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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fumaric acid
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Accession:CHEBI:18012 term browser browse the term
Definition:A butenedioic acid in which the C=C double bond has E geometry. It is an intermediate metabolite in the citric acid cycle.
Synonyms:related_synonym: (2E)-2-butenedioic acid;   (2E)-But-2-enedioic acid;   (E)-2-butenedioic acid;   E297;   Formula=C4H4O4;   Fumarsaeure;   InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+;   InChIKey=VZCYOOQTPOCHFL-OWOJBTEDSA-N;   SMILES=OC(=O)\\C=C\\C(O)=O;   trans-1,2-ethylenedicarboxylic acid;   trans-Butenedioic acid;   trans-but-2-enedioic acid;   trans-ethene-1,2-dioic acid
 alt_id: CHEBI:24124;   CHEBI:42743;   CHEBI:5190
 xref: Beilstein:605763;   CAS:110-17-8;   DrugBank:DB01677;   Drug_Central:3229;   FooDB:FDB003291;   Gmelin:49855;   HMDB:HMDB0000134;   KEGG:C00122;   KEGG:D02308;   KNApSAcK:C00001183
 xref_mesh: MESH:C032005
 xref: MetaCyc:FUM;   PDBeChem:FUM;   PMID:17439666;   PMID:21414846;   PMID:22113915;   PMID:22217732;   PMID:22516248;   PMID:23472183;   PPDB:1347;   Reaxys:605763;   Wikipedia:Fumaric_Acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:37154


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fumaric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 protein] CTD PMID:23707484 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 multiple interactions ISO fumaric acid inhibits the reaction [TNF protein results in increased expression of CCR3 protein] CTD PMID:23707484 NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990 		JBrowse link
G Hlcs holocarboxylase synthetase decreases activity ISO fumaric acid results in decreased activity of HLCS protein CTD PMID:26303405 NCBI chr11:33,455,806...33,635,197
Ensembl chr11:33,455,809...33,624,222 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO fumaric acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:23707484 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of fumaric acid CTD PMID:20567778 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO fumaric acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:23707484 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO fumaric acid inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:23707484 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO fumaric acid inhibits the reaction [TNF protein affects the localization of RELA protein]; fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 protein]; fumaric acid inhibits the reaction [TNF protein results in increased expression of CCR3 protein]; fumaric acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; fumaric acid inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; fumaric acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:23707484 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO fumaric acid inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:23707484 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
diethyl fumarate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases cleavage ISO diethyl fumarate results in increased cleavage of CASP3 protein CTD PMID:21105742 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO diethyl fumarate results in increased cleavage of PARP1 protein CTD PMID:21105742 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases cleavage ISO diethyl fumarate results in increased cleavage of SPTAN1 protein CTD PMID:21105742 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046 		JBrowse link
dimethyl fumarate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of ACSL4 protein] CTD PMID:35870111 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Dimethyl Fumarate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:30703375 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein] CTD PMID:36999408 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA] CTD PMID:30742845 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354 		JBrowse link
G Bach1 BTB domain and CNC homolog 1 affects localization ISO Dimethyl Fumarate affects the localization of BACH1 protein CTD PMID:27277809 NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Dimethyl Fumarate inhibits the reaction [Propylthiouracil results in decreased expression of BDNF mRNA]; Dimethyl Fumarate inhibits the reaction [Propylthiouracil results in decreased expression of BDNF protein] CTD PMID:35869475 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP1 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP1 protein] CTD PMID:36999408 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Cat catalase multiple interactions EXP [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein] CTD PMID:36999408 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of CCL2 mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to CCL2 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCL2 mRNA]
Dimethyl Fumarate results in decreased expression of CCL2 mRNA		 CTD PMID:26683377 PMID:27277809 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD68 mRNA] CTD PMID:27277809 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Cd74 CD74 molecule multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CD74 mRNA] CTD PMID:30021835 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Ciita class II, major histocompatibility complex, transactivator multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CIITA mRNA] CTD PMID:30021835 NCBI chr10:5,139,947...5,187,493
Ensembl chr10:5,140,178...5,187,440 		JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions ISO Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]; Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Ctsk cathepsin K multiple interactions ISO Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CXCL10 mRNA] CTD PMID:30021835 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CXCL9 mRNA] CTD PMID:30021835 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435 		JBrowse link
G Fth1 ferritin heavy chain 1 increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of FTH1 mRNA; Dimethyl Fumarate results in increased expression of FTH1 protein
Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of FTH1 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTH1 mRNA]		 CTD PMID:28289076 PMID:35870111 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Ftl1 ferritin light chain 1 increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of FTL mRNA; Dimethyl Fumarate results in increased expression of FTL protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL protein]		 CTD PMID:28289076 NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression		 ISO
EXP		 NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLC mRNA]
