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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:piperidine
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Accession:CHEBI:18049 term browser browse the term
Definition:An azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. It is a metabolite of cadaverine, a polyamine found in the human intestine.
Synonyms:related_synonym: Azacyclohexane;   Formula=C5H11N;   Hexahydropyridine;   InChI=1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2;   InChIKey=NQRYJNQNLNOLGT-UHFFFAOYSA-N;   Piperidin;   SMILES=C1CCNCC1;   azinane;   cyclopentimine;   cypentil;   hexazane;   pentamethyleneamine;   pentamethyleneimine;   pentamethylenimine;   perhydropyridine;   pip
 alt_id: CHEBI:14841;   CHEBI:26146;   CHEBI:45123;   CHEBI:8238
 xref: CAS:110-89-4;   Chemspider:7791;   FooDB:FDB012644;   HMDB:HMDB0034301;   KEGG:C01746;   KNApSAcK:C00051876
 xref_mesh: MESH:C032727
 xref: MetaCyc:PIPERIDINE;   PDBeChem:PIP;   PMID:12355363;   PMID:15017096;   PMID:15412;   PMID:25897321;   PMID:32120931;   PMID:33021609;   PMID:5300194;   PMID:5308835;   PMID:799462;   Reaxys:102438;   Wikipedia:Piperidine
 cyclic_relationship: is_conjugate_base_of CHEBI:589779


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piperidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Yt blood group) decreases activity
multiple interactions		 EXP piperidine analog results in decreased activity of ACHE protein
piperidine analog inhibits the reaction [ACHE protein promotes the reaction [APP protein binds to APP protein]]		 CTD PMID:17681794 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G APP amyloid beta precursor protein multiple interactions EXP piperidine analog inhibits the reaction [ACHE protein promotes the reaction [APP protein binds to APP protein]]; piperidine analog inhibits the reaction [APP protein binds to APP protein] CTD PMID:17681794 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G BCHE butyrylcholinesterase decreases activity EXP piperidine analog results in decreased activity of BCHE protein CTD PMID:17681794 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO piperidine inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein] CTD PMID:17706638 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CASP3 caspase 3 multiple interactions ISO piperidine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein] CTD PMID:17706638 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G IFNG interferon gamma multiple interactions ISO piperidine inhibits the reaction [Cadmium Chloride results in decreased secretion of IFNG protein] CTD PMID:17706638 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL2 interleukin 2 decreases expression
multiple interactions		 EXP
ISO		 piperidine analog results in decreased expression of IL2 mRNA
piperidine inhibits the reaction [Cadmium Chloride results in decreased secretion of IL2 protein]		 CTD PMID:11859000 PMID:17706638 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G SRD5A1 steroid 5 alpha-reductase 1 decreases activity EXP
ISO		 piperidine analog results in decreased activity of SRD5A1 protein CTD PMID:10896124 NCBI chr 5:6,633,440...6,674,386
Ensembl chr 5:6,633,290...6,676,539 		JBrowse link
G SRD5A2 steroid 5 alpha-reductase 2 decreases activity EXP
ISO		 piperidine analog results in decreased activity of SRD5A2 protein CTD PMID:10896124 NCBI chr 2:31,522,480...31,663,009
Ensembl chr 2:31,522,480...31,580,938 		JBrowse link
N-nitrosopiperidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 increases metabolic processing
multiple interactions		 EXP CYP2A6 protein results in increased metabolism of N-nitrosopiperidine
CYP2A6 protein affects the metabolism of and results in increased activity of N-nitrosopiperidine		 CTD PMID:11774366 PMID:12214673 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions EXP CYP2E1 protein affects the metabolism of and results in increased activity of N-nitrosopiperidine CTD PMID:11774366 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP N-nitrosopiperidine results in increased cleavage of PARP1 protein CTD PMID:17929238 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
phencyclidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor decreases expression ISO Phencyclidine results in decreased expression of ADORA2A mRNA CTD PMID:17266109 NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357 		JBrowse link
