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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-hydroxy-TEMPO
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Accession:CHEBI:180664 term browser browse the term
Definition:A member of the class of aminoxyls that is TEMPO carrying a hydroxy substituent at position 4. It is a radical scavenger which exhibits anti-inflammatory and analgesic properties.
Synonyms:exact_synonym: (4-hydroxy-2,2,6,6-tetramethylpiperidin-1-yl)oxidanyl
 related_synonym: 2,2,6,6-tetramethyl-1-oxy-4-hydroxypiperidine;   2,2,6,6-tetramethyl-4-hydroxypiperidin-1-oxyl;   2,2,6,6-tetramethyl-4-hydroxypiperidine 1-oxide radical;   2,2,6,6-tetramethyl-4-hydroxypiperidine-1-oxyl;   2,2,6,6-tetramethyl-4-hydroxypiperidinooxy;   2,2,6,6-tetramethyl-4-hydroxypiperidinooxy radical;   2,2,6,6-tetramethyl-4-hydroxypiperidyl 1-oxyl;   2,2,6,6-tetramethyl-4-oxypiperidine-1-oxyl;   2,2,6,6-tetramethyl-4-piperidinol 1-oxide;   2,2,6,6-tetramethyl-4-piperidinol 1-oxyl;   2,2,6,6-tetramethyl-4-piperidinol N-oxyl;   2,2,6,6-tetramethyl-4-piperidinol nitroxide;   2,2,6,6-tetramethyl-4-piperidinol-1-oxy;   2,2,6,6-tetramethyl-4-piperidinol-1-oxyl radical;   2,2,6,6-tetramethylpiperidine-N-oxyl-4-ol;   4-Hydroxy-2,2,6,6-tetramethylpiperidinyloxyl;   4-OH-TEMPO;   4-hydroxy-2,2,6,6-tetramethyl-1-piperidinoxyl;   4-hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy;   4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl;   4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl;   4-hydroxy-2,2,6,6-tetramethylpiperidine N-oxide;   4-hydroxy-2,2,6,6-tetramethylpiperidinooxy;   4-hydroxy-2,2,6,6-tetramethylpiperidinooxy radical;   4-hydroxy-TEMPO free radical;   Formula=C9H18NO2;   HyTEMPO;   InChI=1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3;   InChIKey=UZFMOKQJFYMBGY-UHFFFAOYSA-N;   SMILES=CC1(C)CC(O)CC(C)(C)N1[O];   TEMPOL;   TMPN;   Tanol
 xref: CAS:2226-96-2;   Chemspider:121639;   DrugBank:DB12449
 xref_mesh: MESH:C001803
 xref: PMID:24769526;   PMID:2610866;   PMID:27044831;   PMID:28320189;   PMID:28714295;   PMID:30549080;   PMID:30924375;   PMID:31504248;   PMID:31825758;   PMID:32366855;   PMID:32573229;   PMID:32726580;   PMID:33061560;   PMID:33078650;   PMID:33098599;   PMID:33467068;   PMID:33669093;   PMID:34248639;   PMID:34290305;   PMID:34425240;   PMID:34522067;   PMID:34630119;   PMID:34632934;   Reaxys:11328213;   Wikipedia:4-Hydroxy-TEMPO


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4-hydroxy-TEMPO term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP tempol inhibits the reaction [Aldosterone results in increased expression of ACTA2 protein] CTD PMID:25204689 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agt angiotensinogen multiple interactions EXP
ISO		 tempol inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 mRNA]; tempol inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 protein]; tempol inhibits the reaction [AGT protein results in decreased export of Sodium]; tempol inhibits the reaction [AGT protein results in increased abundance of Oxygen]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]
tempol inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]; tempol inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; tempol inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]; tempol inhibits the reaction [ATP7A mutant form inhibits the reaction [AGT protein results in increased susceptibility to Acetylcholine]]; tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]]; tempol promotes the reaction [ATOX1 protein inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]]		 CTD PMID:14597645 PMID:17391658 PMID:17620961 PMID:18250367 PMID:18768397 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO tempol inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA] CTD PMID:17620961 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b multiple interactions ISO tempol inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA] CTD PMID:17620961 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation ISO tempol affects the phosphorylation of AKT1 protein CTD PMID:24550650 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apoe apolipoprotein E multiple interactions ISO tempol inhibits the reaction [APOE gene mutant form results in decreased susceptibility to Arachidonic Acid]
tempol inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]		 CTD PMID:20530721 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Atox1 antioxidant 1 copper chaperone multiple interactions ISO tempol promotes the reaction [ATOX1 protein inhibits the reaction [AGT protein modified form results in decreased susceptibility to Acetylcholine]] CTD PMID:22753205 NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950 		JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO tempol inhibits the reaction [ATP7A mutant form inhibits the reaction [AGT protein results in increased susceptibility to Acetylcholine]]; tempol inhibits the reaction [ATP7A mutant form promotes the reaction [AGT protein results in increased abundance of Superoxides]] CTD PMID:18768397 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression
decreases expression		 ISO
EXP		 tempol affects the expression of BAX protein
tempol results in decreased expression of BAX protein		 CTD PMID:18714161 PMID:24550650 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO tempol affects the expression of BCL2 protein CTD PMID:24550650 NCBI chr13:22,689,783...22,853,920 JBrowse link
