Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,2,4-triazole-3-carboxamide
go back to main search page
Accession:CHEBI:180482 term browser browse the term
Definition:A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an aminocarbonyl group at position 3. It is the major catabolite and aglycon of ribavirin.
Synonyms:exact_synonym: 1H-1,2,4-triazole-3-carboxamide
 related_synonym: 3-(aminocarbonyl)-1H-1,2,4-triazole;   3-carbamoyl-1H-1,2,4-triazole;   Formula=C3H4N4O;   InChI=1S/C3H4N4O/c4-2(8)3-5-1-6-7-3/h1H,(H2,4,8)(H,5,6,7);   InChIKey=ZEWJFUNFEABPGL-UHFFFAOYSA-N;   SMILES=NC(=O)C1=NNC=N1
 xref: CAS:3641-08-5;   Chemspider:58634;   HMDB:HMDB0244869;   PMID:1368697;   PMID:1368721;   PMID:17845853;   PMID:21202621;   PMID:212973;   PMID:2737800;   PMID:6660848;   Reaxys:775120



show annotations for term's descendants           Sort by:
 
ribavirin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn2 actinin alpha 2 decreases expression ISO Ribavirin results in decreased expression of ACTN2 protein CTD PMID:32112805 NCBI chr17:58,143,334...58,210,622
Ensembl chr17:58,142,625...58,210,622
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO Ribavirin results in decreased phosphorylation of AKT1 protein CTD PMID:29112301 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Carm1 coactivator-associated arginine methyltransferase 1 multiple interactions
decreases expression
ISO Ribavirin inhibits the reaction [CARM1 protein binds to EIF4E promoter]; Ribavirin inhibits the reaction [CARM1 protein binds to VEGFA promoter]
Ribavirin results in decreased expression of CARM1 protein
CTD PMID:34919946 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Ribavirin results in increased activity of CASP3 protein
Ribavirin promotes the reaction [FAS protein results in increased activity of CASP3 protein]
CTD PMID:12760867 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Ribavirin promotes the reaction [FAS protein results in increased activity of CASP7 protein] CTD PMID:12760867 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Ribavirin promotes the reaction [FAS protein results in increased activity of CASP8 protein] CTD PMID:12760867 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Ribavirin results in decreased expression of CCNA2 protein CTD PMID:33577917 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Ribavirin results in decreased expression of CCND1 protein CTD PMID:29112301 PMID:33577917 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Ribavirin results in decreased expression of CCNE1 protein CTD PMID:33577917 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions
decreases phosphorylation
decreases expression
ISO Ribavirin inhibits the reaction [CARM1 protein binds to EIF4E promoter]; Ribavirin inhibits the reaction [Doxorubicin results in increased phosphorylation of EIF4E protein]
Ribavirin results in decreased phosphorylation of EIF4E protein
Ribavirin results in decreased expression of EIF4E mRNA; Ribavirin results in decreased expression of EIF4E protein
CTD PMID:29112301 PMID:33577917 PMID:34919946 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO Ribavirin results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:29112301 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Epo erythropoietin multiple interactions
increases expression
ISO [peginterferon alfa-2b co-treated with Ribavirin] affects the expression of EPO protein; [Ribavirin co-treated with Interferons] results in increased expression of EPO protein
Ribavirin results in increased expression of EPO
CTD PMID:12713065 PMID:15232364 PMID:20009130 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Ribavirin promotes the reaction [FAS protein results in increased activity of CASP3 protein]; Ribavirin promotes the reaction [FAS protein results in increased activity of CASP7 protein]; Ribavirin promotes the reaction [FAS protein results in increased activity of CASP8 protein] CTD PMID:12760867 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Gas5 growth arrest specific 5 increases expression ISO Ribavirin results in increased expression of GAS5 mRNA CTD PMID:32112805 NCBI chr13:73,303,611...73,306,932 JBrowse link
G Gata4 GATA binding protein 4 decreases expression ISO Ribavirin results in decreased expression of GATA4 mRNA CTD PMID:32112805 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
JBrowse link
G H2ax H2A.X variant histone increases expression ISO Ribavirin results in increased expression of H2AX protein modified form CTD PMID:32112805 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Ribavirin results in decreased expression of ICAM1 protein modified form CTD PMID:12853993 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
increases expression
ISO [Ribavirin co-treated with IFNA2 protein] affects the reaction [Lipopolysaccharides results in increased secretion of IFNG protein]; [Ribavirin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA; Ribavirin inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein]; Ribavirin results in increased expression of and results in increased secretion of IFNG protein
Ribavirin results in decreased expression of IFNG mRNA
Ribavirin results in increased expression of IFNG mRNA; Ribavirin results in increased expression of IFNG protein
