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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydrogen chloride
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Accession:CHEBI:17883 term browser browse the term
Definition:A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms.
Synonyms:exact_synonym: chlorane;   chloridohydrogen
 related_synonym: Chlorwasserstoff;   Formula=ClH;   Formula=HCl;   HCl;   Hydrochloride;   Hydrogenchlorid;   InChI=1S/ClH/h1H;   InChIKey=VEXZGXHMUGYJMC-UHFFFAOYSA-N;   SMILES=Cl[H];   Wasserstoffchlorid;   chlorure d'hydrogene;   cloruro de hidrogeno;   hydrochloric acid
 alt_id: CHEBI:13364;   CHEBI:24635;   CHEBI:5590
 xref: CAS:7647-01-0;   Drug_Central:4568;   Gmelin:322;   HMDB:HMDB0002306;   KEGG:C01327;   KEGG:D02057
 xref_mesh: MESH:D006851
 xref: MetaCyc:HCL;   PMID:15823700;   PMID:17492841;   PMID:22804993;   Reaxys:1098214;   Wikipedia:HCl;   Wikipedia:Hydrochloric_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:17996;   is_conjugate_base_of CHEBI:50315



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hydrogen chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions
increases expression
ISO 7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane inhibits the reaction [Hydrochloric Acid results in increased expression of ALB protein]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of ALB protein] CTD PMID:15044056 PMID:15607125 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
JBrowse link
G Aqp4 aquaporin 4 increases expression ISO Hydrochloric Acid results in increased expression of AQP4 protein CTD PMID:18406487 NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039
JBrowse link
G Areg amphiregulin decreases expression ISO Hydrochloric Acid results in decreased expression of AREG mRNA CTD PMID:15046208 NCBI chr 5:91,287,458...91,296,291
Ensembl chr 5:91,287,458...91,296,291
JBrowse link
G Bag3 BCL2-associated athanogene 3 increases expression ISO Hydrochloric Acid results in increased expression of BAG3 mRNA CTD PMID:15046208 NCBI chr 7:128,125,307...128,148,705
Ensembl chr 7:128,125,340...128,148,705
JBrowse link
G Bglap bone gamma carboxyglutamate protein increases expression ISO Hydrochloric Acid results in increased expression of BGLAP CTD PMID:17183249 NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha affects response to substance ISO CALCA protein affects the susceptibility to Hydrochloric Acid CTD PMID:19483072 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592
JBrowse link
G Car3 carbonic anhydrase 3 multiple interactions EXP [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of CAR3 mRNA CTD PMID:29618784 NCBI chr 3:14,928,598...14,937,441
Ensembl chr 3:14,928,572...14,937,583
JBrowse link
G Casp1 caspase 1 increases cleavage EXP Hydrochloric Acid results in increased cleavage of CASP1 protein CTD PMID:31900028 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 decreases expression ISO Hydrochloric Acid results in decreased expression of CASP3 protein modified form CTD PMID:15046208 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Casp9 caspase 9 decreases expression ISO Hydrochloric Acid results in decreased expression of CASP9 mRNA CTD PMID:15046208 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase multiple interactions ISO
EXP
CAT protein inhibits the reaction [Hydrochloric Acid results in increased susceptibility to Indomethacin]
[Ethanol co-treated with Hydrochloric Acid] results in increased activity of CAT protein; boldine inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of CAT protein]
CTD PMID:1887894 PMID:32531310 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
ISO Hydrochloric Acid results in increased expression of CCL2 mRNA; Hydrochloric Acid results in increased expression of CCL2 protein
pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL2 protein]
CTD PMID:16129981 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression
multiple interactions
ISO Hydrochloric Acid results in increased expression of CCL4 mRNA; Hydrochloric Acid results in increased expression of CCL4 protein
pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL4 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CCL4 protein]
CTD PMID:16129981 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509
JBrowse link
G Ccna1 cyclin A1 increases expression ISO Hydrochloric Acid results in increased expression of CCNA1 mRNA CTD PMID:15046208 NCBI chr 3:54,952,890...54,965,055
