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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:biphenyl-4-amine
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Accession:CHEBI:1784 term browser browse the term
Definition:An aminobiphenyl that is biphenyl substituted by an amino group at position 4.
Synonyms:exact_synonym: [1,1'-biphenyl]-4-amine
 related_synonym: 4-Aminobiphenyl;   4-amino-1,1'-biphenyl;   4-aminodiphenyl;   4-biphenylamine;   Formula=C12H11N;   InChI=1S/C12H11N/c13-12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H,13H2;   InChIKey=DMVOXQPQNTYEKQ-UHFFFAOYSA-N;   SMILES=Nc1ccc(cc1)-c1ccccc1;   biphenyl-4-ylamine;   p-aminodiphenyl;   p-biphenylamine;   p-phenylaniline;   p-xenylamine;   paraaminodiphenyl
 xref: Beilstein:386533;   CAS:92-67-1;   Gmelin:365629;   HMDB:HMDB0013195;   KEGG:C10998
 xref_mesh: MESH:C006757
 xref: PMID:12778203;   PMID:15880493;   PMID:20433335;   PMID:841184;   PMID:8847111;   Reaxys:386533;   Wikipedia:4-Aminobiphenyl


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biphenyl-4-amine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO 4-biphenylamine binds to ALB protein CTD PMID:11697451 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Blm BLM RecQ like helicase multiple interactions
decreases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BLM mRNA] CTD PMID:32905825 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312 		JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of BRCA1 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCA1 mRNA]		 CTD PMID:24857880 PMID:32905825 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 multiple interactions
decreases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCC3 mRNA] CTD PMID:32905825 NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080 		JBrowse link
G Ccnd3 cyclin D3 multiple interactions
decreases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCND3 mRNA] CTD PMID:32905825 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccne2 cyclin E2 decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of CCNE2 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCNE2 mRNA]		 CTD PMID:32905825 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of CDK1 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK1 mRNA]		 CTD PMID:32905825 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of CDK2 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK2 mRNA]		 CTD PMID:32905825 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of CDKN1A mRNA] CTD PMID:32905825 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO 4-biphenylamine results in decreased expression of CHEK1 mRNA CTD PMID:24857880 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Cidea cell death-inducing DFFA-like effector a decreases expression ISO 4-biphenylamine results in decreased expression of CIDEA mRNA CTD PMID:24857880 NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression
multiple interactions		 ISO 4-biphenylamine results in increased expression of CREB1 protein
Acetylcysteine inhibits the reaction [4-biphenylamine results in increased expression of CREB1 protein]; CREB1 protein affects the reaction [4-biphenylamine results in increased expression of MIR630 mRNA]		 CTD PMID:32433928 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases oxidation EXP CYP1A1 protein results in increased oxidation of 4-biphenylamine CTD PMID:2908851 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
affects metabolic processing
increases metabolic processing
multiple interactions
increases oxidation		 ISO
EXP		 CYP1A2 protein results in increased activity of 4-biphenylamine
CYP1A2 protein affects the metabolism of 4-biphenylamine
CYP1A2 protein results in increased metabolism of 4-biphenylamine
[furafylline results in decreased activity of CYP1A2 protein] which results in decreased susceptibility to 4-biphenylamine; CYP1A2 protein results in increased hydroxylation of and results in increased activity of 4-biphenylamine
CYP1A2 protein results in increased oxidation of 4-biphenylamine		 CTD PMID:2655891 PMID:2908851 PMID:11376689 PMID:15450435 PMID:16988941 More... NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 multiple interactions ISO CYP2A13 protein results in increased hydroxylation of and results in increased activity of 4-biphenylamine CTD PMID:16988941 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases oxidation EXP CYP2B1 protein results in increased oxidation of 4-biphenylamine CTD PMID:2908851 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases hydroxylation
multiple interactions
decreases response to substance		 ISO CYP2E1 protein results in increased hydroxylation of 4-biphenylamine
[CYP2E1 protein results in increased hydroxylation of 4-biphenylamine] which results in increased abundance of Reactive Oxygen Species
