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G |
Alb |
albumin |
affects binding |
ISO |
4-biphenylamine binds to ALB protein |
CTD |
PMID:11697451 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Blm |
BLM RecQ like helicase |
multiple interactions decreases expression |
ISO |
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BLM mRNA] |
CTD |
PMID:32905825 |
|
NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
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G |
Brca1 |
BRCA1, DNA repair associated |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of BRCA1 mRNA TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCA1 mRNA] |
CTD |
PMID:24857880 PMID:32905825 |
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NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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|
G |
Brcc3 |
BRCA1/BRCA2-containing complex, subunit 3 |
multiple interactions decreases expression |
ISO |
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCC3 mRNA] |
CTD |
PMID:32905825 |
|
NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080
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G |
Ccnd3 |
cyclin D3 |
multiple interactions decreases expression |
ISO |
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCND3 mRNA] |
CTD |
PMID:32905825 |
|
NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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G |
Ccne2 |
cyclin E2 |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of CCNE2 mRNA TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCNE2 mRNA] |
CTD |
PMID:32905825 |
|
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of CDK1 mRNA TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK1 mRNA] |
CTD |
PMID:32905825 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of CDK2 mRNA TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK2 mRNA] |
CTD |
PMID:32905825 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression |
ISO |
TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of CDKN1A mRNA] |
CTD |
PMID:32905825 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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|
G |
Chek1 |
checkpoint kinase 1 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of CHEK1 mRNA |
CTD |
PMID:24857880 |
|
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
|
|
G |
Cidea |
cell death-inducing DFFA-like effector a |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of CIDEA mRNA |
CTD |
PMID:24857880 |
|
NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
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|
G |
Creb1 |
cAMP responsive element binding protein 1 |
increases expression multiple interactions |
ISO |
4-biphenylamine results in increased expression of CREB1 protein Acetylcysteine inhibits the reaction [4-biphenylamine results in increased expression of CREB1 protein]; CREB1 protein affects the reaction [4-biphenylamine results in increased expression of MIR630 mRNA] |
CTD |
PMID:32433928 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases oxidation |
EXP |
CYP1A1 protein results in increased oxidation of 4-biphenylamine |
CTD |
PMID:2908851 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases activity affects metabolic processing increases metabolic processing multiple interactions increases oxidation |
ISO EXP |
CYP1A2 protein results in increased activity of 4-biphenylamine CYP1A2 protein affects the metabolism of 4-biphenylamine CYP1A2 protein results in increased metabolism of 4-biphenylamine [furafylline results in decreased activity of CYP1A2 protein] which results in decreased susceptibility to 4-biphenylamine; CYP1A2 protein results in increased hydroxylation of and results in increased activity of 4-biphenylamine CYP1A2 protein results in increased oxidation of 4-biphenylamine |
CTD |
PMID:2655891 PMID:2908851 PMID:11376689 PMID:15450435 PMID:16988941 PMID:23898916 More...
