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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:butyrate
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Accession:CHEBI:17968 term browser browse the term
Definition:A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group.
Synonyms:related_synonym: 1-butanoate;   1-butyrate;   1-propanecarboxylate;   CH3-[CH2]2-COO(-);   Formula=C4H7O2;   InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1;   InChIKey=FERIUCNNQQJTOY-UHFFFAOYSA-M;   SMILES=CCCC([O-])=O;   butanate;   butanoate;   butanoic acid, ion(1-);   n-butanoate;   n-butyrate;   propanecarboxylate;   propylformate
 alt_id: CHEBI:13924;   CHEBI:22946
 xref: Beilstein:3601060;   CAS:461-55-2;   Gmelin:324289;   KEGG:C00246;   MetaCyc:BUTYRIC_ACID;   PMID:17190852;   PMID:7496326;   Reaxys:3601060;   UM-BBD_compID:c0035
 cyclic_relationship: is_conjugate_base_of CHEBI:30772


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(R)-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Carnitine results in increased expression of ADIPOQ protein CTD PMID:30256492 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation
multiple interactions		 ISO Carnitine results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in increased phosphorylation of AKT1 protein]		 CTD PMID:29186614 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Carnitine promotes the reaction [Paraquat deficiency inhibits the reaction [Paraquat promotes the reaction [APP protein binds to APP protein]]] CTD PMID:33290254 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Bax BCL2-associated X protein decreases expression
multiple interactions		 ISO Carnitine results in decreased expression of BAX protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in decreased expression of BAX protein]; Carnitine inhibits the reaction [Atrazine results in increased expression of BAX mRNA]; Carnitine inhibits the reaction [Methotrexate results in increased expression of BAX protein]		 CTD PMID:29186614 PMID:36282381 PMID:37312617 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 multiple interactions
increases chemical synthesis		 ISO Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]; Hydrogen Peroxide inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]; Ketoglutaric Acids inhibits the reaction [Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]]; Ketoglutaric Acids inhibits the reaction [Hydrogen Peroxide inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]] CTD PMID:21439360 NCBI chr 2:110,094,401...110,145,158
Ensembl chr 2:110,093,042...110,144,905 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
increases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in increased phosphorylation of BCL2 protein]; Carnitine inhibits the reaction [Atrazine results in decreased expression of BCL2 mRNA]; Carnitine inhibits the reaction [Ifosfamide results in decreased expression of BCL2 mRNA]; Carnitine inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein] CTD PMID:23213347 PMID:29186614 PMID:36282381 PMID:37312617 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO Carnitine inhibits the reaction [Gentamicins results in decreased expression of BCL2L1 protein] CTD PMID:19491382 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Carnitine inhibits the reaction [Atrazine results in increased expression of CASP3 mRNA]; Carnitine inhibits the reaction [Gentamicins results in increased cleavage of CASP3 protein]; Carnitine inhibits the reaction [Ifosfamide results in increased expression of CASP3 mRNA]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of CASP3 mRNA]]; Carnitine inhibits the reaction [Methotrexate results in increased expression of CASP3 protein]
Carnitine inhibits the reaction [quinone results in increased activity of CASP3 protein]		 CTD PMID:19491382 PMID:23213347 PMID:26562095 PMID:32478940 PMID:36282381 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO Carnitine inhibits the reaction [quinone results in increased activity of CASP8 protein] CTD PMID:32478940 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Carnitine inhibits the reaction [Ifosfamide results in increased expression of CASP9 mRNA]
Carnitine inhibits the reaction [quinone results in increased activity of CASP9 protein]		 CTD PMID:23213347 PMID:32478940 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions ISO Carnitine inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; Carnitine inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]; Carnitine inhibits the reaction [Ifosfamide results in decreased expression of CAT mRNA] CTD PMID:16889571 PMID:19294768 PMID:23213347 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO Carnitine inhibits the reaction [Sunitinib results in increased expression of CCN2 mRNA] CTD PMID:26581635 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of CDH1 protein] CTD PMID:28973641 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of COL1A1 mRNA]; Carnitine inhibits the reaction [sunitinib results in increased expression of COL1A1 mRNA] CTD PMID:26581635 PMID:28973641 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Col2a1 collagen, type II, alpha 1 multiple interactions ISO [COL2A1 protein co-treated with Freund's Adjuvant] affects the abundance of Carnitine; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine] CTD PMID:24709313 NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver multiple interactions ISO valproyl-coenzyme A inhibits the reaction [CPT1A protein results in increased metabolism of Carnitine]
