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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:fumaric acid
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Accession:CHEBI:18012 term browser browse the term
Definition:A butenedioic acid in which the C=C double bond has E geometry. It is an intermediate metabolite in the citric acid cycle.
Synonyms:related_synonym: (2E)-2-butenedioic acid;   (2E)-But-2-enedioic acid;   (E)-2-butenedioic acid;   E297;   Formula=C4H4O4;   Fumarsaeure;   InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+;   InChIKey=VZCYOOQTPOCHFL-OWOJBTEDSA-N;   SMILES=OC(=O)\\C=C\\C(O)=O;   trans-1,2-ethylenedicarboxylic acid;   trans-Butenedioic acid;   trans-but-2-enedioic acid
 alt_id: CHEBI:24124;   CHEBI:42743;   CHEBI:5190
 xref: Beilstein:605763;   CAS:110-17-8;   Drug_Central:3229;   Gmelin:49855;   HMDB:HMDB0000134;   KEGG:C00122;   KEGG:D02308;   KNApSAcK:C00001183
 xref_mesh: MESH:C032005
 xref: MetaCyc:FUM;   PDBeChem:FUM;   PMID:17439666;   PMID:21414846;   PMID:22113915;   PMID:22217732;   PMID:22516248;   PPDB:1347;   Reaxys:605763;   Wikipedia:Fumaric_Acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:37154

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fumaric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 protein] CTD PMID:23707484 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 multiple interactions ISO fumaric acid inhibits the reaction [TNF protein results in increased expression of CCR3 protein] CTD PMID:23707484 NCBI chr 8:133,026,539...133,040,999
Ensembl chr 8:133,029,625...133,040,997 		JBrowse link
G Hlcs holocarboxylase synthetase decreases activity ISO fumaric acid results in decreased activity of HLCS protein CTD PMID:26303405 NCBI chr11:34,357,372...34,537,798
Ensembl chr11:34,352,287...34,526,931 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO fumaric acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:23707484 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of fumaric acid CTD PMID:20567778 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO fumaric acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:23707484 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO fumaric acid inhibits the reaction [TNF protein affects the localization of RELA protein] CTD PMID:23707484 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO fumaric acid inhibits the reaction [TNF protein affects the localization of RELA protein]; fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; fumaric acid inhibits the reaction [TNF protein results in increased expression of CCL11 protein]; fumaric acid inhibits the reaction [TNF protein results in increased expression of CCR3 protein]; fumaric acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; fumaric acid inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; fumaric acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:23707484 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO fumaric acid inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:23707484 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
diethyl fumarate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases cleavage ISO diethyl fumarate results in increased cleavage of CASP3 protein CTD PMID:21105742 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO diethyl fumarate results in increased cleavage of PARP1 protein CTD PMID:21105742 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases cleavage ISO diethyl fumarate results in increased cleavage of SPTAN1 protein CTD PMID:21105742 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260 		JBrowse link
dimethyl fumarate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Dimethyl Fumarate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:30703375 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA] CTD PMID:30742845 NCBI chr 5:33,843,591...33,892,446
Ensembl chr 5:33,843,519...33,892,462 		JBrowse link
G Bach1 BTB domain and CNC homolog 1 affects localization ISO Dimethyl Fumarate affects the localization of BACH1 protein CTD PMID:27277809 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
Ensembl chr11:27,364,916...27,398,842 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of CCL2 mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to CCL2 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCL2 mRNA]
Dimethyl Fumarate results in decreased expression of CCL2 mRNA		 CTD PMID:26683377 PMID:27277809 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CD68 mRNA] CTD PMID:27277809 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640 		JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions ISO Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]; Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300 		JBrowse link
G Ctsk cathepsin K multiple interactions ISO Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446 		JBrowse link
G Fth1 ferritin heavy chain 1 increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of FTH1 mRNA; Dimethyl Fumarate results in increased expression of FTH1 protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTH1 mRNA]		 CTD PMID:28289076 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228 		JBrowse link
G Ftl1 ferritin light chain 1 increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of FTL mRNA; Dimethyl Fumarate results in increased expression of FTL protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL protein]		 CTD PMID:28289076 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression		 ISO
EXP		 NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLC mRNA]
Dimethyl Fumarate results in increased expression of GCLC protein		 CTD PMID:27277809 PMID:30248482 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
increases expression		 ISO
EXP		 NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLM mRNA]
Dimethyl Fumarate results in increased expression of GCLM protein		 CTD PMID:27277809 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874 		JBrowse link