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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|
G |
Cyp2a1 |
cytochrome P450, family 2, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
CYP2A13 protein results in increased hydroxylation of and results in increased activity of 4-biphenylamine |
CTD |
PMID:16988941 |
|
NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
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|
G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
increases oxidation |
EXP |
CYP2B1 protein results in increased oxidation of 4-biphenylamine |
CTD |
PMID:2908851 |
|
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
increases hydroxylation decreases response to substance multiple interactions increases expression |
ISO |
CYP2E1 protein results in increased hydroxylation of 4-biphenylamine CYP2E1 gene mutant form results in decreased susceptibility to 4-biphenylamine [CYP2E1 protein results in increased hydroxylation of 4-biphenylamine] which results in increased abundance of Reactive Oxygen Species [Propolis co-treated with allyl sulfide] inhibits the reaction [4-biphenylamine results in increased expression of CYP2E1 protein]; allyl sulfide inhibits the reaction [4-biphenylamine results in increased expression of CYP2E1 protein]; Propolis inhibits the reaction [4-biphenylamine results in increased expression of CYP2E1 protein] |
CTD |
PMID:25601990 PMID:33847444 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp2s1 |
cytochrome P450, family 2, subfamily s, polypeptide 1 |
increases reduction |
ISO |
CYP2S1 protein results in increased reduction of 4-biphenylamine analog |
CTD |
PMID:23682735 |
|
NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303
|
|
G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
4-biphenylamine results in increased expression of DDIT3 mRNA |
CTD |
PMID:24857880 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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|
G |
Exo1 |
exonuclease 1 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of EXO1 mRNA |
CTD |
PMID:24857880 |
|
NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654
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G |
Fancg |
FA complementation group G |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of FANCG mRNA; 4-biphenylamine results in decreased expression of FANCG protein |
CTD |
PMID:24857880 |
|
NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029
|
|
G |
Fen1 |
flap structure-specific endonuclease 1 |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of FEN1 mRNA TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of FEN1 mRNA] |
CTD |
PMID:24857880 PMID:32905825 |
|
NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
|
|
G |
Gadd45g |
growth arrest and DNA-damage-inducible, gamma |
increases expression |
ISO |
4-biphenylamine results in increased expression of GADD45G mRNA |
CTD |
PMID:24857880 |
|
NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
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|
G |
H2ax |
H2A.X variant histone |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [4-biphenylamine results in increased expression of H2AX protein]; Propolis inhibits the reaction [4-biphenylamine results in increased expression of H2AX protein]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of H2AX protein] |
CTD |
PMID:32433928 PMID:32905825 PMID:33847444 |
|
NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
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|
G |
H3f4 |
H3.4 histone |
decreases methylation multiple interactions |
ISO |
4-biphenylamine results in decreased methylation of H3-4 protein [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene co-treated with Tetrachlorodibenzodioxin] results in decreased methylation of H3-4 protein |
CTD |
PMID:17468514 |
|
NCBI chr10:43,740,797...43,741,207
|
|
G |
Hdac2 |
histone deacetylase 2 |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of HDAC2 mRNA TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of HDAC2 mRNA] |
CTD |
PMID:32905825 |
|
NCBI chr20:40,548,250...40,571,609
Ensembl chr20:40,548,250...40,571,609
|
|
G |
Hprt1 |
hypoxanthine phosphoribosyltransferase 1 |
multiple interactions |
ISO |
[NAT1 polymorphism results in increased susceptibility to 4-biphenylamine] which results in increased mutagenesis of HPRT1 gene |
CTD |
PMID:22114069 |
|
NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154
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|
G |
Hras |
HRas proto-oncogene, GTPase |
increases mutagenesis |
ISO |
4-biphenylamine results in increased mutagenesis of HRAS gene |
CTD |
PMID:15761837 |
|
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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|
G |
Il6 |
interleukin 6 |
increases expression |
ISO |
4-biphenylamine results in increased expression of IL6 protein |
CTD |
PMID:27746196 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Ip6k3 |
inositol hexakisphosphate kinase 3 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of IP6K3 mRNA |
CTD |
PMID:24857880 |
|
NCBI chr20:5,223,863...5,245,443
Ensembl chr20:5,224,120...5,245,428
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|
G |
Kdm1a |
lysine demethylase 1A |
multiple interactions |
ISO |
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with 4-biphenylamine co-treated with Benzo(a)pyrene] affects the localization of KDM1A protein |
CTD |
PMID:17468514 |
|
NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319
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|
G |
Lig1 |
DNA ligase 1 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of LIG1 mRNA |
CTD |
PMID:24857880 |
|
NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413
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|
G |
Lig4 |
DNA ligase 4 |
increases expression multiple interactions |
ISO |
4-biphenylamine results in increased expression of LIG4 mRNA TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of LIG4 mRNA] |