[Doxorubicin co-treated with Carnitine] results in increased expression of CPT1A mRNA; [Genistein co-treated with Carnitine] results in increased expression of CPT1A protein; Carnitine inhibits the reaction [quinone results in decreased expression of CPT1A protein]		 CTD PMID:16283381 PMID:16362726 PMID:19854160 PMID:32478940 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions ISO Carnitine promotes the reaction [[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate] CTD PMID:21816645 NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807 		JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions ISO Carnitine inhibits the reaction [Sunitinib results in increased expression of CYBB mRNA]; Carnitine inhibits the reaction [Sunitinib results in increased expression of CYBB protein] CTD PMID:26581635 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO Carnitine inhibits the reaction [Atrazine results in decreased expression of CYP17A1 mRNA] CTD PMID:29710542 NCBI chr19:46,655,604...46,661,439
Ensembl chr19:46,655,604...46,661,611 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Carnitine promotes the reaction [Ethanol results in increased expression of CYP2E1 protein] CTD PMID:8130774 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Fabp3 fatty acid binding protein 3, muscle and heart multiple interactions ISO Carnitine inhibits the reaction [Doxorubicin results in decreased expression of FABP3 mRNA] CTD PMID:20470772 NCBI chr 4:130,202,531...130,209,256
Ensembl chr 4:130,202,388...130,209,256 		JBrowse link
G Fabp9 fatty acid binding protein 9, testis multiple interactions ISO Carnitine inhibits the reaction [carbendazim results in decreased expression of FABP9 mRNA]; Carnitine inhibits the reaction [carbendazim results in decreased expression of FABP9 protein] CTD PMID:33965443 NCBI chr 3:10,258,683...10,262,343
Ensembl chr 3:10,258,681...10,262,343 		JBrowse link
G Fshb follicle stimulating hormone beta multiple interactions ISO Carnitine inhibits the reaction [carbendazim results in decreased expression of FSHB protein] CTD PMID:33965443 NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Carnitine inhibits the reaction [Atrazine results in increased expression of GFAP protein] CTD PMID:36282381 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions ISO Carnitine inhibits the reaction [Atrazine results in increased activity of GPT protein] CTD PMID:36282381 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Carnitine inhibits the reaction [Ifosfamide results in decreased expression of GPX1 mRNA] CTD PMID:23213347 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions ISO Carnitine inhibits the reaction [quinone results in decreased expression of HADHA protein] CTD PMID:32478940 NCBI chr 5:30,324,421...30,359,978
Ensembl chr 5:30,323,302...30,360,160 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Carnitine inhibits the reaction [Methotrexate results in decreased expression of HMOX1 protein] CTD PMID:37312617 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hrk harakiri, BCL2 interacting protein (contains only BH3 domain) multiple interactions EXP Carnitine inhibits the reaction [Gentamicins results in increased expression of HRK mRNA]; Carnitine inhibits the reaction [Gentamicins results in increased expression of HRK protein] CTD PMID:16239342 NCBI chr 5:118,307,829...118,327,543
Ensembl chr 5:118,302,713...118,327,543 		JBrowse link
G Hspa2 heat shock protein 2 multiple interactions ISO Carnitine inhibits the reaction [Cadmium Chloride results in increased expression of HSPA2 protein] CTD PMID:22359436 NCBI chr12:76,450,688...76,453,712
Ensembl chr12:76,450,950...76,453,712 		JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions
increases abundance		 EXP Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Carnitine] CTD PMID:27469509 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Carnitine inhibits the reaction [carbendazim results in decreased expression of IL10 protein]; Carnitine inhibits the reaction [Sunitinib results in decreased expression of IL10 mRNA] CTD PMID:26581635 PMID:33965443 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of IL1B mRNA]]; Carnitine inhibits the reaction [sunitinib results in increased expression of IL1B mRNA] CTD PMID:26562095 PMID:26581635 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Carnitine inhibits the reaction [carbendazim results in increased expression of IL6 protein]; Carnitine inhibits the reaction [Methotrexate results in increased expression of IL6 protein]; Carnitine inhibits the reaction [Sunitinib results in increased expression of IL6 mRNA] CTD PMID:26581635 PMID:33965443 PMID:37312617 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Ins1 insulin I decreases uptake