G Gpx4 glutathione peroxidase 4 increases metabolic processing ISO Dimethyl Fumarate results in increased metabolism of GPX4 protein CTD PMID:29917289 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression
multiple interactions		 EXP
ISO		 Dimethyl Fumarate results in increased expression of GSR protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GSR mRNA]		 CTD PMID:27277809 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO
EXP		 Dimethyl Fumarate results in increased expression of HMOX1 mRNA; Dimethyl Fumarate results in increased expression of HMOX1 protein
Acetylcysteine inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; HMOX1 protein inhibits the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]
[Dimethyl Fumarate results in decreased abundance of Glutathione] which results in increased expression of HMOX1 protein; [Dimethyl Fumarate results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein; Glutathione inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]		 CTD PMID:20961405 PMID:23942037 PMID:26683377 PMID:27277809 PMID:28790194 PMID:29950142 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to ICAM1 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]
Dimethyl Fumarate results in decreased expression of ICAM1 mRNA		 CTD PMID:26683377 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Dimethyl Fumarate inhibits the reaction [nickel sulfate results in increased secretion of IFNG protein]
Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; tin protoporphyrin IX inhibits the reaction [Dimethyl Fumarate inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]		 CTD PMID:15663561 PMID:23942037 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of CCL2 mRNA]; Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of TNF mRNA] CTD PMID:26683377 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Dimethyl Fumarate results in decreased expression of IL6R protein CTD PMID:28134847 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of LAMP2 protein alternative form] CTD PMID:29950142 NCBI chr  X:124,722,628...124,766,079
Ensembl chr  X:124,722,628...124,766,044 		JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of COX3 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of COX3 mRNA]		 CTD PMID:27277809 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382 		JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of CYTB mRNA] CTD PMID:27277809 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278 		JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND1 mRNA] CTD PMID:27277809 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694 		JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND2 mRNA] CTD PMID:27277809 NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942 		JBrowse link
G Mt-nd5 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND5 mRNA] CTD PMID:27277809 NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565 		JBrowse link
G Mterf1 mitochondrial transcription termination factor 1 increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of MTERF1A mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of MTERF1A mRNA]		 CTD PMID:27277809 NCBI chr 4:27,365,310...27,372,374
Ensembl chr 4:27,365,376...27,372,372 		JBrowse link
G Mterf3 mitochondrial transcription termination factor 3 increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of MTERF3 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of MTERF3 mRNA]		 CTD PMID:27277809 NCBI chr 7:71,275,544...71,293,842
Ensembl chr 7:71,273,275...71,293,823 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
affects localization		 ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of COX3 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of CYTB mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GCLM mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of GSR mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of LAMP2 protein alternative form]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of MTERF1A mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of MTERF3 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND2 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of ND5 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLG2 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLRMT mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of SQSTM1 protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of SSBP1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFAM mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB1M mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB2M mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TWNK mRNA]; NFE2L2 protein inhibits the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; NFE2L2 protein promotes the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]
Dimethyl Fumarate results in increased expression of NFE2L2 protein
Dimethyl Fumarate affects the localization of NFE2L2 protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTH1 mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL mRNA]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of FTL protein]; NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]		 CTD PMID:23942037 PMID:27277809 PMID:28289076 PMID:28790194 PMID:29950142 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
multiple interactions
increases expression		 ISO
EXP		 Dimethyl Fumarate results in increased activity of NQO1 protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of NQO1 mRNA]
Dimethyl Fumarate results in increased expression of NQO1 mRNA; Dimethyl Fumarate results in increased expression of NQO1 protein
[Dimethyl Fumarate results in increased activity of NQO1 protein] which results in increased susceptibility to Mitomycin; [Dimethyl Fumarate results in increased activity of NQO1 protein] which results in increased susceptibility to Streptonigrin		 CTD PMID:15655414 PMID:16045903 PMID:27277809 PMID:28790194 PMID:30248482 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO [Dimethyl Fumarate results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein CTD PMID:20961405 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741 		JBrowse link