CTD |
PMID:32905825 |
|
NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040
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|
G |
Mcm8 |
minichromosome maintenance 8 homologous recombination repair factor |
multiple interactions decreases expression |
ISO |
Acetylcysteine inhibits the reaction [4-biphenylamine results in decreased expression of MCM8 protein] |
CTD |
PMID:32433928 |
|
NCBI chr 3:120,086,741...120,117,008
Ensembl chr 3:120,086,763...120,117,008
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|
G |
Mdm2 |
MDM2 proto-oncogene |
increases expression multiple interactions |
ISO |
4-biphenylamine results in increased expression of MDM2 mRNA TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of MDM2 mRNA] |
CTD |
PMID:32905825 |
|
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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|
G |
Mir17 |
microRNA 17 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR17 mRNA |
CTD |
PMID:24857880 |
|
NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712
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|
G |
Mir18a |
microRNA 18a |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR18A mRNA |
CTD |
PMID:24857880 |
|
NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860
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|
G |
Mir20b |
microRNA 20b |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR20B mRNA |
CTD |
PMID:24857880 |
|
NCBI chr X:132,422,211...132,422,282
Ensembl chr X:132,422,211...132,422,282
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|
G |
Mir21 |
microRNA 21 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR21 mRNA |
CTD |
PMID:24857880 |
|
NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
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|
G |
Mir22 |
microRNA 22 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR22 mRNA |
CTD |
PMID:24857880 |
|
NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133
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|
G |
Mir295-1 |
microRNA 295-1 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR372 mRNA |
CTD |
PMID:24857880 |
|
NCBI chr 1:65,962,566...65,962,646
Ensembl chr 1:65,962,566...65,962,646
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|
G |
Mir29a |
microRNA 29a |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR29A mRNA |
CTD |
PMID:24857880 |
|
NCBI chr 4:59,650,608...59,650,695
|
|
G |
Mir320a |
microRNA 320a |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR320A mRNA |
CTD |
PMID:24857880 |
|
NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473
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|
G |
Mir340-1 |
microRNA 340-1 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR340 mRNA |
CTD |
PMID:24857880 |
|
NCBI chr10:34,393,568...34,393,665
Ensembl chr10:34,393,568...34,393,665
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|
G |
Mir425 |
microRNA 425 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR425 mRNA |
CTD |
PMID:24857880 |
|
NCBI chr 8:109,264,555...109,264,637
Ensembl chr 8:109,264,555...109,264,637
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|
G |
Mir431 |
microRNA 431 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR431 mRNA |
CTD |
PMID:24857880 |
|
NCBI chr 6:128,544,210...128,544,323
Ensembl chr 6:128,544,210...128,544,323
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|
G |
Mir494 |
microRNA 494 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR494 mRNA |
CTD |
PMID:24857880 |
|
NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793
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|
G |
Mir7-1 |
microRNA 7-1 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR7-1 mRNA |
CTD |
PMID:24857880 |
|
NCBI chr17:6,273,264...6,273,360
Ensembl chr17:6,273,264...6,273,360
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|
G |
Mir874 |
microRNA 874 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR874 mRNA |
CTD |
PMID:24857880 |
|
NCBI chr17:6,620,649...6,620,724
Ensembl chr17:6,620,649...6,620,724
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|
G |
Mir93 |
microRNA 93 |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIR93 mRNA |
CTD |
PMID:24857880 |
|
NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221
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|
G |
Mirlet7b |
microRNA let-7b |
increases expression |
ISO |
4-biphenylamine results in increased expression of MIRLET7B mRNA |
CTD |
PMID:24857880 |
|
NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270
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G |
Mpo |
myeloperoxidase |
affects metabolic processing |
ISO |
MPO protein affects the metabolism of 4-biphenylamine |
CTD |
PMID:9288889 |
|
NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Msh2 |
mutS homolog 2 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of MSH2 mRNA |
CTD |
PMID:24857880 |
|
NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
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G |
Nat1 |
N-acetyltransferase 1 |
increases activity affects response to substance increases response to substance multiple interactions increases acetylation increases metabolic processing |
ISO |
NAT1 protein results in increased activity of 4-biphenylamine NAT1 mRNA alternative form affects the susceptibility to 4-biphenylamine NAT1 polymorphism results in increased susceptibility to 4-biphenylamine; NAT1 protein polymorphism results in increased susceptibility to 4-biphenylamine [NAT1 polymorphism results in increased susceptibility to 4-biphenylamine] which results in increased mutagenesis of HPRT1 gene NAT1 protein polymorphism results in increased acetylation of 4-biphenylamine; NAT1 protein results in increased acetylation of 4-biphenylamine NAT1 protein results in increased metabolism of 4-biphenylamine |
CTD |
PMID:12088197 PMID:15450435 PMID:16815960 PMID:21837760 PMID:22010219 PMID:22114069 More...
