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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isoorientin
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Accession:CHEBI:17965 term browser browse the term
Definition:A flavone C-glycoside consisting of luteolin having a beta-D-glucosyl residue at the 6-position.
Synonyms:exact_synonym: (1S)-1,5-anhydro-1-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-6-yl]-D-glucitol
 related_synonym: 2-(3,4-dihydroxyphenyl)-6-beta-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one;   Formula=C21H20O11;   Homoorientin;   InChI=1S/C21H20O11/c22-6-14-17(27)19(29)20(30)21(32-14)16-11(26)5-13-15(18(16)28)10(25)4-12(31-13)7-1-2-8(23)9(24)3-7/h1-5,14,17,19-24,26-30H,6H2/t14-,17-,19+,20-,21+/m1/s1;   InChIKey=ODBRNZZJSYPIDI-VJXVFPJBSA-N;   Luteolin-6-C-beta-D-glucoside;   SMILES=OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1c(O)cc2oc(cc(=O)c2c1O)-c1ccc(O)c(O)c1
 alt_id: CHEBI:14471;   CHEBI:24905;   CHEBI:6034
 xref: CAS:4261-42-1;   KEGG:C01821;   KNApSAcK:C00001055;   LIPID_MAPS_instance:LMPK12110469
 xref_mesh: MESH:C057912
 xref: PMID:21080643;   PMID:22529049;   PMID:22948221;   PMID:22980875;   PMID:23026832;   PMID:23220614;   Reaxys:68256;   Wikipedia:Isoorientin
 cyclic_relationship: is_conjugate_acid_of CHEBI:58333


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isoorientin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP homoorientin inhibits the reaction [Ethanol results in increased expression of ACTA2 protein] CTD PMID:22446813 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
ISO homoorientin results in decreased phosphorylation of AKT1 protein
homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of AKT1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of AKT1 protein]
CTD PMID:24374571 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP homoorientin inhibits the reaction [Ethanol results in increased expression of BCL2 mRNA] CTD PMID:22446813 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Il6 interleukin 6 multiple interactions EXP homoorientin inhibits the reaction [Ethanol results in increased expression of IL6 protein] CTD PMID:22446813 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK1 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK1 protein] CTD PMID:24374571 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO homoorientin promotes the reaction [Zinc Oxide analog results in decreased phosphorylation of MAPK3 protein]; Zinc Oxide analog promotes the reaction [homoorientin results in decreased phosphorylation of MAPK3 protein] CTD PMID:24374571 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP homoorientin inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:22446813 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP homoorientin inhibits the reaction [Ethanol results in increased expression of TGFB1 protein] CTD PMID:22446813 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP homoorientin inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:22446813 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        immunomodulator 14893
          luteolin 198
            isoorientin 9
              7-O-(6-feruoylglucosyl)isoorientin 0
              7-O-(6-sinapoylglucosyl)isoorientin 0
              7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]isoorientin 0
              isoorientin 2''-O-glucoside 0
              isoorientin 2''-O-rhamnoside + 0
              isoorientin 7,3'-dimethyl ether 0
              isoorientin 7-O-glucoside 0
              swertiajaponin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  oxacycle 17587
                                    benzopyran 10402
                                      1-benzopyran 10129
                                        flavonoid 6513
                                          flavones 4203
                                            hydroxyflavone 4191
                                              3'-hydroxyflavonoid 254
                                                luteolin 198
                                                  isoorientin 9
                                                    7-O-(6-feruoylglucosyl)isoorientin 0
                                                    7-O-(6-sinapoylglucosyl)isoorientin 0
                                                    7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]isoorientin 0
                                                    isoorientin 2''-O-glucoside 0
                                                    isoorientin 2''-O-rhamnoside + 0
                                                    isoorientin 7,3'-dimethyl ether 0
                                                    isoorientin 7-O-glucoside 0
                                                    swertiajaponin 0
paths to the root