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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:calcidiol
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Accession:CHEBI:17933 term browser browse the term
Definition:A hydroxycalciol that is calciol in which the hydrogen at position 25 has been replaced by a hydroxy group. A prehormone resulting from the oxidation of calciol in the liver, it is further hydroxylated in the kidney to give calcitriol, the active form of vitamin D3.
Synonyms:related_synonym: (3S,5Z,7E)-9,10-secocholesta-5,7,10-triene-3,25-diol;   (3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol;   (5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol;   25(OH)D3;   25-Hydroxyvitamin D3;   25-hydroxycholecalciferol;   3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL;   Calcifediol;   Calcifediol anhydrous;   Formula=C27H44O2;   InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1;   InChIKey=JWUBBDSIWDLEOM-DTOXIADCSA-N;   Rayaldee;   SMILES=[H][C@@]1(CC[C@]2([H])[C@]1(C)CCC\\C2=C/C=C1/C[C@@H](O)CCC1=C)[C@H](C)CCCC(C)(C)O;   calcifediolum
 alt_id: CHEBI:13931;   CHEBI:19815;   CHEBI:3304;   CHEBI:46387
 xref: Beilstein:4270041;   CAS:19356-17-3;   DrugBank:DB00146;   Drug_Central:464;   KEGG:C01561;   LIPID_MAPS_instance:LMST03020246
 xref_mesh: MESH:D002112
 xref: PDBeChem:VDY;   PMID:16549446;   PMID:18689406;   PMID:22487892;   PMID:22536761;   PMID:23090338;   PMID:23566108;   PMID:9080330;   Reaxys:4270041;   Wikipedia:Calcifediol


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calcidiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aard alanine and arginine rich domain containing protein increases expression EXP Calcifediol deficiency results in increased expression of AARD mRNA CTD PMID:17293106 NCBI chr 7:91,588,458...91,593,299
Ensembl chr 7:91,588,458...91,593,297
JBrowse link
G Actb actin, beta decreases expression EXP Calcifediol deficiency results in decreased expression of ACTB mRNA CTD PMID:17293106 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A decreases expression EXP Calcifediol deficiency results in decreased expression of ALDOA mRNA CTD PMID:17293106 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression
multiple interactions
ISO Calcifediol results in increased expression of ALPL mRNA; Calcifediol results in increased expression of ALPL protein
CYP27B1 protein promotes the reaction [Calcifediol results in increased expression of ALPL mRNA]; CYP27B1 protein promotes the reaction [Calcifediol results in increased expression of ALPL protein]; Ketoconazole inhibits the reaction [Calcifediol results in increased expression of ALPL mRNA]
CTD PMID:21542014 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Apob apolipoprotein B decreases expression EXP Calcifediol deficiency results in decreased expression of APOB mRNA CTD PMID:17293106 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Aqp4 aquaporin 4 decreases expression EXP Calcifediol deficiency results in decreased expression of AQP4 mRNA CTD PMID:17293106 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 decreases expression EXP Calcifediol deficiency results in decreased expression of ATP1A1 mRNA CTD PMID:17293106 NCBI chr 2:204,003,742...204,032,023
Ensembl chr 2:204,003,742...204,032,023
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression EXP Calcifediol deficiency results in decreased expression of ATP1A3 mRNA CTD PMID:17293106 NCBI chr 1:81,852,423...81,881,565
Ensembl chr 1:81,852,429...81,881,549
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 decreases expression EXP Calcifediol deficiency results in decreased expression of ATP1B1 mRNA CTD PMID:17293106 NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004
JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 decreases expression EXP Calcifediol deficiency results in decreased expression of ATP6V1B2 mRNA CTD PMID:17293106 NCBI chr16:22,326,537...22,350,143
Ensembl chr16:22,326,529...22,350,155
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions
ISO Calcifediol results in decreased expression of BAX mRNA; Calcifediol results in decreased expression of BAX protein
Ketoconazole inhibits the reaction [Calcifediol results in decreased expression of BAX mRNA]
CTD PMID:21542014 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcat1 branched chain amino acid transaminase 1 decreases expression EXP Calcifediol deficiency results in decreased expression of BCAT1 mRNA CTD PMID:17293106 NCBI chr 4:179,259,305...179,340,021
Ensembl chr 4:179,259,308...179,339,795
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
ISO Calcifediol results in increased expression of BCL2 mRNA; Calcifediol results in increased expression of BCL2 protein
Ketoconazole inhibits the reaction [Calcifediol results in increased expression of BCL2 mRNA]
CTD PMID:21542014 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Canx calnexin decreases expression EXP Calcifediol deficiency results in decreased expression of CANX mRNA CTD PMID:17293106 NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861
JBrowse link
G Cat catalase decreases expression EXP Calcifediol deficiency results in decreased expression of CAT mRNA CTD PMID:17293106 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Calcifediol results in decreased expression of CCND1 protein CTD PMID:21542014 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd247 Cd247 molecule multiple interactions ISO Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr13:83,996,045...84,071,408
Ensembl chr13:83,996,080...84,071,400
JBrowse link
G Cd28 Cd28 molecule multiple interactions ISO Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871
JBrowse link
G Cd3d CD3d molecule multiple interactions ISO Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr 8:49,282,502...49,287,095
Ensembl chr 8:49,282,460...49,287,110
JBrowse link
G Cd3e CD3e molecule multiple interactions ISO Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr 8:49,297,604...49,309,370
Ensembl chr 8:49,297,608...49,308,806
JBrowse link
G Cd3g CD3g molecule multiple interactions ISO Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]] CTD PMID:24792400 NCBI chr 8:49,274,553...49,280,943
Ensembl chr 8:49,274,960...49,280,901
JBrowse link
G Cdh2 cadherin 2 decreases expression EXP Calcifediol deficiency results in decreased expression of CDH2 protein CTD PMID:26210580 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Calcifediol results in increased expression of CDKN1A protein CTD PMID:21542014 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Ckb creatine kinase B decreases expression EXP Calcifediol deficiency results in decreased expression of CKB mRNA CTD PMID:17293106 NCBI chr 6:136,142,956...136,145,838
Ensembl chr 6:136,142,956...136,145,837
JBrowse link
G Clta clathrin, light chain A increases expression EXP Calcifediol deficiency results in increased expression of CLTA mRNA CTD PMID:17293106 NCBI chr 5:59,490,689...59,509,139
Ensembl chr 5:59,491,096...59,509,138
JBrowse link
G Cplx2 complexin 2 decreases expression EXP Calcifediol deficiency results in decreased expression of CPLX2 mRNA CTD PMID:17293106 NCBI chr17:10,756,871...10,828,811
Ensembl chr17:10,756,285...10,818,835
JBrowse link
G Cspg5 chondroitin sulfate proteoglycan 5 decreases expression EXP Calcifediol deficiency results in decreased expression of CSPG5 mRNA CTD PMID:17293106 NCBI chr 8:118,333,695...118,348,040
Ensembl chr 8:118,333,706...118,347,582
JBrowse link
G Cyb5a cytochrome b5 type A decreases expression EXP Calcifediol deficiency results in decreased expression of CYB5A mRNA CTD PMID:17293106 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821
JBrowse link
G Cycs cytochrome c, somatic increases expression EXP Calcifediol deficiency results in increased expression of CYCS mRNA CTD PMID:17293106 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO Dihydrotestosterone inhibits the reaction [Calcifediol results in increased expression of CYP24A1 mRNA]; Tretinoin inhibits the reaction [Calcifediol results in increased expression of CYP24A1 mRNA]
Ketoconazole inhibits the reaction [Calcifediol results in increased expression of CYP24A1 mRNA]