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|
NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
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G |
Nat2 |
N-acetyltransferase 2 |
increases acetylation increases activity increases metabolic processing multiple interactions decreases activity affects response to substance |
ISO EXP |
NAT2 protein results in increased acetylation of 4-biphenylamine NAT2 protein results in increased activity of 4-biphenylamine NAT2 protein results in increased metabolism of 4-biphenylamine 4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 2-aminofluorene]; 4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; 4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 4-Aminobenzoic Acid]; 4-biphenylamine inhibits the reaction [NAT2 protein results in increased acetylation of 4-biphenylamine] 4-biphenylamine results in decreased activity of NAT2 protein NAT2 gene polymorphism affects the susceptibility to 4-biphenylamine |
CTD |
PMID:12222688 PMID:15450435 PMID:16815960 PMID:16857729 PMID:18842621 PMID:29180287 PMID:33136180 More...
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|
NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
ISO |
4-biphenylamine results in increased expression of and affects the localization of NFE2L2 protein |
CTD |
PMID:25601990 |
|
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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|
G |
Ogg1 |
8-oxoguanine DNA glycosylase |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of OGG1 mRNA; 4-biphenylamine results in decreased expression of OGG1 protein Propolis inhibits the reaction [4-biphenylamine results in decreased expression of OGG1 protein] |
CTD |
PMID:16112689 PMID:33847444 |
|
NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
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|
G |
Pcna |
proliferating cell nuclear antigen |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of PCNA mRNA |
CTD |
PMID:24857880 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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|
G |
Pold3 |
DNA polymerase delta 3, accessory subunit |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of POLD3 mRNA TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of POLD3 mRNA] |
CTD |
PMID:32905825 |
|
NCBI chr 1:154,417,893...154,456,687
Ensembl chr 1:154,418,084...154,456,665
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|
G |
Prkdc |
protein kinase, DNA-activated, catalytic subunit |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of PRKDC mRNA TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of PRKDC mRNA] |
CTD |
PMID:32905825 |
|
NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
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|
G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
increases metabolic processing |
ISO |
PTGS1 protein results in increased metabolism of 4-biphenylamine |
CTD |
PMID:11159734 |
|
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
increases metabolic processing |
ISO |
PTGS2 protein results in increased metabolism of 4-biphenylamine |
CTD |
PMID:11159734 |
|
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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|
G |
Rad18 |
RAD18 E3 ubiquitin protein ligase |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of RAD18 mRNA; 4-biphenylamine results in decreased expression of RAD18 protein Acetylcysteine inhibits the reaction [4-biphenylamine results in decreased expression of RAD18 protein] |
CTD |
PMID:24857880 PMID:32433928 |
|
NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069
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G |
Rad51 |
RAD51 recombinase |
decreases expression multiple interactions |
ISO |
4-biphenylamine results in decreased expression of RAD51 mRNA; 4-biphenylamine results in decreased expression of RAD51 protein Propolis inhibits the reaction [4-biphenylamine results in decreased expression of RAD51 protein]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD51 mRNA] |
CTD |
PMID:24857880 PMID:32905825 PMID:33847444 |
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NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
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G |
Rad54b |
RAD54 homolog B |
multiple interactions decreases expression |
ISO |
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD54B mRNA] |
CTD |
PMID:32905825 |
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NCBI chr 5:25,030,885...25,104,616
Ensembl chr 5:25,032,066...25,104,616
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G |
Rpa1 |
replication protein A1 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of RPA1 mRNA |
CTD |
PMID:24857880 |
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NCBI chr10:60,148,869...60,199,999
Ensembl chr10:60,148,793...60,199,949
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G |
Rpa2 |