Ensembl chr 3:54,952,890...54,962,922
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Hydrochloric Acid results in increased expression of CCND1 mRNA CTD PMID:15046208 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Ccne1 cyclin E1 increases expression ISO Hydrochloric Acid results in increased expression of CCNE1 mRNA CTD PMID:15046208 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959
JBrowse link
G Ccne2 cyclin E2 increases expression ISO Hydrochloric Acid results in increased expression of CCNE2 mRNA CTD PMID:15046208 NCBI chr 4:11,190,489...11,204,781
Ensembl chr 4:11,191,351...11,204,779
JBrowse link
G Cd86 CD86 antigen multiple interactions ISO Hydrochloric Acid inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; Hydrochloric Acid inhibits the reaction [imidazolidinyl urea results in increased expression of CD86 protein] CTD PMID:29743441 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443
JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B affects localization ISO Hydrochloric Acid affects the localization of CDKN1B protein CTD PMID:20818264 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3, cardiac decreases expression ISO Hydrochloric Acid results in decreased expression of CHRM3 protein CTD PMID:20719367 NCBI chr13:9,925,522...10,411,131
Ensembl chr13:9,925,522...10,410,883
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
increases expression
ISO JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL1 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL1 mRNA]
Hydrochloric Acid results in increased expression of CXCL1 mRNA; Hydrochloric Acid results in increased expression of CXCL1 protein
CTD PMID:15044056 PMID:16129981 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974
JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 decreases expression ISO Hydrochloric Acid results in decreased expression of CXCL8 mRNA CTD PMID:15046208 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
multiple interactions
ISO Hydrochloric Acid results in increased expression of CXCL2 mRNA; Hydrochloric Acid results in increased expression of CXCL2 protein
pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL2 protein]
CTD PMID:16129981 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797
JBrowse link
G Cyba cytochrome b-245, alpha polypeptide increases expression EXP Hydrochloric Acid results in increased expression of CYBA protein CTD PMID:31900028 NCBI chr 8:123,151,510...123,159,679
Ensembl chr 8:123,151,515...123,159,669
JBrowse link
G Cybb cytochrome b-245, beta polypeptide increases expression EXP Hydrochloric Acid results in increased expression of CYBB protein CTD PMID:31900028 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010
JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 increases expression
multiple interactions
EXP Hydrochloric Acid results in increased expression of CYP2A5 mRNA
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of CYP2A5 mRNA]
CTD PMID:29618784 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973
JBrowse link
G Dpys dihydropyrimidinase increases expression
multiple interactions
EXP Hydrochloric Acid results in increased expression of DPYS mRNA
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of DPYS mRNA]
CTD PMID:29618784 NCBI chr15:39,631,881...39,720,866
Ensembl chr15:39,631,883...39,720,866
JBrowse link
G Dusp2 dual specificity phosphatase 2 decreases expression ISO Hydrochloric Acid results in decreased expression of DUSP2 mRNA CTD PMID:15046208 NCBI chr 2:127,178,079...127,180,297
Ensembl chr 2:127,178,079...127,180,296
JBrowse link
G Dusp8 dual specificity phosphatase 8 decreases expression ISO Hydrochloric Acid results in decreased expression of DUSP8 mRNA CTD PMID:15046208 NCBI chr 7:141,633,224...141,649,799
Ensembl chr 7:141,633,227...141,649,580
JBrowse link
G E2f5 E2F transcription factor 5 increases expression ISO Hydrochloric Acid results in increased expression of E2F5 mRNA CTD PMID:15046208 NCBI chr 3:14,638,370...14,671,369
Ensembl chr 3:14,643,701...14,671,369
JBrowse link
G Edn1 endothelin 1 increases expression ISO Hydrochloric Acid results in increased expression of EDN1 protein CTD PMID:19262391 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466
JBrowse link
G Efna4 ephrin A4 increases expression ISO Hydrochloric Acid results in increased expression of EFNA4 mRNA CTD PMID:15046208 NCBI chr 3:89,240,700...89,245,335