multiple interactions		 EXP
ISO		 INS1 protein results in decreased uptake of Carnitine
Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased secretion of INS1 protein]		 CTD PMID:28298333 PMID:30256492 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions EXP Carnitine inhibits the reaction [Doxorubicin results in increased activity of LDHA protein] CTD PMID:37453608 NCBI chr 7:46,491,698...46,505,051
Ensembl chr 7:46,490,899...46,505,051 		JBrowse link
G Lepr leptin receptor affects abundance EXP LEPR affects the abundance of Carnitine CTD PMID:20567778 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
G Lhb luteinizing hormone beta multiple interactions ISO Carnitine inhibits the reaction [carbendazim results in decreased expression of LHB protein] CTD PMID:33965443 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Carnitine inhibits the reaction [sunitinib results in decreased expression of MMP9 mRNA] CTD PMID:26581635 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity		 ISO [Carboplatin co-treated with Carnitine deficiency] results in increased expression of MPO protein; Acetaminophen promotes the reaction [Carnitine deficiency results in increased activity of MPO protein] CTD PMID:18597074 PMID:18852009 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G mt-Co1 cytochrome c oxidase I, mitochondrial multiple interactions EXP Carnitine inhibits the reaction [nickel chloride results in decreased expression of COX1 mRNA] CTD PMID:21419151 NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872 		JBrowse link
G mt-Nd6 NADH dehydrogenase 6, mitochondrial multiple interactions EXP Carnitine inhibits the reaction [nickel chloride results in decreased expression of ND6 mRNA] CTD PMID:21419151 NCBI chr MT:13,552...14,070
Ensembl chr MT:13,552...14,070 		JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO Carnitine inhibits the reaction [Stavudine results in decreased expression of MTTP mRNA] CTD PMID:18299183 NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO Carnitine inhibits the reaction [Methotrexate results in decreased expression of NFE2L2 protein] CTD PMID:37312617 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Carnitine inhibits the reaction [carbendazim results in increased expression of NOS2 protein]; Carnitine inhibits the reaction [Ifosfamide results in increased expression of NOS2 mRNA] CTD PMID:23213347 PMID:33965443 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell increases expression ISO Carnitine results in increased expression of NOS3 CTD PMID:20123095 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Ocln occludin multiple interactions ISO Carnitine inhibits the reaction [carbendazim results in decreased expression of OCLN protein] CTD PMID:33965443 NCBI chr13:100,633,012...100,689,226
Ensembl chr13:100,633,015...100,689,226 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases activity		 ISO [pirinixic acid results in increased activity of PPARA protein] promotes the reaction [SLC22A21 protein results in increased uptake of Carnitine]; PPARA protein promotes the reaction [Carnitine results in decreased susceptibility to Gentamicins]
Carnitine results in increased activity of PPARA protein		 CTD PMID:19491382 PMID:19735737 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma increases expression
multiple interactions		 ISO Carnitine results in increased expression of PPARG protein
Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]		 CTD PMID:30256492 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha multiple interactions ISO Carnitine inhibits the reaction [Methotrexate results in decreased expression of PPARGC1A protein] CTD PMID:37312617 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Ptgis prostaglandin I2 (prostacyclin) synthase increases expression
increases response to substance
multiple interactions		 ISO Carnitine results in increased expression of PTGIS mRNA
PTGIS protein results in increased susceptibility to Carnitine
[Carnitine results in increased expression of PTGIS mRNA] which results in increased chemical synthesis of 6-Ketoprostaglandin F1 alpha		 CTD PMID:19491382 NCBI chr 2:167,045,114...167,095,069
Ensembl chr 2:167,033,725...167,082,524 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Carnitine inhibits the reaction [carbendazim results in increased expression of RELA protein] CTD PMID:33965443 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Carnitine inhibits the reaction [Methotrexate results in decreased expression of SIRT1 protein] CTD PMID:37312617 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Slc22a21 solute carrier family 22 (organic cation transporter), member 21 multiple interactions