replication protein A2 |
multiple interactions increases expression |
ISO |
TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of RPA2 mRNA] |
CTD |
PMID:32905825 |
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NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350
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G |
Rrm2 |
ribonucleotide reductase regulatory subunit M2 |
multiple interactions decreases expression |
ISO |
TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RRM2 mRNA] |
CTD |
PMID:32905825 |
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NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
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G |
Slc22a1 |
solute carrier family 22 member 1 |
multiple interactions |
ISO |
4-biphenylamine inhibits the reaction [SLC22A1 protein results in increased import of Tetraethylammonium] |
CTD |
PMID:27450509 |
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NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G |
Sult1a1 |
sulfotransferase family 1A member 1 |
multiple interactions |
ISO |
4-biphenylamine inhibits the reaction [SULT1A1 protein results in increased sulfation of Estradiol] |
CTD |
PMID:17433394 |
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NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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G |
Tp53 |
tumor protein p53 |
affects response to substance affects binding affects expression decreases expression multiple interactions |
ISO |
TP53 protein affects the susceptibility to 4-biphenylamine 4-biphenylamine binds to TP53 gene 4-biphenylamine affects the expression of TP53 protein 4-biphenylamine results in decreased expression of TP53 mRNA Acetylcysteine affects the reaction [4-biphenylamine affects the expression of TP53 protein]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BLM mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCA1 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of BRCC3 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCND3 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CCNE2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK1 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of CDK2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of FEN1 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of HDAC2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of POLD3 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of PRKDC mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD51 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RAD54B mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of RRM2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC5 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC6 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of CDKN1A mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of H2AX protein]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of LIG4 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of MDM2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of RPA2 mRNA]; TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of TP53BP1 mRNA] |
CTD |
PMID:11804609 PMID:12376482 PMID:32905825 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tp53bp1 |
tumor protein p53 binding protein 1 |
multiple interactions increases expression |
ISO |
TP53 protein inhibits the reaction [4-biphenylamine results in increased expression of TP53BP1 mRNA] |
CTD |
PMID:32905825 |
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NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
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G |
Tp73 |
tumor protein p73 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of TP73 mRNA |
CTD |
PMID:24857880 |
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NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
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G |
Trex1 |
three prime repair exonuclease 1 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of TREX1 mRNA |
CTD |
PMID:24857880 |
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NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796
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G |
Ugt1a5 |
UDP glucuronosyltransferase family 1 member A5 |
increases glucuronidation multiple interactions |
ISO |
UGT1A4 protein results in increased glucuronidation of 4-biphenylamine [Alamethicin results in increased activity of UGT1A4 protein] which results in increased glucuronidation of 4-biphenylamine; hecogenin inhibits the reaction [UGT1A4 protein binds to and results in increased glucuronidation of 4-biphenylamine]; UGT1A4 protein binds to and results in increased glucuronidation of 4-biphenylamine |
CTD |
PMID:15840509 PMID:17080401 |
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NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ugt1a9 |
UDP glucuronosyltransferase family 1 member A9 |