Dimethyl Fumarate results in increased expression of GCLC protein		 CTD PMID:27277809 PMID:30248482 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression		 ISO
EXP		 NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLM mRNA]
Dimethyl Fumarate results in increased expression of GCLM protein		 CTD PMID:27277809 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gpx4 glutathione peroxidase 4 increases metabolic processing
multiple interactions		 ISO
EXP		 Dimethyl Fumarate results in increased metabolism of GPX4 protein
Dimethyl Fumarate inhibits the reaction [sodium aescinate results in decreased expression of GPX4 protein]
Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of GPX4 protein]		 CTD PMID:29917289 PMID:35870111 PMID:38364601 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression
multiple interactions		 EXP
ISO		 Dimethyl Fumarate results in increased expression of GSR protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GSR mRNA]		 CTD PMID:27277809 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [sodium aescinate results in increased expression of HAVCR1] CTD PMID:38364601 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO
EXP		 Dimethyl Fumarate results in increased expression of HMOX1 mRNA; Dimethyl Fumarate results in increased expression of HMOX1 protein
[Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]
Acetylcysteine inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; HMOX1 protein inhibits the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]
[Dimethyl Fumarate results in decreased abundance of Glutathione] which results in increased expression of HMOX1 protein; [Dimethyl Fumarate results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein; Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of HMOX1 protein]; Glutathione inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]		 CTD PMID:20961405 PMID:23942037 PMID:26683377 PMID:27277809 PMID:28790194 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to ICAM1 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
Dimethyl Fumarate results in decreased expression of ICAM1 mRNA		 CTD PMID:26683377 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CD74 mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CIITA mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CXCL10 mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of CXCL9 mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of HLA-DRA mRNA]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA]; Dimethyl Fumarate inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]
Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; tin protoporphyrin IX inhibits the reaction [Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]		 CTD PMID:15663561 PMID:23942037 PMID:30021835 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IGF1 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IGF1 protein] CTD PMID:36999408 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of CCL2 mRNA]; Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of TNF mRNA] CTD PMID:26683377 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Dimethyl Fumarate results in decreased expression of IL6R protein CTD PMID:28134847 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA] CTD PMID:30021835 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of LAMP2 protein alternative form] CTD PMID:29950142 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522 		JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of COX3 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of COX3 mRNA]		 CTD PMID:27277809 NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382 		JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of CYTB mRNA] CTD PMID:27277809 NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278 		JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND1 mRNA] CTD PMID:27277809 NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694 		JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND2 mRNA] CTD PMID:27277809 NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942 		JBrowse link
G Mt-nd5 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND5 mRNA] CTD PMID:27277809 NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565 		JBrowse link
G Mterf3 mitochondrial transcription termination factor 3 increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of MTERF3 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of MTERF3 mRNA]		 CTD PMID:27277809 NCBI chr 7:63,826,418...63,844,747
Ensembl chr 7:63,826,427...63,844,658 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
affects localization		 ISO
EXP		 Dimethyl Fumarate inhibits the reaction [sodium aescinate results in decreased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of COX3 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of CYTB mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GSR mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of LAMP2 protein alternative form]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of MTERF1A mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of MTERF3 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND2 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND5 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLG2 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLRMT mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of SQSTM1 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of SSBP1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFAM mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB1M mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB2M mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TWNK mRNA]; NFE2L2 protein inhibits the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; NFE2L2 protein promotes the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]
[Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of NFE2L2 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]
Dimethyl Fumarate results in increased expression of NFE2L2 protein
Dimethyl Fumarate affects the localization of NFE2L2 protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTH1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]		 CTD PMID:23942037 PMID:27277809 PMID:28289076 PMID:28790194 PMID:29950142 More... NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 protein] CTD PMID:36999408 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NLRP3 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NLRP3 protein] CTD PMID:36999408 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
multiple interactions
increases expression		 ISO
EXP		 Dimethyl Fumarate results in increased activity of NQO1 protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of NQO1 mRNA]
Dimethyl Fumarate results in increased expression of NQO1 mRNA; Dimethyl Fumarate results in increased expression of NQO1 protein