G C1qa complement C1q A chain decreases expression ISO tempol results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C4b complement C4B (Chido blood group) decreases expression ISO tempol results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO tempol inhibits the reaction [7-ketocholesterol results in increased activity of CASP1 protein]; tempol inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein] CTD PMID:28633109 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression		 ISO
EXP		 [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein]
tempol results in decreased expression of CASP3 protein		 CTD PMID:18714161 PMID:20153346 PMID:20371263 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein]; tempol results in increased cleavage of and results in increased activity of CASP7 protein CTD PMID:20371263 PMID:26177467 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 decreases expression EXP tempol results in decreased expression of CASP9 protein CTD PMID:18714161 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP CAT protein results in increased susceptibility to [tert-Butylhydroperoxide co-treated with Desoxycorticosterone co-treated with tempol] CTD PMID:12646410 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP tempol results in decreased expression of CCN2 mRNA CTD PMID:16685210 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO tempol results in decreased expression of CCND1 protein CTD PMID:26177467 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd38 CD38 molecule multiple interactions ISO tempol inhibits the reaction [Superoxides affects the localization of CD38 protein] CTD PMID:23940720 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO tempol promotes the reaction [CDKN1A protein results in increased susceptibility to Doxorubicin]
tempol results in increased expression of CDKN1A protein		 CTD PMID:15601469 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ctss cathepsin S decreases expression ISO tempol results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO tempol results in decreased expression of CXCL14 mRNA CTD PMID:19555370 NCBI chr17:8,317,933...8,325,956
Ensembl chr17:8,317,933...8,324,839 		JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression EXP tempol results in decreased expression of CYBA mRNA CTD PMID:16685210 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain decreases expression EXP tempol results in decreased expression of CYBB; tempol results in decreased expression of CYBB mRNA CTD PMID:16685210 PMID:20943769 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP tempol inhibits the reaction [CYP2E1 protein results in increased reduction of Tirapazamine] CTD PMID:7710944 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions		 EXP
ISO		 tempol results in decreased expression of EDN1 mRNA; tempol results in decreased expression of EDN1 protein
tempol inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]		 CTD PMID:17391658 PMID:28039404 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Epas1 endothelial PAS domain protein 1 affects localization ISO tempol affects the localization of EPAS1 protein CTD PMID:24755467 NCBI chr 6:7,790,236...7,871,246
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Fancd2 FA complementation group D2 decreases response to substance ISO tempol results in decreased susceptibility to FANCD2 gene mutant form CTD PMID:22628295 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412 		JBrowse link
G Foxo3 forkhead box O3 affects phosphorylation ISO tempol affects the phosphorylation of FOXO3 protein CTD PMID:24550650 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP tempol inhibits the reaction [Aldosterone results in increased expression of GCLC protein] CTD PMID:24512358 PMID:25204689 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [tempol co-treated with Tobacco Smoke Pollution] results in increased expression of GPX2 mRNA; tempol promotes the reaction [Tobacco Smoke Pollution results in increased expression of GPX2 protein] CTD PMID:32726580 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression ISO tempol results in increased expression of GPX4 mRNA CTD PMID:22221582 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP tempol inhibits the reaction [Nitric Oxide deficiency results in increased expression of GSR protein] CTD PMID:15925750 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression		 EXP tempol inhibits the reaction [Sodium Chloride results in increased expression of HIF1A protein]
tempol results in increased expression of HIF1A protein		 CTD PMID:12595275 PMID:20232302 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO tempol inhibits the reaction [Asbestos, Crocidolite results in decreased activity of HMGCR protein]; tempol inhibits the reaction [Vitamin K 3 results in decreased activity of HMGCR protein] CTD PMID:21257924 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 EXP
ISO		 tempol results in increased expression of HMOX1 mRNA
[tempol co-treated with Tobacco Smoke Pollution] results in increased expression of HMOX1 mRNA		 CTD PMID:12595275 PMID:32726580 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO tempol inhibits the reaction [PRKAA2 protein affects the expression of HSPA5 protein] CTD PMID:21145922 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Htra2 HtrA serine peptidase 2 multiple interactions ISO [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione affects the localization of HTRA2 protein] CTD PMID:20153346 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095 		JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon decreases expression ISO tempol results in decreased expression of IKBKE protein CTD PMID:26177467 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO tempol inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of IL10 mRNA] CTD PMID:32726580 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO tempol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL17A mRNA] CTD PMID:32726580 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO		 tempol inhibits the reaction [Phenol results in decreased expression of IL1B mRNA]