Ensembl chr 3:89,240,697...89,245,335
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases expression
ISO Celecoxib promotes the reaction [Hydrochloric Acid results in increased expression of EGFR protein]; Dipyrone promotes the reaction [Hydrochloric Acid results in increased expression of EGFR protein]; Piroxicam promotes the reaction [Hydrochloric Acid results in increased expression of EGFR protein] CTD PMID:15309881 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Hydrochloric Acid results in increased expression of EMP1 mRNA CTD PMID:15046208 NCBI chr 6:135,339,548...135,360,171
Ensembl chr 6:135,339,543...135,360,171
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO Hydrochloric Acid results in decreased expression of FGF2 mRNA CTD PMID:15046208 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 increases expression ISO Hydrochloric Acid results in increased expression of FGFR3 mRNA CTD PMID:15046208 NCBI chr 5:33,879,068...33,894,412
Ensembl chr 5:33,879,018...33,894,412
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
increases expression
ISO [Hydrochloric Acid co-treated with PGA5 protein] results in increased expression of FOS protein; Capsaicin inhibits the reaction [Hydrochloric Acid results in increased expression of FOS protein]; Hexamethonium inhibits the reaction [Hydrochloric Acid results in increased expression of FOS protein]; SB 222200 affects the reaction [Hydrochloric Acid results in increased expression of FOS mRNA]; vofopitant affects the reaction [Hydrochloric Acid results in increased expression of FOS mRNA]
Hydrochloric Acid results in increased expression of FOS mRNA; Hydrochloric Acid results in increased expression of FOS protein
CTD PMID:11730984 PMID:12588467 PMID:12928072 PMID:14750966 PMID:16162281 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Fosl2 fos-like antigen 2 decreases expression ISO Hydrochloric Acid results in decreased expression of FOSL2 mRNA CTD PMID:15046208 NCBI chr 5:32,292,599...32,315,184
Ensembl chr 5:32,293,145...32,315,186
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha decreases expression ISO Hydrochloric Acid results in decreased expression of GADD45A mRNA CTD PMID:15046208 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions
EXP Hydrochloric Acid results in increased expression of GCLC mRNA
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GCLC mRNA]
CTD PMID:29618784 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression
multiple interactions
EXP Hydrochloric Acid results in increased expression of GCLM mRNA
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GCLM mRNA]
CTD PMID:29618784 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381
JBrowse link
G Gls glutaminase multiple interactions
increases expression
EXP [Hydrochloric Acid results in decreased expression of GLS protein] which results in increased secretion of Ammonia
Hydrochloric Acid results in increased expression of GLS mRNA; Hydrochloric Acid results in increased expression of GLS protein
CTD PMID:20719974 PMID:29618784 NCBI chr 1:52,202,608...52,274,168
Ensembl chr 1:52,202,607...52,272,391
JBrowse link
G Glul glutamate-ammonia ligase multiple interactions EXP Hydrochloric Acid promotes the reaction [RHBG protein mutant form results in decreased expression of GLUL protein] CTD PMID:20719974 NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469
JBrowse link
G Gsta3 glutathione S-transferase, alpha 3 increases expression
multiple interactions
EXP Hydrochloric Acid results in increased expression of GSTA3 mRNA
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GSTA3 mRNA]
CTD PMID:29618784 NCBI chr 1:21,310,837...21,335,885
Ensembl chr 1:21,310,813...21,335,885
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 multiple interactions
increases expression
EXP NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GSTM1 mRNA] CTD PMID:29618784 NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289
JBrowse link
G Gtpbp2 GTP binding protein 2 decreases expression ISO Hydrochloric Acid results in decreased expression of GTPBP2 mRNA CTD PMID:15046208 NCBI chr17:46,470,153...46,480,294
Ensembl chr17:46,471,958...46,480,296
