propan-2-ol - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	propan-2-ol	go back to main search page
Accession:	CHEBI:17824	browse the term
Definition:	A secondary alcohol that is propane in which one of the hydrogens attached to the central carbon is substituted by a hydroxy group.
Synonyms:	related_synonym:	1-methylethanol; 1-methylethyl alcohol; 2-Propanol; 2-hydroxypropane; Formula=C3H8O; IPA; InChI=1S/C3H8O/c1-3(2)4/h3-4H,1-2H3; InChIKey=KFZMGEQAYNKOFK-UHFFFAOYSA-N; Isopropanol; Isopropyl alcohol; Isopropylalkohol; SMILES=CC(C)O; i-Propylalkohol; i-propanol; sec-propanol
	alt_id:	CHEBI:14897; CHEBI:26280; CHEBI:43588; CHEBI:8467
	xref:	Beilstein:635639; CAS:67-63-0; DrugBank:DB04402; Drug_Central:4215; Gmelin:1464; HMDB:HMDB0000863; KEGG:C01845; KEGG:D00137; KNApSAcK:C00048438
	xref_mesh:	MESH:D019840
	xref:	MetaCyc:ISO-PROPANOL; PDBeChem:IPA; PMID:24524727; PMID:24653974; Reaxys:635639; UM-BBD_compID:c0519; Wikipedia:Isopropyl_Alcohol; YMDB:YMDB01718

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Genes (791)

propan-2-ol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alcohol dehydrogenase 1 (class I)

increases oxidation

ADH1C protein results in increased oxidation of 2-Propanol
ADH1 protein results in increased oxidation of 2-Propanol

PMID:11981770 PMID:21167143

NCBI chr 3:137,983,346...137,996,459
Ensembl chr 3:137,966,752...137,996,459

G

alcohol dehydrogenase 4 (class II), pi polypeptide

increases oxidation

ADH4 protein results in increased oxidation of 2-Propanol

NCBI chr 3:138,121,217...138,138,444
Ensembl chr 3:138,121,227...138,136,653

G

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

increases oxidation

ADH7 protein results in increased oxidation of 2-Propanol

NCBI chr 3:137,903,828...137,937,803
Ensembl chr 3:137,923,521...137,939,143

G

aldo-keto reductase family 1 member B

increases expression

2-Propanol results in increased expression of AKR1B1 mRNA

NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413

G

aldo-keto reductase family 1, member B10

increases expression

2-Propanol results in increased expression of AKR1B10 mRNA

NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885

G

aldo-keto reductase family 1, member C18

increases expression

2-Propanol results in increased expression of AKR1C3 mRNA

NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653

G

aldo-keto reductase family 1, member C20

increases expression

2-Propanol results in increased expression of AKR1C1 mRNA

NCBI chr13:4,536,855...4,573,353
Ensembl chr13:4,536,848...4,573,344

G

caspase 3

increases expression

2-Propanol results in increased expression of CASP3 mRNA

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

C-C motif chemokine ligand 2

multiple interactions

2-Propanol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL2 protein]
2-Propanol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL2 protein]

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

cholinergic receptor nicotinic alpha 2 subunit

multiple interactions

2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]

NCBI chr14:66,370,685...66,390,397
Ensembl chr14:66,372,488...66,390,397

G

cholinergic receptor, nicotinic, beta polypeptide 4

multiple interactions

2-Propanol promotes the reaction [Acetylcholine promotes the reaction [[CHRNA2 protein binds to CHRNB4 protein] which results in increased transport of Barium]]

NCBI chr 9:54,935,438...54,956,236
Ensembl chr 9:54,935,438...54,956,063

G

colony stimulating factor 2 (granulocyte-macrophage)

increases secretion

2-Propanol results in increased secretion of CSF2 protein

NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493

G

C-X-C motif chemokine ligand 2

decreases expression

2-Propanol results in decreased expression of CXCL2 protein

NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
increases expression

2-Propanol binds to and results in increased expression of CYP2E1 protein; 2-Propanol inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]
2-Propanol results in increased expression of CYP2E1 protein

PMID:3337723 PMID:7710944 PMID:9118891

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

ferrochelatase

increases expression

2-Propanol results in increased expression of FECH mRNA

NCBI chr18:64,589,613...64,622,169
Ensembl chr18:64,585,985...64,623,322

G

FBJ osteosarcoma oncogene

multiple interactions
decreases activity

2-Propanol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of FOS protein]
2-Propanol results in decreased activity of FOS protein

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

ferritin light polypeptide 1

increases expression

2-Propanol results in increased expression of FTL mRNA

NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308

G

glucose-6-phosphate dehydrogenase X-linked

increases expression

2-Propanol results in increased expression of G6PD mRNA

NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800

G

glutamate-cysteine ligase, catalytic subunit

increases expression

2-Propanol results in increased expression of GCLC mRNA

NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767

G

glutamate-cysteine ligase, modifier subunit

increases expression

2-Propanol results in increased expression of GCLM mRNA

NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381

G

growth hormone

affects folding

2-Propanol affects the folding of GH1 protein

NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691

G

glutathione reductase

increases expression

2-Propanol results in increased expression of GSR mRNA

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

hydroxyacyl-Coenzyme A dehydrogenase

increases metabolic processing

HADH protein results in increased metabolism of 2-Propanol

NCBI chr 3:131,027,068...131,065,750
Ensembl chr 3:131,027,068...131,065,750

G

heme oxygenase 1

increases expression

2-Propanol results in increased expression of HMOX1 mRNA

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

interleukin 1 alpha

decreases expression

2-Propanol results in decreased expression of IL1A protein

NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892

G

interleukin 6

multiple interactions
increases secretion

2-Propanol promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; [Tetradecanoylphorbol Acetate co-treated with 2-Propanol] results in increased expression of and results in increased secretion of IL6 protein
2-Propanol results in increased secretion of IL6 protein

PMID:22020770 PMID:22245253 PMID:24964617

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

jun proto-oncogene

decreases activity
multiple interactions

2-Propanol results in decreased activity of JUN protein
2-Propanol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of JUN protein]

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)

increases expression

2-Propanol results in increased expression of MAFG mRNA

NCBI chr11:120,515,943...120,525,771
Ensembl chr11:120,515,943...120,524,426

G

mitogen-activated protein kinase 1

multiple interactions

2-Propanol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

malic enzyme 1, NADP(+)-dependent, cytosolic

increases expression

2-Propanol results in increased expression of ME1 mRNA

NCBI chr 9:86,463,416...86,577,967
Ensembl chr 9:86,463,424...86,578,006

G

neurofilament, heavy polypeptide

affects expression

2-Propanol affects the expression of NEFH mRNA

NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064

G

NAD(P)H dehydrogenase, quinone 1

increases expression

2-Propanol results in increased expression of NQO1 mRNA

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

phosphogluconate dehydrogenase

increases expression

2-Propanol results in increased expression of PGD mRNA

NCBI chr 4:149,234,448...149,251,162
Ensembl chr 4:149,234,448...149,251,228

G

prostaglandin reductase 1

increases expression

2-Propanol results in increased expression of PTGR1 mRNA

NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119

G

sulfiredoxin 1 homolog (S. cerevisiae)

increases expression

2-Propanol results in increased expression of SRXN1 mRNA

NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296

G

tumor necrosis factor

multiple interactions
increases secretion

2-Propanol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
2-Propanol results in increased secretion of TNF protein
2-Propanol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]

PMID:22020770 PMID:22245253

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

thioredoxin reductase 1

increases expression

2-Propanol results in increased expression of TXNRD1 mRNA

NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546

Azelnidipine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

decreases activity

azelnidipine results in decreased activity of AR protein

NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821

G

cytochrome P450, family 2, subfamily j, polypeptide 9

decreases activity
multiple interactions

azelnidipine results in decreased activity of CYP2J2 protein
NADP promotes the reaction [azelnidipine results in decreased activity of CYP2J2 protein]

NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815

chloropropylate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

multiple interactions

Dihydrotestosterone inhibits the reaction [chloropropylate results in increased activity of AR protein]

NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821

G

estrogen receptor 1 (alpha)

increases activity

chloropropylate results in increased activity of ESR1 protein

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

G

estrogen receptor 2 (beta)

increases activity

chloropropylate results in increased activity of ESR2 protein

NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

chloropropylate binds to and results in increased activity of NR1I2 protein

NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186

fenofibrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RIKEN cDNA 1600014C10 gene

increases expression

Fenofibrate results in increased expression of C19ORF12 mRNA

NCBI chr 7:37,882,642...37,896,992
Ensembl chr 7:37,882,642...37,896,992

G

alpha-1-B glycoprotein

decreases expression

Fenofibrate results in decreased expression of A1BG protein

NCBI chr15:60,789,438...60,793,119
Ensembl chr15:60,768,708...60,794,861

G

arylacetamide deacetylase

increases expression

Fenofibrate results in increased expression of AADAC mRNA

NCBI chr 3:59,939,209...59,947,578
Ensembl chr 3:59,933,138...59,947,581

G

alanyl-tRNA synthetase 1

increases expression

Fenofibrate results in increased expression of AARS1 mRNA

NCBI chr 8:111,759,781...111,784,237
Ensembl chr 8:111,759,776...111,784,296

G

ATP-binding cassette, sub-family A member 1

increases expression

Fenofibrate results in increased expression of ABCA1 mRNA; Fenofibrate results in increased expression of ABCA1 protein

NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895

G

ATP-binding cassette, sub-family B member 11

multiple interactions
decreases expression
decreases activity

Fenofibrate inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Fenofibrate results in decreased expression of ABCB11 mRNA
Fenofibrate results in decreased activity of ABCB11 protein

PMID:20829430 PMID:23956101 PMID:24014644 PMID:27765674

NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958

G

ATP-binding cassette, sub-family B member 1A

multiple interactions

Fenofibrate inhibits the reaction [ABCB1 protein results in increased transport of Vincristine]

NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575

G

ATP-binding cassette, sub-family B member 4

increases expression

Fenofibrate results in increased expression of ABCB4 mRNA

PMID:17118139 PMID:19118567

NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231

G

ATP-binding cassette, sub-family B member 6

decreases expression

Fenofibrate results in decreased expression of ABCB6 mRNA

NCBI chr 1:75,148,284...75,157,066
Ensembl chr 1:75,148,361...75,157,036

G

ATP-binding cassette, sub-family B member 9

increases expression

Fenofibrate results in increased expression of ABCB9 mRNA

NCBI chr 5:124,199,920...124,234,009
Ensembl chr 5:124,199,593...124,233,861

G

ATP-binding cassette, sub-family member 2

increases expression

Fenofibrate results in increased expression of ABCC2 mRNA

NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179

G

ATP-binding cassette, sub-family C member 3

decreases expression

Fenofibrate results in decreased expression of ABCC3 mRNA

NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823

G

ATP-binding cassette, sub-family C member 4

increases expression

Fenofibrate results in increased expression of ABCC4 mRNA

NCBI chr14:118,720,104...118,945,475
Ensembl chr14:118,720,104...118,943,631

G

ATP-binding cassette, sub-family D member 3

increases expression

Fenofibrate results in increased expression of ABCD3 mRNA

NCBI chr 3:121,552,553...121,609,851
Ensembl chr 3:121,552,423...121,608,951

G

ATP binding cassette subfamily G member 1

increases expression

Fenofibrate results in increased expression of ABCG1 mRNA

NCBI chr17:31,276,668...31,336,958
Ensembl chr17:31,276,649...31,336,962

G

ATP binding cassette subfamily G member 5

increases expression

Fenofibrate results in increased expression of ABCG5 mRNA

NCBI chr17:84,965,602...84,990,439
Ensembl chr17:84,965,662...84,990,439

G

ATP binding cassette subfamily G member 8

increases expression

Fenofibrate results in increased expression of ABCG8 mRNA

NCBI chr17:84,983,730...85,007,761
Ensembl chr17:84,983,730...85,007,761

G

abhydrolase domain containing 4

increases expression

Fenofibrate results in increased expression of ABHD4 mRNA

NCBI chr14:54,491,586...54,506,626
Ensembl chr14:54,491,645...54,508,094

G

ABI family member 3 binding protein

decreases expression

Fenofibrate results in decreased expression of ABI3BP mRNA

NCBI chr16:56,298,179...56,510,498
Ensembl chr16:56,298,241...56,510,498

G

acetyl-Coenzyme A acyltransferase 1A

increases expression
multiple interactions
affects expression

Fenofibrate results in increased expression of ACAA1A mRNA
Fenofibrate promotes the reaction [Pyrazinamide results in increased expression of ACAA1 mRNA]; Pyrazinamide promotes the reaction [Fenofibrate results in increased expression of ACAA1 mRNA]
Fenofibrate results in increased expression of ACAA1 mRNA; Fenofibrate results in increased expression of ACAA1A mRNA
Fenofibrate affects the expression of ACAA1A mRNA

