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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:180480 term browser browse the term
Definition:A member of the class of ureas that is urea in which three of the four hydrogens are replaced by ethyl and 4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl groups. An atypical antipsychotic which was in clinical development for the treatment of schizophrenia and substance-related disorders. It is a potent 5-HT2A antagonist and used in veterinary medicine because of its sedative effect on pigs.
Synonyms:exact_synonym: 4-[4,4-bis(4-fluorophenyl)butyl]-N-ethylpiperazine-1-carboxamide
 related_synonym: 4-(4,4-bis(p-fluorophenyl)butyl)-N-ethyl-1-piperazinecarboxamide;   Formula=C23H29F2N3O;   InChI=1S/C23H29F2N3O/c1-2-26-23(29)28-16-14-27(15-17-28)13-3-4-22(18-5-9-20(24)10-6-18)19-7-11-21(25)12-8-19/h5-12,22H,2-4,13-17H2,1H3,(H,26,29);   InChIKey=NNAIYOXJNVGUOM-UHFFFAOYSA-N;   SMILES=CCNC(=O)N1CCN(CCCC(C2=CC=C(F)C=C2)C2=CC=C(F)C=C2)CC1;   amperozida;   amperozidum
 alt_id: CHEBI:92913
 xref: CAS:75558-90-6;   Chemspider:66062;   DrugBank:DB08927;   Drug_Central:193;   HMDB:HMDB0248358;   LINCS:LSM-3159
 xref_mesh: MESH:C049058
 xref: PMID:10068147;   PMID:10512574;   PMID:10627067;   PMID:10975635;   PMID:12127016;   PMID:12213521;   PMID:18666714;   PMID:19850474;   PMID:2106131;   PMID:2111999;   PMID:2154737;   PMID:2224491;   PMID:2304894;   PMID:2304896;   PMID:2406715;   PMID:24134630;   PMID:2746728;   PMID:3751811;   PMID:7879876;   PMID:8050470;   PMID:8060520;   PMID:8255902;   PMID:8405119;   PMID:9443541;   PMID:9597673;   PMID:9631953;   PMID:9686999;   Patent:EP0517787;   Patent:WO9112805;   Wikipedia:Amperozide
 cyclic_relationship: is_conjugate_base_of CHEBI:180484

show annotations for term's descendants           Sort by:
amperozide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO amperozide inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Path 1
Term Annotations click to browse term
  CHEBI ontology 20039
    role 19990
      application 19729
        pharmaceutical 19603
          drug 19603
            protective agent 17981
              geroprotector 16931
                amperozide 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20039
    subatomic particle 20037
      composite particle 20037
        hadron 20037
          baryon 20037
            nucleon 20037
              atomic nucleus 20037
                atom 20037
                  main group element atom 19938
                    p-block element atom 19938
                      carbon group element atom 19861
                        carbon atom 19852
                          organic molecular entity 19852
                            organic group 18932
                              organic divalent group 18916
                                organodiyl group 18916
                                  carbonyl group 18865
                                    carbonyl compound 18865
                                      carboxylic acid 18553
                                        carboacyl group 17652
                                          univalent carboacyl group 17652
                                            carbamoyl group 17487
                                              carboxamide 17487
                                                monocarboxylic acid amide 15057
                                                  urea 5127
                                                    ureas 5124
                                                      amperozide 1
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