[Dimethyl Fumarate results in increased activity of NQO1 protein] which results in increased susceptibility to Mitomycin; [Dimethyl Fumarate results in increased activity of NQO1 protein] which results in increased susceptibility to Streptonigrin		 CTD PMID:15655414 PMID:16045903 PMID:27277809 PMID:28790194 PMID:30248482 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO [Dimethyl Fumarate results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein CTD PMID:20961405 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Polg2 DNA polymerase gamma 2, accessory subunit increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of POLG2 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLG2 mRNA]		 CTD PMID:27277809 NCBI chr10:91,712,586...91,723,008
Ensembl chr10:91,712,586...91,723,008 		JBrowse link
G Polrmt RNA polymerase mitochondrial increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of POLRMT mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLRMT mRNA]		 CTD PMID:27277809 NCBI chr 7:9,959,532...9,969,791
Ensembl chr 7:9,959,576...9,969,791 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Dimethyl Fumarate binds to and affects the localization of and results in decreased activity of RELA protein; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to CCL2 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to ICAM1 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:26683377 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions EXP Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of RIPK3 protein] CTD PMID:36000575 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G RT1-Da RT1 class II, locus Da multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased expression of HLA-DRA mRNA] CTD PMID:30021835 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of SLC40A1 protein] CTD PMID:35870111 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [1,3-dichloro-2-propanol results in decreased expression of SLC7A11 protein] CTD PMID:35870111 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP [Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SOD1 protein]; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SOD1 protein] CTD PMID:36999408 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of SQSTM1 protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of SQSTM1 protein]		 CTD PMID:29950142 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Ssbp1 single stranded DNA binding protein 1 increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of SSBP1 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of SSBP1 mRNA]		 CTD PMID:27277809 NCBI chr 4:69,266,024...69,276,135
Ensembl chr 4:69,266,102...69,276,135 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of TFAM mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFAM mRNA]		 CTD PMID:27277809 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tfb1m transcription factor B1, mitochondrial multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB1M mRNA] CTD PMID:27277809 NCBI chr 1:44,115,240...44,161,737
Ensembl chr 1:44,119,166...44,161,709 		JBrowse link
G Tfb2m transcription factor B2, mitochondrial increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of TFB2M mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB2M mRNA]		 CTD PMID:27277809 NCBI chr13:91,278,889...91,296,709
Ensembl chr13:91,278,898...91,296,657 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Dimethyl Fumarate inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:30703375 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of TNF mRNA]]; Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of TNF mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to CCL2 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to ICAM1 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased activity of RELA protein]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of TNF mRNA]
Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF mRNA]
Dimethyl Fumarate results in decreased expression of TNF mRNA		 CTD PMID:26683377 PMID:27277809 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]; Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Twnk twinkle mtDNA helicase multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TWNK mRNA] CTD PMID:27277809 NCBI chr 1:243,867,568...243,874,802
Ensembl chr 1:243,868,330...243,874,802 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      application 19741
        food additive 16193
          food acidity regulator 11982
            fumaric acid 68
              (2E)-2-(methoxycarbonylmethyl)but-2-enedioic acid 0
              (E)-3-carboxyprop-2-enoyl group 0
              3-amino-N-(trans-3-carbamoyloxirane-2-carbonyl)-L-alanine 0
              N(3)-fumaramoyl-(S)-2,3-diaminopropanoic acid 0
              N(3)-fumaroyl-(S)-2,3-diaminopropanoic acid 0
              O-fumaryl-L-carnitine 0
              O-fumarylcarnitine + 0
              dapdiamide + 0
              diethyl fumarate 3
              dihydroxyfumaric acid 0
              dimethyl fumarate 59
              fumaroyl group 0
              mesaconic acid + 0
              monomethyl fumarate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            heteroorganic entity 19559
                              organochalcogen compound 19317
                                organooxygen compound 19231
                                  carbonyl compound 18945
                                    dicarboxylic acids and O-substituted derivatives 11130
                                      dicarboxylic acid 11124
                                        C4-dicarboxylic acid 1357
                                          butenedioic acid 621
                                            fumaric acid 68
                                              (2E)-2-(methoxycarbonylmethyl)but-2-enedioic acid 0
                                              (E)-3-carboxyprop-2-enoyl group 0
                                              3-amino-N-(trans-3-carbamoyloxirane-2-carbonyl)-L-alanine 0
                                              N(3)-fumaramoyl-(S)-2,3-diaminopropanoic acid 0
                                              N(3)-fumaroyl-(S)-2,3-diaminopropanoic acid 0
                                              O-fumaryl-L-carnitine 0
                                              O-fumarylcarnitine + 0
                                              dapdiamide + 0
                                              diethyl fumarate 3
                                              dihydroxyfumaric acid 0
                                              dimethyl fumarate 59
                                              fumaroyl group 0
                                              mesaconic acid + 0
                                              monomethyl fumarate 0
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