CTD PMID:16289102, PMID:16524720, PMID:18840526, PMID:21542014, PMID:24792400 NCBI chr 3:168,097,484...168,111,920
Ensembl chr 3:168,097,485...168,111,920
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 affects metabolic processing
increases hydroxylation
multiple interactions
ISO
EXP
CYP27B1 protein affects the metabolism of Calcifediol
CYP27B1 protein results in increased hydroxylation of Calcifediol
CYP27B1 protein promotes the reaction [Calcifediol results in increased expression of ALPL mRNA]; CYP27B1 protein promotes the reaction [Calcifediol results in increased expression of ALPL protein]; CYP27B1 protein promotes the reaction [Calcifediol results in increased expression of IBSP mRNA]; CYP27B1 protein promotes the reaction [Calcifediol results in increased expression of RUNX2 mRNA]
CTD PMID:16061850, PMID:21542014 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005
JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 decreases expression EXP Calcifediol deficiency results in decreased expression of CYP4B1 mRNA CTD PMID:17293106 NCBI chr 5:134,508,728...134,526,103
Ensembl chr 5:134,508,730...134,526,089
JBrowse link
G Dctn4 dynactin subunit 4 decreases expression EXP Calcifediol deficiency results in decreased expression of DCTN4 mRNA CTD PMID:17293106 NCBI chr18:55,797,188...55,824,195
Ensembl chr18:55,797,198...55,822,036
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 decreases expression EXP Calcifediol deficiency results in decreased expression of DLG1 mRNA CTD PMID:17293106 NCBI chr11:72,164,566...72,378,895
Ensembl chr11:72,163,749...72,378,895
JBrowse link
G Dpp6 dipeptidyl peptidase like 6 decreases expression EXP Calcifediol deficiency results in decreased expression of DPP6 mRNA CTD PMID:17293106 NCBI chr 4:4,021,021...4,943,675
Ensembl chr 4:4,021,008...4,473,307
JBrowse link
G Eif4h eukaryotic translation initiation factor 4H decreases expression EXP Calcifediol deficiency results in decreased expression of EIF4H mRNA CTD PMID:17293106 NCBI chr12:25,093,119...25,109,805
Ensembl chr12:25,093,149...25,109,799
JBrowse link
G Fgf23 fibroblast growth factor 23 multiple interactions EXP Calcifediol inhibits the reaction [Theophylline results in increased expression of FGF23 protein] CTD PMID:26851681 NCBI chr 4:159,622,404...159,630,082
Ensembl chr 4:159,622,404...159,630,082
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A decreases expression EXP Calcifediol deficiency results in decreased expression of FKBP1A mRNA CTD PMID:17293106 NCBI chr 3:147,042,944...147,062,725
Ensembl chr 3:147,042,944...147,062,724
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 decreases expression EXP Calcifediol deficiency results in decreased expression of GABBR1 mRNA CTD PMID:17293106 NCBI chr20:1,955,344...1,984,907
Ensembl chr20:1,955,359...1,984,863
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha decreases expression EXP Calcifediol deficiency results in decreased expression of GADD45A mRNA CTD PMID:17293106 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gas5 growth arrest specific 5 increases expression EXP Calcifediol deficiency results in increased expression of GAS5 mRNA CTD PMID:17293106 NCBI chr13:78,852,523...78,855,844 JBrowse link
G Gfap glial fibrillary acidic protein decreases expression EXP Calcifediol deficiency results in decreased expression of GFAP mRNA CTD PMID:17293106 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression EXP Calcifediol deficiency results in decreased expression of GJA1 mRNA CTD PMID:17293106 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Glul glutamate-ammonia ligase decreases expression EXP Calcifediol deficiency results in decreased expression of GLUL mRNA CTD PMID:17293106 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Gna12 G protein subunit alpha 12 decreases expression EXP Calcifediol deficiency results in decreased expression of GNA12 mRNA CTD PMID:17293106 NCBI chr12:15,890,202...15,971,212
Ensembl chr12:15,890,170...15,971,212
JBrowse link