G AJUBA ajuba LIM protein increases expression ISO Phencyclidine results in increased expression of AJUBA mRNA CTD PMID:12105081 NCBI chr14:22,971,177...22,982,551
Ensembl chr14:22,971,177...22,982,551 		JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 increases expression ISO Phencyclidine results in increased expression of ALDH1A1 mRNA CTD PMID:17266109 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442 		JBrowse link
G APOD apolipoprotein D increases expression ISO Phencyclidine results in increased expression of APOD mRNA CTD PMID:17266109 NCBI chr 3:195,568,705...195,583,940
Ensembl chr 3:195,568,705...195,584,033 		JBrowse link
G APOL2 apolipoprotein L2 increases expression EXP Phencyclidine results in increased expression of APOL2 mRNA CTD PMID:17205118 NCBI chr22:36,226,209...36,239,954
Ensembl chr22:36,226,209...36,239,954 		JBrowse link
G ARHGEF9 Cdc42 guanine nucleotide exchange factor 9 decreases expression ISO Phencyclidine results in decreased expression of ARHGEF9 mRNA CTD PMID:17266109 NCBI chr  X:63,634,967...63,785,214
Ensembl chr  X:63,634,967...63,809,274 		JBrowse link
G CALM1 calmodulin 1 decreases expression EXP Phencyclidine results in decreased expression of CALM1 mRNA CTD PMID:17205118 NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268 		JBrowse link
G CALM2 calmodulin 2 decreases expression EXP Phencyclidine results in decreased expression of CALM2 mRNA CTD PMID:17205118 NCBI chr 2:47,160,082...47,176,936
Ensembl chr 2:47,160,084...47,176,921 		JBrowse link
G CAMK2A calcium/calmodulin dependent protein kinase II alpha increases expression
decreases expression		 ISO Phencyclidine results in increased expression of CAMK2A mRNA
Phencyclidine results in decreased expression of CAMK2A mRNA		 CTD PMID:17266109 NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,093 		JBrowse link
G CAMK2B calcium/calmodulin dependent protein kinase II beta decreases expression EXP Phencyclidine results in decreased expression of CAMK2B mRNA CTD PMID:17205118 NCBI chr 7:44,217,154...44,326,013
Ensembl chr 7:44,210,019...44,334,577 		JBrowse link
G CASP1 caspase 1 increases expression ISO Phencyclidine results in increased expression of CASP1 mRNA CTD PMID:12105081 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity		 ISO 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]; Cadmium Chloride inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; Nifedipine inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; omega-agatoxin-Aa4b inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]]; staurosporine aglycone inhibits the reaction [alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid inhibits the reaction [Phencyclidine results in increased activity of CASP3 protein]] CTD PMID:24995437 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CCKBR cholecystokinin B receptor increases expression ISO Phencyclidine results in increased expression of CCKBR mRNA CTD PMID:17266109 NCBI chr11:6,259,838...6,272,127
Ensembl chr11:6,259,806...6,272,127 		JBrowse link
G CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 increases expression ISO Phencyclidine results in increased expression of CDK5R1 mRNA CTD PMID:17266109 NCBI chr17:32,486,993...32,491,253
Ensembl chr17:32,486,993...32,491,253 		JBrowse link
G CNP 2',3'-cyclic nucleotide 3' phosphodiesterase decreases expression
increases expression		 ISO Phencyclidine results in decreased expression of CNP mRNA
Phencyclidine results in increased expression of CNP mRNA		 CTD PMID:17266109 NCBI chr17:41,966,795...41,977,740
Ensembl chr17:41,966,763...41,977,740 		JBrowse link
G CNR1 cannabinoid receptor 1 multiple interactions ISO [Phencyclidine co-treated with Dronabinol] results in decreased expression of CNR1 protein CTD PMID:28648819 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347 		JBrowse link
G CPLX2 complexin 2 decreases expression ISO Phencyclidine results in decreased expression of CPLX2 mRNA CTD PMID:17266109 NCBI chr 5:175,796,533...175,884,021
Ensembl chr 5:175,796,310...175,884,021 		JBrowse link
G CYBA cytochrome b-245 alpha chain increases activity
multiple interactions		 ISO Phencyclidine results in increased activity of CYBA protein
