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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diisopropyl fluorophosphate
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Accession:CHEBI:17941 term browser browse the term
Definition:A dialkyl phosphate that has formula C6H14FO3P.
Synonyms:exact_synonym: bis(propan-2-yl) fluorophosphate
 related_synonym: DFP;   Diisopropoxyphosphoryl fluoride;   Diisopropyl fluorophosphonate;   Diisopropyl phosphofluoridate;   Diisopropyl phosphorofluoridate;   Diisopropylfluorophosphate;   Diisopropylfluorophosphoric acid ester;   Diisopropylphosphorofluoridate;   Fluorodiisopropyl phosphate;   Formula=C6H14FO3P;   InChI=1S/C6H14FO3P/c1-5(2)9-11(7,8)10-6(3)4/h5-6H,1-4H3;   InChIKey=MUCZHBLJLSDCSD-UHFFFAOYSA-N;   Isofluorphate;   Isoflurophate;   Isoflurophosphate;   Isopropyl fluophosphate;   Isopropyl phosphorofluoridate;   Neoglaucit;   O,O'-Diisopropyl phosphoryl fluoride;   SMILES=CC(C)OP(F)(=O)OC(C)C
 alt_id: CHEBI:14166;   CHEBI:4598
 xref: CAS:55-91-4;   DrugBank:DB00677;   Drug_Central:1494;   KEGG:C00202;   KEGG:D00043
 xref_mesh: MESH:D007531
 xref: Wikipedia:Isoflurophate


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diisopropyl fluorophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadac arylacetamide deacetylase multiple interactions ISO Isoflurophate inhibits the reaction [AADAC protein results in decreased acetylation of Rifabutin]; Isoflurophate inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin]; Isoflurophate inhibits the reaction [AADAC protein results in decreased acetylation of rifapentine] CTD PMID:21856291 NCBI chr 2:150,146,234...150,157,480
Ensembl chr 2:150,146,234...150,157,480
JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases expression
decreases activity
decreases response to substance
ISO
EXP
Fullerenes analog inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]; Glucosides inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]; N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]; Oximes inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]; Trimedoxime inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]
Isoflurophate results in decreased expression of ACHE mRNA
Isoflurophate analog results in decreased activity of ACHE protein; Isoflurophate results in decreased activity of ACHE protein
Corticosterone inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]; Isoflurophate binds to and results in increased phosphorylation of and results in decreased activity of ACHE protein
ACHE protein results in decreased susceptibility to Isoflurophate; ACHE results in decreased susceptibility to Isoflurophate
CTD PMID:1609424 PMID:3215484 PMID:7150809 PMID:7178195 PMID:7234437 PMID:7713347 PMID:8336138 PMID:9268605 PMID:9515941 PMID:16443250 PMID:16978018 PMID:17192637 PMID:17402711 PMID:18344198 PMID:20227398 PMID:20888407 PMID:21513723 PMID:21673941 PMID:21767560 PMID:21783513 PMID:22209767 PMID:22986948 PMID:24291005 PMID:24395470 PMID:26965078 PMID:28500787 PMID:29272548 PMID:29894704 PMID:33176172 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Aif1 allograft inflammatory factor 1 increases expression EXP Isoflurophate results in increased expression of AIF1 protein CTD PMID:28329845 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Alb albumin affects binding ISO Isoflurophate binds to ALB protein CTD PMID:15525694 PMID:17188226 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Apoh apolipoprotein H increases expression EXP Isoflurophate results in increased expression of APOH protein CTD PMID:30389396 NCBI chr10:96,640,013...96,653,939
Ensembl chr10:96,639,924...96,653,938
JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases response to substance
decreases activity
ISO
EXP
Glucosides inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]; Isoflurophate inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]; pralidoxime inhibits the reaction [Isoflurophate inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]]; pralidoxime inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]
BCHE protein results in decreased susceptibility to Isoflurophate
diacetylmonoxime inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]
CTD PMID:1276991 PMID:4631366 PMID:7150809 PMID:16213467 PMID:17698511 PMID:20227398 PMID:21673941 PMID:21767560 PMID:22209767 PMID:22982776 PMID:30389396 PMID:32278739 PMID:33592259 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
multiple interactions
EXP Isoflurophate results in decreased expression of BDNF protein
Ketamine inhibits the reaction [Isoflurophate results in decreased expression of BDNF protein]
CTD PMID:32592718 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
decreases expression
EXP
ISO