G Gnai1 G protein subunit alpha i1 decreases expression EXP Calcifediol deficiency results in decreased expression of GNAI1 mRNA CTD PMID:17293106 NCBI chr 4:13,405,136...13,486,866
Ensembl chr 4:13,405,136...13,485,883
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor increases expression EXP Calcifediol deficiency results in increased expression of GNRHR mRNA CTD PMID:17293106 NCBI chr14:23,480,462...23,498,450
Ensembl chr14:23,480,462...23,498,450
JBrowse link
G Guca2b guanylate cyclase activator 2B increases expression EXP Calcifediol deficiency results in increased expression of GUCA2B mRNA CTD PMID:17293106 NCBI chr 5:138,695,591...138,697,641
Ensembl chr 5:138,695,591...138,697,641
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 decreases expression EXP Calcifediol deficiency results in decreased expression of HSD17B4 mRNA CTD PMID:17293106 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 decreases expression EXP Calcifediol deficiency results in decreased expression of HSP90AB1 mRNA CTD PMID:17293106 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Ibsp integrin-binding sialoprotein increases expression
multiple interactions
ISO Calcifediol results in increased expression of IBSP mRNA
CYP27B1 protein promotes the reaction [Calcifediol results in increased expression of IBSP mRNA]; Ketoconazole inhibits the reaction [Calcifediol results in increased expression of IBSP mRNA]
CTD PMID:21542014 NCBI chr14:6,801,200...6,813,987
Ensembl chr14:6,801,204...6,813,945
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression EXP Calcifediol deficiency results in increased expression of IGF1 mRNA CTD PMID:17293106 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Ins2 insulin 2 affects secretion ISO Calcifediol affects the secretion of INS protein CTD PMID:24401716 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Kdr kinase insert domain receptor decreases expression EXP Calcifediol deficiency results in decreased expression of KDR mRNA CTD PMID:17293106 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Klc1 kinesin light chain 1 decreases expression EXP Calcifediol deficiency results in decreased expression of KLC1 mRNA CTD PMID:17293106 NCBI chr 6:136,330,151...136,373,716
Ensembl chr 6:136,330,383...136,373,721
JBrowse link
G Krt14 keratin 14 increases expression EXP Calcifediol deficiency results in increased expression of KRT14 mRNA CTD PMID:17293106 NCBI chr10:88,118,029...88,122,233
Ensembl chr10:88,055,823...88,122,233
JBrowse link
G Lre3 LINE retrotransposable element 3 decreases expression EXP Calcifediol deficiency results in decreased expression of LRE3 mRNA CTD PMID:17293106
G Map2 microtubule-associated protein 2 decreases expression EXP Calcifediol deficiency results in decreased expression of MAP2 mRNA CTD PMID:17293106 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases expression EXP Calcifediol deficiency results in decreased expression of MAPK9 mRNA CTD PMID:17293106 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate decreases expression EXP Calcifediol deficiency results in decreased expression of MARCKS mRNA CTD PMID:17293106 NCBI chr20:42,966,140...42,971,838
Ensembl chr20:42,966,140...42,971,838
JBrowse link
G Mobp myelin-associated oligodendrocyte basic protein decreases expression EXP Calcifediol deficiency results in decreased expression of MOBP mRNA CTD PMID:17293106 NCBI chr 8:128,824,420...128,854,492
Ensembl chr 8:128,824,508...128,850,358
JBrowse link
G Nckap1 NCK-associated protein 1 decreases expression EXP Calcifediol deficiency results in decreased expression of NCKAP1 mRNA CTD PMID:17293106 NCBI chr 3:67,725,180...67,804,680
Ensembl chr 3:67,725,947...67,787,990
JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase decreases expression EXP Calcifediol deficiency results in decreased expression of NSF mRNA CTD PMID:17293106 NCBI chr10:91,879,608...91,986,242
Ensembl chr10:91,878,633...92,008,082
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta decreases expression EXP Calcifediol deficiency results in decreased expression of P4HB mRNA CTD PMID:17293106 NCBI chr10:109,736,459...109,748,070
