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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:molnupiravir
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Accession:CHEBI:180653 term browser browse the term
Definition:A nucleoside analogue that is N(4)-hydroxycytidine in which the 5'-hydroxy group is replaced by a (2-methylpropanoyl)oxy group. It is the prodrug of the active antiviral ribonucleoside analog N(4)-hydroxycytidine (EIDD-1931), has activity against a number of RNA viruses including SARS-CoV-2, MERS-CoV, and seasonal and pandemic influenza viruses. It is currently in phase III trials for the treatment of patients with COVID-19.
Synonyms:exact_synonym: N-hydroxy-5'-O-(2-methylpropanoyl)-3,4-dihydrocytidine
 related_synonym: EIDD 1931 5'-isopropylester;   EIDD-2801;   Formula=C13H19N3O7;   InChI=1S/C13H19N3O7/c1-6(2)12(19)22-5-7-9(17)10(18)11(23-7)16-4-3-8(15-21)14-13(16)20/h3-4,6-7,9-11,17-18,21H,5H2,1-2H3,(H,14,15,20)/t7-,9-,10-,11-/m1/s1;   InChIKey=HTNPEHXGEKVIHG-QCNRFFRDSA-N;   MK-4482;   N(4)-hydroxycytidine 5'-isopropylester;   SMILES=CC(C)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(NC1=O)=NO;   beta-D-N(4)-hydroxycytidine-5'-isopropyl ester;   molnupiravirum;   {(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl]tetrahydrofuran-2-yl}methyl 2-methylpropanoate
 xref: CAS:2349386-89-4;   CAS:2492423-29-5;   Chemspider:84400552;   KEGG:D11943;   PMCID:PMC8461366;   PMID:31645453;   PMID:31910262;   PMID:31945316;   PMID:32253226;   PMID:32503814;   PMID:32714193;   PMID:33030468;   PMID:33273742;   PMID:33290476;   PMID:33561864;   PMID:33588727;   PMID:33649113;   PMID:33664631;   PMID:33863887;   PMID:33902254;   PMID:33961695;   PMID:33989635;   PMID:34056192;   PMID:34118236;   PMID:34244768;   PMID:34271264;   PMID:34337170;   PMID:34381216;   PMID:34425873;   PMID:34509661;   PMID:34518697;   PMID:34571361;   Wikipedia:Molnupiravir



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Path 1
Term Annotations click to browse term
  CHEBI ontology 19863
    role 19835
      application 19677
        pro-agent 11550
          prodrug 11311
            molnupiravir 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19863
    subatomic particle 19861
      composite particle 19861
        hadron 19861
          baryon 19861
            nucleon 19861
              atomic nucleus 19861
                atom 19861
                  main group element atom 19807
                    p-block element atom 19807
                      carbon group element atom 19748
                        carbon atom 19744
                          organic molecular entity 19744
                            heteroorganic entity 19498
                              organochalcogen compound 19259
                                organooxygen compound 19175
                                  carbohydrates and carbohydrate derivatives 15294
                                    carbohydrate 15294
                                      carbohydrate derivative 14300
                                        glycosyl compound 13053
                                          N-glycosyl compound 5828
                                            nucleoside 5684
                                              ribonucleoside 1141
                                                pyrimidine ribonucleosides 417
                                                  cytidines 330
                                                    cytidine 245
                                                      N(4)-hydroxycytidine 235
                                                        molnupiravir 0
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