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; ginsenoside Re inhibits the reaction [Phencyclidine results in increased activity of CYBA protein]; GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]		 CTD PMID:29037473 NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 affects metabolic processing
affects oxidation
decreases activity		 EXP CYP2B6 protein affects the metabolism of Phencyclidine analog
CYP2B6 protein affects the oxidation of Phencyclidine
Phencyclidine analog results in decreased activity of CYP2B6 protein; Phencyclidine results in decreased activity of CYP2B6 protein		 CTD PMID:16782764 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity
affects oxidation		 EXP Phencyclidine results in decreased activity of CYP2C19 protein
CYP2C19 protein affects the oxidation of Phencyclidine		 CTD PMID:16782764 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 affects metabolic processing EXP CYP2C8 protein affects the metabolism of Phencyclidine CTD PMID:16782764 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 affects metabolic processing EXP CYP2C9 protein affects the metabolism of Phencyclidine CTD PMID:16782764 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 affects metabolic processing EXP CYP2D6 protein affects the metabolism of Phencyclidine CTD PMID:16782764 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 affects metabolic processing EXP CYP3A4 protein affects the metabolism of Phencyclidine CTD PMID:16782764 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 affects metabolic processing EXP CYP3A5 protein affects the metabolism of Phencyclidine CTD PMID:16782764 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996 		JBrowse link
G DDO D-aspartate oxidase affects response to substance
multiple interactions		 ISO DDO protein affects the susceptibility to Phencyclidine
[DDO protein affects the susceptibility to Phencyclidine] which affects the expression of DLG4 mRNA; [DDO protein affects the susceptibility to Phencyclidine] which affects the expression of HOMER1 mRNA; DDO protein affects the reaction [Phencyclidine results in decreased expression of HOMER1 mRNA]; DDO protein affects the reaction [Phencyclidine results in increased expression of DLG4 mRNA]		 CTD PMID:25979765 NCBI chr 6:110,388,321...110,415,575
Ensembl chr 6:110,391,771...110,415,575 		JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 multiple interactions
increases expression		 ISO [DDO protein affects the susceptibility to Phencyclidine] which affects the expression of DLG4 mRNA; DDO protein affects the reaction [Phencyclidine results in increased expression of DLG4 mRNA] CTD PMID:25979765 NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,187,187...7,219,841 		JBrowse link
G DNAJC1 DnaJ heat shock protein family (Hsp40) member C1 decreases expression ISO Phencyclidine results in decreased expression of DNAJC1 mRNA CTD PMID:12105081 NCBI chr10:21,756,548...22,003,730
Ensembl chr10:21,756,548...22,003,769 		JBrowse link
G DRD1 dopamine receptor D1 decreases expression
multiple interactions		 ISO Phencyclidine results in decreased expression of DRD1 mRNA; Phencyclidine results in decreased expression of DRD1 protein
NTSR1 gene affects the reaction [Phencyclidine results in decreased expression of DRD1 protein]		 CTD PMID:17266109 PMID:20659557 NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182 		JBrowse link
G DRD2 dopamine receptor D2 decreases expression
affects binding		 ISO Phencyclidine results in decreased expression of DRD2 mRNA; Phencyclidine results in decreased expression of DRD2 protein
Phencyclidine binds to Drd2 protein		 CTD
RGD		 PMID:17266109 PMID:20659557 PMID:15852061 RGD:1581406 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691 		JBrowse link
G EGF epidermal growth factor increases expression ISO Phencyclidine results in increased expression of EGF mRNA CTD PMID:12105081 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766 		JBrowse link
G FDFT1 farnesyl-diphosphate farnesyltransferase 1 increases expression EXP Phencyclidine results in increased expression of FDFT1 mRNA CTD PMID:17205118 NCBI chr 8:11,795,582...11,839,309