PMID:11798191 PMID:20801182 PMID:27071702 PMID:32741897

NCBI chr 9:119,170,113...119,179,361
Ensembl chr 9:119,168,742...119,179,365

G

acetyl-Coenzyme A acyltransferase 1B

increases expression

Fenofibrate results in increased expression of ACAA1 mRNA

NCBI chr 9:118,977,111...118,986,149
Ensembl chr 9:118,977,091...118,986,161

G

acetyl-CoA acyltransferase 2

affects expression
increases expression

Fenofibrate affects the expression of ACAA2 mRNA
Fenofibrate results in increased expression of ACAA2 mRNA
Fenofibrate results in increased expression of ACAA2 mRNA; Fenofibrate results in increased expression of ACAA2 protein

PMID:20118634 PMID:20801182 PMID:25572481 PMID:27665778 PMID:32741897

NCBI chr18:74,912,283...74,939,278
Ensembl chr18:74,912,268...74,939,279

G

acetyl-Coenzyme A carboxylase alpha

multiple interactions
decreases expression
increases expression

NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACACA mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACACA mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACACA mRNA]
Fenofibrate inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA]
Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of ACACA protein modified form]; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of ACACA protein]
Fenofibrate results in decreased expression of ACACA protein

PMID:23063693 PMID:24752549 PMID:32730863 PMID:38216941

NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477

G

acetyl-Coenzyme A carboxylase beta

multiple interactions
increases expression

NR1H2 gene mutant form affects the reaction [Fenofibrate results in increased expression of ACACB mRNA]; NR1H3 gene mutant form affects the reaction [Fenofibrate results in increased expression of ACACB mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACACB mRNA]

PMID:17118139 PMID:23063693

NCBI chr 5:114,284,748...114,388,822
Ensembl chr 5:114,284,596...114,388,822

G

acyl-Coenzyme A dehydrogenase, long-chain

increases expression

Fenofibrate results in increased expression of ACADL mRNA

NCBI chr 1:66,869,998...66,902,468
Ensembl chr 1:66,869,998...66,902,436

G

acyl-Coenzyme A dehydrogenase, medium chain

increases expression
multiple interactions

Fenofibrate results in increased expression of ACADM mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of ACADM mRNA]

PMID:11798191 PMID:17690133 PMID:19124612 PMID:24752549 PMID:25572481 More...

NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269

G

acyl-Coenzyme A dehydrogenase, short chain

multiple interactions

Fenofibrate inhibits the reaction [ACADS protein affects the cleavage of CASP3 protein]; Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of ACADS mRNA]; Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of and results in decreased activity of ACADS protein]

NCBI chr 5:115,248,358...115,257,405
Ensembl chr 5:115,248,358...115,257,405

G

acyl-Coenzyme A dehydrogenase, very long chain

increases expression

Fenofibrate results in increased expression of ACADVL mRNA

PMID:17118139 PMID:24752549 PMID:27665778

NCBI chr11:69,901,009...69,906,254
Ensembl chr11:69,901,009...69,906,237

G

acetyl-Coenzyme A acetyltransferase 1

multiple interactions
increases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of ACAT1 mRNA
Fenofibrate results in increased expression of ACAT1 mRNA

PMID:18253720 PMID:24752549

NCBI chr 9:53,491,822...53,521,650
Ensembl chr 9:53,491,822...53,521,682

G

ATP citrate lyase

increases expression
multiple interactions

Fenofibrate results in increased expression of ACLY mRNA
PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACLY mRNA]

NCBI chr11:100,367,178...100,418,826
Ensembl chr11:100,367,179...100,418,826

G

aconitase 1

increases expression

Fenofibrate results in increased expression of ACO1 mRNA

NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338

G

aconitase 2, mitochondrial

increases expression

Fenofibrate results in increased expression of ACO2 mRNA

NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334

G

acyl-CoA thioesterase 1

increases expression

Fenofibrate results in increased expression of ACOT1 mRNA

PMID:11798191 PMID:17690133 PMID:27665778 PMID:32741897

NCBI chr12:84,056,276...84,064,444
Ensembl chr12:84,056,264...84,065,145

G

acyl-CoA thioesterase 2

affects expression
multiple interactions
increases expression

Fenofibrate affects the expression of ACOT2 mRNA
Fenofibrate results in increased expression of and results in increased activity of ACOT2 protein
Fenofibrate results in increased expression of ACOT2 mRNA

PMID:16595124 PMID:20801182 PMID:27665778 PMID:32741897

NCBI chr12:84,034,635...84,040,651
Ensembl chr12:84,034,635...84,040,647

G

acyl-CoA thioesterase 3

increases expression

Fenofibrate results in increased expression of ACOT3 mRNA

NCBI chr12:84,098,918...84,107,174
Ensembl chr12:84,098,918...84,107,176

G

acyl-CoA thioesterase 4

increases expression

Fenofibrate results in increased expression of ACOT4 mRNA

PMID:27665778 PMID:32741897

NCBI chr12:84,084,028...84,091,497
Ensembl chr12:84,085,153...84,095,375

G

acyl-CoA thioesterase 7

increases expression

Fenofibrate results in increased expression of ACOT7 mRNA

NCBI chr 4:152,258,872...152,356,312
Ensembl chr 4:152,262,591...152,356,312

G

acyl-Coenzyme A oxidase 1, palmitoyl

affects expression
multiple interactions
increases expression

Fenofibrate affects the expression of ACOX1 mRNA
[Fenofibrate co-treated with Fatty Acids, Nonesterified] results in increased expression of ACOX1 protein; [Fenofibrate co-treated with Oleic Acid] results in increased expression of ACOX1 mRNA; Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of ACOX1 mRNA]; Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of ACOX1 protein]; Fenofibrate promotes the reaction [Fatty Acids, Nonesterified results in increased expression of ACOX1 mRNA]; PPARA protein promotes the reaction [Fenofibrate results in increased expression of ACOX1 protein]
Fenofibrate results in increased expression of ACOX1 mRNA; Fenofibrate results in increased expression of ACOX1 protein
Fenofibrate inhibits the reaction [Zoledronic Acid results in decreased expression of ACOX1 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 protein]
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of ACOX1 mRNA

PMID:16707586 PMID:17118139 PMID:17690133 PMID:18253720 PMID:18775883 More...

NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871

G

acyl-Coenzyme A oxidase 2, branched chain

multiple interactions

Fenofibrate inhibits the reaction [zoledronic acid results in decreased expression of ACOX2 mRNA]

NCBI chr14:14,210,406...14,244,262
Ensembl chr14:14,210,420...14,244,262

G

acyl-CoA synthetase long-chain family member 1

increases expression
multiple interactions
decreases expression
affects expression

Fenofibrate results in increased expression of ACSL1 mRNA; Fenofibrate results in increased expression of ACSL1 protein
PPARA protein promotes the reaction [Fenofibrate results in increased expression of ACSL1 protein]
PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACSL1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACSL1 protein]
Fenofibrate results in decreased expression of ACSL1 protein
Fenofibrate affects the expression of ACSL1 mRNA

PMID:10600944 PMID:17118139 PMID:20118634 PMID:20801182 PMID:24752549 More...

NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088

G

acyl-CoA synthetase long-chain family member 3

increases expression

Fenofibrate results in increased expression of ACSL3 mRNA

NCBI chr 1:78,635,600...78,685,462
Ensembl chr 1:78,635,542...78,685,460

G

acyl-CoA synthetase long-chain family member 4

increases expression

Fenofibrate results in increased expression of ACSL4 mRNA

NCBI chr X:141,100,989...141,173,792
Ensembl chr X:141,100,989...141,173,531

G

acyl-CoA synthetase long-chain family member 5

increases expression

Fenofibrate results in increased expression of ACSL5 mRNA

NCBI chr19:55,240,298...55,285,060
Ensembl chr19:55,240,370...55,286,152

G

acyl-CoA synthetase long-chain family member 6

increases expression

Fenofibrate results in increased expression of ACSL6 mRNA

NCBI chr11:54,194,580...54,255,582
Ensembl chr11:54,194,624...54,255,582

G

acyl-CoA synthetase short-chain family member 2

decreases expression

Fenofibrate results in decreased expression of ACSS2 mRNA

NCBI chr 2:155,359,963...155,404,663
Ensembl chr 2:155,359,868...155,427,644

G

actin alpha 2, smooth muscle, aorta

multiple interactions

Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of ACTA2 protein]
Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]

PMID:28871336 PMID:32613381

NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990

G

a disintegrin and metallopeptidase domain 22

increases expression

Fenofibrate results in increased expression of ADAM22 mRNA

NCBI chr 5:8,122,353...8,418,312
Ensembl chr 5:8,122,352...8,418,160

G

adenylate cyclase 1

decreases expression

Fenofibrate results in decreased expression of ADCY1 mRNA

NCBI chr11:7,013,433...7,128,506
Ensembl chr11:7,013,489...7,128,506

G

alcohol dehydrogenase 1 (class I)

decreases expression

Fenofibrate results in decreased expression of ADH1C mRNA

NCBI chr 3:137,983,346...137,996,459
Ensembl chr 3:137,966,752...137,996,459

G

alcohol dehydrogenase 4 (class II), pi polypeptide

decreases expression

Fenofibrate results in decreased expression of ADH4 mRNA

NCBI chr 3:138,121,217...138,138,444
Ensembl chr 3:138,121,227...138,136,653

G

adiponectin, C1Q and collagen domain containing

increases expression
multiple interactions

Fenofibrate results in increased expression of ADIPOQ protein
[candesartan co-treated with Fenofibrate] results in increased expression of ADIPOQ protein; Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of ADIPOQ protein]

PMID:16443859 PMID:24735863

NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778

G

adiponectin receptor 2

increases expression

Fenofibrate results in increased expression of ADIPOR2 mRNA

NCBI chr 6:119,330,111...119,394,489
Ensembl chr 6:119,330,111...119,394,665

G

agrin

decreases expression

Fenofibrate results in decreased expression of AGRN mRNA

NCBI chr 4:156,249,747...156,281,997
Ensembl chr 4:156,249,747...156,281,945

G

angiotensinogen

multiple interactions

Fenofibrate affects the reaction [[AHR protein affects the susceptibility to AGT protein] which affects the expression of EDN1 mRNA]; Fenofibrate affects the reaction [[AHR protein affects the susceptibility to AGT protein] which affects the expression of JUN mRNA]; Fenofibrate inhibits the reaction [AHR protein affects the reaction [AGT protein results in increased expression of COL1A1 mRNA]]; Fenofibrate inhibits the reaction [AHR protein affects the reaction [AGT protein results in increased expression of COL3A1 mRNA]]; Fenofibrate inhibits the reaction [AHR protein affects the reaction [AGT protein results in increased expression of VEGFA protein]]

NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445

G

alanine-glyoxylate aminotransferase 2

decreases expression

Fenofibrate results in decreased expression of AGXT2 mRNA

NCBI chr15:10,358,602...10,410,244
Ensembl chr15:10,358,618...10,410,239

G

aryl-hydrocarbon receptor

affects activity
multiple interactions

Fenofibrate affects the activity of AHR protein
Fenofibrate affects the reaction [[AHR protein affects the susceptibility to AGT protein] which affects the expression of EDN1 mRNA]; Fenofibrate affects the reaction [[AHR protein affects the susceptibility to AGT protein] which affects the expression of JUN mRNA]; Fenofibrate inhibits the reaction [AHR protein affects the reaction [AGT protein results in increased expression of COL1A1 mRNA]]; Fenofibrate inhibits the reaction [AHR protein affects the reaction [AGT protein results in increased expression of COL3A1 mRNA]]; Fenofibrate inhibits the reaction [AHR protein affects the reaction [AGT protein results in increased expression of VEGFA protein]]

PMID:25596134 PMID:31016362

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

apoptosis-inducing factor, mitochondrion-associated 2

increases expression

Fenofibrate results in increased expression of AIFM2 mRNA

NCBI chr10:61,551,042...61,575,474
Ensembl chr10:61,551,042...61,575,039

G

androgen-induced 1

increases expression

Fenofibrate results in increased expression of AIG1 mRNA

NCBI chr10:13,522,798...13,744,980
Ensembl chr10:13,522,798...13,744,724

G

adenylate kinase 4

affects expression

Fenofibrate affects the expression of AK4 mRNA

NCBI chr 4:101,273,675...101,324,968
Ensembl chr 4:101,276,474...101,324,192

G

aldo-keto reductase family 1, member B10

multiple interactions
decreases activity

Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]
Fenofibrate results in decreased activity of AKR1B10 protein; Fenofibrate results in decreased activity of AKR1B10 protein mutant form