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of HAVCR1 mRNA CTD PMID:29618784 NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO beraprost inhibits the reaction [Hydrochloric Acid results in increased expression of HMOX1 protein]; Capsaicin promotes the reaction [Hydrochloric Acid results in increased expression of HMOX1 protein] CTD PMID:18617559 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
JBrowse link
G Hsf1 heat shock factor 1 affects response to substance EXP HSF1 protein affects the susceptibility to Hydrochloric Acid CTD PMID:17189318 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113
JBrowse link
G Hspa1a heat shock protein 1A affects response to substance ISO HSPA1A protein affects the susceptibility to Hydrochloric Acid CTD PMID:16945336 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132
JBrowse link
G Hspa1b heat shock protein 1B affects response to substance ISO HSPA1B protein affects the susceptibility to Hydrochloric Acid CTD PMID:15338365 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
multiple interactions
ISO Hydrochloric Acid results in increased expression of ICAM1 mRNA
pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of ICAM1 mRNA]
Hydrochloric Acid inhibits the reaction [Dinitrochlorobenzene results in increased expression of ICAM1 protein]; Hydrochloric Acid inhibits the reaction [imidazolidinyl urea results in increased expression of ICAM1 protein]
CTD PMID:16129981 PMID:29743441 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO Hydrochloric Acid results in increased expression of ID2 mRNA CTD PMID:15046208 NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO
EXP
[Celecoxib co-treated with Hydrochloric Acid] results in increased expression of IL1B protein
Hydrochloric Acid results in increased expression of IL1B protein
[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL1B protein; MitoTEMPO inhibits the reaction [Hydrochloric Acid results in increased expression of IL1B mRNA]; MitoTEMPO inhibits the reaction [Hydrochloric Acid results in increased expression of IL1B protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL1B protein]
Hydrochloric Acid results in increased expression of IL1B mRNA; Hydrochloric Acid results in increased expression of IL1B protein
CTD PMID:15309881 PMID:25478868 PMID:31900028 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il5 interleukin 5 increases expression ISO Hydrochloric Acid results in increased expression of IL5 protein CTD PMID:19951613 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO
EXP
7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane inhibits the reaction [Hydrochloric Acid results in increased expression of IL6 protein]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of IL6 mRNA]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of IL6 protein]
Hydrochloric Acid results in increased expression of IL6 mRNA; Hydrochloric Acid results in increased expression of IL6 protein
[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL6 protein; MitoTEMPO inhibits the reaction [Hydrochloric Acid results in increased expression of IL6 mRNA]; MitoTEMPO inhibits the reaction [Hydrochloric Acid results in increased expression of IL6 protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL6 protein]
CTD PMID:11850527 PMID:12771618 PMID:15044056 PMID:15607125 PMID:19951613 More... NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Kcna4 potassium voltage-gated channel, shaker-related subfamily, member 4 decreases activity
decreases expression
ISO Hydrochloric Acid results in decreased activity of KCNA4 protein
Hydrochloric Acid results in decreased expression of KCNA4 protein
CTD PMID:19279288 NCBI chr 2:107,120,934...107,157,149
Ensembl chr 2:107,120,984...107,128,847
JBrowse link
G Kdm5b lysine demethylase 5B decreases expression ISO Hydrochloric Acid results in decreased expression of KDM5B mRNA CTD PMID:15046208 NCBI chr 1:134,487,916...134,560,621
Ensembl chr 1:134,487,909...134,563,023
JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 decreases expression ISO Hydrochloric Acid results in decreased expression of MCL1 mRNA CTD PMID:15046208 NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 increases expression ISO Hydrochloric Acid results in increased expression of MCM4 mRNA CTD PMID:15046208 NCBI chr16:15,441,761...15,455,264
Ensembl chr16:15,441,761...15,455,264
JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) increases expression ISO Hydrochloric Acid results in increased expression of MIF mRNA; Hydrochloric Acid results in increased expression of MIF protein CTD PMID:12853844 NCBI chr10:75,695,187...75,696,111