Ensembl chr 8:11,795,573...11,839,395 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO [Dextroamphetamine co-treated with Phencyclidine] promotes the reaction [FOS protein binds to FOS promoter]; [Dextroamphetamine co-treated with Phencyclidine] promotes the reaction [SRF protein binds to FOS promoter]; [Dextroamphetamine co-treated with Phencyclidine] results in increased expression of FOS protein; [Phencyclidine co-treated with Dextroamphetamine] results in increased expression of FOS protein; Phencyclidine promotes the reaction [FOS protein binds to FOS promoter]; Phencyclidine promotes the reaction [SRF protein binds to FOS promoter]
Phencyclidine results in increased expression of FOS protein		 CTD PMID:12510024 PMID:16678866 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO [Phencyclidine co-treated with Dextroamphetamine] results in increased expression of FOSB protein
Phencyclidine results in increased expression of FOSB protein		 CTD PMID:16678866 NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179 		JBrowse link
G FOXP2 forkhead box P2 increases expression ISO Phencyclidine results in increased expression of FOXP2 mRNA CTD PMID:17266109 NCBI chr 7:114,086,327...114,693,765
Ensembl chr 7:114,086,327...114,693,772 		JBrowse link
G GABBR1 gamma-aminobutyric acid type B receptor subunit 1 decreases expression ISO Phencyclidine results in decreased expression of GABBR1 mRNA CTD PMID:17266109 NCBI chr 6:29,602,238...29,633,183
Ensembl chr 6:29,555,629...29,633,976 		JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 increases expression ISO Phencyclidine results in increased expression of GABRA1 mRNA CTD PMID:17266109 NCBI chr 5:161,847,191...161,899,971
Ensembl chr 5:161,847,063...161,899,981 		JBrowse link
G GAD2 glutamate decarboxylase 2 increases expression ISO Phencyclidine results in increased expression of GAD2 mRNA CTD PMID:17266109 NCBI chr10:26,216,372...26,304,558
Ensembl chr10:26,216,665...26,304,558 		JBrowse link
G GAP43 growth associated protein 43 increases expression ISO Phencyclidine results in increased expression of GAP43 mRNA CTD PMID:11377751 NCBI chr 3:115,623,510...115,721,483
Ensembl chr 3:115,623,510...115,721,490 		JBrowse link
G GCC1 GRIP and coiled-coil domain containing 1 increases expression EXP Phencyclidine results in increased expression of GCC1 mRNA CTD PMID:17205118 NCBI chr 7:127,580,628...127,585,596
Ensembl chr 7:127,580,628...127,593,611 		JBrowse link
G GFAP glial fibrillary acidic protein increases expression ISO Phencyclidine results in increased expression of GFAP mRNA CTD PMID:17266109 NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937 		JBrowse link
G GNAS GNAS complex locus increases expression ISO Phencyclidine results in increased expression of GNAS mRNA CTD PMID:12105081 NCBI chr20:58,839,748...58,911,192
Ensembl chr20:58,839,718...58,911,192 		JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions ISO acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]; GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]; GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]; GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]; GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein] CTD PMID:29037473 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605 		JBrowse link
G GRIA4 glutamate ionotropic receptor AMPA type subunit 4 increases expression ISO Phencyclidine results in increased expression of GRIA4 mRNA CTD PMID:17266109 NCBI chr11:105,609,616...105,982,090
Ensembl chr11:105,609,535...105,982,090 		JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression
multiple interactions		 ISO Phencyclidine results in decreased expression of GRIN1 mRNA; Phencyclidine results in decreased expression of GRIN1 protein
[Phencyclidine co-treated with Dronabinol] results in decreased expression of GRIN1 protein		 CTD PMID:17266109 PMID:28648819 NCBI chr 9:137,139,154...137,168,756
Ensembl chr 9:137,138,346...137,168,756 		JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A decreases expression ISO Phencyclidine results in decreased expression of GRIN2A mRNA; Phencyclidine results in decreased expression of GRIN2A protein CTD PMID:20659557 NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,182,928 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions		 ISO Phencyclidine results in increased expression of HMOX1 mRNA; Phencyclidine results in increased expression of HMOX1 protein
1,3-dimethylthiourea inhibits the reaction [Phencyclidine results in increased expression of HMOX1 protein]		 CTD PMID:9875361 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HOMER1 homer scaffold protein 1 multiple interactions
