478977 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740
JBrowse link
G Prkcd protein kinase C, delta multiple interactions EXP tempol inhibits the reaction [Streptozocin results in increased expression of and results in increased activity of PRKCD protein] CTD PMID:16478977 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions EXP tempol inhibits the reaction [Glucose results in decreased expression of PRKG1 protein] CTD PMID:17320767 NCBI chr 1:237,818,950...239,052,184
Ensembl chr 1:237,823,053...239,103,005
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP tempol inhibits the reaction [Ketoconazole results in increased expression of PRKN mRNA]; tempol inhibits the reaction [Ketoconazole results in increased expression of PRKN protein] CTD PMID:25787151 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP tempol inhibits the reaction [copper histidine results in increased expression of PTGS2 mRNA]; tempol inhibits the reaction [Copper results in increased expression of PTGS2 mRNA]; tempol inhibits the reaction [Lead results in increased expression of PTGS2 mRNA]; tempol inhibits the reaction [Mercuric Chloride results in increased expression of PTGS2 mRNA] CTD PMID:16987042 PMID:23415682 PMID:25596430 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
tempol inhibits the reaction [Benzene results in increased phosphorylation of RELA protein]
tempol inhibits the reaction [copper histidine results in increased activity of RELA protein]; tempol inhibits the reaction [Copper results in increased activity of RELA protein]
CTD PMID:16987042 PMID:30346588 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP
ISO
tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]
tempol inhibits the reaction [Asbestos, Crocidolite inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]]; tempol inhibits the reaction [Asbestos, Crocidolite results in decreased prenylation of RHOA protein]; tempol inhibits the reaction [Vitamin K 3 inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]]; tempol inhibits the reaction [Vitamin K 3 results in decreased prenylation of RHOA protein]
CTD PMID:18250367 PMID:21257924 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions EXP tempol inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 mRNA]; tempol inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 protein] CTD PMID:29609002 NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:205,900,836...206,328,689
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO tempol inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]; tempol inhibits the reaction [Hydrogen Peroxide results in increased expression of SERPINE1 mRNA] CTD PMID:17620961 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357
JBrowse link
G Skap2 src kinase associated phosphoprotein 2 decreases expression ISO tempol results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 4:82,281,221...82,431,664
Ensembl chr 4:82,263,709...82,432,886
JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions EXP tempol inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; tempol inhibits the reaction [Manganese results in increased oxidation of SLC12A2 protein] CTD PMID:25817889 NCBI chr18:53,546,263...53,614,478
Ensembl chr18:53,546,333...53,614,470
JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions ISO tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SLC7A11 protein]
NFE2L2 protein affects the reaction [tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SLC7A11 protein]]; tempol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SLC7A11 protein]; tempol promotes the reaction [NFE2L2 protein inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SLC7A11 protein]]
CTD PMID:38454815 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695
JBrowse link
G Socs1 suppressor of cytokine signaling 1 multiple interactions ISO tempol inhibits the reaction [Benzene results in increased expression of SOCS1 mRNA] CTD PMID:30346588 NCBI chr10:5,389,574...5,391,265
Ensembl chr10:5,389,334...5,391,847
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP tempol inhibits the reaction [Desoxycorticosterone results in decreased expression of SOD1 protein] CTD PMID:12646410 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
JBrowse link
G Sod2 superoxide dismutase 2 affects expression
multiple interactions
ISO
EXP
tempol affects the expression of SOD2 protein
tempol inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of SOD2 protein]; tempol inhibits the reaction [Nitric Oxide deficiency results in increased expression of SOD2 protein]
tempol affects the reaction [SOD2 protein affects the susceptibility to Acetylcholine]; tempol inhibits the reaction [Capsaicin results in decreased activity of SOD2 protein]; tempol inhibits the reaction [Capsaicin results in increased expression of SOD2 protein modified form]
CTD PMID:15925750 PMID:17693941 PMID:19129394 PMID:20304815 PMID:24550650 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
JBrowse link
G Tfrc transferrin receptor increases expression ISO tempol results in increased expression of TFRC protein CTD PMID:18073202 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318
JBrowse link
G Tgfb1 transforming growth factor, beta 1 affects expression
multiple interactions
ISO
EXP
tempol affects the expression of TGFB1 protein
tempol inhibits the reaction [Aldosterone results in increased expression of TGFB1 mRNA]; tempol inhibits the reaction [Sodium Chloride results in increased expression of TGFB1 protein]
tempol inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of TGFB1 mRNA]
CTD PMID:20232302 PMID:24550650 PMID:25204689 PMID:32726580 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein]; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein]
tempol inhibits the reaction [copper histidine results in increased expression of TNF protein]; tempol inhibits the reaction [Copper results in increased expression of TNF protein]
tempol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; tempol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF mRNA]
CTD PMID:15795323 PMID:16987042 PMID:20371263 PMID:32726580 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tp53 tumor protein p53 increases expression ISO tempol results in increased expression of TP53 protein CTD PMID:15601469 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
G Traf3 Tnf receptor-associated factor 3 multiple interactions ISO tempol inhibits the reaction [Glucose results in increased expression of TRAF3 protein] CTD PMID:25516495 NCBI chr 6:136,025,097...136,128,363
Ensembl chr 6:136,027,157...136,128,363
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 multiple interactions ISO tempol inhibits the reaction [Arsenic Trioxide results in increased expression of TRPM4 protein] CTD PMID:31054354 NCBI chr 1:104,918,462...104,949,453
Ensembl chr 1:104,918,462...104,948,653
JBrowse link
G Ucp2 uncoupling protein 2 decreases expression
increases expression
EXP tempol results in decreased expression of UCP2 mRNA
tempol results in increased expression of UCP2 protein
CTD PMID:16685210 PMID:24591154 NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20870
    role 20828
      chemical role 20407
        catalyst 8405
          4-hydroxy-TEMPO 94
            4-hydroxy-TEMPO benzoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20870
    subatomic particle 20868
      composite particle 20868
        hadron 20868
          baryon 20868
            nucleon 20868
              atomic nucleus 20868
                atom 20868
                  main group element atom 20791
                    p-block element atom 20791
                      carbon group element atom 20724
                        carbon atom 20719
                          organic molecular entity 20719
                            organic molecule 20663
                              organic cyclic compound 20413
                                organic heterocyclic compound 19385
                                  organic heteromonocyclic compound 18213
                                    piperidines 7814
                                      TEMPO 109
                                        4-hydroxy-TEMPO 94
                                          4-hydroxy-TEMPO benzoate 0
paths to the root