Ensembl chr10:75,695,187...75,696,074
JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) increases expression ISO Hydrochloric Acid results in increased expression of MMP1 protein CTD PMID:11850527 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
JBrowse link
G Mpo myeloperoxidase increases activity
multiple interactions
ISO
EXP
Hydrochloric Acid results in increased activity of MPO protein
[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein; [Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein; [lupeol binds to stearic acid] inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein]; baicalein inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; boldine inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Carbenoxolone inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Carbenoxolone inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of MPO protein]; Omeprazole inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]
CTD PMID:11574821 PMID:15309881 PMID:25478868 PMID:27780710 PMID:31900028 More... NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 increases expression EXP Hydrochloric Acid results in increased expression of NCF2 protein CTD PMID:31900028 NCBI chr 1:152,675,904...152,712,743
Ensembl chr 1:152,675,945...152,712,742
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases localization
multiple interactions
increases response to substance
ISO
EXP
Hydrochloric Acid results in increased localization of NFE2L2 protein
[NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of CAR3 mRNA; [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of HAVCR1 mRNA; [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of SLC38A1 mRNA; [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of SLC9A4 mRNA; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC38A4 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC3A2 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC7A9 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of CYP2A5 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of DPYS mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GCLC mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GCLM mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GSTA3 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of GSTM1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of SLC38A3 mRNA]; NFE2L2 protein promotes the reaction [Hydrochloric Acid results in increased expression of SLC38A3 mRNA]
CTD PMID:18617559 PMID:29618784 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression EXP Hydrochloric Acid results in increased expression of NLRP3 protein CTD PMID:31900028 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
JBrowse link
G Nos2 nitric oxide synthase 2, inducible affects response to substance
multiple interactions
increases expression
EXP
ISO
NOS2 protein affects the susceptibility to Hydrochloric Acid
pimagedine inhibits the reaction [Hydrochloric Acid results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Hydrochloric Acid results in increased expression of NOS2 protein]; S-methylisothiopseudouronium inhibits the reaction [Hydrochloric Acid results in increased expression of NOS2 protein]
CTD PMID:11574821 PMID:12646421 PMID:12771618 PMID:18573544 PMID:24122261 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell decreases expression ISO Hydrochloric Acid results in decreased expression of NOS3 protein CTD PMID:12771618 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
JBrowse link
G Nox1 NADPH oxidase 1 affects response to substance EXP NOX1 protein affects the susceptibility to Hydrochloric Acid CTD PMID:21339339 NCBI chr  X:132,987,170...133,038,455
Ensembl chr  X:132,987,170...133,122,705
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression
multiple interactions
EXP Hydrochloric Acid results in increased expression of NQO1 mRNA
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of NQO1 mRNA]
CTD PMID:29618784 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic increases expression EXP Hydrochloric Acid results in increased expression of PCK1 protein CTD PMID:20719974 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Hydrochloric Acid results in increased expression of PCNA mRNA CTD PMID:15046208 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel multiple interactions ISO Hydrochloric Acid results in decreased activity of [PKD2 protein binds to PKD2 protein] CTD PMID:19193631 NCBI chr 5:104,599,379...104,653,685