PMID:18325492 PMID:19028477

NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885

G

aldo-keto reductase family 1, member C21

increases expression

Fenofibrate results in increased expression of AKR1C2 mRNA

NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540

G

albumin

multiple interactions

dorsomorphin inhibits the reaction [Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of ICAM1 mRNA]]; dorsomorphin inhibits the reaction [Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of SELE mRNA]]; dorsomorphin inhibits the reaction [Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of VCAM1 mRNA]]; Fenofibrate inhibits the reaction [ALB protein modified form results in increased degradation of NFKBIA protein]; Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of ICAM1 mRNA]; Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of NFKB1 protein]; Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of RELA protein]; Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of SELE mRNA]; Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of VCAM1 mRNA]; PRKAA1 protein affects the reaction [Fenofibrate results in decreased susceptibility to ALB protein modified form]
Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of ALB mRNA]

PMID:20580385 PMID:37076581

NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461

G

aldehyde dehydrogenase family 1, subfamily A2

increases expression

Fenofibrate results in increased expression of ALDH1A2 mRNA

NCBI chr 9:71,123,071...71,203,525
Ensembl chr 9:71,123,071...71,203,525

G

aldehyde dehydrogenase family 6, subfamily A1

increases expression

Fenofibrate results in increased expression of ALDH6A1 mRNA

NCBI chr12:84,477,491...84,497,798
Ensembl chr12:84,477,491...84,497,778

G

arachidonate 12-lipoxygenase

increases expression

Fenofibrate results in increased expression of ALOX12 mRNA

NCBI chr11:70,132,283...70,146,206
Ensembl chr11:70,132,283...70,146,179

G

alpha-kinase 2

increases expression

Fenofibrate results in increased expression of ALPK2 mRNA

NCBI chr18:65,398,600...65,526,959
Ensembl chr18:65,398,600...65,527,137

G

alkaline phosphatase, liver/bone/kidney

decreases expression

Fenofibrate results in decreased expression of ALPL mRNA

NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695

G

anaphase promoting complex subunit 11

multiple interactions
decreases expression

PPARA protein affects the reaction [Fenofibrate results in decreased expression of ANAPC11 mRNA]

NCBI chr11:120,489,247...120,499,024
Ensembl chr11:120,489,247...120,499,024

G

angiopoietin-like 4

increases expression

Fenofibrate results in increased expression of ANGPTL4 mRNA

PMID:17118139 PMID:25572481 PMID:25596134 PMID:27665778 PMID:32741897

NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804

G

ankyrin repeat family A member 2

increases expression

Fenofibrate results in increased expression of ANKRA2 mRNA

NCBI chr13:98,399,584...98,411,262
Ensembl chr13:98,399,582...98,411,262

G

annexin A3

decreases expression

Fenofibrate results in decreased expression of ANXA3 protein

NCBI chr 5:96,941,257...96,993,825
Ensembl chr 5:96,941,198...96,993,825

G

apurinic/apyrimidinic endonuclease 1

multiple interactions
increases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of APEX1 mRNA
Fenofibrate results in increased expression of APEX1 mRNA

PMID:17264098 PMID:18253720 PMID:18775883

NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596

G

apolipoprotein A-I

decreases expression
multiple interactions

Fenofibrate results in decreased expression of APOA1 mRNA; Fenofibrate results in decreased expression of APOA1 protein
[Fenofibrate co-treated with Pyrazinamide] results in increased expression of APOA1 mRNA
Fenofibrate promotes the reaction [APOA1 protein results in increased secretion of Lipids]; PPARA protein affects the reaction [Fenofibrate promotes the reaction [APOA1 protein results in increased secretion of Lipids]]
Fenofibrate promotes the reaction [APOA1 protein results in increased secretion of Lipids]; PPARA protein inhibits the reaction [Fenofibrate results in decreased expression of APOA1 mRNA]

PMID:7983038 PMID:19201410 PMID:19445040 PMID:27071702

NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764

G

apolipoprotein A-IV

decreases expression

Fenofibrate results in decreased expression of APOA4 mRNA

NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757

G

apolipoprotein B

decreases expression

Fenofibrate results in decreased expression of APOB protein

NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835

G

apolipoprotein C-III

affects expression
decreases expression

Fenofibrate affects the expression of APOC3 mRNA
Fenofibrate results in decreased expression of APOC3 mRNA
Fenofibrate results in decreased expression of APOC3 mRNA; Fenofibrate results in decreased expression of APOC3 protein

PMID:8847480 PMID:10799317 PMID:20801182 PMID:24752549

NCBI chr 9:46,144,348...46,146,934
Ensembl chr 9:46,144,231...46,146,934

G

amyloid beta precursor protein

multiple interactions

Fenofibrate affects the reaction [PSEN1 protein affects the cleavage of APP protein]

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

aquaporin 3

increases expression

Fenofibrate results in increased expression of AQP3 mRNA

NCBI chr 4:41,092,724...41,098,183
Ensembl chr 4:41,092,722...41,098,183

G

aquaporin 7

increases expression

Fenofibrate results in increased expression of AQP7 mRNA

NCBI chr 4:41,033,074...41,048,237
Ensembl chr 4:41,033,074...41,048,139

G

aquaporin 9

decreases expression

Fenofibrate results in decreased expression of AQP9 mRNA

NCBI chr 9:71,017,941...71,075,170
Ensembl chr 9:71,017,941...71,075,964

G

ADP ribosylation factor guanine nucleotide exchange factor 2

increases expression
decreases expression

Fenofibrate results in increased expression of ARFGEF2 mRNA
Fenofibrate results in decreased expression of ARFGEF2 mRNA

NCBI chr 2:166,647,371...166,739,972
Ensembl chr 2:166,647,508...166,739,972

G

Rho guanine nucleotide exchange factor 10

decreases expression

Fenofibrate results in decreased expression of ARHGEF10 mRNA

NCBI chr 8:14,956,405...15,051,085
Ensembl chr 8:14,961,663...15,051,085

G

ariadne RBR E3 ubiquitin protein ligase 1

increases expression
multiple interactions

Fenofibrate results in increased expression of ARIH1 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of ARIH1 mRNA]

NCBI chr 9:59,295,837...59,395,469
Ensembl chr 9:59,295,541...59,393,901

G

ADP-ribosylation factor-like 1

decreases expression

Fenofibrate results in decreased expression of ARL1 mRNA

NCBI chr10:88,566,720...88,579,956
Ensembl chr10:88,566,720...88,579,956

G

ankyrin repeat and SOCS box-containing 6

multiple interactions
increases expression

[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of ASB6 mRNA
Fenofibrate results in increased expression of ASB6 mRNA

NCBI chr 2:30,713,109...30,718,312
Ensembl chr 2:30,713,109...30,720,345

G

asparagine synthetase

increases expression

Fenofibrate results in increased expression of ASNS mRNA

NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254

G

arginyltransferase 1

increases expression
multiple interactions

Fenofibrate results in increased expression of ATE1 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of ATE1 mRNA]

NCBI chr 7:129,993,219...130,122,349
Ensembl chr 7:129,993,223...130,122,099

G

activating transcription factor 3

multiple interactions
increases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of ATF3 mRNA
Fenofibrate results in increased expression of ATF3 mRNA

PMID:18978307 PMID:25596134

NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236

G

activating transcription factor 4

affects activity
multiple interactions

Fenofibrate affects the activity of ATF4 protein
Fenofibrate inhibits the reaction [Dietary Fats results in increased expression of ATF4 mRNA]; Fenofibrate inhibits the reaction [Dietary Fats results in increased expression of ATF4 protein]

PMID:25596134 PMID:38216941

NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742

G

activating transcription factor 6

multiple interactions

Fenofibrate inhibits the reaction [Dietary Fats results in increased expression of ATF6 mRNA]; Fenofibrate inhibits the reaction [Dietary Fats results in increased expression of ATF6 protein]

NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340

G

autophagy related 12

increases expression
multiple interactions

Fenofibrate results in increased expression of ATG12 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of ATG12 mRNA]

NCBI chr18:46,865,484...46,874,683
Ensembl chr18:46,863,211...46,874,647

G

autophagy related 7

increases expression
multiple interactions

Fenofibrate results in increased expression of ATG7 mRNA
Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of ATG7 protein]; PPARA protein affects the reaction [Fenofibrate results in increased expression of ATG7 mRNA]

PMID:21318169 PMID:36905866

NCBI chr 6:114,620,075...114,837,565
Ensembl chr 6:114,620,058...114,837,575

G

atos homolog A

decreases expression

Fenofibrate results in decreased expression of ATOSA mRNA

NCBI chr 9:74,860,162...74,939,750
Ensembl chr 9:74,860,166...74,939,750

G

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

decreases expression

Fenofibrate results in decreased expression of ATP2A2 protein

NCBI chr 5:122,591,576...122,640,288
Ensembl chr 5:122,591,576...122,640,288

G

ATPase, Ca++ transporting, plasma membrane 4

increases expression

Fenofibrate results in increased expression of ATP2B4 mRNA

NCBI chr 1:133,630,416...133,728,755
Ensembl chr 1:133,627,195...133,728,779

G

BCL2-associated X protein

multiple interactions

Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in increased expression of BAX protein]

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

breast cancer anti-estrogen resistance 3

decreases expression

Fenofibrate results in decreased expression of BCAR3 mRNA

NCBI chr 3:122,213,406...122,323,840
Ensembl chr 3:122,087,785...122,323,840

G

branched chain aminotransferase 1, cytosolic

decreases expression

Fenofibrate results in decreased expression of BCAT1 mRNA

NCBI chr 6:144,939,561...145,021,883
Ensembl chr 6:144,939,561...145,021,910

G

branched chain aminotransferase 2, mitochondrial

increases expression

Fenofibrate results in increased expression of BCAT2 mRNA

NCBI chr 7:45,219,773...45,239,134
Ensembl chr 7:45,219,577...45,239,135

G

branched chain ketoacid dehydrogenase kinase

decreases activity

Fenofibrate results in decreased activity of BCKDK protein

NCBI chr 7:127,503,245...127,508,836
Ensembl chr 7:127,503,254...127,509,393

G

B cell leukemia/lymphoma 2

decreases expression
multiple interactions

Fenofibrate results in decreased expression of BCL2 mRNA
Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of BCL2 protein]

PMID:15843896 PMID:26989860

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

B cell leukemia/lymphoma 2 related protein A1b

decreases expression

Fenofibrate results in decreased expression of BCL2A1 mRNA

NCBI chr 9:89,081,326...89,089,891
Ensembl chr 9:89,081,262...89,089,880

G

BCL2-like 1

decreases expression

Fenofibrate results in decreased expression of BCL2L1 mRNA

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

B cell leukemia/lymphoma 3

decreases expression

Fenofibrate results in decreased expression of BCL3 mRNA

NCBI chr 7:19,542,387...19,556,691
Ensembl chr 7:19,542,387...19,556,695

G

BCR activator of RhoGEF and GTPase

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of BCR mRNA

NCBI chr10:74,896,384...75,020,753
Ensembl chr10:74,896,424...75,020,753

G

3-hydroxybutyrate dehydrogenase, type 1

decreases expression

Fenofibrate results in decreased expression of BDH1 protein

NCBI chr16:31,241,115...31,277,719
Ensembl chr16:31,241,098...31,277,719

G

beclin 1, autophagy related

multiple interactions

Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of BECN1 protein]

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112

G

basic helix-loop-helix family, member e40

decreases expression

Fenofibrate results in decreased expression of BHLHE40 mRNA

NCBI chr 6:108,637,590...108,643,886
Ensembl chr 6:108,637,590...108,643,886

G

baculoviral IAP repeat-containing 3

decreases expression

Fenofibrate results in decreased expression of BIRC3 mRNA

NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187

G

BCL2 modifying factor

increases expression
decreases expression

Fenofibrate results in increased expression of BMF mRNA
Fenofibrate results in decreased expression of BMF mRNA

PMID:25572481 PMID:25596134

NCBI chr 2:118,359,238...118,385,240
Ensembl chr 2:118,359,238...118,380,168

G

BCL2/adenovirus E1B interacting protein 3

increases expression

Fenofibrate results in increased expression of BNIP3 mRNA

NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248

G

BRCA1 associated protein

affects expression
multiple interactions

Fenofibrate affects the expression of BRAP mRNA
PPARA protein affects the reaction [Fenofibrate affects the expression of BRAP mRNA]

NCBI chr 5:121,798,626...121,825,312
Ensembl chr 5:121,798,626...121,825,319

G

BRCA1/BRCA2-containing complex, subunit 3

increases expression
multiple interactions

Fenofibrate results in increased expression of BRCC3 mRNA
[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of BRCC3 mRNA