Corticosterone promotes the reaction [Isoflurophate results in increased expression of CCL2 mRNA]
Isoflurophate results in decreased expression of CCL2 mRNA
CORT protein inhibits the reaction [Isoflurophate results in decreased expression of CCL2 mRNA]; Corticosterone promotes the reaction [Isoflurophate results in increased expression of CCL2 mRNA]
CTD PMID:28500787 PMID:28782715 PMID:30339781 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cort cortistatin multiple interactions ISO [CORT protein co-treated with Isoflurophate] affects the secretion of IL5 protein; [CORT protein co-treated with Isoflurophate] results in decreased secretion of IL4 protein; [CORT protein co-treated with Isoflurophate] results in increased expression of LIF mRNA; [CORT protein co-treated with Pyridostigmine Bromide co-treated with DEET co-treated with Isoflurophate] affects the secretion of IL10 protein; [Pyridostigmine Bromide co-treated with DEET] affects the reaction [[CORT protein co-treated with Isoflurophate] affects the secretion of IL5 protein]; [Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [[CORT protein co-treated with Isoflurophate] results in increased expression of LIF mRNA]; [Pyridostigmine Bromide co-treated with DEET] promotes the reaction [CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL1B mRNA]]; [Pyridostigmine Bromide co-treated with DEET] promotes the reaction [CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL6 mRNA]]; [Pyridostigmine Bromide co-treated with DEET] promotes the reaction [CORT protein inhibits the reaction [Isoflurophate results in increased expression of OSM mRNA]]; CORT protein inhibits the reaction [Isoflurophate results in decreased expression of CCL2 mRNA]; CORT protein inhibits the reaction [Isoflurophate results in decreased expression of TNF mRNA]; CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL10 mRNA]; CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL1B mRNA]; CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL6 mRNA]; CORT protein inhibits the reaction [Isoflurophate results in increased expression of OSM mRNA]; CORT protein inhibits the reaction [Isoflurophate results in increased secretion of CXCL1 protein]; CORT protein inhibits the reaction [Isoflurophate results in increased secretion of IL6 protein] CTD PMID:30339781 NCBI chr 5:165,942,780...165,944,221 JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression
multiple interactions
EXP Isoflurophate results in increased expression of CXCL1 protein
AEOL 10150 inhibits the reaction [Isoflurophate results in increased expression of CXCL1 protein]
CTD PMID:29272548 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases secretion
multiple interactions
ISO Isoflurophate results in increased secretion of CXCL1 protein
[Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [Isoflurophate results in increased secretion of CXCL1 protein]; CORT protein inhibits the reaction [Isoflurophate results in increased secretion of CXCL1 protein]
CTD PMID:30339781 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Fga fibrinogen alpha chain increases expression EXP Isoflurophate results in increased expression of FGA protein CTD PMID:30389396 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fgg fibrinogen gamma chain increases expression EXP Isoflurophate results in increased expression of FGG protein CTD PMID:30389396 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514
JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B decreases expression EXP Isoflurophate results in decreased expression of FKBP1B protein CTD PMID:30859209 NCBI chr 6:29,975,863...29,987,252
Ensembl chr 6:29,977,797...29,987,451
JBrowse link
G Hp haptoglobin increases expression
decreases expression
EXP Isoflurophate results in increased expression of HP protein
Isoflurophate results in decreased expression of HP protein
CTD PMID:30389396 NCBI chr19:42,096,255...42,100,805
Ensembl chr19:42,097,995...42,100,804
JBrowse link
G IgG-2a gamma-2a immunoglobulin heavy chain increases expression EXP Isoflurophate results in increased expression of IGG-2A protein CTD PMID:30389396
G Il10 interleukin 10 multiple interactions
increases expression
ISO [CORT protein co-treated with Pyridostigmine Bromide co-treated with DEET co-treated with Isoflurophate] affects the secretion of IL10 protein; [Pyridostigmine Bromide co-treated with DEET co-treated with Isoflurophate] affects the secretion of IL10 protein; [Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [Isoflurophate results in increased expression of IL10 mRNA]; CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL10 mRNA] CTD PMID:30339781 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP
ISO
