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ONTOLOGY REPORT - ANNOTATIONS


Term:puromycin
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Accession:CHEBI:17939 term browser browse the term
Definition:An aminonucleoside antibiotic, derived from the Streptomyces alboniger bacterium, that causes premature chain termination during translation taking place in the ribosome.
Synonyms:exact_synonym: 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine
 related_synonym: (S)-3'-((2-Amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-N,N-dimethyladenosine;   3'-(L-alpha-Amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine;   3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-diemthyladenosine;   9-{3-deoxy-3-[(O-methyl-L-tyrosyl)amino]-beta-D-xylofuranosyl}-N,N-dimethyl-9H-purin-6-amine;   Achromycin;   Formula=C22H29N7O5;   InChI=1S/C22H29N7O5/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32)/t14-,15+,16+,18+,22+/m0/s1;   InChIKey=RXWNCPJZOCPEPQ-NVWDDTSBSA-N;   SMILES=COc1ccc(C[C@H](N)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)n2cnc3c(ncnc23)N(C)C)cc1;   puromicina;   puromycine;   puromycinum
 alt_id: CHEBI:14970;   CHEBI:26402;   CHEBI:45182;   CHEBI:8641
 xref: CAS:53-79-2 "ChemIDplus";   CAS:53-79-2 "KEGG COMPOUND";   DrugBank:DB08437;   KEGG:C01610;   KEGG:D05653;   KNApSAcK:C00001507;   LINCS:LSM-2788
 xref_mesh: MESH:D011691
 xref: PMID:13945541 "Europe PMC";   PMID:15843471 "Europe PMC";   PMID:18322149 "Europe PMC";   PMID:323854 "Europe PMC";   Reaxys:70234 "Reaxys";   Wikipedia:Puromycin
 cyclic_relationship: is_conjugate_base_of CHEBI:60255


show annotations for term's descendants       view all columns           Sort by:
 
puromycin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcc1 ATP binding cassette subfamily C member 1 JBrowse link 10 549,537 672,235 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 JBrowse link 10 47,490,168 47,499,855 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl4 C-C motif chemokine ligand 4 JBrowse link 10 70,870,926 70,886,357 RGD:6480464
G Cd2ap CD2-associated protein JBrowse link 9 20,794,680 20,858,438 RGD:6480464
G Cdh3 cadherin 3 JBrowse link 19 38,668,957 38,719,801 RGD:6480464
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Def6 DEF6 guanine nucleotide exchange factor JBrowse link 20 7,788,120 7,809,011 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Il6r interleukin 6 receptor JBrowse link 2 189,196,180 189,255,987 RGD:6480464
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:6480464
G Ldlr low density lipoprotein receptor JBrowse link 8 22,750,425 22,773,305 RGD:6480464
G Mir122 microRNA 122 JBrowse link 18 60,755,285 60,755,369 RGD:6480464
G Mir143 microRNA 143 JBrowse link 18 56,971,273 56,971,377 RGD:6480464
G Mir155 microRNA 155 JBrowse link 11 24,176,603 24,176,667 RGD:6480464
G Mir3473 microRNA 3473 JBrowse link 13 44,719,335 44,719,401 RGD:6480464
G Nphs1 NPHS1 adhesion molecule, nephrin JBrowse link 1 88,922,346 88,950,560 RGD:6480464
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 31,728,373 32,704,022 RGD:6480464
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:6480464
G Ptger4 prostaglandin E receptor 4 JBrowse link 2 54,951,625 54,966,470 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Tbxa2r thromboxane A2 receptor JBrowse link 7 11,253,153 11,259,233 RGD:6480464
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase JBrowse link 2 157,316,293 157,342,979 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        antimicrobial agent 17154
          puromycin 32
            puromycin 5'-phosphate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            heteroorganic entity 18998
                              organochalcogen compound 18715
                                organooxygen compound 18625
                                  carbohydrates and carbohydrate derivatives 11731
                                    carbohydrate 11731
                                      carbohydrate derivative 11345
                                        glycosyl compound 10297
                                          N-glycosyl compound 4207
                                            nucleoside 4030
                                              ribonucleoside 685
                                                purine ribonucleoside 580
                                                  adenosines 527
                                                    puromycins 32
                                                      puromycin 32
                                                        puromycin 5'-phosphate + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.