increases uptake		 ISO [pirinixic acid results in increased activity of PPARA protein] promotes the reaction [SLC22A21 protein results in increased uptake of Carnitine] CTD PMID:19735737 NCBI chr11:53,840,780...53,871,159
Ensembl chr11:53,840,791...53,871,158 		JBrowse link
G Slc22a27 solute carrier family 22, member 27 multiple interactions
increases uptake		 EXP Acetylcarnitine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Betaine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Carnitine analog inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Choline inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Cimetidine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Corticosterone inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Cyclic AMP inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; estrone sulfate inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; octanoylcarnitine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Salicylic Acid inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; Tetraethylammonium inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine]; tetramethylammonium inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine] CTD PMID:20332632 NCBI chr19:7,841,753...7,943,899
Ensembl chr19:7,841,753...7,943,392 		JBrowse link
G Slc22a4 solute carrier family 22 (organic cation transporter), member 4 increases uptake ISO SLC22A4 protein results in increased uptake of Carnitine CTD PMID:21256917 PMID:33007874 NCBI chr11:53,873,941...53,920,866
Ensembl chr11:53,873,949...53,918,916 		JBrowse link
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 multiple interactions
decreases expression
increases transport
increases uptake
increases expression
affects uptake
affects binding		 ISO
EXP		 [Doxorubicin co-treated with Carnitine] results in increased expression of SLC22A5 mRNA; Amiodarone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Atorvastatin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Betaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Carnitine inhibits the reaction [SLC22A5 protein results in increased abundance of Doxorubicin]; Carnitine inhibits the reaction [SLC22A5 protein results in increased transport of pivaloylcarnitine]; Choline inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Clozapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; grepafloxacin affects the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Ipratropium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Lidocaine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Nifedipine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Ofloxacin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Olanzapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine analog]; pivaloylcarnitine inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]; Propranolol inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Quetiapine Fumarate inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Spironolactone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; talinolol inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; ziprasidone inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]
Carnitine inhibits the reaction [SLC22A5 protein results in increased abundance of and results in increased localization of Doxorubicin]
Carnitine results in decreased expression of SLC22A5 mRNA; Carnitine results in decreased expression of SLC22A5 protein
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of SLC22A5 mRNA]; Carnitine inhibits the reaction [Cyclophosphamide results in decreased expression of SLC22A5 protein]; Carnitine inhibits the reaction [Doxorubicin results in decreased expression of SLC22A5 mRNA]; Carnitine inhibits the reaction [SLC22A5 protein results in increased uptake of Tetraethylammonium]; Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]]; Ofloxacin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]; Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]; Tetraethylammonium inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine]
Carnitine deficiency results in increased expression of SLC22A5 mRNA
SLC22A5 protein results in increased uptake of Carnitine; SLC22A5 protein results in increased uptake of Carnitine analog
SLC22A5 protein affects the uptake of Carnitine
Carnitine binds to SLC22A5 protein		 CTD PMID:12644265 PMID:15486076 PMID:16283381 PMID:16928358 PMID:18762717 More... NCBI chr11:53,755,368...53,782,609
Ensembl chr11:53,755,368...53,782,486 		JBrowse link
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 increases transport EXP SLC22A8 protein results in increased transport of Carnitine CTD PMID:15100168 NCBI chr19:8,568,576...8,589,199
Ensembl chr19:8,568,618...8,589,199 		JBrowse link
G Slc25a20 solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 multiple interactions
