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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:180480 term browser browse the term
Definition:A member of the class of ureas that is urea in which three of the four hydrogens are replaced by ethyl and 4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl groups. An atypical antipsychotic which was in clinical development for the treatment of schizophrenia and substance-related disorders. It is a potent 5-HT2A antagonist and used in veterinary medicine because of its sedative effect on pigs.
Synonyms:exact_synonym: 4-[4,4-bis(4-fluorophenyl)butyl]-N-ethylpiperazine-1-carboxamide
 related_synonym: 4-(4,4-bis(p-fluorophenyl)butyl)-N-ethyl-1-piperazinecarboxamide;   Formula=C23H29F2N3O;   InChI=1S/C23H29F2N3O/c1-2-26-23(29)28-16-14-27(15-17-28)13-3-4-22(18-5-9-20(24)10-6-18)19-7-11-21(25)12-8-19/h5-12,22H,2-4,13-17H2,1H3,(H,26,29);   InChIKey=NNAIYOXJNVGUOM-UHFFFAOYSA-N;   SMILES=CCNC(=O)N1CCN(CCCC(C2=CC=C(F)C=C2)C2=CC=C(F)C=C2)CC1;   amperozida;   amperozidum
 alt_id: CHEBI:92913
 xref: CAS:75558-90-6;   Chemspider:66062;   DrugBank:DB08927;   Drug_Central:193;   HMDB:HMDB0248358;   LINCS:LSM-3159
 xref_mesh: MESH:C049058
 xref: PMID:10068147;   PMID:10512574;   PMID:10627067;   PMID:10975635;   PMID:12127016;   PMID:12213521;   PMID:18666714;   PMID:19850474;   PMID:2106131;   PMID:2111999;   PMID:2154737;   PMID:2224491;   PMID:2304894;   PMID:2304896;   PMID:2406715;   PMID:24134630;   PMID:2746728;   PMID:3751811;   PMID:7879876;   PMID:8050470;   PMID:8060520;   PMID:8255902;   PMID:8405119;   PMID:9443541;   PMID:9597673;   PMID:9631953;   PMID:9686999;   Patent:EP0517787;   Patent:WO9112805;   Wikipedia:Amperozide
 cyclic_relationship: is_conjugate_base_of CHEBI:180484

show annotations for term's descendants           Sort by:
amperozide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO amperozide inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19908
    role 19883
      application 19717
        pharmaceutical 19544
          drug 19544
            protective agent 18214
              geroprotector 17345
                amperozide 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19908
    subatomic particle 19906
      composite particle 19906
        hadron 19906
          baryon 19906
            nucleon 19906
              atomic nucleus 19906
                atom 19906
                  main group element atom 19853
                    p-block element atom 19853
                      carbon group element atom 19799
                        carbon atom 19794
                          organic molecular entity 19794
                            organic group 18960
                              organic divalent group 18941
                                organodiyl group 18941
                                  carbonyl group 18893
                                    carbonyl compound 18893
                                      carboxylic acid 18614
                                        carboacyl group 17709
                                          univalent carboacyl group 17709
                                            carbamoyl group 17556
                                              carboxamide 17556
                                                monocarboxylic acid amide 15656
                                                  urea 5566
                                                    ureas 5564
                                                      amperozide 1
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