decreases expression		 ISO [DDO protein affects the susceptibility to Phencyclidine] which affects the expression of HOMER1 mRNA; DDO protein affects the reaction [Phencyclidine results in decreased expression of HOMER1 mRNA] CTD PMID:25979765 NCBI chr 5:79,372,636...79,514,134
Ensembl chr 5:79,372,636...79,514,134 		JBrowse link
G HOXB9 homeobox B9 decreases expression ISO Phencyclidine results in decreased expression of HOXB9 mRNA CTD PMID:12105081 NCBI chr17:48,621,156...48,626,358
Ensembl chr17:48,621,156...48,626,358 		JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A multiple interactions
decreases activity		 ISO [Phencyclidine co-treated with Haloperidol] affects the activity of HTR2A protein; Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein] CTD PMID:15380371 NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,546...46,897,076 		JBrowse link
G JUND JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Phencyclidine co-treated with Dextroamphetamine] results in increased expression of JUND protein CTD PMID:16678866 NCBI chr19:18,279,694...18,281,622
Ensembl chr19:18,279,694...18,281,622 		JBrowse link
G KCNH1 potassium voltage-gated channel subfamily H member 1 decreases expression ISO Phencyclidine results in decreased expression of KCNH1 mRNA CTD PMID:12105081 NCBI chr 1:210,678,314...211,134,148
Ensembl chr 1:210,676,823...211,134,165 		JBrowse link
G KCNIP3 potassium voltage-gated channel interacting protein 3 increases expression ISO Phencyclidine results in increased expression of KCNIP3 mRNA CTD PMID:17266109 NCBI chr 2:95,297,347...95,386,077
Ensembl chr 2:95,297,327...95,386,077 		JBrowse link
G KCNJ4 potassium inwardly rectifying channel subfamily J member 4 increases expression ISO Phencyclidine results in increased expression of KCNJ4 mRNA CTD PMID:17266109 NCBI chr22:38,426,327...38,455,199
Ensembl chr22:38,426,327...38,455,199 		JBrowse link
G KITLG KIT ligand increases expression ISO Phencyclidine results in increased expression of KITL mRNA CTD PMID:12105081 NCBI chr12:88,492,793...88,580,471
Ensembl chr12:88,492,793...88,580,851 		JBrowse link
G LEP leptin increases expression ISO Phencyclidine results in increased expression of LEP mRNA CTD PMID:12105081 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G LPL lipoprotein lipase increases expression ISO Phencyclidine results in increased expression of LPL mRNA CTD PMID:17266109 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259 		JBrowse link
G MAL mal, T cell differentiation protein decreases expression ISO Phencyclidine results in decreased expression of MAL mRNA CTD PMID:17266109 NCBI chr 2:95,025,708...95,053,992
Ensembl chr 2:95,025,677...95,053,992 		JBrowse link
G MAOB monoamine oxidase B increases expression ISO Phencyclidine results in increased expression of MAOB mRNA CTD PMID:17266109 NCBI chr  X:43,766,610...43,882,450
Ensembl chr  X:43,766,610...43,882,450 		JBrowse link
G MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 increases expression ISO Phencyclidine results in increased expression of MAPK8IP1 mRNA CTD PMID:17266109 NCBI chr11:45,885,651...45,906,465
Ensembl chr11:45,885,651...45,906,465 		JBrowse link
G MBP myelin basic protein increases expression ISO Phencyclidine results in increased expression of MBP mRNA CTD PMID:17266109 NCBI chr18:76,978,833...77,133,708
Ensembl chr18:76,978,827...77,133,683 		JBrowse link
G MOBP myelin associated oligodendrocyte basic protein increases expression ISO Phencyclidine results in increased expression of MOBP mRNA CTD PMID:17266109 NCBI chr 3:39,467,680...39,529,497
Ensembl chr 3:39,467,198...39,529,479 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 affects localization
multiple interactions		 ISO Phencyclidine affects the localization of NCF1 protein
acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; ginsenoside Re inhibits the reaction [Phencyclidine affects the localization of NCF1 protein]; GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]		 CTD PMID:29037473 NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315 		JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 increases expression ISO Phencyclidine results in increased expression of NR4A2 mRNA CTD PMID:17266109 NCBI chr 2:156,324,437...156,332,721