NCBI chr X:74,460,234...74,499,307
Ensembl chr X:74,460,234...74,497,607

G

bromodomain containing 2

decreases expression

Fenofibrate results in decreased expression of BRD2 mRNA

NCBI chr17:34,330,993...34,341,581
Ensembl chr17:34,330,997...34,341,608

G

BTG anti-proliferation factor 2

affects expression

Fenofibrate affects the expression of BTG2 mRNA

NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858

G

complement component 9

decreases expression

Fenofibrate results in decreased expression of C9 mRNA

NCBI chr15:6,474,827...6,528,306
Ensembl chr15:6,474,808...6,528,232

G

calcium channel, voltage-dependent, alpha2/delta subunit 3

increases expression

Fenofibrate results in increased expression of CACNA2D3 mRNA

NCBI chr14:28,626,900...29,444,732
Ensembl chr14:28,626,900...29,443,821

G

calmodulin 1

affects expression

Fenofibrate affects the expression of CALM1 mRNA

NCBI chr12:100,165,694...100,176,083
Ensembl chr12:100,165,694...100,176,073

G

calnexin

increases expression
multiple interactions

Fenofibrate results in increased expression of CANX mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of CANX mRNA]

NCBI chr11:50,184,784...50,216,500
Ensembl chr11:50,184,788...50,216,500

G

carbonic anhydrase 9

multiple interactions

Fenofibrate inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA]; Fenofibrate inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]

NCBI chr 4:43,507,026...43,513,729
Ensembl chr 4:43,506,966...43,513,729

G

caspase 3

increases cleavage
decreases expression
multiple interactions

Fenofibrate results in increased cleavage of CASP3 protein
Fenofibrate results in decreased expression of CASP3 protein
[ESR1 protein results in increased susceptibility to Estradiol] inhibits the reaction [Fenofibrate results in decreased expression of CASP3 protein]; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased activity of CASP3 protein]
[Fenofibrate co-treated with Pioglitazone] inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; Fenofibrate inhibits the reaction [ACADS protein affects the cleavage of CASP3 protein]; Fenofibrate inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in increased cleavage of CASP3 protein]

PMID:20520642 PMID:26989860 PMID:29134746 PMID:32730863 PMID:36988379

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 4, apoptosis-related cysteine peptidase

increases expression

Fenofibrate results in increased expression of CASP4 mRNA

NCBI chr 9:5,308,816...5,336,791
Ensembl chr 9:5,308,828...5,336,783

G

catalase

multiple interactions
increases expression
increases activity

[Fenofibrate co-treated with Diethylnitrosamine] results in increased activity of CAT protein; [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CAT mRNA
Fenofibrate results in increased expression of CAT mRNA
Fenofibrate results in increased activity of CAT protein

PMID:17264098 PMID:18253720

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

caveolin 1, caveolae protein

increases expression

Fenofibrate results in increased expression of CAV1 mRNA

NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451

G

Casitas B-lineage lymphoma b

increases expression
multiple interactions

Fenofibrate results in increased expression of CBLB mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of CBLB mRNA]

NCBI chr16:51,851,593...52,028,410
Ensembl chr16:51,851,588...52,028,411

G

coiled-coil domain containing 34

increases expression

Fenofibrate results in increased expression of CCDC34 mRNA

NCBI chr 2:109,847,816...110,006,007
Ensembl chr 2:109,848,162...110,003,705

G

coiled-coil domain containing 90B

increases expression

Fenofibrate results in increased expression of CCDC90B mRNA

NCBI chr 7:92,210,350...92,231,502
Ensembl chr 7:92,210,357...92,231,502

G

C-C motif chemokine ligand 12

increases expression

Fenofibrate results in increased expression of CCL13 mRNA

NCBI chr11:81,992,671...81,994,225
Ensembl chr11:81,992,671...81,994,226

G

C-C motif chemokine ligand 2

multiple interactions
decreases expression

Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Fenofibrate inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; Fenofibrate inhibits the reaction [Glucose results in increased expression of CCL2 protein]; Fenofibrate inhibits the reaction [Glucose results in increased secretion of CCL2 protein]
Fenofibrate results in decreased expression of CCL2 mRNA; Fenofibrate results in decreased expression of CCL2 protein
Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]

PMID:15968640 PMID:16306350 PMID:16600694 PMID:18356826 PMID:19132243 More...

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

C-C motif chemokine ligand 5

multiple interactions

Fenofibrate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of CCL5 mRNA]; Fenofibrate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of CCL5 protein]; Fenofibrate inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Fenofibrate inhibits the reaction [TNF protein results in increased expression of CCL5 protein]

PMID:12126966 PMID:12586603

NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344

G

cellular communication network factor 1

decreases expression

Fenofibrate results in decreased expression of CCN1 mRNA

NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736

G

cyclin D1

decreases expression
increases expression
multiple interactions

Fenofibrate results in decreased expression of CCND1 mRNA; Fenofibrate results in decreased expression of CCND1 protein
Fenofibrate results in increased expression of CCND1 protein
ESR1 protein inhibits the reaction [Fenofibrate results in increased expression of CCND1 protein]; Estradiol inhibits the reaction [Fenofibrate results in increased expression of CCND1 protein]
Fenofibrate results in increased expression of CCND1 mRNA
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CCND1 mRNA

PMID:16569247 PMID:17264098 PMID:18253720 PMID:18978307 PMID:20520642 More...

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

cyclin F

increases expression

Fenofibrate results in increased expression of CCNF mRNA

NCBI chr17:24,441,518...24,470,333
Ensembl chr17:24,441,172...24,470,458

G

cyclin G2

decreases expression
increases expression

Fenofibrate results in decreased expression of CCNG2 mRNA
Fenofibrate results in increased expression of CCNG2 mRNA

NCBI chr 5:93,415,432...93,424,090
Ensembl chr 5:93,415,116...93,424,090

G

cyclin T1

multiple interactions

Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]; Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein]

NCBI chr15:98,436,570...98,468,340
Ensembl chr15:98,436,570...98,468,804

G

CD14 antigen

increases expression

Fenofibrate results in increased expression of CD14 mRNA

NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851

G

CD36 molecule

increases expression
multiple interactions

Fenofibrate results in increased expression of CD36 mRNA
Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]

PMID:16707586 PMID:17118139 PMID:25572481 PMID:32613381

NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799

G

CD40 antigen

decreases expression

Fenofibrate results in decreased expression of CD40 mRNA

NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868

G

CD40 ligand

multiple interactions
decreases expression

candesartan promotes the reaction [Fenofibrate results in decreased expression of CD40LG protein]; Fenofibrate promotes the reaction [candesartan results in decreased expression of CD40LG protein]

NCBI chr X:56,257,448...56,269,402
Ensembl chr X:56,257,503...56,269,402

G

cell division cycle 25A

increases expression

Fenofibrate results in increased expression of CDC25A mRNA

NCBI chr 9:109,704,545...109,722,963
Ensembl chr 9:109,704,647...109,722,963

G

cyclin dependent kinase 20

increases expression

Fenofibrate results in increased expression of CDK20 mRNA

NCBI chr13:64,580,133...64,587,536
Ensembl chr13:64,580,128...64,589,587

G

cyclin dependent kinase 9

multiple interactions

Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 mRNA]; Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 protein]

NCBI chr 2:32,595,794...32,608,098
Ensembl chr 2:32,595,796...32,603,088

G

cyclin dependent kinase inhibitor 1A

multiple interactions
decreases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CDKN1A mRNA
Fenofibrate results in decreased expression of CDKN1A mRNA

PMID:18253720 PMID:25596134

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

cyclin dependent kinase inhibitor 1B

multiple interactions
decreases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CDKN1B mRNA
Fenofibrate results in decreased expression of CDKN1B protein
ESR1 protein inhibits the reaction [Fenofibrate results in decreased expression of CDKN1B protein]; Estradiol inhibits the reaction [Fenofibrate results in decreased expression of CDKN1B protein]

PMID:18253720 PMID:29134746

NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476

G

centrosomal protein 128

increases expression

Fenofibrate results in increased expression of CEP128 mRNA

NCBI chr12:90,965,264...91,351,207
Ensembl chr12:90,965,266...91,351,183

G

ceramide synthase 5

decreases expression

Fenofibrate results in decreased expression of CERS5 mRNA

NCBI chr15:99,633,473...99,670,396
Ensembl chr15:99,632,762...99,670,766

G

carboxylesterase 1D

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CES1 mRNA

NCBI chr 8:93,892,700...93,924,432
Ensembl chr 8:93,892,696...93,924,466

G

checkpoint kinase 1

increases expression

Fenofibrate results in increased expression of CHEK1 mRNA

NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361

G

checkpoint kinase 2

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CHEK2 mRNA

NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011

G

chitinase domain containing 1

decreases expression

Fenofibrate results in decreased expression of CHID1 mRNA

NCBI chr 7:141,073,049...141,119,818
Ensembl chr 7:141,073,049...141,119,770

G

cholinergic receptor nicotinic alpha 2 subunit

increases expression

Fenofibrate results in increased expression of CHRNA2 mRNA

NCBI chr14:66,370,685...66,390,397
Ensembl chr14:66,372,488...66,390,397

G

carbohydrate sulfotransferase 8

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CHST8 mRNA

NCBI chr 7:34,373,893...34,512,136
Ensembl chr 7:34,373,893...34,512,136

G

cytokine inducible SH2-containing protein

decreases expression
multiple interactions

Fenofibrate results in decreased expression of CISH mRNA
PPARA protein affects the reaction [Fenofibrate results in decreased expression of CISH mRNA]

NCBI chr 9:107,173,858...107,179,983
Ensembl chr 9:107,173,225...107,179,983

G

carboxymethylenebutenolidase homolog

increases expression

Fenofibrate results in increased expression of CMBL mRNA

NCBI chr15:31,565,314...31,590,266
Ensembl chr15:31,565,535...31,590,265

G

CCR4-NOT transcription complex, subunit 4

multiple interactions
increases expression

PPARA protein affects the reaction [Fenofibrate results in increased expression of CNOT4 mRNA]

NCBI chr 6:34,999,000...35,110,646
Ensembl chr 6:34,999,000...35,110,659

G

collagen, type I, alpha 1

multiple interactions

Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]
Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]; Fenofibrate inhibits the reaction [AHR protein affects the reaction [AGT protein results in increased expression of COL1A1 mRNA]]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Fenofibrate inhibits the reaction [Zoledronic Acid results in increased expression of COL1A1 mRNA]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]]

PMID:19593819 PMID:28871336 PMID:31016362

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

collagen, type III, alpha 1

multiple interactions

Fenofibrate inhibits the reaction [AHR protein affects the reaction [AGT protein results in increased expression of COL3A1 mRNA]]; Fenofibrate inhibits the reaction [Zoledronic Acid results in increased expression of COL3A1 mRNA]

PMID:28871336 PMID:31016362

NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866

G

collagen, type IV, alpha 1

multiple interactions

Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of COL4A1 mRNA]

NCBI chr 8:11,248,423...11,362,889
Ensembl chr 8:11,248,423...11,362,826

G

collagen like tail subunit of asymmetric acetylcholinesterase

increases expression

Fenofibrate results in increased expression of COLQ mRNA

PMID:27665778 PMID:32741897

NCBI chr14:31,245,039...31,299,820
Ensembl chr14:31,245,039...31,313,300

G

demethyl-Q 7

increases expression

Fenofibrate results in increased expression of COQ7 mRNA

NCBI chr 7:118,108,881...118,132,529
Ensembl chr 7:118,108,882...118,132,579

G

cytochrome c oxidase subunit 6B2

increases expression

Fenofibrate results in increased expression of COX6B2 mRNA

NCBI chr 7:4,754,791...4,756,093
Ensembl chr 7:4,754,791...4,756,093

G

carnitine palmitoyltransferase 1a, liver

increases expression
multiple interactions

Fenofibrate results in increased expression of CPT1A mRNA
Fenofibrate inhibits the reaction [zoledronic acid results in decreased expression of CPT1A mRNA]
Fenofibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of CPT1A protein]; Fenofibrate promotes the reaction [Fatty Acids, Nonesterified results in increased expression of CPT1A mRNA]; Fenofibrate promotes the reaction [Oleic Acid results in increased expression of CPT1A mRNA]

PMID:16595124 PMID:17070643 PMID:17118139 PMID:19124612 PMID:24534255 More...

NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733

G

carnitine palmitoyltransferase 1b, muscle

affects expression
multiple interactions
increases expression

Fenofibrate affects the expression of CPT1B mRNA
Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of CPT1B mRNA]
Fenofibrate results in increased expression of CPT1B mRNA

PMID:16595124 PMID:19395589 PMID:20801182 PMID:27071702 PMID:32741897

NCBI chr15:89,300,608...89,310,065
Ensembl chr15:89,300,608...89,310,066

G

carnitine palmitoyltransferase 2

decreases expression
multiple interactions
increases expression

Fenofibrate results in decreased expression of CPT2 protein
Fenofibrate inhibits the reaction [zoledronic acid results in decreased expression of CPT2 mRNA]
Fenofibrate results in increased expression of CPT2 mRNA
[Oleic Acid co-treated with Fenofibrate] results in increased expression of CPT2 mRNA

PMID:16595124 PMID:16707586 PMID:19395589 PMID:20118634 PMID:24534255 More...

NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807

G

carnitine acetyltransferase

increases expression
increases activity
multiple interactions

Fenofibrate results in increased expression of CRAT mRNA
Fenofibrate results in increased activity of CRAT protein
[Fenofibrate co-treated with Diethylnitrosamine] results in increased activity of CRAT protein; [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CRAT mRNA

PMID:11798191 PMID:17264098 PMID:18253720 PMID:27665778 PMID:32741897

NCBI chr 2:30,290,483...30,305,602
Ensembl chr 2:30,290,483...30,305,825

G

cAMP responsive element binding protein 3-like 3

increases expression

Fenofibrate results in increased expression of CREB3L3 mRNA

PMID:25572481 PMID:32741897

NCBI chr10:80,920,163...80,934,706
Ensembl chr10:80,920,158...80,934,708

G

carnitine O-octanoyltransferase

increases expression

Fenofibrate results in increased expression of CROT mRNA

NCBI chr 5:9,016,033...9,047,926
Ensembl chr 5:9,016,033...9,047,324

G

C-reactive protein, pentraxin-related

multiple interactions
decreases expression

candesartan promotes the reaction [Fenofibrate results in decreased expression of CRP protein]; Fenofibrate promotes the reaction [candesartan results in decreased expression of CRP protein]

PMID:16123850 PMID:16443859

NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598

G

colony stimulating factor 1 receptor

decreases expression

Fenofibrate results in decreased expression of CSF1R mRNA

NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221

G

colony stimulating factor 2 (granulocyte-macrophage)

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CSF2 mRNA

NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493

G

cystathionine gamma lyase

increases expression
decreases expression

Fenofibrate results in increased expression of CTH mRNA
Fenofibrate results in decreased expression of CTH mRNA

NCBI chr 3:157,599,885...157,630,718
Ensembl chr 3:157,599,885...157,630,714

G

cathepsin C

decreases expression

Fenofibrate results in decreased expression of CTSC mRNA

NCBI chr 7:87,927,233...87,960,083
Ensembl chr 7:87,927,293...87,960,096

G

C-X3-C motif chemokine ligand 1

multiple interactions

Fenofibrate inhibits the reaction [Glucose results in increased expression of CX3CL1 mRNA]; Fenofibrate inhibits the reaction [Glucose results in increased expression of CX3CL1 protein]

NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055

G

cytochrome c, somatic

multiple interactions

Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of CYCS protein]

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

G

CYLD lysine 63 deubiquitinase

decreases expression
multiple interactions

Fenofibrate results in decreased expression of CYLD mRNA
PPARA protein affects the reaction [Fenofibrate results in decreased expression of CYLD mRNA]

NCBI chr 8:89,423,506...89,478,574
Ensembl chr 8:89,423,675...89,478,573

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
decreases activity

Fenofibrate results in increased expression of CYP1A1 mRNA
Fenofibrate results in decreased activity of CYP1A1 protein

PMID:19118567 PMID:33814510

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
affects expression

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP1A2 mRNA
Fenofibrate affects the expression of CYP1A2 mRNA

PMID:18253720 PMID:20801182 PMID:25596134

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Fenofibrate results in decreased activity of CYP1B1 protein

NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490

G

cytochrome P450, family 2, subfamily a, polypeptide 4

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CYP2A3 mRNA

NCBI chr 7:26,006,617...26,014,513
Ensembl chr 7:26,006,594...26,014,513

G

cytochrome P450, family 2, subfamily b, polypeptide 10

increases expression

Fenofibrate results in increased expression of CYP2B10 mRNA

NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049

G

cytochrome P450, family 2, subfamily b, polypeptide 9

increases expression

Fenofibrate results in increased expression of CYP2B9 mRNA

NCBI chr 7:25,872,775...25,910,086
Ensembl chr 7:25,872,836...25,910,086

G

cytochrome P450, family 2, subfamily c, polypeptide 29

increases expression
affects expression
decreases activity

Fenofibrate results in increased expression of CYP2C8 mRNA
Fenofibrate affects the expression of CYP2C8 protein
Fenofibrate results in decreased activity of CYP2C8 protein

PMID:15601807 PMID:25572481 PMID:29960002

NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157

G

cytochrome P450, family 2, subfamily c, polypeptide 38

increases expression

Fenofibrate results in increased expression of CYP2C19 mRNA

NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519

G

cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP2C mRNA

NCBI chr19:38,965,106...38,992,071
Ensembl chr19:38,965,091...38,991,733

G

cytochrome P450, family 2, subfamily d, polypeptide 22

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP2D22 mRNA

NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression

Fenofibrate results in increased expression of CYP2E1 mRNA

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

cytochrome P450, family 2, subfamily f, polypeptide 2

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP2F2 mRNA

NCBI chr 7:26,819,380...26,833,085
Ensembl chr 7:26,819,334...26,833,085

G

cytochrome P450, family 2, subfamily j, polypeptide 9

affects expression

Fenofibrate affects the expression of CYP2J2 protein

NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815

G

cytochrome P450, family 3, subfamily a, polypeptide 13

multiple interactions
increases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP3A13 mRNA
Fenofibrate results in increased expression of CYP3A7 mRNA

PMID:18253720 PMID:19118567

NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881

G

cytochrome P450, family 4, subfamily a, polypeptide 10

increases expression
multiple interactions

Fenofibrate results in increased expression of CYP4A10 mRNA
NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A10 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A10 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A10 mRNA]

NCBI chr 4:115,375,484...115,390,846
Ensembl chr 4:115,375,461...115,390,846

G

cytochrome P450, family 4, subfamily a, polypeptide 12B

increases expression
multiple interactions
affects expression

Fenofibrate results in increased expression of CYP4A12B mRNA
Fenofibrate results in increased expression of CYP4A1 mRNA
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of CYP4A1 mRNA
Fenofibrate affects the expression of CYP4A1 mRNA

PMID:11798191 PMID:17264098 PMID:18775883 PMID:20801182 PMID:27665778 More...

NCBI chr 4:115,268,821...115,296,231
Ensembl chr 4:115,268,821...115,296,231

G

cytochrome P450, family 4, subfamily a, polypeptide 14

multiple interactions
increases expression

[Methionine deficiency co-treated with Choline deficiency co-treated with Fenofibrate] results in increased expression of CYP4A14 mRNA; NR0B2 protein promotes the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Fenofibrate] results in increased expression of CYP4A14 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A14 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A14 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A14 mRNA]

PMID:11798191 PMID:19593819 PMID:23063693

NCBI chr 4:115,343,397...115,353,355
Ensembl chr 4:115,343,397...115,353,339

G

cytochrome P450, family 4, subfamily a, polypeptide 31

increases expression

Fenofibrate results in increased expression of CYP4A22 mRNA

NCBI chr 4:115,420,824...115,436,212
Ensembl chr 4:115,420,846...115,436,212

G

cytochrome P450, family 4, subfamily b, polypeptide 1

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP4B1 mRNA

NCBI chr 4:115,481,895...115,504,918
Ensembl chr 4:115,481,922...115,504,920

G

cytochrome P450, family 4, subfamily x, polypeptide 1

increases expression

Fenofibrate results in increased expression of CYP4X1 mRNA

NCBI chr 4:114,963,518...114,991,276
Ensembl chr 4:114,963,520...114,991,478

G

cytochrome P450, family 7, subfamily a, polypeptide 1

multiple interactions
decreases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP7A1 mRNA
Fenofibrate results in decreased expression of CYP7A1 mRNA

PMID:14685799 PMID:18253720

NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633

G

cytochrome P450, family 7, subfamily b, polypeptide 1

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP7B1 mRNA

NCBI chr 3:18,126,108...18,298,054
Ensembl chr 3:18,126,114...18,297,502

G

cytochrome P450, family 8, subfamily b, polypeptide 1

multiple interactions
increases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP8B1 mRNA
Fenofibrate results in increased expression of CYP8B1 mRNA

PMID:18253720 PMID:32741897

NCBI chr 9:121,743,422...121,745,371
Ensembl chr 9:121,743,422...121,745,371

G

dishevelled-binding antagonist of beta-catenin 2

increases expression

Fenofibrate results in increased expression of DACT2 mRNA

NCBI chr17:14,415,492...14,424,595
Ensembl chr17:14,415,314...14,424,566

G

diazepam binding inhibitor

increases expression

Fenofibrate results in increased expression of DBI mRNA

NCBI chr 1:120,041,010...120,048,826
Ensembl chr 1:120,041,010...120,048,808

G

defective in cullin neddylation 1 domain containing 1

increases expression

Fenofibrate results in increased expression of DCUN1D1 mRNA

NCBI chr 3:35,946,254...35,991,626
Ensembl chr 3:35,946,254...35,991,594

G

DNA-damage inducible transcript 3

increases expression

Fenofibrate results in increased expression of DDIT3 mRNA

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

DNA-damage-inducible transcript 4

decreases expression
increases expression

Fenofibrate results in decreased expression of DDIT4 mRNA
Fenofibrate results in increased expression of DDIT4 mRNA

NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656

G

DEAD box helicase 24

decreases expression

Fenofibrate results in decreased expression of DDX24 mRNA

NCBI chr12:103,374,235...103,392,106
Ensembl chr12:103,374,241...103,392,089

G

2,4-dienoyl CoA reductase 1, mitochondrial

increases expression
affects expression

Fenofibrate results in increased expression of DECR1 mRNA
Fenofibrate results in increased expression of DECR1 mRNA; Fenofibrate results in increased expression of DECR1 protein
Fenofibrate affects the expression of DECR1 mRNA

PMID:11798191 PMID:20118634 PMID:20801182 PMID:27665778 PMID:32741897

NCBI chr 4:15,917,240...15,945,377
Ensembl chr 4:15,917,240...15,945,507

G

2-4-dienoyl-Coenzyme A reductase 2, peroxisomal

increases expression

Fenofibrate results in increased expression of DECR2 mRNA

NCBI chr17:26,300,182...26,309,096
Ensembl chr17:26,300,182...26,309,311

G

DEAH-box helicase 37

increases expression

Fenofibrate results in increased expression of DHX37 mRNA

NCBI chr 5:125,490,811...125,511,203
Ensembl chr 5:125,490,922...125,511,185

G

dystrophin, muscular dystrophy

decreases expression

Fenofibrate results in decreased expression of DMD mRNA

NCBI chr X:81,858,244...84,248,656
Ensembl chr X:81,992,476...84,249,747

G

DnaJ heat shock protein family (Hsp40) member A2

multiple interactions
increases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of DNAJA2 mRNA
Fenofibrate results in increased expression of DNAJA2 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of DNAJA2 mRNA]

PMID:18253720 PMID:21318169

NCBI chr 8:86,264,262...86,281,990
Ensembl chr 8:86,264,262...86,281,973

G

DnaJ heat shock protein family (Hsp40) member A3

increases expression

Fenofibrate results in increased expression of DNAJA3 mRNA

NCBI chr16:4,501,934...4,525,559
Ensembl chr16:4,457,853...4,525,559

G

DnaJ heat shock protein family (Hsp40) member B1

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of DNAJB1 mRNA

NCBI chr 8:84,334,804...84,339,282
Ensembl chr 8:84,334,822...84,339,282

G

DnaJ heat shock protein family (Hsp40) member B4

decreases expression
multiple interactions

Fenofibrate results in decreased expression of DNAJB4 mRNA
PPARA protein affects the reaction [Fenofibrate results in decreased expression of DNAJB4 mRNA]

NCBI chr 3:151,887,217...151,915,720
Ensembl chr 3:151,884,148...151,915,939

G

DnaJ heat shock protein family (Hsp40) member B6

increases expression
multiple interactions

Fenofibrate results in increased expression of DNAJB6 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of DNAJB6 mRNA]

NCBI chr 5:29,940,896...29,991,476
Ensembl chr 5:29,940,686...30,023,132

G

DnaJ heat shock protein family (Hsp40) member B9

decreases expression

Fenofibrate results in decreased expression of DNAJB9 mRNA

NCBI chr12:44,252,680...44,256,851
Ensembl chr12:44,252,342...44,257,109

G

DnaJ heat shock protein family (Hsp40) member C14

increases expression
multiple interactions

Fenofibrate results in increased expression of DNAJC14 mRNA
[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of DNAJC14 mRNA

NCBI chr10:128,641,423...128,655,317
Ensembl chr10:128,639,931...128,655,315

G

DnaJ heat shock protein family (Hsp40) member C19

increases expression
multiple interactions

Fenofibrate results in increased expression of DNAJC19 mRNA
[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of DNAJC19 mRNA