Ensembl chr10:109,736,458...109,747,987
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Calcifediol results in decreased expression of PCNA protein CTD PMID:21542014 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 decreases expression EXP Calcifediol deficiency results in decreased expression of PDIA3 mRNA CTD PMID:17293106 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 increases expression EXP Calcifediol deficiency results in increased expression of PDPK1 mRNA CTD PMID:17293106 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Pmch pro-melanin-concentrating hormone increases expression EXP Calcifediol deficiency results in increased expression of PMCH mRNA CTD PMID:17293106 NCBI chr 7:28,655,206...28,656,522
Ensembl chr 7:28,654,733...28,657,522
JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B decreases expression EXP Calcifediol deficiency results in decreased expression of PPM1B mRNA CTD PMID:17293106 NCBI chr 6:8,219,385...8,280,127
Ensembl chr 6:8,218,696...8,280,124
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha decreases expression EXP Calcifediol deficiency results in decreased expression of PPP3R1 mRNA CTD PMID:17293106 NCBI chr14:100,311,224...100,360,879
Ensembl chr14:100,311,173...100,360,879
JBrowse link
G Psap prosaposin decreases expression EXP Calcifediol deficiency results in decreased expression of PSAP mRNA CTD PMID:17293106 NCBI chr20:29,831,302...29,856,876
Ensembl chr20:29,831,314...29,856,875
JBrowse link
G Psat1 phosphoserine aminotransferase 1 decreases expression EXP Calcifediol deficiency results in decreased expression of PSAT1 mRNA CTD PMID:17293106 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941
JBrowse link
G Psma2 proteasome 20S subunit alpha 2 increases expression EXP Calcifediol deficiency results in increased expression of PSMA2 mRNA CTD PMID:17293106 NCBI chr17:53,091,937...53,102,324
Ensembl chr17:53,091,933...53,102,342
JBrowse link
G Pth parathyroid hormone multiple interactions EXP Calcifediol inhibits the reaction [Theophylline results in increased expression of PTH protein] CTD PMID:26851681 NCBI chr 1:178,215,829...178,218,761
Ensembl chr 1:178,215,829...178,218,761
JBrowse link
G Pygb glycogen phosphorylase B decreases expression EXP Calcifediol deficiency results in decreased expression of PYGB mRNA CTD PMID:17293106 NCBI chr 3:146,581,063...146,629,504
Ensembl chr 3:146,582,752...146,634,535
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 decreases expression EXP Calcifediol deficiency results in decreased expression of RASGRP1 mRNA CTD PMID:17293106 NCBI chr 3:108,984,029...109,044,420
Ensembl chr 3:108,984,029...109,044,420
JBrowse link
G Rasl11a RAS-like family 11 member A decreases expression EXP Calcifediol deficiency results in decreased expression of RASL11A mRNA CTD PMID:17293106 NCBI chr12:9,986,150...9,990,284
Ensembl chr12:9,985,928...9,990,284
JBrowse link
G Rhoa ras homolog family member A decreases expression EXP Calcifediol deficiency results in decreased expression of RHOA mRNA CTD PMID:17293106 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions
increases expression
ISO CYP27B1 protein promotes the reaction [Calcifediol results in increased expression of RUNX2 mRNA]; Ketoconazole inhibits the reaction [Calcifediol results in increased expression of RUNX2 mRNA] CTD PMID:21542014 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 decreases expression EXP Calcifediol deficiency results in decreased expression of SCD2 mRNA CTD PMID:17293106 NCBI chr 1:264,059,374...264,072,433
Ensembl chr 1:264,059,374...264,072,433
JBrowse link
G Sdc4 syndecan 4 increases expression EXP Calcifediol deficiency results in increased expression of SDC4 mRNA CTD PMID:17293106 NCBI chr 3:160,872,503...160,891,190
Ensembl chr 3:160,872,503...160,891,190
JBrowse link
G Slc1a3 solute carrier family 1 member 3 decreases expression EXP Calcifediol deficiency results in decreased expression of SLC1A3 mRNA CTD PMID:17293106 NCBI chr 2:57,860,881...57,935,363
Ensembl chr 2:57,860,834...57,935,363
JBrowse link