increases transport		 ISO Ampicillin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Carnitine inhibits the reaction [Hydrogen Peroxide results in decreased activity of SLC25A20 protein]; Cefazolin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Cefonicid inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Cephalothin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine]; Piperacillin inhibits the reaction [SLC25A20 protein results in increased transport of Carnitine] CTD PMID:18452908 PMID:23402788 NCBI chr 9:108,539,335...108,561,841
Ensembl chr 9:108,539,287...108,561,840 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions
increases expression		 ISO Carnitine inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]
Carnitine results in increased expression of SLC2A4 protein		 CTD PMID:30256492 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Snai1 snail family zinc finger 1 multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of SNAI1 protein] CTD PMID:28973641 NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Carnitine inhibits the reaction [Stavudine results in increased expression of SREBF1 mRNA] CTD PMID:18299183 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Carnitine inhibits the reaction [carbendazim results in decreased expression of STAR mRNA]; Carnitine inhibits the reaction [carbendazim results in decreased expression of STAR protein] CTD PMID:33965443 NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TGFB1 mRNA]]; Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of TGFB1 mRNA]; Carnitine inhibits the reaction [sunitinib results in increased expression of TGFB1 mRNA] CTD PMID:26562095 PMID:26581635 PMID:28973641 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions ISO Carnitine inhibits the reaction [sunitinib results in increased expression of TIMP1 mRNA] CTD PMID:26581635 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of TJP1 protein] CTD PMID:28973641 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
decreases expression		 ISO Carnitine deficiency results in increased expression of TNF mRNA
[Carboplatin co-treated with Carnitine deficiency] results in increased expression of TNF protein; Acetaminophen promotes the reaction [Carnitine deficiency results in increased expression of TNF mRNA]; Carnitine inhibits the reaction [carbendazim results in increased expression of TNF protein]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF mRNA]]; Carnitine inhibits the reaction [Iohexol promotes the reaction [Glycerol results in increased expression of TNF protein]]; Carnitine inhibits the reaction [Methotrexate results in increased expression of TNF protein]
Carnitine results in decreased expression of TNF protein		 CTD PMID:18597074 PMID:18629605 PMID:18852009 PMID:26562095 PMID:33965443 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Vim vimentin multiple interactions ISO Carnitine inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of VIM protein] CTD PMID:28973641 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637 		JBrowse link
4-(trimethylammonio)butanoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbox1 gamma-butyrobetaine hydroxylase 1 multiple interactions ISO [BBOX1 protein co-treated with Ketoglutaric Acids] results in increased metabolism of gamma-butyrobetaine CTD PMID:21439360 NCBI chr 2:110,094,401...110,145,158
Ensembl chr 2:110,093,042...110,144,905 		JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions
increases abundance		 EXP Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of gamma-butyrobetaine] CTD PMID:27469509 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140 		JBrowse link
CAR(3:0(Me2)) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a5 solute carrier family 22 (organic cation transporter), member 5 increases transport
multiple interactions
affects binding
increases uptake		 ISO SLC22A5 protein results in increased transport of pivaloylcarnitine
Carnitine inhibits the reaction [SLC22A5 protein results in increased transport of pivaloylcarnitine]; pivaloylcarnitine inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]
pivaloylcarnitine binds to SLC22A5 protein
SLC22A5 protein results in increased uptake of pivaloylcarnitine		 CTD PMID:18762717 PMID:19539806 NCBI chr11:53,755,368...53,782,609
Ensembl chr11:53,755,368...53,782,486 		JBrowse link
carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acacb acetyl-Coenzyme A carboxylase beta decreases expression ISO L-carnitine decreases expression of Acacb mRNA and protein in rat heart RGD PMID:30644033 RGD:329955369 NCBI chr 5:114,284,748...114,388,822
Ensembl chr 5:114,284,596...114,388,822 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver increases expression
multiple interactions		 ISO L-carnitine increases expression of Cpt1a mRNA and protein in rat heart
L-carnitine inhibits the reaction [sunitinib decreases expression of Cpt1a mRNA and protein in rat heart]		 RGD PMID:30644033 PMID:30644033 RGD:329955369, RGD:329955369 NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733 		JBrowse link
G Mlycd malonyl-CoA decarboxylase increases expression
