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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2,3-dihydroxybenzoic acid
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Accession:CHEBI:18026 term browser browse the term
Definition:A dihydroxybenzoic acid that is benzoic acid substituted by hydroxy groups at positions 2 and 3. It occurs naturally in Phyllanthus acidus and in the aquatic fern Salvinia molesta.
Synonyms:related_synonym: 2,3 DHB;   2,3-DIHYDROXY-BENZOIC ACID;   2-pyrocatechuic acid;   3-hydroxysalicylic acid;   DOBK;   Formula=C7H6O4;   InChI=1S/C7H6O4/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,8-9H,(H,10,11);   InChIKey=GLDQAMYCGOIJDV-UHFFFAOYSA-N;   SMILES=OC(=O)c1cccc(O)c1O;   catechol-3-carboxylic acid;   o-pyrocatechuic acid;   pyrocatechuic acid
 alt_id: CHEBI:19320;   CHEBI:41901;   CHEBI:885
 xref: Beilstein:2209117;   CAS:303-38-8;   DrugBank:DB01672;   HMDB:HMDB0000397;   KEGG:C00196;   KNApSAcK:C00002669
 xref_mesh: MESH:C009135
 xref: PDBeChem:DBH;   PMID:17065237;   PMID:24171385;   PMID:3575393;   Reaxys:2209117;   Wikipedia:2\,3-Dihydroxybenzoic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:36654


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2,3-dihydroxybenzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO 2,3-dihydroxybenzoic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]; Gallic Acid inhibits the reaction [2,3-dihydroxybenzoic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]] CTD PMID:22129351 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
ISO Calcium Chloride inhibits the reaction [2,3-dihydroxybenzoic acid results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [2,3-dihydroxybenzoic acid results in decreased activity of MMP2 protein] CTD PMID:10086886 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions ISO 2,3-dihydroxybenzoic acid promotes the reaction [Kanamycin results in increased expression of PRDX3 protein] CTD PMID:23626763 NCBI chr 1:282,238,774...282,251,193
Ensembl chr 1:282,238,773...282,251,257
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          antimicrobial food preservative 11603
            benzoic acid 3839
              2,3-dihydroxybenzoic acid 3
                2,3-dihydroxybenzoic acid 3-O-beta-D-xyloside 0
                N-(2,3-dihydroxybenzoyl)serine 0
                myxochelin B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        aromatic carboxylic acid 10889
                                          benzoic acids 10858
                                            benzoic acid 3839
                                              hydroxybenzoic acid 3227
                                                dihydroxybenzoic acid 48
                                                  2,3-dihydroxybenzoic acid 3
                                                    2,3-dihydroxybenzoic acid 3-O-beta-D-xyloside 0
                                                    N-(2,3-dihydroxybenzoyl)serine 0
                                                    myxochelin B 0
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