NCBI chr 3:34,111,429...34,135,503
Ensembl chr 3:34,110,169...34,135,470

G

DnaJ heat shock protein family (Hsp40) member C2

multiple interactions
increases expression

[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of DNAJC2 mRNA
Fenofibrate results in increased expression of DNAJC2 mRNA

NCBI chr 5:21,962,279...21,990,183
Ensembl chr 5:21,962,265...21,990,249

G

DnaJ heat shock protein family (Hsp40) member C27

decreases expression
multiple interactions

Fenofibrate results in decreased expression of RBJ mRNA
PPARA protein affects the reaction [Fenofibrate results in decreased expression of RBJ mRNA]

NCBI chr12:4,132,569...4,174,140
Ensembl chr12:4,132,583...4,160,606

G

DnaJ heat shock protein family (Hsp40) member C3

increases expression
multiple interactions

Fenofibrate results in increased expression of DNAJC3 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of DNAJC3 mRNA]

NCBI chr14:119,175,371...119,219,114
Ensembl chr14:119,175,388...119,219,109

G

DnaJ heat shock protein family (Hsp40) member C5

increases expression
multiple interactions

Fenofibrate results in increased expression of DNAJC5 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of DNAJC5 mRNA]

NCBI chr 2:181,162,141...181,194,679
Ensembl chr 2:181,162,278...181,196,926

G

DnaJ heat shock protein family (Hsp40) member C5 beta

increases expression

Fenofibrate results in increased expression of DNAJC5B mRNA

NCBI chr 3:19,562,755...19,665,026
Ensembl chr 3:19,562,759...19,665,026

G

dynamin 1-like

multiple interactions

Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of DNM1L protein]

NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823

G

dynamin binding protein

decreases expression

Fenofibrate results in decreased expression of DNMBP mRNA

NCBI chr19:43,835,259...43,930,930
Ensembl chr19:43,835,260...43,928,630

G

dual specificity phosphatase 5

increases expression

Fenofibrate results in increased expression of DUSP5 mRNA

NCBI chr19:53,517,576...53,530,240
Ensembl chr19:53,517,540...53,530,862

G

enoyl coenzyme A hydratase 1, peroxisomal

affects expression
increases expression

Fenofibrate affects the expression of ECH1 mRNA
Fenofibrate results in increased expression of ECH1 mRNA; Fenofibrate results in increased expression of ECH1 protein

PMID:11798191 PMID:17118139 PMID:20118634 PMID:20801182 PMID:27665778 More...

NCBI chr 7:28,524,763...28,531,664
Ensembl chr 7:28,524,642...28,531,672

G

enoyl Coenzyme A hydratase, short chain, 1, mitochondrial

increases expression

Fenofibrate results in increased expression of ECHS1 mRNA

NCBI chr 7:139,685,623...139,696,334
Ensembl chr 7:139,685,623...139,696,389

G

enoyl-Coenzyme A delta isomerase 1

increases expression
affects expression

Fenofibrate results in increased expression of ECI1 mRNA
Fenofibrate affects the expression of ECI1 mRNA

PMID:11798191 PMID:20801182 PMID:27665778 PMID:32741897

NCBI chr17:24,645,657...24,658,290
Ensembl chr17:24,645,615...24,658,322

G

enoyl-Coenzyme A delta isomerase 2

increases expression

Fenofibrate results in increased expression of ECI2 mRNA

NCBI chr13:35,161,731...35,211,098
Ensembl chr13:35,161,731...35,211,079

G

endothelin 1

multiple interactions

EDN1 protein promotes the reaction [Fenofibrate promotes the reaction [NFATC4 protein binds to PPARA protein]]; Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]; Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to NPPB promoter]]; Fenofibrate inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; PPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]]; PPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]]
Fenofibrate affects the reaction [[AHR protein affects the susceptibility to AGT protein] which affects the expression of EDN1 mRNA]

PMID:22198280 PMID:31016362

NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466

G

epidermal growth factor receptor

decreases expression

Fenofibrate results in decreased expression of EGFR mRNA

NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158

G

enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase

increases expression
affects expression

Fenofibrate results in increased expression of EHHADH mRNA
Fenofibrate affects the expression of EHHADH mRNA

PMID:11798191 PMID:17118139 PMID:20801182 PMID:27665778 PMID:32741897

NCBI chr16:21,580,035...21,606,589
Ensembl chr16:21,580,037...21,606,557

G

eukaryotic translation initiation factor 1

decreases expression
increases expression

Fenofibrate results in decreased expression of EIF1 mRNA
Fenofibrate results in increased expression of EIF1 mRNA

NCBI chr11:100,210,775...100,212,925
Ensembl chr11:100,210,711...100,212,922

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

Fenofibrate inhibits the reaction [Dietary Fats results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229

G

eukaryotic translation initiation factor 2 subunit 2 beta

affects expression

Fenofibrate affects the expression of EIF2S2 mRNA

NCBI chr 2:154,713,330...154,734,826
Ensembl chr 2:154,713,330...154,734,855

G

eukaryotic translation initiation factor 3, subunit C

increases expression

Fenofibrate results in increased expression of EIF3C mRNA

NCBI chr 7:126,146,083...126,165,538
Ensembl chr 7:126,145,627...126,165,583

G

ELK4, member of ETS oncogene family

increases expression

Fenofibrate results in increased expression of ELK4 mRNA

NCBI chr 1:131,935,129...131,954,186
Ensembl chr 1:131,935,345...131,960,350

G

ELOVL fatty acid elongase 6

multiple interactions
increases expression

[Oleic Acid co-treated with Fenofibrate] affects the expression of ELOVL6 mRNA
Fenofibrate results in increased expression of ELOVL6 mRNA
NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ELOVL6 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ELOVL6 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ELOVL6 mRNA]

PMID:23063693 PMID:24534255 PMID:27665778

NCBI chr 3:129,326,035...129,432,144
Ensembl chr 3:129,326,004...129,432,144

G

ectodermal-neural cortex 1

increases expression
multiple interactions

Fenofibrate results in increased expression of ENC1 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of ENC1 mRNA]

NCBI chr13:97,377,613...97,389,548
Ensembl chr13:97,377,613...97,389,542

G

enolase 1, alpha non-neuron

increases expression

Fenofibrate results in increased expression of ENO1 mRNA

NCBI chr 4:150,321,165...150,333,336
Ensembl chr 4:150,321,178...150,333,336

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

decreases expression

Fenofibrate results in decreased expression of ENPP2 mRNA

NCBI chr15:54,702,297...54,816,284
Ensembl chr15:54,702,297...54,816,288

G

ectonucleoside triphosphate diphosphohydrolase 7

decreases expression

Fenofibrate results in decreased expression of ENTPD7 mRNA

NCBI chr19:43,678,128...43,722,292
Ensembl chr19:43,678,111...43,722,136

G

E1A binding protein p400

decreases expression

Fenofibrate results in decreased expression of EP400 mRNA

NCBI chr 5:110,812,239...110,918,583
Ensembl chr 5:110,812,239...110,918,583

G

epoxide hydrolase 2, cytoplasmic

affects expression
increases expression

Fenofibrate affects the expression of EPHX2 mRNA
Fenofibrate results in increased expression of EPHX2 mRNA
Fenofibrate affects the expression of EPHX2 protein

PMID:20801182 PMID:29960002 PMID:32741897

NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949

G

glutamyl-prolyl-tRNA synthetase 1

increases expression

Fenofibrate results in increased expression of EPRS1 mRNA

NCBI chr 1:185,093,614...185,160,557
Ensembl chr 1:185,095,241...185,160,557

G

endoplasmic reticulum oxidoreductase 1 alpha

increases expression

Fenofibrate results in increased expression of ERO1A mRNA

NCBI chr14:45,520,544...45,556,029
Ensembl chr14:45,520,544...45,556,228

G

estrogen receptor 1 (alpha)

multiple interactions

[ESR1 protein results in increased susceptibility to Estradiol] inhibits the reaction [Fenofibrate results in decreased expression of CASP3 protein]; ESR1 protein inhibits the reaction [Estradiol inhibits the reaction [Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]]]; ESR1 protein inhibits the reaction [Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]]; ESR1 protein inhibits the reaction [Fenofibrate results in decreased expression of CDKN1B protein]; ESR1 protein inhibits the reaction [Fenofibrate results in increased expression of CCND1 protein]; ESR1 protein inhibits the reaction [Fenofibrate results in increased expression of PCNA protein]; Estradiol inhibits the reaction [ESR1 protein inhibits the reaction [Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]]]; Estradiol inhibits the reaction [Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]]; Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

G

electron transferring flavoprotein, alpha polypeptide

increases expression

Fenofibrate results in increased expression of ETFA mRNA

NCBI chr 9:55,361,720...55,419,528
Ensembl chr 9:55,361,792...55,419,527

G

electron transferring flavoprotein, dehydrogenase

decreases expression
increases expression

Fenofibrate results in decreased expression of ETFDH protein
Fenofibrate results in increased expression of ETFDH mRNA

PMID:20118634 PMID:25572481

NCBI chr 3:79,511,095...79,536,074
Ensembl chr 3:79,511,095...79,536,807

G

ethanolamine kinase 2

decreases expression

Fenofibrate results in decreased expression of ETNK2 mRNA

NCBI chr 1:133,291,308...133,308,056
Ensembl chr 1:133,291,310...133,308,074

G

coagulation factor II

multiple interactions

Fenofibrate promotes the reaction [Warfarin results in decreased expression of F2 protein]

NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759

G

coagulation factor VII

multiple interactions

Fenofibrate promotes the reaction [Warfarin results in decreased expression of F7 protein]

NCBI chr 8:13,075,499...13,085,809
Ensembl chr 8:13,076,034...13,085,809

G

fatty acid binding protein 1, liver

increases expression
multiple interactions

Fenofibrate results in increased expression of FABP1 mRNA
Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of FABP1 mRNA]

PMID:17118139 PMID:24752549 PMID:27071702 PMID:32741897

NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007

G

fatty acid binding protein 2, intestinal

increases expression

Fenofibrate results in increased expression of FABP2 mRNA

NCBI chr 3:122,688,721...122,693,155
Ensembl chr 3:122,688,721...122,693,155

G

fatty acid binding protein 3, muscle and heart

increases expression

Fenofibrate results in increased expression of FABP3 mRNA

NCBI chr 4:130,202,531...130,209,256
Ensembl chr 4:130,202,388...130,209,256

G

fatty acid binding protein 4, adipocyte

increases expression

Fenofibrate results in increased expression of FABP4 mRNA

PMID:11798191 PMID:12759900 PMID:25572481

NCBI chr 3:10,269,406...10,273,653
Ensembl chr 3:10,269,148...10,273,636

G

fatty acid desaturase 1

multiple interactions
increases expression

beta-hydroxy simvastatin acid promotes the reaction [Fenofibrate results in increased expression of FADS1 mRNA]; Fenofibrate promotes the reaction [beta-hydroxy simvastatin acid results in increased expression of FADS1 mRNA]

NCBI chr19:10,160,245...10,174,238
Ensembl chr19:10,160,252...10,174,241

G

fumarylacetoacetate hydrolase

increases expression

Fenofibrate results in increased expression of FAH mRNA

NCBI chr 7:84,234,367...84,255,150
Ensembl chr 7:84,234,367...84,255,930

G

family with sequence similarity 210, member A

affects expression

Fenofibrate affects the expression of FAM210A mRNA

NCBI chr18:68,393,248...68,433,404
Ensembl chr18:68,393,258...68,433,404

G

family with sequence similarity 222, member A

increases expression

Fenofibrate results in increased expression of FAM222A mRNA

NCBI chr 5:114,706,312...114,751,281
Ensembl chr 5:114,706,077...114,751,281

G

family with sequence similarity 241, member A

increases expression

Fenofibrate results in increased expression of FAM241A mRNA

NCBI chr 3:127,663,337...127,689,972
Ensembl chr 3:127,662,707...127,689,973

G

family with sequence similarity 89, member A

increases expression

Fenofibrate results in increased expression of FAM89A mRNA

NCBI chr 8:125,466,996...125,478,605
Ensembl chr 8:125,466,996...125,478,571

G

Fas cell surface death receptor

multiple interactions
decreases expression

Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FAS mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FAS mRNA]]
fenofibrate co-treated with fructose diet increases expression of Fas mRNA in liver
Fenofibrate results in decreased expression of FAS mRNA

CTD
RGD

PMID:19593819 PMID:25596134 PMID:11934685

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

fatty acid synthase

multiple interactions
increases expression

[Oleic Acid co-treated with Fenofibrate] affects the expression of FASN mRNA; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of FASN protein]
[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of FASN mRNA]; Fenofibrate inhibits the reaction [Fructose results in increased expression of FASN mRNA]
Fenofibrate results in increased expression of FASN mRNA
NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FASN mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FASN mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FASN mRNA]

