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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:glutathione disulfide
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Accession:CHEBI:17858 term browser browse the term
Definition:A glutathione derivative that has formula C20H32N6O12S2.
Synonyms:exact_synonym: (2S,2'S)-5,5'-[disulfanediylbis({(2R)-3-[(carboxymethyl)amino]-3-oxopropane-1,2-diyl}imino)]bis(2-amino-5-oxopentanoic acid)
 related_synonym: Formula=C20H32N6O12S2;   GSSG;   InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/t9-,10-,11-,12-/m0/s1;   InChIKey=YPZRWBKMTBYPTK-BJDJZHNGSA-N;   OXIDIZED GLUTATHIONE DISULFIDE;   Oxidized glutathione;   Oxiglutatione;   SMILES=N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O;   glutathione disulphide;   oxidised glutathione
 alt_id: CHEBI:14328;   CHEBI:14720;   CHEBI:24336;   CHEBI:42832;   CHEBI:7840
 xref: CAS:27025-41-8;   DrugBank:DB03310;   Drug_Central:5130;   KEGG:C00127;   KEGG:D00031
 xref_mesh: MESH:D019803
 xref: PDBeChem:GDS
 cyclic_relationship: is_conjugate_acid_of CHEBI:58297


show annotations for term's descendants           Sort by:
glutathione disulfide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP-binding cassette, sub-family C member 1 increases export
multiple interactions
increases activity		 ISO
EXP		 ABCC1 protein results in increased export of Glutathione Disulfide
ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione Disulfide]
Glutathione Disulfide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; Glutathione Disulfide promotes the reaction [Leukotriene C4 analog binds to ABCC1 protein]
[Epinephrine co-treated with [verlukast results in decreased activity of ABCC1 protein]] results in increased abundance of Glutathione Disulfide
Glutathione Disulfide results in increased activity of ABCC1 protein		 CTD PMID:11306701 PMID:15628876 PMID:17272743 PMID:19053318 PMID:21918036 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 increases transport
multiple interactions		 ISO ABCC2 protein results in increased transport of Glutathione Disulfide
Acetaminophen promotes the reaction [ABCC2 protein results in increased transport of Glutathione Disulfide]		 CTD PMID:15276087 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Agt angiotensinogen multiple interactions
decreases abundance
increases export		 EXP ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione Disulfide]
AGT protein results in increased export of Glutathione Disulfide		 CTD PMID:17272743 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase affects response to substance
increases activity
increases glutathionylation		 EXP ALOX12 protein affects the susceptibility to Glutathione Disulfide
Glutathione Disulfide results in increased activity of ALOX12 protein
Glutathione Disulfide results in increased glutathionylation of ALOX12 protein		 CTD PMID:19373248 NCBI chr11:70,132,283...70,146,206
Ensembl chr11:70,132,283...70,146,179 		JBrowse link
G Ar androgen receptor multiple interactions
affects localization		 ISO Glutathione Disulfide binds to and results in increased activity of AR protein
Glutathione Disulfide affects the localization of AR protein		 CTD PMID:28478275 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A increases expression ISO Glutathione Disulfide results in increased expression of CDKN1A protein CTD PMID:15993333 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator decreases activity ISO Glutathione Disulfide results in decreased activity of CFTR protein CTD PMID:15657297 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767 		JBrowse link
G Crygd crystallin, gamma D increases oxidation ISO Glutathione Disulfide results in increased oxidation of CRYGD protein mutant form CTD PMID:30242128 NCBI chr 1:65,101,001...65,102,598
Ensembl chr 1:65,101,031...65,102,611 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions ISO [Benzo(a)pyrene co-treated with CXCL8 protein] results in increased abundance of Glutathione Disulfide CTD PMID:28238931 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Fas Fas cell surface death receptor decreases activity EXP Glutathione Disulfide results in decreased activity of FAS protein CTD PMID:10385654 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fndc5 fibronectin type III domain containing 5 decreases abundance ISO FNDC5 protein results in decreased abundance of Glutathione Disulfide CTD PMID:32165127 NCBI chr 4:129,030,672...129,038,386
Ensembl chr 4:129,030,477...129,038,386 		JBrowse link
G Glrx glutaredoxin affects response to substance EXP GLRX protein affects the susceptibility to Glutathione Disulfide CTD PMID:19373248 NCBI chr13:75,988,004...75,998,270