CYP2E1 gene mutant form results in decreased susceptibility to 4-biphenylamine		 CTD PMID:25601990 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 increases reduction ISO CYP2S1 protein results in increased reduction of 4-biphenylamine analog CTD PMID:23682735 NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO 4-biphenylamine results in increased expression of DDIT3 mRNA CTD PMID:24857880 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Exo1 exonuclease 1 decreases expression ISO 4-biphenylamine results in decreased expression of EXO1 mRNA CTD PMID:24857880 NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654 		JBrowse link
G Fancg FA complementation group G decreases expression ISO 4-biphenylamine results in decreased expression of FANCG mRNA; 4-biphenylamine results in decreased expression of FANCG protein CTD PMID:24857880 NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029 		JBrowse link
G Fen1 flap structure-specific endonuclease 1 decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of FEN1 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of FEN1 mRNA]		 CTD PMID:24857880 PMID:32905825 NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression ISO 4-biphenylamine results in increased expression of GADD45G mRNA CTD PMID:24857880 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610 		JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of H2AX protein] CTD PMID:32905825 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G H3f4 H3.4 histone decreases methylation
multiple interactions		 ISO 4-biphenylamine results in decreased methylation of H3-4 protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene co-treated with Tetrachlorodibenzodioxin] results in decreased methylation of H3-4 protein		 CTD PMID:17468514 NCBI chr10:43,740,797...43,741,207 JBrowse link
G Hdac2 histone deacetylase 2 decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of HDAC2 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of HDAC2 mRNA]		 CTD PMID:32905825 NCBI chr20:40,548,250...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO [NAT1 polymorphism results in increased susceptibility to 4-biphenylamine] which results in increased mutagenesis of HPRT1 gene CTD PMID:22114069 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Hras HRas proto-oncogene, GTPase increases mutagenesis ISO 4-biphenylamine results in increased mutagenesis of HRAS gene CTD PMID:15761837 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Il6 interleukin 6 increases expression ISO 4-biphenylamine results in increased expression of IL6 protein CTD PMID:27746196 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ip6k3 inositol hexakisphosphate kinase 3 decreases expression ISO 4-biphenylamine results in decreased expression of IP6K3 mRNA CTD PMID:24857880 NCBI chr20:5,223,863...5,245,443
Ensembl chr20:5,224,120...5,245,428 		JBrowse link
G Kdm1a lysine demethylase 1A multiple interactions ISO [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene] affects the localization of KDM1A protein CTD PMID:17468514 NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319 		JBrowse link
G Lig1 DNA ligase 1 decreases expression ISO 4-biphenylamine results in decreased expression of LIG1 mRNA CTD PMID:24857880 NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413 		JBrowse link
G Lig4 DNA ligase 4 increases expression
multiple interactions		 ISO 4-biphenylamine results in increased expression of LIG4 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of LIG4 mRNA]		 CTD PMID:32905825 NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040 		JBrowse link
G Mcm8 minichromosome maintenance 8 homologous recombination repair factor multiple interactions
decreases expression		 ISO Acetylcysteine inhibits the reaction [4-biphenylamine results in decreased expression of MCM8 protein] CTD PMID:32433928 NCBI chr 3:120,086,741...120,117,008
Ensembl chr 3:120,086,763...120,117,008 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression
multiple interactions		 ISO 4-biphenylamine results in increased expression of MDM2 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of MDM2 mRNA]		 CTD PMID:32905825 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mir17 microRNA 17 increases expression ISO 4-biphenylamine results in increased expression of MIR17 mRNA CTD PMID:24857880 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir18a microRNA 18a increases expression ISO 4-biphenylamine results in increased expression of MIR18A mRNA CTD PMID:24857880 NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860 		JBrowse link
G Mir20b microRNA 20b increases expression ISO 4-biphenylamine results in increased expression of MIR20B mRNA CTD PMID:24857880 NCBI chr  X:132,422,211...132,422,282
Ensembl chr  X:132,422,211...132,422,282 		JBrowse link
G Mir21 microRNA 21 increases expression ISO 4-biphenylamine results in increased expression of MIR21 mRNA CTD PMID:24857880 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir22 microRNA 22 increases expression ISO 4-biphenylamine results in increased expression of MIR22 mRNA CTD PMID:24857880 NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133 		JBrowse link