PMID:17118139 PMID:23063693 PMID:24534255 PMID:26973390 PMID:32730863

NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373

G

fructose bisphosphatase 2

increases expression

Fenofibrate results in increased expression of FBP2 mRNA

NCBI chr13:62,984,698...63,006,214
Ensembl chr13:62,984,691...63,006,236

G

F-box protein 21

increases expression

Fenofibrate results in increased expression of FBXO21 mRNA

NCBI chr 5:118,114,835...118,148,263
Ensembl chr 5:118,114,795...118,148,266

G

F-box protein 22

decreases expression

Fenofibrate results in decreased expression of FBXO22 mRNA

NCBI chr 9:55,116,219...55,131,717
Ensembl chr 9:55,116,209...55,131,717

G

F-box protein 3

increases expression
multiple interactions

Fenofibrate results in increased expression of FBXO3 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of FBXO3 mRNA]

NCBI chr 2:103,858,144...103,893,582
Ensembl chr 2:103,858,066...103,893,585

G

F-box protein 30

increases expression
multiple interactions

Fenofibrate results in increased expression of FBXO30 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of FBXO30 mRNA]

PMID:21318169 PMID:25596134

NCBI chr10:11,157,009...11,181,494
Ensembl chr10:11,157,074...11,173,796

G

F-box protein 32

increases expression
multiple interactions

Fenofibrate results in increased expression of FBXO32 mRNA; Fenofibrate results in increased expression of FBXO32 protein
Lovastatin promotes the reaction [Fenofibrate results in increased expression of FBXO32 protein]; PPARA protein affects the reaction [Fenofibrate results in increased expression of FBXO32 mRNA]

NCBI chr15:58,039,275...58,078,288
Ensembl chr15:58,039,275...58,078,328

G

F-box protein 36

decreases expression

Fenofibrate results in decreased expression of FBXO36 mRNA

NCBI chr 1:84,817,562...84,878,208
Ensembl chr 1:84,817,562...84,878,208

G

f-box protein 9

increases expression

Fenofibrate results in increased expression of FBXO9 mRNA

NCBI chr 9:77,988,781...78,016,347
Ensembl chr 9:77,988,781...78,016,347

G

farnesyl diphosphate farnesyl transferase 1

increases expression
multiple interactions

Fenofibrate results in increased expression of FDFT1 mRNA
NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FDFT1 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FDFT1 mRNA]

NCBI chr14:63,382,599...63,419,136
Ensembl chr14:63,382,599...63,417,027

G

fibrinogen alpha chain

multiple interactions
decreases expression

PPARA promotes the reaction [Fenofibrate results in decreased expression of FGA mRNA]

NCBI chr 3:82,933,460...82,940,934
Ensembl chr 3:82,933,383...82,940,934

G

fibrinogen beta chain

decreases expression

Fenofibrate results in decreased expression of FGB mRNA

NCBI chr 3:82,949,553...82,957,170
Ensembl chr 3:82,947,448...82,957,170

G

fibroblast growth factor 21

increases expression

Fenofibrate results in increased expression of FGF21 mRNA; Fenofibrate results in increased expression of FGF21 protein

NCBI chr 7:45,263,314...45,264,914
Ensembl chr 7:45,263,310...45,264,914

G

fibrinogen gamma chain

decreases expression

Fenofibrate results in decreased expression of FGG mRNA

NCBI chr 3:82,915,031...82,922,363
Ensembl chr 3:82,915,031...82,922,356

G

FGR proto-oncogene, Src family tyrosine kinase

affects expression

Fenofibrate affects the expression of FGR mRNA

NCBI chr 4:132,701,406...132,729,204
Ensembl chr 4:132,701,406...132,729,221

G

fission, mitochondrial 1

multiple interactions

Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in increased expression of FIS1 protein]

NCBI chr 5:136,982,129...136,995,088
Ensembl chr 5:136,982,129...136,995,088

G

FK506 binding protein 15

increases expression
multiple interactions

Fenofibrate results in increased expression of FKBP15 mRNA
[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of FKBP15 mRNA

NCBI chr 4:62,218,579...62,278,828
Ensembl chr 4:62,218,579...62,278,785

G

FK506 binding protein 8

increases expression

Fenofibrate results in increased expression of FKBP8 mRNA

NCBI chr 8:70,980,371...70,987,978
Ensembl chr 8:70,980,374...70,987,978

G

flavin containing monooxygenase 1

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of FMO1 mRNA

NCBI chr 1:162,657,130...162,694,170
Ensembl chr 1:162,657,130...162,694,179

G

flavin containing monooxygenase 5

multiple interactions
decreases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of FMO5 mRNA
Fenofibrate results in decreased expression of FMO5 mRNA

PMID:18253720 PMID:25572481

NCBI chr 3:97,517,248...97,562,603
Ensembl chr 3:97,536,120...97,562,598

G

fibronectin 1

affects expression
multiple interactions

Fenofibrate affects the expression of FN1 mRNA
Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of FN1 protein]

PMID:20801182 PMID:28871336

NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359

G

forkhead box O1

increases expression
multiple interactions

Fenofibrate results in increased expression of FOXO1 mRNA; Fenofibrate results in increased expression of FOXO1 protein
Lovastatin promotes the reaction [Fenofibrate results in increased expression of FOXO1 protein]; PPARA protein affects the reaction [Fenofibrate results in increased expression of FOXO1 mRNA]

NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642

G

forkhead box Q1

decreases expression

Fenofibrate results in decreased expression of FOXQ1 mRNA

NCBI chr13:31,742,153...31,744,959
Ensembl chr13:31,740,117...31,744,959

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

Fenofibrate results in decreased expression of G6PC1 mRNA

NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729

G

growth arrest and DNA-damage-inducible 45 alpha

multiple interactions
increases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of GADD45A mRNA
Fenofibrate results in increased expression of GADD45A mRNA

PMID:17264098 PMID:18253720 PMID:18775883 PMID:25596134

NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441

G

growth arrest and DNA-damage-inducible 45 beta

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of GADD45B mRNA

NCBI chr10:80,765,925...80,768,038
Ensembl chr10:80,765,907...80,768,038

G

galactose-1-phosphate uridyl transferase

increases expression

Fenofibrate results in increased expression of GALT mRNA

NCBI chr 4:41,755,517...41,759,243
Ensembl chr 4:41,755,228...41,758,695

G

glycyl-tRNA synthetase 1

increases expression

Fenofibrate results in increased expression of GARS1 mRNA

NCBI chr 6:55,014,986...55,056,489
Ensembl chr 6:55,014,992...55,056,485

G

GATA binding protein 4

multiple interactions

Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]; PPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]]

NCBI chr14:63,436,363...63,509,161
Ensembl chr14:63,436,371...63,509,141

G

1,4-alpha-glucan branching enzyme 1

decreases expression
increases expression

Fenofibrate results in decreased expression of GBE1 mRNA
Fenofibrate results in increased expression of GBE1 mRNA

NCBI chr16:70,110,837...70,366,608
Ensembl chr16:70,110,837...70,366,604

G

glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase)

decreases expression

Fenofibrate results in decreased expression of GCAT mRNA

NCBI chr15:78,915,074...78,926,731
Ensembl chr15:78,915,074...78,922,553
Ensembl chr15:78,915,074...78,922,553

G

glutamate-cysteine ligase, catalytic subunit

decreases expression
multiple interactions

Fenofibrate results in decreased expression of GCLC mRNA
Fenofibrate inhibits the reaction [tyloxapol results in decreased expression of GCLC protein]

PMID:25596134 PMID:36905866

NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767

G

glutamate-cysteine ligase, modifier subunit

increases expression

Fenofibrate results in increased expression of GCLM mRNA

NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381

G

glucosaminyl (N-acetyl) transferase 3, mucin type

increases expression

Fenofibrate results in increased expression of GCNT3 mRNA

NCBI chr 9:69,938,777...69,947,172
Ensembl chr 9:69,938,778...69,945,370

G

glycerophosphodiester phosphodiesterase 1

affects expression

Fenofibrate affects the expression of GDE1 mRNA

NCBI chr 7:118,287,781...118,304,961
Ensembl chr 7:118,287,768...118,305,001

G

growth differentiation factor 15

increases expression

Fenofibrate results in increased expression of GDF15 mRNA

NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106

G

glycerol kinase

increases expression

Fenofibrate results in increased expression of GK mRNA

PMID:25572481 PMID:32741897

NCBI chr X:84,745,543...84,820,425
Ensembl chr X:84,745,543...84,820,425

G

predicted gene, 20348

decreases expression

Fenofibrate results in decreased expression of TP53I3 mRNA

NCBI chr12:4,860,475...4,867,155
Ensembl chr12:4,860,494...4,867,142

G

geminin

increases expression

Fenofibrate results in increased expression of GMNN mRNA

NCBI chr13:24,935,828...24,954,222
Ensembl chr13:24,935,828...24,945,906

G

glycine N-methyltransferase

decreases expression

Fenofibrate results in decreased expression of GNMT mRNA

NCBI chr17:47,036,590...47,040,091
Ensembl chr17:47,036,590...47,040,094

G

glutamic-oxaloacetic transaminase 1, soluble

increases expression
multiple interactions

Fenofibrate results in increased expression of GOT1 mRNA
Fenofibrate inhibits the reaction [Dietary Fats results in increased expression of GOT1 protein]

PMID:25596134 PMID:38216941

NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044

G

glutamatic-oxaloacetic transaminase 2, mitochondrial

increases expression

Fenofibrate results in increased expression of GOT2 mRNA

NCBI chr 8:96,590,761...96,615,029
Ensembl chr 8:96,590,762...96,615,175

G

glycerol-3-phosphate acyltransferase, mitochondrial

increases expression

Fenofibrate results in increased expression of GPAM mRNA

NCBI chr19:55,056,067...55,115,666
Ensembl chr19:55,055,700...55,115,670

G

glycerol-3-phosphate acyltransferase 3

increases expression

Fenofibrate results in increased expression of GPAT3 mRNA

NCBI chr 5:100,994,095...101,046,968
Ensembl chr 5:100,993,579...101,046,968

G

gephyrin

increases expression

Fenofibrate results in increased expression of GPHN mRNA

NCBI chr12:78,264,099...78,731,546
Ensembl chr12:78,273,153...78,731,546

G

glutamic pyruvic transaminase, soluble

multiple interactions

Fenofibrate inhibits the reaction [Dietary Fats results in increased expression of GPT protein]; Fenofibrate inhibits the reaction [Pyrazinamide results in increased expression of GPT protein]
Fenofibrate inhibits the reaction [tyloxapol results in increased expression of GPT protein]

PMID:27071702 PMID:36905866 PMID:38216941

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

glutathione peroxidase 1

multiple interactions

Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX1 mRNA]

NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542

G

glutathione peroxidase 2

multiple interactions
increases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA
Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX2 mRNA]
Fenofibrate results in increased expression of GPX2 mRNA

PMID:17264098 PMID:18253720 PMID:18775883 PMID:31241159

NCBI chr12:76,839,109...76,842,328
Ensembl chr12:76,839,107...76,842,273

G

glutathione peroxidase 3

multiple interactions

Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX3 mRNA]

NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203

G

glutathione peroxidase 4

multiple interactions

Fenofibrate inhibits the reaction [triptolide results in increased expression of GPX4 mRNA]

NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273

G

glutamate receptor, metabotropic 3

increases expression

Fenofibrate results in increased expression of GRM3 mRNA

NCBI chr 5:9,535,235...9,776,087
Ensembl chr 5:9,535,541...9,775,170

G

GrpE-like 2, mitochondrial

increases expression
multiple interactions

Fenofibrate results in increased expression of GRPEL2 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of GRPEL2 mRNA]

NCBI chr18:61,845,495...61,860,068
Ensembl chr18:61,845,495...61,859,396

G

glutathione reductase

increases expression

Fenofibrate results in increased expression of GSR mRNA

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione S-transferase, alpha 1 (Ya)

multiple interactions
increases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA
Fenofibrate results in increased expression of GSTA5 mRNA

PMID:17264098 PMID:18253720 PMID:18775883

NCBI chr 9:78,137,951...78,149,965
Ensembl chr 9:78,137,938...78,149,966

G

glutathione S-transferase, alpha 2 (Yc2)

decreases expression
multiple interactions

Fenofibrate results in decreased expression of GSTA2 mRNA
[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of GSTA2 mRNA

PMID:18253720 PMID:18775883

NCBI chr 9:78,238,300...78,254,474
Ensembl chr 9:78,238,300...78,263,070

G

glutathione S-transferase, mu 2

multiple interactions
decreases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of GSTM2 mRNA
Fenofibrate results in decreased expression of GSTM2 mRNA