CTD PMID:9722937 PMID:10190717 PMID:10770762 PMID:17210188 PMID:29594315 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ifnl3 interferon, lambda 3 multiple interactions ISO IFNL3 gene polymorphism affects the susceptibility to [Ribavirin co-treated with IFNA2 protein modified form]; IFNL3 gene SNP affects the susceptibility to [peginterferon alfa-2a co-treated with Ribavirin]; IFNL3 protein results in increased susceptibility to [Ribavirin co-treated with IFNA2 protein modified form] CTD PMID:19749757 PMID:19749758 PMID:22003405 NCBI chr 1:83,814,456...83,816,096
Ensembl chr 1:83,814,564...83,816,096
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression
ISO
EXP
[Ribavirin co-treated with IFNA2 protein] affects the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]; Ribavirin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]; Ribavirin results in decreased expression of and results in decreased secretion of IL10 protein
Ribavirin results in decreased expression of IL10 mRNA
Ribavirin results in decreased expression of IL10 protein
[peginterferon alfa-2a co-treated with Ribavirin co-treated with Danazol] results in decreased expression of IL10 mRNA; [peginterferon alfa-2a co-treated with Ribavirin] results in increased expression of IL10 mRNA
CTD PMID:9722937 PMID:10190717 PMID:10770762 PMID:17210188 PMID:18007553 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12a interleukin 12A multiple interactions ISO [Ribavirin co-treated with IFNA2 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; Ribavirin promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:9722937 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions ISO [Ribavirin co-treated with IFNA2 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; Ribavirin promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:9722937 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO Ribavirin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
Ribavirin results in increased expression of IL1B mRNA
CTD PMID:9722937 PMID:29594315 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions
increases expression
ISO [Ribavirin co-treated with IFNA2 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of IL2 protein]; [Ribavirin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA; Ribavirin promotes the reaction [Lipopolysaccharides results in increased secretion of IL2 protein]; Ribavirin results in increased expression of and results in increased secretion of IL2 protein
Ribavirin results in increased expression of IL2 protein
Ribavirin results in increased expression of IL2 mRNA; Ribavirin results in increased expression of IL2 protein
CTD PMID:9722937 PMID:10190717 PMID:10770762 PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 decreases expression
multiple interactions
ISO Ribavirin results in decreased expression of IL4 mRNA; Ribavirin results in decreased expression of IL4 protein
Ribavirin promotes the reaction [Lipopolysaccharides results in increased secretion of IL4 protein]; Ribavirin results in decreased expression of and results in decreased secretion of IL4 protein
CTD PMID:9722937 PMID:10190717 PMID:10770762 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 decreases expression
multiple interactions
ISO Ribavirin results in decreased expression of IL5 mRNA; Ribavirin results in decreased expression of IL5 protein
Ribavirin results in decreased expression of and results in decreased secretion of IL5 protein
CTD PMID:10190717 PMID:10770762 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [peginterferon alfa-2a co-treated with Ribavirin co-treated with Danazol] results in decreased expression of IL6 mRNA CTD PMID:18007553 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Isl1 ISL LIM homeobox 1 decreases expression ISO Ribavirin results in decreased expression of ISL1 mRNA CTD PMID:32112805 NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584
JBrowse link
G Itpa inosine triphosphatase increases response to substance ISO ITPA 5' UTR SNP results in increased susceptibility to Ribavirin CTD PMID:20637204 NCBI chr 3:117,885,464...117,897,247
Ensembl chr 3:117,885,099...117,897,249
JBrowse link
G Klrc1 killer cell lectin like receptor C1 affects expression ISO Ribavirin co-treated with Interferon alfa-2a affects expression of KLRC1 protein in Natural Killer cells RGD PMID:20550548 RGD:40818079 NCBI chr 4:163,142,142...163,152,425
Ensembl chr 4:163,147,189...163,152,425
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Ribavirin results in decreased phosphorylation of MTOR protein CTD PMID:29112301 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Ribavirin results in decreased expression of MYC protein CTD PMID:29112301 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myh6 myosin heavy chain 6 decreases expression ISO Ribavirin results in decreased expression of MYH6 mRNA CTD PMID:32112805 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A multiple interactions ISO [Ribavirin co-treated with IFNA2 protein] results in increased activity of OAS1 protein CTD PMID:9722937 NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Ribavirin results in decreased expression of PCNA protein CTD PMID:33577917 PMID:34919946 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Prmt1 protein arginine methyltransferase 1 affects expression ISO Ribavirin affects the expression of PRMT1 protein CTD PMID:34919946 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G Prmt2 protein arginine methyltransferase 2 decreases expression ISO Ribavirin results in decreased expression of PRMT2 protein CTD PMID:34919946 NCBI chr20:12,394,748...12,420,643