Ensembl chr13:75,987,987...75,998,273 		JBrowse link
G Gsr glutathione reductase multiple interactions ISO
EXP		 Glutathione Disulfide inhibits the reaction [Carmustine results in decreased activity of GSR protein]
[[Carmustine results in decreased activity of GSR protein] which co-treated with Oligodeoxyribonucleotides analog] results in increased abundance of Glutathione Disulfide; [[Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein] which results in increased abundance of Glutathione Disulfide
arsenic trioxide inhibits the reaction [GSR protein results in increased reduction of Glutathione Disulfide]; arsenic trioxide promotes the reaction [GSR protein binds to Glutathione Disulfide]; GSR protein binds to and results in increased reduction of Glutathione Disulfide		 CTD PMID:12114195 PMID:12477282 PMID:19668867 PMID:24634002 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO Glutathione Disulfide analog promotes the reaction [cobaltous chloride results in increased activity of HIF1A protein]; Glutathione Disulfide analog promotes the reaction [Oxygen deficiency results in increased activity of HIF1A protein] CTD PMID:19374849 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [MPO protein results in increased oxidation of Phenolsulfonphthalein] which results in increased abundance of Glutathione Disulfide CTD PMID:31288001 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP
ISO		 Glutathione Disulfide promotes the reaction [Oligodeoxyribonucleotides analog results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; Glutathione Disulfide promotes the reaction [Oligodeoxyribonucleotides analog results in increased activity of [NFKB1 protein binds to RELA protein]]
Glutathione Disulfide results in decreased activity of [NFKB1 protein binds to RELA protein]		 CTD PMID:12433058 PMID:12477282 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Ngf nerve growth factor affects abundance EXP NGF protein affects the abundance of Glutathione Disulfide CTD PMID:23472850 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Nnmt nicotinamide N-methyltransferase increases abundance ISO NNMT protein results in increased abundance of Glutathione Disulfide CTD PMID:31909875 NCBI chr 9:48,448,905...48,518,958
Ensembl chr 9:48,503,177...48,516,453 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP
ISO		 Glutathione Disulfide promotes the reaction [Oligodeoxyribonucleotides analog results in increased activity of [NFKB1 protein binds to RELA protein]]
Glutathione Disulfide results in decreased activity of [NFKB1 protein binds to RELA protein]		 CTD PMID:12433058 PMID:12477282 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 multiple interactions
increases abundance		 EXP manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [SLC2A4 gene mutant form results in increased abundance of Glutathione Disulfide] CTD PMID:22221582 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Snca synuclein, alpha decreases abundance ISO SNCA protein results in decreased abundance of Glutathione Disulfide CTD PMID:27424009 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases abundance ISO SOD2 protein results in increased abundance of Glutathione Disulfide CTD PMID:15130278 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases glutathionylation		 ISO Dithiothreitol inhibits the reaction [Glutathione Disulfide results in increased glutathionylation of TP53 protein]; Glutathione Disulfide results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein CTD PMID:15993333 PMID:17555331 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      chemical role 21407
        antioxidant 16394
          glutathione 373
            glutathione derivative 58
              glutathione disulfide 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  carbon oxoacid 19593
                                    carboxylic acid 19589
                                      carboacyl group 18277
                                        univalent carboacyl group 18277
                                          carbamoyl group 18088
                                            carboxamide 18106
                                              peptide 11229
                                                oligopeptide 1336
                                                  tripeptide 970
                                                    glutathione 373
                                                      glutathione derivative 58
                                                        glutathione disulfide 23
paths to the root