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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:styrene oxide
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Accession:CHEBI:17907 term browser browse the term
Definition:An epoxide that is oxirane in which one of the hydrogens has been replaced by a phenyl group.
Synonyms:exact_synonym: 2-phenyloxirane
 related_synonym: (epoxyethyl)benzene;   1,2-epoxy-1-phenylethane;   1,2-epoxyethylbenzene;   1-phenyl-1,2-epoxyethane;   1-phenyloxirane;   Formula=C8H8O;   InChI=1S/C8H8O/c1-2-4-7(5-3-1)8-6-9-8/h1-5,8H,6H2;   InChIKey=AWMVMTVKBNGEAK-UHFFFAOYSA-N;   SMILES=C1OC1c1ccccc1;   alpha,beta-epoxystyrene;   epoxyethylbenzene;   epoxystyrene;   phenethylene oxide;   phenyl oxirane;   phenylethylene oxide;   phenyloxirane;   styrene 7,8-oxide;   styrene epoxide;   styryl oxide
 alt_id: CHEBI:15124;   CHEBI:26798;   CHEBI:9298
 xref: Beilstein:108582;   CAS:96-09-3;   Gmelin:50213;   KEGG:C02083
 xref_mesh: MESH:C013690
 xref: MetaCyc:2-Phenyloxirane;   PMID:11551533;   PMID:19245253;   PMID:24320693;   Reaxys:108582;   UM-BBD_compID:c0037;   Wikipedia:Styrene_oxide


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styrene oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions
affects binding
ISO styrene oxide promotes the reaction [styrene oxide binds to ALB protein]; Styrene promotes the reaction [styrene oxide binds to ALB protein] CTD PMID:10511253 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression
increases expression
ISO
EXP
styrene oxide affects the expression of BAX mRNA
styrene oxide results in increased expression of BAX protein
CTD PMID:11230554, PMID:12663515 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
decreases expression
ISO
EXP
styrene oxide affects the expression of BCL2 mRNA
styrene oxide results in decreased expression of BCL2 protein
CTD PMID:11230554, PMID:12663515 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO styrene oxide results in increased expression of BCL2L1 protein CTD PMID:16705669 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 increases activity ISO
EXP
styrene oxide results in increased activity of CASP3 protein CTD PMID:11929631, PMID:12663515, PMID:17662326, PMID:19666080 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects expression ISO styrene oxide affects the expression of CDKN1A mRNA CTD PMID:11230554 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO styrene oxide results in increased expression of CHEK1 protein CTD PMID:20025956 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP CYP1A1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide] CTD PMID:12051674 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP CYP2B1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide] CTD PMID:12051674 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP CYP2C11 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide] CTD PMID:12051674 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases chemical synthesis ISO CYP2E1 results in increased chemical synthesis of styrene oxide; CYP2E1 results in increased chemical synthesis of styrene oxide analog CTD PMID:22366341 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 increases chemical synthesis ISO CYP2F2 protein results in increased chemical synthesis of styrene oxide CTD PMID:22386858 NCBI chr 1:83,933,974...83,947,804
Ensembl chr 1:83,933,942...83,947,821
JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions
affects hydrolysis
EXP
ISO
CYP1A1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]; CYP2B1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]; CYP2C11 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]; CYP3A12 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]
EPHX1 protein affects the metabolism of and results in decreased activity of styrene oxide
CTD PMID:11076696, PMID:12051674, PMID:12694745 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO styrene oxide results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases response to substance
multiple interactions
affects metabolic processing
ISO
EXP
GSTM1 protein results in decreased susceptibility to styrene oxide
GSTM1 protein affects the metabolism of [styrene oxide co-treated with Glutathione]
GSTM1 protein affects the metabolism of styrene oxide
CTD PMID:1638515, PMID:2604743, PMID:11424177, PMID:11599931, PMID:14698568, PMID:17689871 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstm2 glutathione S-transferase mu 2 affects metabolic processing
multiple interactions
EXP GSTM2 protein affects the metabolism of styrene oxide
GSTM2 protein affects the metabolism of [styrene oxide co-treated with Glutathione]
CTD PMID:1638515, PMID:2604743 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects response to substance ISO GSTP1 exon polymorphism affects the susceptibility to styrene oxide CTD PMID:12694745 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases response to substance
affects response to substance
ISO GSTT1 gene polymorphism results in increased susceptibility to styrene oxide
GSTT1 protein affects the susceptibility to styrene oxide
CTD PMID:12016165, PMID:15468052 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Hbb hemoglobin subunit beta affects binding ISO styrene oxide binds to HBB protein CTD PMID:11948819 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Hells helicase, lymphoid specific increases expression ISO styrene oxide results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183
Ensembl chr 1:257,766,691...257,949,183
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
increases activity
ISO styrene oxide results in increased expression of HMOX1 protein
styrene oxide results in increased activity of HMOX1 protein
CTD PMID:15582351 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO styrene oxide results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO styrene oxide results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO styrene oxide results in increased expression of MYC protein CTD PMID:16705669 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Orm1 orosomucoid 1 increases expression ISO styrene oxide results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO styrene oxide results in increased cleavage of PARP1 protein CTD PMID:11929631, PMID:17662326 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO styrene oxide results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:40,460,047...40,717,982
Ensembl chr  X:40,460,047...40,717,982
JBrowse link
G Por cytochrome p450 oxidoreductase increases chemical synthesis ISO POR protein results in increased chemical synthesis of styrene oxide CTD PMID:22386858 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO styrene oxide results in decreased expression of RAC1 protein CTD PMID:17662326 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 decreases expression ISO styrene oxide results in decreased expression of SCGB1A1 mRNA; styrene oxide results in decreased expression of SCGB1A1 protein CTD PMID:19428955 NCBI chr 1:225,279,698...225,283,246
Ensembl chr 1:225,279,676...225,283,326
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases cleavage ISO styrene oxide results in increased cleavage of SPTAN1 protein CTD PMID:11929631 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
JBrowse link
G Syp synaptophysin decreases expression ISO styrene oxide results in decreased expression of SYP protein CTD PMID:17662326 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436
JBrowse link
G Tgfb2 transforming growth factor, beta 2 affects expression ISO styrene oxide affects the expression of TGFB2 mRNA; styrene oxide affects the expression of TGFB2 protein CTD PMID:16705669 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 affects expression ISO styrene oxide affects the expression of TGFBR3 mRNA; styrene oxide affects the expression of TGFBR3 protein CTD PMID:16705669 NCBI chr14:3,506,416...3,680,508
Ensembl chr14:3,506,339...3,682,545
JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 increases expression ISO styrene oxide results in increased expression of TNFRSF9 mRNA CTD PMID:22723965 NCBI chr 5:168,009,245...168,035,813
Ensembl chr 5:168,009,393...168,035,810
JBrowse link
G Tp53 tumor protein p53 affects expression ISO styrene oxide affects the expression of TP53 mRNA CTD PMID:11230554 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 affects response to substance ISO XRCC1 protein polymorphism affects the susceptibility to styrene oxide CTD PMID:15468052 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        aetiopathogenetic role 18937
          genotoxin 16961
            mutagen 16777
              styrene 107
                styrene oxide 37
                  (R)-styrene oxide 0
                  (S)-styrene oxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                carbocyclic compound 18183
                                  benzenoid aromatic compound 17180
                                    benzenes 16922
                                      styrenes 221
                                        styrene 107
                                          styrene oxide 37
                                            (R)-styrene oxide 0
                                            (S)-styrene oxide 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.