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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N(4)-hydroxycytidine
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Accession:CHEBI:180654 term browser browse the term
Definition:A nucleoside analogue that is cytidine which carries a hydroxy group at the N(4)-positon. It has broad-spectrum antiviral activity against influenza, SARS-CoV , SARS-CoV-2 and MERS-CoV.
Synonyms:exact_synonym: N-hydroxy-3,4-dihydrocytidine
 related_synonym: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1H)-one;   4-oxime uridine;   EIDD 1931;   Formula=C9H13N3O6;   InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6-,7-,8-/m1/s1;   InChIKey=XCUAIINAJCDIPM-XVFCMESISA-N;   N-hydroxycytidine;   NHC;   SMILES=OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(NC1=O)=NO;   beta-D-N(4)-hydroxycytidine
 xref: CAS:3258-02-4;   Chemspider:170635;   DrugBank:DB15660
 xref_mesh: MESH:C010737
 xref: PMID:31494195;   PMID:31578288;   PMID:31645453;   PMID:32253226;   PMID:33290476;   PMID:33327924;   PMID:33649113;   PMID:33807492;   PMID:33989635;   PMID:34186107;   PMID:34357881;   PMID:34381216;   PMID:34503974;   PMID:34509661



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N(4)-hydroxycytidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5b cytochrome b5 type B multiple interactions ISO [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC1 protein] results in increased reduction of N(4)-hydroxycytidine; [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC2 protein] results in increased reduction of N(4)-hydroxycytidine CTD PMID:22924387 NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249
JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 multiple interactions ISO [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC1 protein] results in increased reduction of N(4)-hydroxycytidine; [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC2 protein] results in increased reduction of N(4)-hydroxycytidine CTD PMID:22924387 NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298
JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions ISO [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC1 protein] results in increased reduction of N(4)-hydroxycytidine CTD PMID:22924387 NCBI chr13:96,324,377...96,362,677
Ensembl chr13:96,339,757...96,397,796
JBrowse link
G Mtarc2 mitochondrial amidoxime reducing component 2 multiple interactions ISO [CYB5B protein co-treated with CYB5R3 protein co-treated with MTARC2 protein] results in increased reduction of N(4)-hydroxycytidine CTD PMID:22924387 NCBI chr13:96,362,810...96,397,284 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20024
      biological role 20023
        antimicrobial agent 17788
          antiviral agent 10536
            N(4)-hydroxycytidine 4
              molnupiravir 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19894
                        carbon atom 19887
                          organic molecular entity 19887
                            heteroorganic entity 19577
                              organochalcogen compound 19339
                                organooxygen compound 19239
                                  carbohydrates and carbohydrate derivatives 13962
                                    carbohydrate 13962
                                      carbohydrate derivative 13693
                                        glycosyl compound 12943
                                          N-glycosyl compound 5605
                                            nucleoside 5460
                                              ribonucleoside 701
                                                pyrimidine ribonucleosides 162
                                                  cytidines 77
                                                    cytidine 14
                                                      N(4)-hydroxycytidine 4
                                                        molnupiravir 0
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