tempol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL1B mRNA]		 CTD PMID:16785328 PMID:32726580 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO tempol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA]
tempol inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of and results in increased secretion of IL6 protein]		 CTD PMID:24296301 PMID:32726580 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ireb2 iron responsive element binding protein 2 increases expression ISO tempol results in increased expression of IREB2 protein CTD PMID:18073202 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611 		JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO tempol inhibits the reaction [Benzene results in decreased phosphorylation of IRS2 protein] CTD PMID:30346588 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO tempol inhibits the reaction [Paraquat results in increased expression of JUN mRNA] CTD PMID:7662713 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO tempol inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]] CTD PMID:20530721 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lep leptin multiple interactions EXP tempol inhibits the reaction [LEP protein results in decreased activity of PON1 protein] CTD PMID:15829432 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lepr leptin receptor multiple interactions ISO tempol inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine] CTD PMID:19478208 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tempol results in increased phosphorylation of MAPK1 protein] CTD PMID:20056918 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tempol results in increased phosphorylation of MAPK3 protein] CTD PMID:20056918 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mir322 microRNA 322 multiple interactions ISO tempol inhibits the reaction [Glucose results in decreased expression of MIR322] CTD PMID:25516495 NCBI chr  X:132,806,594...132,806,688
Ensembl chr  X:132,806,594...132,806,688 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity EXP tempol results in increased activity of MMP2 protein CTD PMID:17196988 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity EXP tempol results in increased activity of MMP9 protein CTD PMID:17196988 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO tempol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of and results in increased activity of MPO protein] CTD PMID:32726580 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP tempol inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:25204689 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP tempol inhibits the reaction [copper histidine results in increased activity of NFKB1 protein]; tempol inhibits the reaction [Copper results in increased activity of NFKB1 protein] CTD PMID:16987042 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO tempol inhibits the reaction [Particulate Matter results in decreased expression of NFKBIA protein] CTD PMID:27128347 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
increases phosphorylation		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tempol results in increased phosphorylation of NOS1 protein]; tempol inhibits the reaction [lead acetate results in increased expression of NOS1 protein]; tempol inhibits the reaction [Phenol results in decreased expression of NOS1 mRNA] CTD PMID:11454931 PMID:16785328 PMID:20056918 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP tempol inhibits the reaction [copper histidine results in increased expression of NOS2 protein]; tempol inhibits the reaction [Copper results in increased expression of NOS2 protein]; tempol inhibits the reaction [lead acetate results in increased expression of NOS2 protein] CTD PMID:11454931 PMID:16987042 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP
ISO		 tempol inhibits the reaction [lead acetate results in increased expression of NOS3 protein]; tempol inhibits the reaction [Sodium Chloride results in decreased expression of NOS3 protein] CTD PMID:11230275 PMID:11454931 PMID:20232302 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO tempol inhibits the reaction [Paraquat results in increased activity of ODC1 protein] CTD PMID:7662713 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Pah phenylalanine hydroxylase decreases expression ISO tempol results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO tempol inhibits the reaction [sodium arsenite results in increased expression of PECAM1 protein] CTD PMID:19033667 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions EXP tempol inhibits the reaction [LEP protein results in decreased activity of PON1 protein] CTD PMID:15829432 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions ISO tempol inhibits the reaction [PRKAA2 protein affects the expression of HSPA5 protein] CTD PMID:21145922 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions EXP tempol inhibits the reaction [Glucose results in decreased expression of PRKG1 protein] CTD PMID:17320767 NCBI chr 1:228,409,883...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP tempol inhibits the reaction [Ketoconazole results in increased expression of PRKN mRNA]; tempol inhibits the reaction [Ketoconazole results in increased expression of PRKN protein] CTD PMID:25787151 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP tempol inhibits the reaction [copper histidine results in increased expression of PTGS2 mRNA]; tempol inhibits the reaction [Copper results in increased expression of PTGS2 mRNA]; tempol inhibits the reaction [Lead results in increased expression of PTGS2 mRNA]; tempol inhibits the reaction [Mercuric Chloride results in increased expression of PTGS2 mRNA] CTD PMID:16987042 PMID:23415682 PMID:25596430 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 tempol inhibits the reaction [Benzene results in increased phosphorylation of RELA protein]