Ensembl chr20:12,394,798...12,420,643
JBrowse link
G Prmt3 protein arginine methyltransferase 3 decreases expression ISO Ribavirin results in decreased expression of PRMT3 protein CTD PMID:34919946 NCBI chr 1:99,492,712...99,581,774
Ensembl chr 1:99,492,724...99,579,435
JBrowse link
G Prmt5 protein arginine methyltransferase 5 decreases expression ISO Ribavirin results in decreased expression of PRMT5 protein CTD PMID:33577917 PMID:34919946 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296
JBrowse link
G Prmt6 protein arginine methyltransferase 6 affects expression ISO Ribavirin affects the expression of PRMT6 protein CTD PMID:34919946 NCBI chr 2:197,927,750...197,932,980
Ensembl chr 2:197,927,220...197,933,648
JBrowse link
G Prmt7 protein arginine methyltransferase 7 decreases expression ISO Ribavirin results in decreased expression of PRMT7 protein CTD PMID:33577917 PMID:34919946 NCBI chr19:34,110,724...34,161,531
Ensembl chr19:34,110,747...34,162,577
JBrowse link
G Prmt8 protein arginine methyltransferase 8 decreases expression ISO Ribavirin results in decreased expression of PRMT8 protein CTD PMID:34919946 NCBI chr 4:160,535,813...160,618,193
Ensembl chr 4:160,535,813...160,617,930
JBrowse link
G Slc29a1 solute carrier family 29 member 1 increases uptake ISO SLC29A1 protein results in increased uptake of Ribavirin CTD PMID:20185188 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
JBrowse link
G Slc29a3 solute carrier family 29 member 3 affects transport ISO SLC29A3 protein affects the transport of Ribavirin CTD PMID:19164483 NCBI chr20:28,645,265...28,685,388
Ensembl chr20:28,647,391...28,685,388
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions
increases expression
ISO Ribavirin promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Ribavirin results in increased expression of and results in increased activity of SLC6A4 protein
Ribavirin results in increased expression of SLC6A4 mRNA
CTD PMID:16476009 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
Ribavirin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Ribavirin results in increased expression of and results in increased secretion of TNF protein
Ribavirin results in increased expression of TNF mRNA; Ribavirin results in increased expression of TNF protein
[peginterferon alfa-2a co-treated with Ribavirin co-treated with Danazol] results in decreased expression of TNF mRNA
CTD PMID:9722937 PMID:10190717 PMID:10770762 PMID:18007553 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases response to substance ISO Ribavirin results in decreased susceptibility to TNFSF10 protein CTD PMID:12637521 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tnnt2 troponin T2, cardiac type decreases expression ISO Ribavirin results in decreased expression of TNNT2 protein CTD PMID:32112805 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Ribavirin results in increased expression of TP53 protein
Ribavirin results in increased expression of TRP53 protein
CTD PMID:32112805 PMID:33577917 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Txn1 thioredoxin 1 decreases expression ISO Ribavirin results in decreased expression of TXN protein CTD PMID:16198661 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
decreases secretion
ISO Ribavirin results in decreased expression of VEGFA mRNA; Ribavirin results in decreased expression of VEGFA protein
Ribavirin inhibits the reaction [CARM1 protein binds to VEGFA promoter]
Ribavirin results in decreased secretion of VEGFA protein
CTD PMID:29112301 PMID:34919946 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20072
    role 20024
      biological role 20023
        biochemical role 19658
          metabolite 19642
            xenobiotic metabolite 14904
              human xenobiotic metabolite 14226
                drug metabolite 4480
                  1,2,4-triazole-3-carboxamide 51
                    ribavirin + 51
Path 2
Term Annotations click to browse term
  CHEBI ontology 20072
    subatomic particle 20071
      composite particle 20071
        hadron 20071
          baryon 20071
            nucleon 20071
              atomic nucleus 20071
                atom 20071
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19894
                        carbon atom 19887
                          organic molecular entity 19887
                            organic group 18965
                              organic divalent group 18951
                                organodiyl group 18951
                                  carbonyl group 18903
                                    carbonyl compound 18903
                                      carboxylic acid 18601
                                        carboacyl group 17713
                                          univalent carboacyl group 17713
                                            carbamoyl group 17552
                                              carboxamide 17552
                                                primary carboxamide 5925
                                                  1,2,4-triazole-3-carboxamide 51
                                                    ribavirin + 51
paths to the root