multiple interactions		 ISO L-carnitine increases expression of Mlycd protein in rat heart
L-carnitine inhibits the reaction [sunitinib increases expression of Mlycd protein in rat heart]		 RGD PMID:30644033 PMID:30644033 RGD:329955369, RGD:329955369 NCBI chr 8:120,121,591...120,148,577
Ensembl chr 8:120,121,617...120,137,841 		JBrowse link
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit increases expression
multiple interactions		 ISO L-carnitine increases expression of Ampka2 protein in rat serum and heart
L-carnitine inhibits the reaction [sunitinib decreases expression of Ampka2 protein in rat serum and heart]		 RGD PMID:30644033 PMID:30644033 RGD:329955369, RGD:329955369 NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087 		JBrowse link
O-acetyl-L-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO Acetylcarnitine inhibits the reaction [Dexamethasone results in decreased activity of ACHE protein]; Acetylcarnitine inhibits the reaction [Dexamethasone results in increased activity of ACHE protein] CTD PMID:21986892 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 increases expression ISO Acetylcarnitine results in increased expression of APEX1 mRNA CTD PMID:14654561 NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596 		JBrowse link
G Atp6v1f ATPase, H+ transporting, lysosomal V1 subunit F increases expression ISO Acetylcarnitine results in increased expression of ATP6V1F mRNA CTD PMID:14654561 NCBI chr 6:29,467,782...29,470,508
Ensembl chr 6:29,467,717...29,470,511 		JBrowse link
G C1qa complement component 1, q subcomponent, alpha polypeptide decreases expression EXP Acetylcarnitine results in decreased expression of C1QA mRNA CTD PMID:19555370 NCBI chr 4:136,623,227...136,626,155
Ensembl chr 4:136,623,228...136,626,114 		JBrowse link
G C4b complement C4B (Chido blood group) decreases expression EXP Acetylcarnitine results in decreased expression of C4B mRNA CTD PMID:19555370 NCBI chr17:34,947,249...34,962,876
Ensembl chr17:34,947,354...34,962,856 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Acetylcarnitine inhibits the reaction [Sodium Selenite results in increased expression of CASP3 mRNA] CTD PMID:20067779 PMID:29278859 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased activity of CASP9 protein] CTD PMID:29278859 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Acetylcarnitine inhibits the reaction [Sodium Selenite results in decreased expression of CAT mRNA] CTD PMID:20067779 PMID:26349760 PMID:29278859 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Col2a1 collagen, type II, alpha 1 multiple interactions ISO [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Acetylcarnitine CTD PMID:24709313 NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576 		JBrowse link
G Csprs component of Sp100-rs decreases expression EXP Acetylcarnitine results in decreased expression of CSPRS mRNA CTD PMID:19555370
G Ctss cathepsin S decreases expression EXP Acetylcarnitine results in decreased expression of CTSS mRNA CTD PMID:19555370 NCBI chr 3:95,434,097...95,463,716
Ensembl chr 3:95,434,097...95,463,714 		JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression EXP Acetylcarnitine results in decreased expression of CXCL14 mRNA CTD PMID:19555370 NCBI chr13:56,436,456...56,444,624
Ensembl chr13:56,436,456...56,444,364 		JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Acetylcarnitine inhibits the reaction [Sodium Selenite results in increased expression of EGR1 mRNA] CTD PMID:20067779 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037 		JBrowse link
G Gfap glial fibrillary acidic protein decreases expression EXP Acetylcarnitine results in decreased expression of GFAP mRNA CTD PMID:19555370 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738 		JBrowse link
G Gsr glutathione reductase multiple interactions EXP Acetylcarnitine inhibits the reaction [Acetaminophen results in decreased expression of GSR protein] CTD PMID:26265018 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in decreased expression of GSTP1 mRNA] CTD PMID:21986892 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of HMOX1 mRNA] CTD PMID:21986892 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hmox2 heme oxygenase 2 multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of HMOX2 mRNA] CTD PMID:21986892 NCBI chr16:4,544,225...4,584,606
Ensembl chr16:4,544,225...4,584,606 		JBrowse link
G Hspb1 heat shock protein 1 decreases expression ISO Acetylcarnitine results in decreased expression of HSPB1 mRNA CTD PMID:14654561 NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417 		JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial increases abundance
multiple interactions		 EXP IDH2 protein mutant form results in increased abundance of Acetylcarnitine
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Acetylcarnitine]		 CTD PMID:27469509 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of IL1B protein] CTD PMID:29278859 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of IL6 protein] CTD PMID:29278859 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Lyz1 lysozyme 1 decreases expression EXP Acetylcarnitine results in decreased expression of LYZ1 mRNA CTD PMID:19555370 NCBI chr10:117,123,700...117,128,773