Ensembl chr 2:156,324,437...156,342,348 		JBrowse link
G NTSR1 neurotensin receptor 1 multiple interactions ISO NTSR1 gene affects the reaction [Phencyclidine results in decreased expression of DRD1 protein] CTD PMID:20659557 NCBI chr20:62,708,836...62,762,771
Ensembl chr20:62,708,836...62,762,771 		JBrowse link
G P2RY1 purinergic receptor P2Y1 increases expression ISO Phencyclidine results in increased expression of P2RY1 mRNA CTD PMID:12105081 NCBI chr 3:152,835,131...152,841,439
Ensembl chr 3:152,835,131...152,841,439 		JBrowse link
G PDE10A phosphodiesterase 10A increases expression ISO Phencyclidine results in increased expression of PDE10A mRNA CTD PMID:17266109 NCBI chr 6:165,327,289...165,988,052
Ensembl chr 6:165,327,287...165,988,117 		JBrowse link
G PLP1 proteolipid protein 1 increases expression ISO Phencyclidine results in increased expression of PLP1 mRNA CTD PMID:17266109 NCBI chr  X:103,776,506...103,792,619
Ensembl chr  X:103,773,718...103,792,619 		JBrowse link
G PRKCD protein kinase C delta increases expression ISO Phencyclidine results in increased expression of PRKCD mRNA CTD PMID:12105081 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717 		JBrowse link
G PRKCG protein kinase C gamma increases expression ISO Phencyclidine results in increased expression of PRKCG mRNA CTD PMID:11169168 NCBI chr19:53,881,094...53,907,652
Ensembl chr19:53,879,190...53,907,652 		JBrowse link
G PTGDS prostaglandin D2 synthase increases expression ISO Phencyclidine results in increased expression of PTGDS mRNA CTD PMID:17266109 NCBI chr 9:136,977,504...136,981,742
Ensembl chr 9:136,975,092...136,981,742 		JBrowse link
G PTPRCAP protein tyrosine phosphatase receptor type C associated protein increases expression ISO Phencyclidine results in increased expression of PTPRCAP mRNA CTD PMID:12105081 NCBI chr11:67,435,510...67,437,682
Ensembl chr11:67,435,510...67,437,682 		JBrowse link
G PVALB parvalbumin multiple interactions
decreases expression		 ISO Clozapine inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA]; Haloperidol inhibits the reaction [Phencyclidine results in decreased expression of PVALB mRNA] CTD PMID:12589379 NCBI chr22:36,800,703...36,819,499
Ensembl chr22:36,800,684...36,819,479 		JBrowse link
G RELN reelin decreases expression ISO Phencyclidine results in decreased expression of RELN mRNA CTD PMID:17266109 NCBI chr 7:103,471,789...103,989,658
Ensembl chr 7:103,471,381...103,989,658 		JBrowse link
G RGS4 regulator of G protein signaling 4 increases expression ISO Phencyclidine results in increased expression of RGS4 mRNA CTD PMID:17266109 NCBI chr 1:163,068,871...163,076,802
Ensembl chr 1:163,068,775...163,076,802 		JBrowse link
G RTN4 reticulon 4 increases expression ISO Phencyclidine results in increased expression of RTN4 mRNA CTD PMID:17266109 NCBI chr 2:54,972,189...55,137,831
Ensembl chr 2:54,972,187...55,112,621 		JBrowse link
G SCARB1 scavenger receptor class B member 1 increases expression EXP Phencyclidine results in increased expression of SCARB1 mRNA CTD PMID:17205118 NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668 		JBrowse link
G SELPLG selectin P ligand increases expression ISO Phencyclidine results in increased expression of SELPLG mRNA CTD PMID:12105081 NCBI chr12:108,621,895...108,633,894
Ensembl chr12:108,621,895...108,633,894 		JBrowse link
G SEMA3B semaphorin 3B decreases expression EXP Phencyclidine results in decreased expression of SEMA3B mRNA CTD PMID:17205118 NCBI chr 3:50,267,652...50,277,546
Ensembl chr 3:50,267,558...50,277,546 		JBrowse link
G SGK1 serum/glucocorticoid regulated kinase 1 increases expression ISO Phencyclidine results in increased expression of SGK1 mRNA CTD PMID:17266109 NCBI chr 6:134,169,256...134,318,112
Ensembl chr 6:134,169,248...134,318,112 		JBrowse link
G SLC17A6 solute carrier family 17 member 6 increases expression ISO Phencyclidine results in increased expression of SLC17A6 mRNA CTD PMID:17266109 NCBI chr11:22,338,381...22,379,503
Ensembl chr11:22,338,381...22,379,503 		JBrowse link
G SMAD5 SMAD family member 5 decreases expression ISO Phencyclidine results in decreased expression of SMAD5 mRNA CTD PMID:12105081 NCBI chr 5:136,132,845...136,182,733
Ensembl chr 5:136,132,845...136,188,747 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions
increases activity		 ISO acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]; GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein] CTD PMID:29037473 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
decreases activity		 ISO acetovanillone inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]; GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein] CTD PMID:29037473 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase increases expression ISO Phencyclidine results in increased expression of SRC mRNA CTD PMID:11249956 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G SRF serum response factor multiple interactions ISO [Dextroamphetamine co-treated with Phencyclidine] promotes the reaction [SRF protein binds to FOS promoter]; Phencyclidine promotes the reaction [SRF protein binds to FOS promoter] CTD PMID:12510024 NCBI chr 6:43,171,269...43,181,506
Ensembl chr 6:43,171,269...43,181,506 		JBrowse link
G SYN2 synapsin II decreases expression ISO Phencyclidine results in decreased expression of SYN2 mRNA CTD PMID:17266109 NCBI chr 3:12,004,388...12,192,032
Ensembl chr 3:12,004,388...12,192,032 		JBrowse link
G SYT2 synaptotagmin 2 increases expression ISO Phencyclidine results in increased expression of SYT2 mRNA CTD PMID:17266109 NCBI chr 1:202,590,596...202,710,454
Ensembl chr 1:202,590,596...202,710,454 		JBrowse link
G TAC1 tachykinin precursor 1 decreases expression ISO Phencyclidine results in decreased expression of TAC1 mRNA CTD PMID:17266109 NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472 		JBrowse link
G TEAD4 TEA domain transcription factor 4 decreases expression ISO Phencyclidine results in decreased expression of TEAD4 mRNA CTD PMID:12105081 NCBI chr12:2,959,397...3,040,676
Ensembl chr12:2,959,330...3,040,676 		JBrowse link
G TH tyrosine hydroxylase multiple interactions
increases expression		 ISO Phencyclidine inhibits the reaction [Methamphetamine results in decreased activity of TH protein]
Phencyclidine results in increased expression of TH mRNA		 CTD PMID:1381816 PMID:12105081 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815 		JBrowse link
G TNF tumor necrosis factor multiple interactions
affects expression		 ISO Haloperidol affects the reaction [Phencyclidine affects the expression of TNF mRNA] CTD PMID:16478754 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TTR transthyretin decreases expression ISO Phencyclidine results in decreased expression of TTR mRNA CTD PMID:17266109 NCBI chr18:31,591,877...31,598,821
Ensembl chr18:31,557,009...31,598,833 		JBrowse link
G YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta decreases expression ISO Phencyclidine results in decreased expression of YWHAB mRNA CTD PMID:17266109 NCBI chr20:44,885,705...44,908,532
Ensembl chr20:44,885,702...44,908,532 		JBrowse link
pizotifen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNH2 potassium voltage-gated channel subfamily H member 2 decreases activity EXP Pizotyline results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      chemical role 24242
        base 19961
          piperidine 106
            N-[(Z)-11-methyldodec-2-enoyl]piperidine 0
            N-[(Z)-dodec-2-enoyl]piperidine 0
            N-nitrosopiperidine 3
            phencyclidine 94
            pizotifen 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    main group molecular entity 25834
                      s-block molecular entity 25166
                        hydrogen molecular entity 24765
                          hydrides 22965
                            inorganic hydride 20483
                              pnictogen hydride 20424
                                nitrogen hydride 20200
                                  azane 19942
                                    ammonia 19941
                                      organic amino compound 19941
                                        secondary amino compound 6948
                                          secondary amine 1827
                                            piperidine 106
                                              N-[(Z)-11-methyldodec-2-enoyl]piperidine 0
                                              N-[(Z)-dodec-2-enoyl]piperidine 0
                                              N-nitrosopiperidine 3
                                              phencyclidine 94
                                              pizotifen 1
paths to the root