increases glucuronidation multiple interactions |
ISO |
UGT1A9 protein results in increased glucuronidation of 4-biphenylamine [Alamethicin results in increased activity of UGT1A9 protein] which affects the glucuronidation of 4-biphenylamine |
CTD |
PMID:15840509 PMID:17080401 |
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NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Ung |
uracil-DNA glycosylase |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of UNG mRNA |
CTD |
PMID:24857880 |
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NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
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G |
Xrcc2 |
X-ray repair cross complementing 2 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of XRCC2 mRNA |
CTD |
PMID:24857880 |
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NCBI chr 4:9,423,873...9,502,980
Ensembl chr 4:9,423,898...9,442,482
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G |
Xrcc3 |
X-ray repair cross complementing 3 |
decreases expression |
ISO |
4-biphenylamine results in decreased expression of XRCC3 mRNA |
CTD |
PMID:24857880 |
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NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444
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G |
Xrcc5 |
X-ray repair cross complementing 5 |
multiple interactions decreases expression |
ISO |
Propolis inhibits the reaction [4-biphenylamine results in decreased expression of XRCC5 protein]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC5 mRNA] 4-biphenylamine results in decreased expression of XRCC5 mRNA; 4-biphenylamine results in decreased expression of XRCC5 protein |
CTD |
PMID:32905825 PMID:33847444 |
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NCBI chr 9:73,955,220...74,044,020
Ensembl chr 9:73,955,216...74,044,018
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G |
Xrcc6 |
X-ray repair cross complementing 6 |
multiple interactions decreases expression |
ISO |
Propolis inhibits the reaction [4-biphenylamine results in decreased expression of XRCC6 protein]; TP53 protein inhibits the reaction [4-biphenylamine results in decreased expression of XRCC6 mRNA] 4-biphenylamine results in decreased expression of XRCC6 mRNA; 4-biphenylamine results in decreased expression of XRCC6 protein |
CTD |
PMID:32905825 PMID:33847444 |
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NCBI chr 7:113,542,992...113,563,762
Ensembl chr 7:113,543,057...113,563,762
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G |
Nat1 |
N-acetyltransferase 1 |
decreases activity |
ISO |
N-hydroxy-4-acetylaminobiphenyl results in decreased activity of NAT1 protein |
CTD |
PMID:15720122 |
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NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
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G |
Nat2 |
N-acetyltransferase 2 |
decreases activity |
ISO |
N-hydroxy-4-acetylaminobiphenyl results in decreased activity of NAT2 protein |
CTD |
PMID:19842618 |
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NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
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G |
Hras |
HRas proto-oncogene, GTPase |
multiple interactions |
ISO |
[N-hydroxy-4-aminobiphenyl co-treated with Copper] results in increased mutagenesis of HRAS gene |
CTD |
PMID:11275476 |
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NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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G |
Nat2 |
N-acetyltransferase 2 |
increases metabolic processing |
ISO |
NAT2 protein results in increased metabolism of N-hydroxy-4-aminobiphenyl |
CTD |
PMID:16857729 |
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NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
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G |
Sult1a1 |
sulfotransferase family 1A member 1 |
multiple interactions increases sulfation |
ISO |
N-hydroxy-4-aminobiphenyl inhibits the reaction [SULT1A1 protein results in increased sulfation of Estradiol] SULT1A1 protein results in increased sulfation of N-hydroxy-4-aminobiphenyl |
CTD |
PMID:17433394 |
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NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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G |
Sult1c2a |
sulfotransferase family 1C member 2A |
increases sulfation |
ISO |
SULT1C2 protein results in increased sulfation of N-hydroxy-4-aminobiphenyl |
CTD |
PMID:17433394 |
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NCBI chr 9:6,873,697...6,904,736
Ensembl chr 9:6,874,249...6,904,734
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
[N-hydroxy-4-aminobiphenyl co-treated with Copper] results in increased mutagenesis of TP53 gene |
CTD |
PMID:11275476 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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