Ensembl chr10:117,123,702...117,128,773 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO Acetylcarnitine results in increased expression of MGST1 mRNA CTD PMID:14654561 NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753 		JBrowse link
G mt-Co1 cytochrome c oxidase I, mitochondrial multiple interactions ISO Acetylcarnitine inhibits the reaction [Sodium Selenite results in decreased expression of COX1 mRNA] CTD PMID:20067779 NCBI chr MT:5,328...6,872
Ensembl chr MT:5,328...6,872 		JBrowse link
G Ngf nerve growth factor multiple interactions ISO Acetylcarnitine inhibits the reaction [Cisplatin results in decreased expression of NGF protein] CTD PMID:14654561 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of NOS1 mRNA] CTD PMID:21986892 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Acetylcarnitine affects the reaction [Dexamethasone results in increased expression of NOS2 mRNA] CTD PMID:21986892 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Pah phenylalanine hydroxylase decreases expression EXP Acetylcarnitine results in decreased expression of PAH mRNA CTD PMID:19555370 NCBI chr10:87,357,657...87,419,999
Ensembl chr10:87,357,657...87,419,998 		JBrowse link
G Pink1 PTEN induced putative kinase 1 multiple interactions EXP Acetylcarnitine inhibits the reaction [Cadmium results in increased expression of PINK1] CTD PMID:25464205 NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression
multiple interactions		 ISO Acetylcarnitine results in increased expression of PPARGC1A protein
[Acetylcarnitine co-treated with Thioctic Acid] results in increased expression of PPARGC1A protein		 CTD PMID:20414966 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP Acetylcarnitine inhibits the reaction [Cadmium results in increased expression of PRKN] CTD PMID:25464205 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248 		JBrowse link
G Psmb6 proteasome (prosome, macropain) subunit, beta type 6 increases expression ISO Acetylcarnitine results in increased expression of PSMB6 mRNA CTD PMID:14654561 NCBI chr11:70,416,116...70,418,684
Ensembl chr11:70,416,193...70,418,684 		JBrowse link
G Ptma prothymosin alpha increases expression ISO Acetylcarnitine results in increased expression of PTMA mRNA CTD PMID:14654561 NCBI chr 1:86,454,442...86,458,434
Ensembl chr 1:86,454,448...86,458,434 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO Acetylcarnitine inhibits the reaction [sodium arsenite results in increased expression of RELA protein] CTD PMID:29278859 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rps17 ribosomal protein S17 increases expression ISO Acetylcarnitine results in increased expression of RPS17 mRNA CTD PMID:14654561 NCBI chr 7:80,992,481...80,994,982
Ensembl chr 7:80,992,480...80,995,002 		JBrowse link
G Skap2 src family associated phosphoprotein 2 decreases expression EXP Acetylcarnitine results in decreased expression of SKAP2 mRNA CTD PMID:19555370 NCBI chr 6:51,836,145...51,989,529
Ensembl chr 6:51,834,402...51,989,529 		JBrowse link
G Slc22a27 solute carrier family 22, member 27 multiple interactions EXP Acetylcarnitine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine] CTD PMID:20332632 NCBI chr19:7,841,753...7,943,899
Ensembl chr19:7,841,753...7,943,392 		JBrowse link
G Slc25a20 solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 multiple interactions ISO Acetylcarnitine inhibits the reaction [Hydrogen Peroxide results in decreased activity of SLC25A20 protein] CTD PMID:23402788 NCBI chr 9:108,539,335...108,561,841
Ensembl chr 9:108,539,287...108,561,840 		JBrowse link
G Snca synuclein, alpha multiple interactions ISO [Acetylcarnitine co-treated with Thioctic Acid] inhibits the reaction [Rotenone results in increased expression of SNCA protein]; Acetylcarnitine inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:20414966 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
G Tnni3 troponin I, cardiac 3 multiple interactions ISO Acetylcarnitine inhibits the reaction [Cisplatin results in increased expression of TNNI3 protein] CTD PMID:21034734 NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228 		JBrowse link
O-butanoyl-L-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial increases abundance
multiple interactions		 EXP IDH2 protein mutant form results in increased abundance of butyrylcarnitine
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of butyrylcarnitine]		 CTD PMID:27469509 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140 		JBrowse link
O-octanoylcarnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crot carnitine O-octanoyltransferase increases chemical synthesis EXP CROT protein results in increased chemical synthesis of octanoylcarnitine CTD PMID:6838215 NCBI chr 5:9,016,033...9,047,926
