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ONTOLOGY REPORT - ANNOTATIONS


Term:dihydrolipoic acid
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Accession:CHEBI:18047 term browser browse the term
Definition:A thio-fatty acid that is reduced form of lipoic acid. A potent antioxidant shown to directly destroy superoxide, hydroperoxy and hydroxyl radicals; also has neuroprotective and anti-tumour effects.
Synonyms:exact_synonym: 6,8-disulfanyloctanoic acid
 related_synonym: 6,8-Dihydrothioctic acid;   6,8-bis-sulfanyloctanoic acid;   6,8-dimercapto-octanoic acid;   6,8-dimercaptooctanoic acid;   DHLA;   Dihydrothioctic acid;   Formula=C8H16O2S2;   InChI=1S/C8H16O2S2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H,9,10);   InChIKey=IZFHEQBZOYJLPK-UHFFFAOYSA-N;   SMILES=OC(=O)CCCCC(S)CCS;   dihydro-alpha-lipoic acid;   dihydro-lipoic acid
 alt_id: CHEBI:23752;   CHEBI:4569
 xref: Beilstein:1722777 "Beilstein";   CAS:462-20-4 "ChemIDplus";   CAS:462-20-4 "KEGG COMPOUND";   CAS:462-20-4 "NIST Chemistry WebBook";   DrugBank:DB03760;   Gmelin:675796 "Gmelin";   HMDB:HMDB0012210;   KEGG:C02147
 xref_mesh: MESH:C015144
 xref: PMID:12127266 "Europe PMC";   PMID:1345759 "Europe PMC";   PMID:17403519 "Europe PMC";   PMID:18951944 "Europe PMC";   Reaxys:1722777 "Reaxys";   Wikipedia:Dihydrolipoic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:30316


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dihydrolipoic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6480464
G Map2 microtubule-associated protein 2 JBrowse link 9 73,204,753 73,462,965 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:6480464
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Pdgfb platelet derived growth factor subunit B JBrowse link 7 121,215,458 121,233,092 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19679
    role 19623
      chemical role 19139
        antioxidant 14073
          dihydrolipoic acid 18
            (R)-dihydrolipoic acid + 0
            (S)-dihydrolipoic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19679
    subatomic particle 19675
      composite particle 19675
        hadron 19675
          baryon 19675
            nucleon 19675
              atomic nucleus 19675
                atom 19675
                  main group element atom 19555
                    p-block element atom 19555
                      carbon group element atom 19438
                        carbon atom 19430
                          organic molecular entity 19430
                            organic group 18351
                              organic divalent group 18340
                                organodiyl group 18340
                                  carbonyl group 18225
                                    carbonyl compound 18225
                                      carboxylic acid 17930
                                        monocarboxylic acid 17259
                                          fatty acid 15815
                                            saturated fatty acid 15783
                                              straight-chain saturated fatty acid 15181
                                                octanoic acid 2174
                                                  dihydrolipoic acid 18
                                                    (R)-dihydrolipoic acid + 0
                                                    (S)-dihydrolipoic acid + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.