Isoflurophate results in increased expression of IL1B mRNA
[Corticosterone co-treated with Isoflurophate] results in increased expression of IL1B mRNA; [Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [Isoflurophate results in increased expression of IL1B mRNA]; [Pyridostigmine Bromide co-treated with DEET] promotes the reaction [CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL1B mRNA]]; CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL1B mRNA]
Corticosterone promotes the reaction [Isoflurophate results in increased expression of IL1B mRNA]
CTD PMID:28500787 PMID:28782715 PMID:30339781 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 increases secretion ISO Isoflurophate results in increased secretion of IL2 protein CTD PMID:30339781 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 decreases secretion
multiple interactions
ISO Isoflurophate results in decreased secretion of IL4 protein
[CORT protein co-treated with Isoflurophate] results in decreased secretion of IL4 protein
CTD PMID:30339781 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions
decreases secretion
ISO [CORT protein co-treated with Isoflurophate] affects the secretion of IL5 protein; [Pyridostigmine Bromide co-treated with DEET] affects the reaction [[CORT protein co-treated with Isoflurophate] affects the secretion of IL5 protein]
Isoflurophate results in decreased secretion of IL5 protein
CTD PMID:30339781 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
increases secretion
EXP
ISO
Isoflurophate results in increased expression of IL6 mRNA; Isoflurophate results in increased expression of IL6 protein
[Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [Isoflurophate results in increased expression of IL6 mRNA]; [Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [Isoflurophate results in increased secretion of IL6 protein]; [Pyridostigmine Bromide co-treated with DEET] promotes the reaction [CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL6 mRNA]]; CORT protein inhibits the reaction [Isoflurophate results in increased expression of IL6 mRNA]; CORT protein inhibits the reaction [Isoflurophate results in increased secretion of IL6 protein]; Isoflurophate inhibits the reaction [Corticosterone results in decreased expression of IL6 mRNA]
AEOL 10150 inhibits the reaction [Isoflurophate results in increased expression of IL6 protein]; Corticosterone inhibits the reaction [Isoflurophate results in increased expression of IL6 mRNA]
CTD PMID:28500787 PMID:28782715 PMID:29272548 PMID:30339781 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions
increases expression
EXP
ISO
[Corticosterone co-treated with Isoflurophate] results in increased expression of LIF mRNA
Isoflurophate results in increased expression of LIF mRNA
[CORT protein co-treated with Isoflurophate] results in increased expression of LIF mRNA; [Corticosterone co-treated with Isoflurophate] results in increased expression of LIF mRNA; [Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [[CORT protein co-treated with Isoflurophate] results in increased expression of LIF mRNA]; [Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [Isoflurophate results in increased expression of LIF mRNA]
CTD PMID:28500787 PMID:28782715 PMID:30339781 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Isoflurophate inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein] CTD PMID:17482686 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Isoflurophate inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein] CTD PMID:17482686 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO Isoflurophate results in decreased activity of NCEH1 protein CTD PMID:16978018 NCBI chr 2:112,868,834...112,932,622
Ensembl chr 2:112,868,707...112,934,953
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases degradation ISO Isoflurophate results in decreased degradation of NR3C1 protein CTD PMID:3545320 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Oprm1 opioid receptor, mu 1 affects response to substance ISO OPRM1 affects the susceptibility to Isoflurophate CTD PMID:15378609 PMID:15800401 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Osm oncostatin M multiple interactions
increases expression
EXP
ISO
[Corticosterone co-treated with Isoflurophate] results in increased expression of OSM mRNA
Isoflurophate results in increased expression of OSM mRNA
[Corticosterone co-treated with Isoflurophate] results in increased expression of OSM mRNA; [Pyridostigmine Bromide co-treated with DEET] inhibits the reaction [Isoflurophate results in increased expression of OSM mRNA]; [Pyridostigmine Bromide co-treated with DEET] promotes the reaction [CORT protein inhibits the reaction [Isoflurophate results in increased expression of OSM mRNA]]; CORT protein inhibits the reaction [Isoflurophate results in increased expression of OSM mRNA]