G Mir295-1 microRNA 295-1 increases expression ISO 4-biphenylamine results in increased expression of MIR372 mRNA CTD PMID:24857880 NCBI chr 1:65,962,566...65,962,646 JBrowse link
G Mir29a microRNA 29a increases expression ISO 4-biphenylamine results in increased expression of MIR29A mRNA CTD PMID:24857880 NCBI chr 4:59,650,608...59,650,695 JBrowse link
G Mir320a microRNA 320a increases expression ISO 4-biphenylamine results in increased expression of MIR320A mRNA CTD PMID:24857880 NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473 		JBrowse link
G Mir425 microRNA 425 increases expression ISO 4-biphenylamine results in increased expression of MIR425 mRNA CTD PMID:24857880 NCBI chr 8:109,264,555...109,264,637
Ensembl chr 8:109,264,555...109,264,637 		JBrowse link
G Mir431 microRNA 431 increases expression ISO 4-biphenylamine results in increased expression of MIR431 mRNA CTD PMID:24857880 NCBI chr 6:128,544,210...128,544,323
Ensembl chr 6:128,544,210...128,544,323 		JBrowse link
G Mir494 microRNA 494 increases expression ISO 4-biphenylamine results in increased expression of MIR494 mRNA CTD PMID:24857880 NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793 		JBrowse link
G Mir7-1 microRNA 7-1 increases expression ISO 4-biphenylamine results in increased expression of MIR7-1 mRNA CTD PMID:24857880 NCBI chr17:6,273,264...6,273,360
Ensembl chr17:6,273,264...6,273,360 		JBrowse link
G Mir874 microRNA 874 increases expression ISO 4-biphenylamine results in increased expression of MIR874 mRNA CTD PMID:24857880 NCBI chr17:6,620,649...6,620,724
Ensembl chr17:6,620,649...6,620,724 		JBrowse link
G Mir93 microRNA 93 increases expression ISO 4-biphenylamine results in increased expression of MIR93 mRNA CTD PMID:24857880 NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221 		JBrowse link
G Mirlet7b microRNA let-7b increases expression ISO 4-biphenylamine results in increased expression of MIRLET7B mRNA CTD PMID:24857880 NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270 		JBrowse link
G Mpo myeloperoxidase affects metabolic processing ISO MPO protein affects the metabolism of 4-biphenylamine CTD PMID:9288889 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Msh2 mutS homolog 2 decreases expression ISO 4-biphenylamine results in decreased expression of MSH2 mRNA CTD PMID:24857880 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Nat1 N-acetyltransferase 1 increases activity
increases metabolic processing
increases acetylation
multiple interactions
increases response to substance
affects response to substance		 ISO NAT1 protein results in increased activity of 4-biphenylamine
NAT1 protein results in increased metabolism of 4-biphenylamine
NAT1 protein polymorphism results in increased acetylation of 4-biphenylamine; NAT1 protein results in increased acetylation of 4-biphenylamine
[NAT1 polymorphism results in increased susceptibility to 4-biphenylamine] which results in increased mutagenesis of HPRT1 gene
NAT1 polymorphism results in increased susceptibility to 4-biphenylamine; NAT1 protein polymorphism results in increased susceptibility to 4-biphenylamine
NAT1 mRNA alternative form affects the susceptibility to 4-biphenylamine		 CTD PMID:12088197 PMID:15450435 PMID:16815960 PMID:21837760 PMID:22010219 More... NCBI chr16:22,218,217...22,238,516 JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation
affects response to substance
decreases activity
multiple interactions
increases metabolic processing
increases activity		 ISO
EXP		 NAT2 protein results in increased acetylation of 4-biphenylamine
NAT2 gene polymorphism affects the susceptibility to 4-biphenylamine
4-biphenylamine results in decreased activity of NAT2 protein
4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 2-aminofluorene]; 4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; 4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 4-Aminobenzoic Acid]; 4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 4-biphenylamine]
NAT2 protein results in increased metabolism of 4-biphenylamine
NAT2 protein results in increased activity of 4-biphenylamine		 CTD PMID:12222688 PMID:15450435 PMID:16815960 PMID:16857729 PMID:18842621 More... NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO 4-biphenylamine results in increased expression of and affects the localization of NFE2L2 protein CTD PMID:25601990 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression ISO 4-biphenylamine results in decreased expression of OGG1 mRNA; 4-biphenylamine results in decreased expression of OGG1 protein CTD PMID:16112689 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO 4-biphenylamine results in decreased expression of PCNA mRNA CTD PMID:24857880 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pold3 DNA polymerase delta 3, accessory subunit decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of POLD3 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of POLD3 mRNA]		 CTD PMID:32905825 NCBI chr 1:154,417,893...154,456,687