tempol inhibits the reaction [copper histidine results in increased activity of RELA protein]; tempol inhibits the reaction [Copper results in increased activity of RELA protein]		 CTD PMID:16987042 PMID:30346588 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP
ISO		 tempol inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]
tempol inhibits the reaction [Asbestos, Crocidolite inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]]; tempol inhibits the reaction [Asbestos, Crocidolite results in decreased prenylation of RHOA protein]; tempol inhibits the reaction [Vitamin K 3 inhibits the reaction [RHOA protein binds to Guanosine Triphosphate]]; tempol inhibits the reaction [Vitamin K 3 results in decreased prenylation of RHOA protein]		 CTD PMID:18250367 PMID:21257924 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions EXP tempol inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 mRNA]; tempol inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 protein] CTD PMID:29609002 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO tempol inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]; tempol inhibits the reaction [Hydrogen Peroxide results in increased expression of SERPINE1 mRNA] CTD PMID:17620961 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Skap2 src kinase associated phosphoprotein 2 decreases expression ISO tempol results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 4:80,948,832...81,100,900
Ensembl chr 4:80,950,580...81,100,891 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions EXP tempol inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; tempol inhibits the reaction [Manganese results in increased oxidation of SLC12A2 protein] CTD PMID:25817889 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 multiple interactions ISO tempol inhibits the reaction [Benzene results in increased expression of SOCS1 mRNA] CTD PMID:30346588 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP tempol inhibits the reaction [Desoxycorticosterone results in decreased expression of SOD1 protein] CTD PMID:12646410 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 affects expression
multiple interactions		 ISO
EXP		 tempol affects the expression of SOD2 protein
tempol affects the reaction [SOD2 protein affects the susceptibility to Acetylcholine]; tempol inhibits the reaction [Capsaicin results in decreased activity of SOD2 protein]; tempol inhibits the reaction [Capsaicin results in increased expression of SOD2 protein modified form]
tempol inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of SOD2 protein]; tempol inhibits the reaction [Nitric Oxide deficiency results in increased expression of SOD2 protein]		 CTD PMID:15925750 PMID:17693941 PMID:19129394 PMID:20304815 PMID:24550650 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tfrc transferrin receptor increases expression ISO tempol results in increased expression of TFRC protein CTD PMID:18073202 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 affects expression
multiple interactions		 ISO
EXP		 tempol affects the expression of TGFB1 protein
tempol inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of TGFB1 mRNA]
tempol inhibits the reaction [Aldosterone results in increased expression of TGFB1 mRNA]; tempol inhibits the reaction [Sodium Chloride results in increased expression of TGFB1 protein]		 CTD PMID:20232302 PMID:24550650 PMID:25204689 PMID:32726580 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein]; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein]
tempol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; tempol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF mRNA]
tempol inhibits the reaction [copper histidine results in increased expression of TNF protein]; tempol inhibits the reaction [Copper results in increased expression of TNF protein]		 CTD PMID:15795323 PMID:16987042 PMID:20371263 PMID:32726580 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO tempol results in increased expression of TP53 protein CTD PMID:15601469 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Traf3 Tnf receptor-associated factor 3 multiple interactions ISO tempol inhibits the reaction [Glucose results in increased expression of TRAF3 protein] CTD PMID:25516495 NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 multiple interactions ISO tempol inhibits the reaction [Arsenic Trioxide results in increased expression of TRPM4 protein] CTD PMID:31054354 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532 		JBrowse link
G Ucp2 uncoupling protein 2 decreases expression
increases expression		 EXP tempol results in decreased expression of UCP2 mRNA
tempol results in increased expression of UCP2 protein		 CTD PMID:16685210 PMID:24591154 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      chemical role 19589
        catalyst 8101
          4-hydroxy-TEMPO 86
            4-hydroxy-TEMPO benzoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  organic heteromonocyclic compound 17151
                                    piperidines 7696
                                      TEMPO 101
                                        4-hydroxy-TEMPO 86
                                          4-hydroxy-TEMPO benzoate 0
paths to the root