Ensembl chr 5:104,607,316...104,653,685
JBrowse link
G Plpp3 phospholipid phosphatase 3 decreases expression ISO Hydrochloric Acid results in decreased expression of PLPP3 mRNA CTD PMID:15046208 NCBI chr 4:105,014,544...105,089,964
Ensembl chr 4:105,014,544...105,089,961
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases response to substance
multiple interactions
EXP PTGS1 results in decreased susceptibility to Hydrochloric Acid
PTGS1 results in decreased susceptibility to [Hydrochloric Acid co-treated with Aspirin]
CTD PMID:15236176 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
EXP
ISO
[[Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 mRNA; [Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 protein
[Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 mRNA; [Hydrochloric Acid co-treated with Piroxicam] results in increased expression of PTGS2 mRNA
Hydrochloric Acid results in increased expression of PTGS2 mRNA; Hydrochloric Acid results in increased expression of PTGS2 protein
CTD PMID:9726391 PMID:12853844 PMID:15236176 PMID:15309881 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Pth parathyroid hormone decreases secretion ISO PTH protein results in decreased secretion of Hydrochloric Acid CTD PMID:20380354 NCBI chr 7:112,984,783...112,987,879
Ensembl chr 7:112,984,787...112,987,777
JBrowse link
G Pycard PYD and CARD domain containing increases expression EXP Hydrochloric Acid results in increased expression of PYCARD protein CTD PMID:31900028 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039
JBrowse link
G Rassf1 Ras association (RalGDS/AF-6) domain family member 1 decreases expression ISO Hydrochloric Acid results in decreased expression of RASSF1 mRNA CTD PMID:15046208 NCBI chr 9:107,428,752...107,439,460
Ensembl chr 9:107,428,754...107,439,466
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
increases phosphorylation
EXP MitoTEMPO inhibits the reaction [Hydrochloric Acid results in increased phosphorylation of RELA protein] CTD PMID:31900028 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
JBrowse link
G Rhbg Rhesus blood group-associated B glycoprotein multiple interactions
increases expression
EXP Hydrochloric Acid promotes the reaction [RHBG protein mutant form results in decreased expression of GLUL protein]; RHBG protein affects the reaction [Hydrochloric Acid results in increased export of Ammonia]
Hydrochloric Acid results in increased expression of RHBG protein
CTD PMID:20719974 NCBI chr 3:88,150,181...88,162,046
Ensembl chr 3:88,150,181...88,162,016
JBrowse link
G Rhcg Rhesus blood group-associated C glycoprotein increases expression
multiple interactions
affects response to substance
EXP
ISO
Hydrochloric Acid results in increased expression of RHCG protein
RHCG protein affects the reaction [Hydrochloric Acid results in increased secretion of Ammonia]
RHCG protein affects the susceptibility to Hydrochloric Acid
[Hydrochloric Acid results in increased expression of RHCG protein] which results in increased secretion of Ammonia
CTD PMID:16144966 PMID:19321595 PMID:20462967 NCBI chr 7:79,243,111...79,267,405
Ensembl chr 7:79,243,111...79,267,405
JBrowse link
G Rrad Ras-related associated with diabetes increases expression ISO Hydrochloric Acid results in increased expression of RRAD mRNA CTD PMID:15046208 NCBI chr 8:105,354,702...105,357,921
Ensembl chr 8:105,354,702...105,357,959
JBrowse link
G Rreb1 ras responsive element binding protein 1 decreases expression ISO Hydrochloric Acid results in decreased expression of RREB1 mRNA CTD PMID:15046208 NCBI chr13:37,962,362...38,135,981
Ensembl chr13:37,962,376...38,135,981
JBrowse link
G Runx2 runt related transcription factor 2 increases expression ISO Hydrochloric Acid results in increased expression of RUNX2 mRNA; Hydrochloric Acid results in increased expression of RUNX2 protein CTD PMID:17183249 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684
JBrowse link
G Scgb1a1 secretoglobin, family 1A, member 1 increases expression
multiple interactions
ISO Hydrochloric Acid results in increased expression of SCGB1A1 protein
Quercetin inhibits the reaction [Hydrochloric Acid results in increased expression of SCGB1A1 protein]
CTD PMID:24122261 NCBI chr19:9,061,006...9,065,320
Ensembl chr19:9,061,000...9,065,322