CTD PMID:28500787 PMID:28782715 PMID:30339781 NCBI chr14:84,457,487...84,469,426
Ensembl chr14:84,465,515...84,470,409
JBrowse link
G Pepd peptidase D increases hydrolysis
decreases response to substance
ISO PEPD protein results in increased hydrolysis of Isoflurophate
PEPD protein results in decreased susceptibility to Isoflurophate
CTD PMID:20176006 PMID:22120822 PMID:22677456 PMID:22982776 NCBI chr 1:90,820,670...91,285,128 JBrowse link
G Plg plasminogen multiple interactions ISO Isoflurophate inhibits the reaction [PLG protein results in increased phosphorylation of MAPK1 protein]; Isoflurophate inhibits the reaction [PLG protein results in increased phosphorylation of MAPK3 protein] CTD PMID:17482686 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 affects response to substance
decreases activity
ISO
EXP
PNPLA6 protein mutant form affects the susceptibility to Isoflurophate
Isoflurophate results in decreased activity of PNPLA6 protein
CTD PMID:7713347 PMID:9268605 PMID:20382209 PMID:24395470 NCBI chr12:2,068,749...2,098,139
Ensembl chr12:2,069,959...2,097,904
JBrowse link
G Pon1 paraoxonase 1 increases hydrolysis
multiple interactions
ISO PON1 protein results in increased hydrolysis of Isoflurophate
2-hydroxyquinoline inhibits the reaction [PON1 protein results in increased hydrolysis of Isoflurophate]
CTD PMID:20176006 PMID:21382471 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Rbfox3 RNA binding fox-1 homolog 3 decreases expression EXP Isoflurophate results in decreased expression of RBFOX3 protein CTD PMID:21513723 NCBI chr10:107,517,916...107,850,764
Ensembl chr10:107,516,995...107,539,658
JBrowse link
G Rgn regucalcin increases hydrolysis ISO RGN protein results in increased hydrolysis of Isoflurophate CTD PMID:20176006 NCBI chr  X:1,833,484...1,848,904
Ensembl chr  X:1,833,492...1,848,904
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Corticosterone co-treated with Isoflurophate] results in increased phosphorylation of STAT3 protein CTD PMID:28500787 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tf transferrin affects binding
decreases expression
increases expression
ISO
EXP
Isoflurophate binds to TRF protein
Isoflurophate results in decreased expression of TF protein
Isoflurophate results in increased expression of TF protein
Isoflurophate binds to TF protein
CTD PMID:18930948 PMID:30389396 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
decreases expression
EXP
ISO
[Corticosterone co-treated with Isoflurophate] results in increased expression of TNF mRNA; AEOL 10150 inhibits the reaction [Isoflurophate results in increased expression of TNF protein]
Isoflurophate results in increased expression of TNF mRNA
CORT protein inhibits the reaction [Isoflurophate results in decreased expression of TNF mRNA]; Corticosterone promotes the reaction [Isoflurophate results in increased expression of TNF mRNA]
CTD PMID:28500787 PMID:28782715 PMID:29272548 PMID:30339781 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
increases expression
EXP Isoflurophate promotes the reaction [XDH protein alternative form results in increased abundance of F2-Isoprostanes]; Isoflurophate promotes the reaction [XDH protein alternative form results in increased abundance of Reactive Oxygen Species]; Tubocurarine inhibits the reaction [Isoflurophate results in increased expression of XDH protein alternative form] CTD PMID:9789800 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      application 19406
        solvent 16547
          phosphoric acid 7954
            phosphoric acid derivative 7634
              organic phosphate 7633
                alkyl phosphate 4121
                  dialkyl phosphate 3439
                    diisopropyl fluorophosphate 39
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      chalcogen 19387
                        oxygen atom 19350
                          oxygen molecular entity 19350
                            hydroxides 19076
                              oxoacid 18275
                                pnictogen oxoacid 10312
                                  phosphorus oxoacid 9234
                                    phosphoric acids 7954
                                      phosphoric acid 7954
                                        phosphoric acid derivative 7634
                                          phosphate 7634
                                            organic phosphate 7633
                                              alkyl phosphate 4121
                                                dialkyl phosphate 3439
                                                  diisopropyl fluorophosphate 39
paths to the root