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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:glutathione disulfide
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Accession:CHEBI:17858 term browser browse the term
Definition:A glutathione derivative that has formula C20H32N6O12S2.
Synonyms:exact_synonym: (2S,2'S)-5,5'-[disulfanediylbis({(2R)-3-[(carboxymethyl)amino]-3-oxopropane-1,2-diyl}imino)]bis(2-amino-5-oxopentanoic acid)
 related_synonym: Formula=C20H32N6O12S2;   GSSG;   InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/t9-,10-,11-,12-/m0/s1;   InChIKey=YPZRWBKMTBYPTK-BJDJZHNGSA-N;   OXIDIZED GLUTATHIONE DISULFIDE;   Oxidized glutathione;   Oxiglutatione;   SMILES=N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O;   glutathione disulphide;   oxidised glutathione
 alt_id: CHEBI:14328;   CHEBI:14720;   CHEBI:24336;   CHEBI:42832;   CHEBI:7840
 xref: CAS:27025-41-8;   DrugBank:DB03310;   Drug_Central:5130;   KEGG:C00127;   KEGG:D00031
 xref_mesh: MESH:D019803
 xref: PDBeChem:GDS
 cyclic_relationship: is_conjugate_acid_of CHEBI:58297


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glutathione disulfide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 increases export
increases activity
multiple interactions
ISO
EXP
ABCC1 protein results in increased export of Glutathione Disulfide
Glutathione Disulfide results in increased activity of ABCC1 protein
[Epinephrine co-treated with [verlukast results in decreased activity of ABCC1 protein]] results in increased abundance of Glutathione Disulfide
ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione Disulfide]
Glutathione Disulfide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; Glutathione Disulfide promotes the reaction [Leukotriene C4 analog binds to ABCC1 protein]
CTD PMID:11306701, PMID:15628876, PMID:17272743, PMID:19053318, PMID:21918036 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases transport
multiple interactions
EXP ABCC2 protein results in increased transport of Glutathione Disulfide
Acetaminophen promotes the reaction [ABCC2 protein results in increased transport of Glutathione Disulfide]
CTD PMID:15276087 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Agt angiotensinogen multiple interactions
increases export
decreases abundance
ISO ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione Disulfide]
AGT protein results in increased export of Glutathione Disulfide
CTD PMID:17272743 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type affects response to substance
increases activity
increases glutathionylation
ISO ALOX12 protein affects the susceptibility to Glutathione Disulfide
Glutathione Disulfide results in increased activity of ALOX12 protein
Glutathione Disulfide results in increased glutathionylation of ALOX12 protein
CTD PMID:19373248 NCBI chr10:56,851,734...56,864,049
Ensembl chr10:56,851,734...56,864,005
JBrowse link
G Ar androgen receptor affects localization
multiple interactions
ISO Glutathione Disulfide affects the localization of AR protein
Glutathione Disulfide binds to and results in increased activity of AR protein
CTD PMID:28478275 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Glutathione Disulfide results in increased expression of CDKN1A protein CTD PMID:15993333 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cftr CF transmembrane conductance regulator decreases activity ISO Glutathione Disulfide results in decreased activity of CFTR protein CTD PMID:15657297 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Crygd crystallin, gamma D increases oxidation ISO Glutathione Disulfide results in increased oxidation of CRYGD protein mutant form CTD PMID:30242128 NCBI chr 9:71,776,568...71,778,323
Ensembl chr 9:71,764,318...71,778,323
JBrowse link
G Fas Fas cell surface death receptor decreases activity ISO Glutathione Disulfide results in decreased activity of FAS protein CTD PMID:10385654 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fndc5 fibronectin type III domain containing 5 decreases abundance EXP FNDC5 protein results in decreased abundance of Glutathione Disulfide CTD PMID:32165127 NCBI chr 5:147,323,240...147,330,266
Ensembl chr 5:147,323,240...147,330,266
JBrowse link
G Glrx glutaredoxin affects response to substance ISO GLRX protein affects the susceptibility to Glutathione Disulfide CTD PMID:19373248 NCBI chr 2:2,606,032...2,615,944
Ensembl chr 2:2,605,996...2,615,944
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO
EXP
Glutathione Disulfide inhibits the reaction [Carmustine results in decreased activity of GSR protein]
arsenic trioxide inhibits the reaction [GSR protein results in increased reduction of Glutathione Disulfide]; arsenic trioxide promotes the reaction [GSR protein binds to Glutathione Disulfide]; GSR protein binds to and results in increased reduction of Glutathione Disulfide
[[Carmustine results in decreased activity of GSR protein] which co-treated with Oligodeoxyribonucleotides analog] results in increased abundance of Glutathione Disulfide; [[Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein] which results in increased abundance of Glutathione Disulfide
CTD PMID:12114195, PMID:12477282, PMID:19668867, PMID:24634002 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Glutathione Disulfide analog promotes the reaction [cobaltous chloride results in increased activity of HIF1A protein]; Glutathione Disulfide analog promotes the reaction [Oxygen deficiency results in increased activity of HIF1A protein] CTD PMID:19374849 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [MPO protein results in increased oxidation of Phenolsulfonphthalein] which results in increased abundance of Glutathione Disulfide CTD PMID:31288001 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP
Glutathione Disulfide promotes the reaction [Oligodeoxyribonucleotides analog results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; Glutathione Disulfide promotes the reaction [Oligodeoxyribonucleotides analog results in increased activity of [NFKB1 protein binds to RELA protein]]
Glutathione Disulfide results in decreased activity of [NFKB1 protein binds to RELA protein]
CTD PMID:12433058, PMID:12477282 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Ngf nerve growth factor affects abundance ISO NGF protein affects the abundance of Glutathione Disulfide CTD PMID:23472850 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nnmt nicotinamide N-methyltransferase increases abundance ISO NNMT protein results in increased abundance of Glutathione Disulfide CTD PMID:31909875 NCBI chr 8:52,918,437...52,938,172
Ensembl chr 8:52,925,175...52,937,972
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
Glutathione Disulfide promotes the reaction [Oligodeoxyribonucleotides analog results in increased activity of [NFKB1 protein binds to RELA protein]]
Glutathione Disulfide results in decreased activity of [NFKB1 protein binds to RELA protein]
CTD PMID:12433058, PMID:12477282 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions
increases abundance
ISO manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [SLC2A4 gene mutant form results in increased abundance of Glutathione Disulfide] CTD PMID:22221582 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Snca synuclein alpha decreases abundance ISO SNCA protein results in decreased abundance of Glutathione Disulfide CTD PMID:27424009 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sod2 superoxide dismutase 2 increases abundance ISO SOD2 protein results in increased abundance of Glutathione Disulfide CTD PMID:15130278 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions EXP Glutathione Disulfide affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]; Glutathione Disulfide affects the reaction [Polychlorinated Biphenyls analog affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]]; Glutathione Disulfide affects the reaction [Polychlorinated Biphenyls analog binds to SULT1A1 protein] CTD PMID:21130751 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases glutathionylation
ISO Dithiothreitol inhibits the reaction [Glutathione Disulfide results in increased glutathionylation of TP53 protein]; Glutathione Disulfide results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein CTD PMID:15993333, PMID:17555331 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      chemical role 19288
        antioxidant 14226
          glutathione 373
            glutathione derivative 59
              glutathione disulfide 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                peptide 9396
                                                  oligopeptide 1199
                                                    tripeptide 883
                                                      glutathione 373
                                                        glutathione derivative 59
                                                          glutathione disulfide 23
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.