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 affects response to substance EXP SERPINE1 protein affects the susceptibility to Hydrochloric Acid CTD PMID:19060228 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122
JBrowse link
G Sftpd surfactant associated protein D decreases expression
increases expression
multiple interactions
ISO Hydrochloric Acid results in decreased expression of SFTPD protein
Hydrochloric Acid results in increased expression of SFTPD protein
S-methylisothiopseudouronium inhibits the reaction [Hydrochloric Acid results in decreased expression of SFTPD protein]
CTD PMID:11880309 PMID:18573544 NCBI chr14:40,894,169...40,907,155
Ensembl chr14:40,894,171...40,907,106
JBrowse link
G Slc38a1 solute carrier family 38, member 1 multiple interactions EXP [NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of SLC38A1 mRNA CTD PMID:29618784 NCBI chr15:96,469,299...96,541,396
Ensembl chr15:96,469,299...96,540,794
JBrowse link
G Slc38a3 solute carrier family 38, member 3 multiple interactions
increases expression
EXP NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in increased expression of SLC38A3 mRNA]; NFE2L2 protein promotes the reaction [Hydrochloric Acid results in increased expression of SLC38A3 mRNA] CTD PMID:29618784 NCBI chr 9:107,528,353...107,546,167
Ensembl chr 9:107,527,833...107,546,729
JBrowse link
G Slc38a4 solute carrier family 38, member 4 decreases expression
multiple interactions
EXP Hydrochloric Acid results in decreased expression of SLC38A4 mRNA
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC38A4 mRNA]
CTD PMID:29618784 NCBI chr15:96,892,701...96,953,837
Ensembl chr15:96,892,701...96,953,837
JBrowse link
G Slc38a7 solute carrier family 38, member 7 decreases expression EXP Hydrochloric Acid results in decreased expression of SLC38A7 mRNA CTD PMID:29618784 NCBI chr 8:96,562,548...96,580,205
Ensembl chr 8:96,562,548...96,580,167
JBrowse link
G Slc3a2 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 decreases expression
multiple interactions
EXP Hydrochloric Acid results in decreased expression of SLC3A2 mRNA
NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC3A2 mRNA]
CTD PMID:29618784 NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733
JBrowse link
G Slc6a19 solute carrier family 6 (neurotransmitter transporter), member 19 decreases expression EXP Hydrochloric Acid results in decreased expression of SLC6A19 mRNA CTD PMID:29618784 NCBI chr13:73,827,864...73,848,899
Ensembl chr13:73,827,864...73,852,984
JBrowse link
G Slc7a7 solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 decreases expression EXP Hydrochloric Acid results in decreased expression of SLC7A7 mRNA CTD PMID:29618784 NCBI chr14:54,606,899...54,657,525
Ensembl chr14:54,606,899...54,655,237
JBrowse link
G Slc7a9 solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 multiple interactions
decreases expression
EXP NFE2L2 gene mutant form inhibits the reaction [Hydrochloric Acid results in decreased expression of SLC7A9 mRNA] CTD PMID:29618784 NCBI chr 7:35,148,152...35,165,459
Ensembl chr 7:35,148,221...35,165,461
JBrowse link
G Slc9a4 solute carrier family 9 (sodium/hydrogen exchanger), member 4 increases expression
multiple interactions
increases activity
EXP
ISO
Hydrochloric Acid results in increased expression of SLC9A4 mRNA
[NFE2L2 gene mutant form results in increased susceptibility to Hydrochloric Acid] which results in increased expression of SLC9A4 mRNA; SLC9A4 protein affects the reaction [Hydrochloric Acid results in increased secretion of Ammonia]
Hydrochloric Acid results in increased activity of SLC9A4 protein
CTD PMID:20484819 PMID:29618784 NCBI chr 1:40,619,146...40,670,188
Ensembl chr 1:40,619,241...40,669,885
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial decreases activity
multiple interactions
EXP Hydrochloric Acid results in decreased activity of SOD2 protein
MitoTEMPO inhibits the reaction [Hydrochloric Acid results in decreased activity of SOD2 protein]
CTD PMID:31900028 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950
JBrowse link
G Sp7 Sp7 transcription factor 7 decreases expression ISO Hydrochloric Acid results in decreased expression of SP7 mRNA; Hydrochloric Acid results in decreased expression of SP7 protein CTD PMID:17183249 NCBI chr15:102,265,038...102,275,498
Ensembl chr15:102,265,041...102,275,617
JBrowse link