Ensembl chr 5:9,016,033...9,047,324 		JBrowse link
G Slc22a27 solute carrier family 22, member 27 multiple interactions EXP octanoylcarnitine inhibits the reaction [SLC22A27 protein alternative form results in increased uptake of Carnitine] CTD PMID:20332632 NCBI chr19:7,841,753...7,943,899
Ensembl chr19:7,841,753...7,943,392 		JBrowse link
O-palmitoylcarnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col2a1 collagen, type II, alpha 1 multiple interactions ISO [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Palmitoylcarnitine CTD PMID:24709313 NCBI chr15:97,873,483...97,902,525
Ensembl chr15:97,873,483...97,902,576 		JBrowse link
G Gls glutaminase increases chemical synthesis ISO GLS protein results in increased chemical synthesis of Palmitoylcarnitine CTD PMID:31040181 NCBI chr 1:52,202,608...52,274,168
Ensembl chr 1:52,202,607...52,272,391 		JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) decreases metabolic processing EXP PPP3R1 gene mutant form results in decreased metabolism of Palmitoylcarnitine CTD PMID:19700627 NCBI chr11:17,109,298...17,150,380
Ensembl chr11:17,109,263...17,150,375 		JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit increases chemical synthesis ISO PRKAA1 protein results in increased chemical synthesis of Palmitoylcarnitine CTD PMID:31040181 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      biological role 22178
        biochemical role 21449
          metabolite 21397
            butyrate 101
              (3R)-4-(dimethylammonio)-3-hydroxybutanoate 0
              (R)-2-hydroxy-4-(hydroxymethylphosphinyl)butyrate 0
              (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate 0
              (S)-2-acetyl-2-hydroxybutanoate 0
              2,3-dihydroxy-3-methylbutanoate + 0
              2-hydroxybutyrate + 0
              2-methyl-3-hydroxybutyrate + 0
              2-methylacetoacetate 0
              2-oxobutanoate 0
              3-hydroxybutyrate + 0
              3-methyl-2-oxobutanoate 0
              4-(hydroxymethylphosphinyl)-2-oxobutyrate 0
              4-(methylamino)butyrate 0
              4-acetamidobutanoate 0
              4-amino-3-hydroxybutanoate 0
              4-hydroxybutyrate 0
              4-methylthio-2-oxobutanoate + 0
              L-2,4-diaminobutyrate 0
              L-2-amino-3-oxobutanoate 0
              L-2-aminobutyrate 0
              O-butyryl-L-serine residue 0
              acetoacetate 0
              carnitine + 101
              gamma-aminobutyrate + 2
              sodium butyrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21920
                        carbon atom 21846
                          organic molecular entity 21846
                            organic ion 10082
                              organic anion 3684
                                carboxylic acid anion 2523
                                  monocarboxylic acid anion 1607
                                    fatty acid anion 129
                                      short-chain fatty acid anion 123
                                        fatty acid anion 4:0 101
                                          butyrate 101
                                            (3R)-4-(dimethylammonio)-3-hydroxybutanoate 0
                                            (R)-2-hydroxy-4-(hydroxymethylphosphinyl)butyrate 0
                                            (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate 0
                                            (S)-2-acetyl-2-hydroxybutanoate 0
                                            2,3-dihydroxy-3-methylbutanoate + 0
                                            2-hydroxybutyrate + 0
                                            2-methyl-3-hydroxybutyrate + 0
                                            2-methylacetoacetate 0
                                            2-oxobutanoate 0
                                            3-hydroxybutyrate + 0
                                            3-methyl-2-oxobutanoate 0
                                            4-(hydroxymethylphosphinyl)-2-oxobutyrate 0
                                            4-(methylamino)butyrate 0
                                            4-acetamidobutanoate 0
                                            4-amino-3-hydroxybutanoate 0
                                            4-hydroxybutyrate 0
                                            4-methylthio-2-oxobutanoate + 0
                                            L-2,4-diaminobutyrate 0
                                            L-2-amino-3-oxobutanoate 0
                                            L-2-aminobutyrate 0
                                            O-butyryl-L-serine residue 0
                                            acetoacetate 0
                                            carnitine + 101
                                            gamma-aminobutyrate + 2
                                            sodium butyrate 0
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