G Polg2 DNA polymerase gamma 2, accessory subunit increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of POLG2 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLG2 mRNA]		 CTD PMID:27277809 NCBI chr10:94,968,836...94,979,259
Ensembl chr10:94,968,836...94,979,259 		JBrowse link
G Polrmt RNA polymerase mitochondrial increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of POLRMT mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of POLRMT mRNA]		 CTD PMID:27277809 NCBI chr 7:12,840,907...12,851,153
Ensembl chr 7:12,840,938...12,851,153 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Dimethyl Fumarate binds to and affects the localization of and results in decreased activity of RELA protein; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to CCL2 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to ICAM1 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:26683377 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of SQSTM1 protein
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of SQSTM1 protein]		 CTD PMID:29950142 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294 		JBrowse link
G Ssbp1 single stranded DNA binding protein 1 increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of SSBP1 mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of SSBP1 mRNA]		 CTD PMID:27277809 NCBI chr 4:68,634,844...68,645,112
Ensembl chr 4:68,634,929...68,645,172 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of TFAM mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFAM mRNA]		 CTD PMID:27277809 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151 		JBrowse link
G Tfb1m transcription factor B1, mitochondrial multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB1M mRNA] CTD PMID:27277809 NCBI chr 1:44,433,116...44,474,674
Ensembl chr 1:44,433,116...44,474,674 		JBrowse link
G Tfb2m transcription factor B2, mitochondrial increases expression
multiple interactions		 ISO Dimethyl Fumarate results in increased expression of TFB2M mRNA
NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TFB2M mRNA]		 CTD PMID:27277809 NCBI chr13:97,820,493...97,838,275
Ensembl chr13:97,820,493...97,838,228
Ensembl chr13:97,820,493...97,838,228 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Dimethyl Fumarate inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:30703375 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]]; Acetylcysteine inhibits the reaction [Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of TNF mRNA]]; Dimethyl Fumarate inhibits the reaction [IKBKB protein results in increased expression of TNF mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to CCL2 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to ICAM1 promoter]]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased activity of RELA protein]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Dimethyl Fumarate inhibits the reaction [TNF protein results in increased expression of TNF mRNA]
Dimethyl Fumarate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF mRNA]
Dimethyl Fumarate results in decreased expression of TNF mRNA		 CTD PMID:26683377 PMID:27277809 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]; Dimethyl Fumarate inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of CTSK mRNA] CTD PMID:30742845 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704 		JBrowse link
G Twnk twinkle mtDNA helicase multiple interactions
increases expression		 ISO NFE2L2 protein affects the reaction [Dimethyl Fumarate results in increased expression of TWNK mRNA] CTD PMID:27277809 NCBI chr 1:264,756,060...264,762,892
Ensembl chr 1:264,756,499...264,762,892 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      application 19401
        food additive 14749
          food acidity regulator 11692
            fumaric acid 50
              (2E)-2-(methoxycarbonylmethyl)but-2-enedioic acid 0
              (E)-3-carboxyprop-2-enoyl group 0
              3-amino-N-(trans-3-carbamoyloxirane-2-carbonyl)-L-alanine 0
              N(3)-fumaramoyl-(S)-2,3-diaminopropanoic acid 0
              N(3)-fumaroyl-(S)-2,3-diaminopropanoic acid 0
              O-fumaryl-L-carnitine 0
              O-fumarylcarnitine + 0
              dapdiamide + 0
              diethyl fumarate 3
              dihydroxyfumaric acid 0
              dimethyl fumarate 41
              fumaroyl group 0
              mesaconic acid + 0
              monomethyl fumarate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      dicarboxylic acids and O-substituted derivatives 10287
                                        dicarboxylic acid 10279
                                          C4-dicarboxylic acid 813
                                            butenedioic acid 528
                                              fumaric acid 50
                                                (2E)-2-(methoxycarbonylmethyl)but-2-enedioic acid 0
                                                (E)-3-carboxyprop-2-enoyl group 0
                                                3-amino-N-(trans-3-carbamoyloxirane-2-carbonyl)-L-alanine 0
                                                N(3)-fumaramoyl-(S)-2,3-diaminopropanoic acid 0
                                                N(3)-fumaroyl-(S)-2,3-diaminopropanoic acid 0
                                                O-fumaryl-L-carnitine 0
                                                O-fumarylcarnitine + 0
                                                dapdiamide + 0
                                                diethyl fumarate 3
                                                dihydroxyfumaric acid 0
                                                dimethyl fumarate 41
                                                fumaroyl group 0
                                                mesaconic acid + 0
                                                monomethyl fumarate 0
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