G Sst somatostatin increases expression ISO Hydrochloric Acid results in increased expression of SST protein CTD PMID:9530148 NCBI chr16:23,708,327...23,710,041
Ensembl chr16:23,708,323...23,709,708
JBrowse link
G Sstr2 somatostatin receptor 2 affects response to substance EXP SSTR2 protein affects the susceptibility to Hydrochloric Acid CTD PMID:17363388 NCBI chr11:113,510,153...113,516,854
Ensembl chr11:113,510,168...113,516,854
JBrowse link
G Tac1 tachykinin 1 multiple interactions
increases secretion
ISO Botulinum Toxins, Type A inhibits the reaction [Hydrochloric Acid results in increased secretion of TAC1 protein] CTD PMID:18184328 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834
JBrowse link
G Tacr1 tachykinin receptor 1 affects response to substance ISO TACR1 protein affects the susceptibility to Hydrochloric Acid CTD PMID:11730984 NCBI chr 6:82,378,990...82,537,085
Ensembl chr 6:82,379,315...82,537,085
JBrowse link
G Tacr3 tachykinin receptor 3 affects response to substance ISO TACR3 protein affects the susceptibility to Hydrochloric Acid CTD PMID:11730984 NCBI chr 3:134,534,768...134,640,342
Ensembl chr 3:134,534,768...134,640,340
JBrowse link
G Tff2 trefoil factor 2 (spasmolytic protein 1) multiple interactions ISO [Aspirin co-treated with Hydrochloric Acid] results in increased expression of TFF2 mRNA CTD PMID:9726391 NCBI chr17:31,360,036...31,363,256
Ensembl chr17:31,360,023...31,363,256
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions
increases expression
ISO [Aspirin co-treated with Hydrochloric Acid] results in increased expression of TGFA mRNA; Celecoxib promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein]; Dipyrone promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein]; Piroxicam promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein] CTD PMID:9726391 PMID:15309881 NCBI chr 6:86,172,020...86,252,726
Ensembl chr 6:86,172,205...86,252,701
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO
EXP
7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane inhibits the reaction [Hydrochloric Acid results in increased expression of TNF protein]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of TNF mRNA]; JTE 607 inhibits the reaction [Hydrochloric Acid results in increased expression of TNF protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Hydrochloric Acid results in increased expression of TNF mRNA]
Hydrochloric Acid results in increased expression of TNF mRNA; Hydrochloric Acid results in increased expression of TNF protein
[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein; boldine inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein]; MitoTEMPO inhibits the reaction [Hydrochloric Acid results in increased expression of TNF mRNA]; MitoTEMPO inhibits the reaction [Hydrochloric Acid results in increased expression of TNF protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein]
CTD PMID:15044056 PMID:15607125 PMID:16129981 PMID:25478868 PMID:31900028 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 affects response to substance
increases activity
EXP
ISO
TRPV1 protein affects the susceptibility to Hydrochloric Acid
Hydrochloric Acid results in increased activity of TRPV1 protein
CTD PMID:15125461 PMID:15331673 PMID:17627983 PMID:18331834 PMID:19483072 NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068
JBrowse link
G Vegfc vascular endothelial growth factor C increases expression ISO Hydrochloric Acid results in increased expression of VEGFC mRNA CTD PMID:15046208 NCBI chr 8:54,530,567...54,639,489
Ensembl chr 8:54,530,641...54,640,131
JBrowse link
G Vgf VGF nerve growth factor inducible decreases expression ISO Hydrochloric Acid results in decreased expression of VGF mRNA CTD PMID:15046208 NCBI chr 5:137,054,156...137,062,205
Ensembl chr 5:137,055,246...137,062,205
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    chemical entity 22208
      molecular entity 22169
        main group molecular entity 22104
          gas molecular entity 19926
            hydrogen chloride 110
              chloro group 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    main group molecular entity 22104
                      s-block molecular entity 21729
                        hydrogen molecular entity 21646
                          hydrides 20758
                            mononuclear parent hydride 18735
                              hydrogen chloride 110
                                chloro group 0
paths to the root