G Snrk SNF related kinase decreases expression EXP Calcifediol deficiency results in decreased expression of SNRK mRNA CTD PMID:17293106 NCBI chr 8:130,749,806...130,805,225
Ensembl chr 8:130,749,838...130,803,597
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression EXP Calcifediol deficiency results in decreased expression of SOD2 mRNA CTD PMID:17293106 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression EXP Calcifediol deficiency results in decreased expression of SULT2A1 mRNA CTD PMID:17293106 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Syt1 synaptotagmin 1 decreases expression EXP Calcifediol deficiency results in decreased expression of SYT1 mRNA CTD PMID:17293106 NCBI chr 7:50,084,063...50,638,996
Ensembl chr 7:50,084,060...50,638,798
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Calcifediol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Calcifediol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Ketoconazole inhibits the reaction [Calcifediol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Ketoconazole inhibits the reaction [Calcifediol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] CTD PMID:11135059 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ubqln1 ubiquilin 1 decreases expression EXP Calcifediol deficiency results in decreased expression of UBQLN1 mRNA CTD PMID:17293106 NCBI chr17:6,840,441...6,878,842
Ensembl chr17:6,840,463...6,878,844
JBrowse link
G Vcp valosin-containing protein decreases expression EXP Calcifediol deficiency results in decreased expression of VCP mRNA CTD PMID:17293106 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases expression EXP Calcifediol deficiency results in decreased expression of VDAC1 mRNA CTD PMID:17293106 NCBI chr10:37,724,915...37,752,827
Ensembl chr10:37,724,915...37,752,826
JBrowse link
G Vdr vitamin D receptor multiple interactions
increases activity
ISO Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]; Calcifediol results in decreased degradation of and affects the localization of VDR protein; Ketoconazole inhibits the reaction [Calcifediol promotes the reaction [[[CD3G protein binds to CD3D protein binds to CD3E protein binds to CD247 protein] which co-treated with CD28 protein] results in increased expression of VDR protein]]; VDR protein promotes the reaction [Calcifediol results in increased abundance of Lipids]
Calcifediol results in increased activity of VDR protein
Calcifediol results in increased activity of VDR protein; Calcifediol results in increased activity of VDR protein mutant form
CTD PMID:17997857, PMID:20079722, PMID:21291553, PMID:24792400 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
G Ybx1 Y box binding protein 1 increases expression EXP Calcifediol deficiency results in increased expression of YBX1 mRNA CTD PMID:17293106 NCBI chr 5:138,319,754...138,336,721
Ensembl chr 5:138,319,762...138,336,475
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            calcidiol 92
              calcidiol 25-O-(beta-D-glucuronate) 0
              calcidiol 25-O-(beta-D-glucuronide) 0
              calcidiol 3-O-(beta-D-glucuronate) 0
              calcidiol 3-O-(beta-D-glucuronide) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic polycyclic compound 16384
                                  steroid 12788
                                    hydroxy steroid 12371
                                      hydroxy seco-steroid 2656
                                        vitamin D 2651
                                          D3 vitamins 2600
                                            calciol 2600
                                              hydroxycalciol 2459
                                                calcidiol 92
                                                  calcidiol 25-O-(beta-D-glucuronate) 0
                                                  calcidiol 25-O-(beta-D-glucuronide) 0
                                                  calcidiol 3-O-(beta-D-glucuronate) 0
                                                  calcidiol 3-O-(beta-D-glucuronide) 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.