Ensembl chr 1:154,418,084...154,456,665 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of PRKDC mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of PRKDC mRNA]		 CTD PMID:32905825 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases metabolic processing ISO PTGS1 protein results in increased metabolism of 4-biphenylamine CTD PMID:11159734 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases metabolic processing ISO PTGS2 protein results in increased metabolism of 4-biphenylamine CTD PMID:11159734 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of RAD18 mRNA; 4-biphenylamine results in decreased expression of RAD18 protein
Acetylcysteine inhibits the reaction [4-biphenylamine results in decreased expression of RAD18 protein]		 CTD PMID:24857880 PMID:32433928 NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069 		JBrowse link
G Rad51 RAD51 recombinase decreases expression
multiple interactions		 ISO 4-biphenylamine results in decreased expression of RAD51 mRNA
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD51 mRNA]		 CTD PMID:24857880 PMID:32905825 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rad54b RAD54 homolog B multiple interactions
decreases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD54B mRNA] CTD PMID:32905825 NCBI chr 5:25,030,885...25,104,616
Ensembl chr 5:25,032,066...25,104,616 		JBrowse link
G Rpa1 replication protein A1 decreases expression ISO 4-biphenylamine results in decreased expression of RPA1 mRNA CTD PMID:24857880 NCBI chr10:60,148,869...60,199,999
Ensembl chr10:60,148,793...60,199,949 		JBrowse link
G Rpa2 replication protein A2 multiple interactions
increases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of RPA2 mRNA] CTD PMID:32905825 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 multiple interactions
decreases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RRM2 mRNA] CTD PMID:32905825 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO 4-biphenylamine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium] CTD PMID:27450509 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO 4-biphenylamine inhibits the reaction [SULT1A1 protein results in increased sulfation of Estradiol] CTD PMID:17433394 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Tp53 tumor protein p53 affects response to substance
multiple interactions
decreases expression
affects expression
affects binding		 ISO TP53 protein affects the susceptibility to 4-biphenylamine
Acetylcysteine affects the reaction [4-biphenylamine affects the expression of TP53 protein]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BLM mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCA1 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCC3 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCND3 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCNE2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK1 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of FEN1 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of HDAC2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of POLD3 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of PRKDC mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD51 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD54B mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RRM2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC5 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC6 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of CDKN1A mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of H2AX protein]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of LIG4 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of MDM2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of RPA2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of TP53BP1 mRNA]
4-biphenylamine results in decreased expression of TP53 mRNA
4-biphenylamine binds to TP53 gene		 CTD PMID:11804609 PMID:12376482 PMID:32905825 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 multiple interactions
increases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of TP53BP1 mRNA] CTD PMID:32905825 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
G Tp73 tumor protein p73 decreases expression ISO 4-biphenylamine results in decreased expression of TP73 mRNA CTD PMID:24857880 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
G Trex1 three prime repair exonuclease 1 decreases expression ISO 4-biphenylamine results in decreased expression of TREX1 mRNA CTD PMID:24857880 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation
multiple interactions		 ISO UGT1A4 protein results in increased glucuronidation of 4-biphenylamine
[Alamethicin results in increased activity of UGT1A4 protein] which results in increased glucuronidation of 4-biphenylamine; hecogenin inhibits the reaction [UGT1A4 protein binds to and results in increased glucuronidation of 4-biphenylamine]; UGT1A4 protein binds to and results in increased glucuronidation of 4-biphenylamine		 CTD PMID:15840509 PMID:17080401 NCBI chr 9:88,762,250...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation
multiple interactions		 ISO UGT1A9 protein results in increased glucuronidation of 4-biphenylamine
[Alamethicin results in increased activity of UGT1A9 protein] which affects the glucuronidation of 4-biphenylamine		 CTD PMID:15840509 PMID:17080401 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Ung uracil-DNA glycosylase decreases expression ISO 4-biphenylamine results in decreased expression of UNG mRNA CTD PMID:24857880 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206 		JBrowse link
G Xrcc2 X-ray repair cross complementing 2 decreases expression ISO 4-biphenylamine results in decreased expression of XRCC2 mRNA CTD PMID:24857880 NCBI chr 4:9,423,873...9,502,980
Ensembl chr 4:9,423,898...9,442,482 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 decreases expression ISO 4-biphenylamine results in decreased expression of XRCC3 mRNA CTD PMID:24857880 NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444 		JBrowse link
G Xrcc5 X-ray repair cross complementing 5 multiple interactions
decreases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC5 mRNA] CTD PMID:32905825 NCBI chr 9:73,955,220...74,044,020
Ensembl chr 9:73,955,216...74,044,018 		JBrowse link
G Xrcc6 X-ray repair cross complementing 6 multiple interactions
decreases expression		 ISO TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC6 mRNA] CTD PMID:32905825 NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762 		JBrowse link
N-hydroxy-4-acetylaminobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nat1 N-acetyltransferase 1 decreases activity ISO N-hydroxy-4-acetylaminobiphenyl results in decreased activity of NAT1 protein CTD PMID:15720122 NCBI chr16:22,218,217...22,238,516 JBrowse link
G Nat2 N-acetyltransferase 2 decreases activity ISO N-hydroxy-4-acetylaminobiphenyl results in decreased activity of NAT2 protein CTD PMID:19842618 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
N-hydroxy-4-aminobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [N-hydroxy-4-aminobiphenyl co-treated with Copper] results in increased mutagenesis of HRAS gene CTD PMID:11275476 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Nat2 N-acetyltransferase 2 increases metabolic processing ISO NAT2 protein results in increased metabolism of N-hydroxy-4-aminobiphenyl CTD PMID:16857729 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions
increases sulfation		 ISO N-hydroxy-4-aminobiphenyl inhibits the reaction [SULT1A1 protein results in increased sulfation of Estradiol]
SULT1A1 protein results in increased sulfation of N-hydroxy-4-aminobiphenyl		 CTD PMID:17433394 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1c2a sulfotransferase family, cytosolic, 1C, member 2a increases sulfation ISO SULT1C2 protein results in increased sulfation of N-hydroxy-4-aminobiphenyl CTD PMID:17433394 NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [N-hydroxy-4-aminobiphenyl co-treated with Copper] results in increased mutagenesis of TP53 gene CTD PMID:11275476 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        aetiopathogenetic role 19050
          carcinogenic agent 18381
            biphenyl-4-amine 81
              4'-aminobiphenyl-4-ol 0
              N-acetoxy-1,1'-biphenyl-4-amine 0
              N-hydroxy-4-acetylaminobiphenyl 2
              N-hydroxy-4-aminobiphenyl 5
              N-hydroxy-4-aminobiphenyl O-glucuronide 0
              N-hydroxy-4-aminobiphenyl O-sulfate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    main group molecular entity 19720
                      s-block molecular entity 19502
                        hydrogen molecular entity 19495
                          hydrides 18855
                            inorganic hydride 17694
                              pnictogen hydride 17675
                                nitrogen hydride 17547
                                  azane 17280
                                    ammonia 17279
                                      organic amino compound 17279
                                        primary amino compound 7980
                                          primary amine 5725
                                            primary arylamine 2989
                                              aminobiphenyl 81
                                                biphenyl-4-amine 81
                                                  4'-aminobiphenyl-4-ol 0
                                                  N-acetoxy-1,1'-biphenyl-4-amine 0
                                                  N-hydroxy-4-acetylaminobiphenyl 2
                                                  N-hydroxy-4-aminobiphenyl 5
                                                  N-hydroxy-4-aminobiphenyl O-glucuronide 0
                                                  N-hydroxy-4-aminobiphenyl O-sulfate 0
paths to the root