Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N(omega),N(omega)-dimethyl-L-arginine
go back to main search page
Accession:CHEBI:17929 term browser browse the term
Definition:A L-arginine derivative having two methyl groups both attached to the primary amino moiety of the guanidino group.
Synonyms:exact_synonym: (2S)-2-amino-5-(N',N'-dimethylcarbamimidamido)pentanoic acid;   (2S)-2-amino-5-{[(dimethylamino)(imino)methyl]amino}pentanoic acid;   N(5)-(N,N-dimethylcarbamimidoyl)-L-ornithine;   N(5)-[(dimethylamino)(imino)methyl]-L-ornithine
 related_synonym: ADMA;   Formula=C8H18N4O2;   InChI=1S/C8H18N4O2/c1-12(2)8(10)11-5-3-4-6(9)7(13)14/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14)/t6-/m0/s1;   InChIKey=YDGMGEXADBMOMJ-LURJTMIESA-N;   N(5)-((dimethylamino)iminomethyl)-L-ornithine;   N(G),N(G)-dimethylarginine;   N(G)-dimethylarginine;   N(G1),N(G1)-dimethylarginine;   N,N-dimethylarginine;   NG,NG-Dimethyl-L-arginine;   SMILES=CN(C)C(=N)NCCC[C@H](N)C(O)=O;   asymmetric dimethylarginine;   guanidino-N,N-dimethylarginine
 alt_id: CHEBI:12680;   CHEBI:21908;   CHEBI:25683;   CHEBI:41833;   CHEBI:7432
 xref: Beilstein:2261521;   CAS:30315-93-6;   DrugBank:DB01686;   KEGG:C03626
 xref_mesh: MESH:C018524
 xref: PDBeChem:DA2
 cyclic_relationship: is_conjugate_base_of CHEBI:58326



show annotations for term's descendants           Sort by:
 
N(omega),N(omega)-dimethyl-L-arginine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddah2 dimethylarginine dimethylaminohydrolase 2 multiple interactions ISO [Iron-Dextran Complex results in decreased expression of DDAH2 protein] which results in increased abundance of N,N-dimethylarginine; Arginine inhibits the reaction [[Iron-Dextran Complex results in decreased expression of DDAH2 protein] which results in increased abundance of N,N-dimethylarginine]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased abundance of N,N-dimethylarginine]]; tetramethylpyrazine inhibits the reaction [[Iron-Dextran Complex results in decreased expression of DDAH2 protein] which results in increased abundance of N,N-dimethylarginine] CTD PMID:32135237 NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511
JBrowse link
G Slco4c1 solute carrier organic anion transporter family, member 4C1 increases uptake ISO SLCO4C1 protein results in increased uptake of N,N-dimethylarginine CTD PMID:30865704 NCBI chr 9:97,180,162...97,229,135
Ensembl chr 9:97,178,861...97,229,715
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      application 19737
        indicator 8699
          biomarker 6480
            L-arginine 57
              L-arginine derivative 49
                N(omega),N(omega)-dimethyl-L-arginine 2
                  N(omega),N(omega)-dimethyl-L-arginine residue 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic group 18937
                              organic divalent group 18922
                                organodiyl group 18922
                                  carbonyl group 18872
                                    carbonyl compound 18872
                                      carboxylic acid 18556
                                        amino acid 14930
                                          alpha-amino acid 12938
                                            L-alpha-amino acid 11598
                                              glutamine family amino acid 10284
                                                L-arginine 57
                                                  L-arginine derivative 49
                                                    N(omega),N(omega)-dimethyl-L-arginine 2
                                                      N(omega),N(omega)-dimethyl-L-arginine residue 0
paths to the root