PMID:18253720 PMID:18775883

NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769

G

glutathione S-transferase, mu 5

multiple interactions
decreases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of GSTM3 mRNA
Fenofibrate results in decreased expression of GSTM3 mRNA

PMID:18253720 PMID:18775883

NCBI chr 3:107,803,240...107,806,002
Ensembl chr 3:107,803,137...107,806,002

G

glutathione S-transferase, pi 1

multiple interactions

Fenofibrate inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985

G

G two S phase expressed protein 1

increases expression

Fenofibrate results in increased expression of GTSE1 mRNA

NCBI chr15:85,743,928...85,760,774
Ensembl chr15:85,743,946...85,760,774

G

H1.2 linker histone, cluster member

decreases expression

Fenofibrate results in decreased expression of H1-2 mRNA

NCBI chr13:23,922,790...23,923,514
Ensembl chr13:23,922,791...23,924,350

G

histocompatibility 2, class II antigen E beta

decreases expression

Fenofibrate results in decreased expression of H2-EB1 mRNA

NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648

G

histocompatibility 2, Q region locus 1

affects response to substance

HLA-A gene polymorphism affects the susceptibility to Fenofibrate

NCBI chr17:35,539,503...35,547,118
Ensembl chr17:35,539,381...35,544,075

G

hydroxyacyl-Coenzyme A dehydrogenase

increases expression

Fenofibrate results in increased expression of HADH mRNA

NCBI chr 3:131,027,068...131,065,750
Ensembl chr 3:131,027,068...131,065,750

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

increases expression
decreases expression

Fenofibrate results in increased expression of HADHA mRNA
Fenofibrate results in decreased expression of HADHA protein

PMID:16707586 PMID:17118139 PMID:20118634 PMID:25572481

NCBI chr 5:30,324,421...30,359,978
Ensembl chr 5:30,323,302...30,360,160

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

increases expression
decreases expression
affects expression

Fenofibrate results in increased expression of HADHB mRNA
Fenofibrate results in decreased expression of HADHB protein
Fenofibrate affects the expression of HADHB mRNA

PMID:17118139 PMID:20118634 PMID:20801182 PMID:24752549 PMID:25572481

NCBI chr 5:30,360,251...30,389,591
Ensembl chr 5:30,360,246...30,389,591

G

histidine ammonia lyase

decreases expression

Fenofibrate results in decreased expression of HAL mRNA

NCBI chr10:93,324,630...93,352,623
Ensembl chr10:93,324,630...93,355,166

G

histidine decarboxylase

increases expression

Fenofibrate results in increased expression of HDC mRNA; Fenofibrate results in increased expression of HDC protein

PMID:32741897 PMID:32741898

NCBI chr 2:126,435,579...126,465,942
Ensembl chr 2:126,435,587...126,461,219

G

HDGF like 3

increases expression

Fenofibrate results in increased expression of HDGFL3 mRNA

NCBI chr 7:81,531,004...81,587,227
Ensembl chr 7:81,530,999...81,584,221

G

HECT domain E3 ubiquitin protein ligase 1

increases expression
multiple interactions

Fenofibrate results in increased expression of HECTD1 mRNA
[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of HECTD1 mRNA

NCBI chr12:51,790,504...51,876,540
Ensembl chr12:51,790,505...51,876,319

G

hect domain and RLD 3

increases expression

Fenofibrate results in increased expression of HERC3 mRNA

NCBI chr 6:58,808,440...58,897,383
Ensembl chr 6:58,808,450...58,897,383

G

hes family bHLH transcription factor 1

multiple interactions

Fenofibrate inhibits the reaction [triptolide results in increased expression of HES1 mRNA]

NCBI chr16:29,883,259...29,886,614
Ensembl chr16:29,883,202...29,886,614

G

hypoxia inducible factor 1, alpha subunit

increases expression
multiple interactions
affects activity

Fenofibrate results in increased expression of HIF1A mRNA
Fenofibrate inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Fenofibrate results in decreased expression of and results in increased degradation of HIF1A protein
Fenofibrate affects the activity of HIF1A protein

PMID:17118139 PMID:25596134 PMID:34520103

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

hypoxia inducible lipid droplet associated

increases expression

Fenofibrate results in increased expression of HILPDA mRNA

NCBI chr 6:29,272,487...29,275,448
Ensembl chr 6:29,272,487...29,275,445

G

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

increases expression
decreases expression
multiple interactions

Fenofibrate results in increased expression of HMGCR mRNA
Fenofibrate results in decreased expression of HMGCR mRNA
NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of HMGCR mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of HMGCR mRNA]

PMID:16595124 PMID:23063693

NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444

G

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1

increases expression

Fenofibrate results in increased expression of HMGCS1 mRNA

NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796

G

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2

increases expression

Fenofibrate results in increased expression of HMGCS2 mRNA

PMID:25572481 PMID:27665778 PMID:32741897

NCBI chr 3:98,187,747...98,218,054
Ensembl chr 3:98,187,751...98,218,054

G

heme oxygenase 1

increases expression
multiple interactions

Fenofibrate results in increased expression of HMOX1 mRNA
dorsomorphin inhibits the reaction [Fenofibrate results in increased expression of HMOX1 protein]
Fenofibrate results in increased expression of HMOX1 mRNA; Fenofibrate results in increased expression of HMOX1 protein

PMID:25596134 PMID:34520103

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

4-hydroxy-2-oxoglutarate aldolase 1

decreases expression

Fenofibrate results in decreased expression of HOGA1 mRNA

NCBI chr19:42,033,998...42,060,128
Ensembl chr19:42,034,049...42,059,392

G

Harvey rat sarcoma virus oncogene

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of HRAS mRNA

NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918

G

hydroxysteroid 11-beta dehydrogenase 1

increases expression

Fenofibrate results in increased expression of HSD11B1 mRNA

NCBI chr 1:192,903,917...192,946,345
Ensembl chr 1:192,903,942...192,946,383

G

hydroxysteroid (17-beta) dehydrogenase 4

increases expression

Fenofibrate results in increased expression of HSD17B4 mRNA

PMID:17118139 PMID:25572481

NCBI chr18:50,261,268...50,329,337
Ensembl chr18:50,261,268...50,329,336

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5

decreases expression

Fenofibrate results in decreased expression of HSD3B5 mRNA

NCBI chr 3:98,525,952...98,552,850
Ensembl chr 3:98,525,950...98,537,568

G

hydroxysteroid dehydrogenase like 2

increases expression

Fenofibrate results in increased expression of HSDL2 mRNA

NCBI chr 4:59,581,515...59,618,694
Ensembl chr 4:59,581,563...59,618,689

G

heat shock factor 1

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of HSF1 mRNA

NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113

G

heat shock protein 90, alpha (cytosolic), class A member 1

increases expression
multiple interactions

Fenofibrate results in increased expression of HSP90AA1 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of HSP90AA1 mRNA]

NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162

G

heat shock protein 90 alpha (cytosolic), class B member 1

multiple interactions
increases expression

PPARA protein affects the reaction [Fenofibrate results in increased expression of HSP90AB1 mRNA]

NCBI chr17:45,878,704...45,884,187
Ensembl chr17:45,878,701...45,884,197

G

heat shock protein 90, beta (Grp94), member 1

increases expression

Fenofibrate results in increased expression of HSP90B1 mRNA

NCBI chr10:86,526,705...86,541,308
Ensembl chr10:86,526,073...86,541,373

G

heat shock protein 70 family, member 13

decreases expression
multiple interactions

Fenofibrate results in decreased expression of HSPA13 mRNA
PPARA protein affects the reaction [Fenofibrate results in decreased expression of HSPA13 mRNA]

NCBI chr16:75,552,078...75,564,575
Ensembl chr16:75,542,319...75,563,992

G

heat shock protein 4 like

increases expression
multiple interactions

Fenofibrate results in increased expression of HSPA4L mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPA4L mRNA]

NCBI chr 3:40,698,664...40,750,538
Ensembl chr 3:40,699,814...40,750,538

G

heat shock protein 5

decreases expression
multiple interactions

Fenofibrate results in decreased expression of HSPA5 mRNA
Fenofibrate inhibits the reaction [Dietary Fats results in increased expression of HSPA5 protein]

PMID:25596134 PMID:38216941

NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559

G

heat shock protein 8

increases expression
multiple interactions

Fenofibrate results in increased expression of HSPA8 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPA8 mRNA]

NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383

G

heat shock protein 9

increases expression
multiple interactions

Fenofibrate results in increased expression of HSPA9 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPA9 mRNA]

NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410

G

heat shock protein 1

affects expression
multiple interactions
increases expression

Fenofibrate affects the expression of HSPB1 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPB1 mRNA]

PMID:20801182 PMID:21318169

NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417

G

heat shock protein 8

multiple interactions
increases expression

[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of HSPB8 mRNA
Fenofibrate results in increased expression of HSPB8 mRNA

NCBI chr 5:116,546,550...116,560,923
Ensembl chr 5:116,546,550...116,560,923

G

heat shock protein 1 (chaperonin 10)

affects expression

Fenofibrate affects the expression of HSPE1 mRNA

NCBI chr 1:55,127,307...55,130,476
Ensembl chr 1:55,127,291...55,130,466

G

heat shock 105kDa/110kDa protein 1

increases expression
multiple interactions

Fenofibrate results in increased expression of HSPH1 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPH1 mRNA]

NCBI chr 5:149,540,308...149,562,594
Ensembl chr 5:149,537,752...149,559,841

G

HIV-1 Tat interactive protein 2

increases expression

Fenofibrate results in increased expression of HTATIP2 mRNA

NCBI chr 7:49,408,761...49,423,748
Ensembl chr 7:49,408,863...49,423,723

G

isoleucyl-tRNA synthetase 1

increases expression

Fenofibrate results in increased expression of IARS1 mRNA

NCBI chr13:49,835,606...49,887,743
Ensembl chr13:49,835,576...49,887,743

G

intercellular adhesion molecule 1

multiple interactions

Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]
dorsomorphin inhibits the reaction [Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of ICAM1 mRNA]]; Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of ICAM1 mRNA]

PMID:20580385 PMID:21300114

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

inhibitor of DNA binding 2

decreases expression

Fenofibrate results in decreased expression of ID2 mRNA

NCBI chr12:25,143,798...25,146,091
Ensembl chr12:25,143,798...25,147,139

G

isocitrate dehydrogenase 3 (NAD+) beta

increases expression

Fenofibrate results in increased expression of IDH3B mRNA

NCBI chr 2:130,121,229...130,126,371
Ensembl chr 2:130,121,229...130,126,467

G

intermediate filament family orphan 1

increases expression

Fenofibrate results in increased expression of IFFO1 mRNA

NCBI chr 6:125,122,167...125,138,746
Ensembl chr 6:125,122,204...125,138,745

G

interferon gamma

multiple interactions

Fenofibrate results in decreased susceptibility to [IFNG protein co-treated with IL1B protein]

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

insulin-like growth factor 2 receptor

decreases expression

Fenofibrate results in decreased expression of IGF2R mRNA

NCBI chr17:12,901,293...12,988,593
Ensembl chr17:12,901,293...12,988,551

G

interleukin 12b

multiple interactions

Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]

NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860

G

interleukin 17 receptor B

decreases expression

Fenofibrate results in decreased expression of IL17RB mRNA

NCBI chr14:29,718,125...29,730,853
Ensembl chr14:29,718,092...29,730,853

G

interleukin 1 beta

multiple interactions

[Fenofibrate co-treated with Alitretinoin] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Fenofibrate inhibits the reaction [triptolide results in increased expression of IL1B mRNA]
Fenofibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]
Fenofibrate inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]; Fenofibrate promotes the reaction [Pioglitazone inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]]; Fenofibrate results in decreased susceptibility to [IFNG protein co-treated with IL1B protein]; Pioglitazone promotes the reaction [Fenofibrate inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]]

PMID:15968640 PMID:20631892 PMID:21300114 PMID:31241159 PMID:32613381 More...

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 6

multiple interactions
affects response to substance

[Fenofibrate co-treated with Alitretinoin] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 mRNA]; Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of IL6 mRNA]; Fenofibrate inhibits the reaction [triptolide results in increased expression of IL6 mRNA]; Fenofibrate inhibits the reaction [tyloxapol results in increased expression of IL6 mRNA]; Fenofibrate promotes the reaction [Dextran Sulfate results in increased expression of IL6 protein]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of IL6 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 mRNA]]
IL6 promoter polymorphism affects the susceptibility to Fenofibrate

PMID:15968640 PMID:16607077 PMID:19593819 PMID:21300114 PMID:25035112 More...

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

insulin I

multiple interactions

Fenofibrate inhibits the reaction [Fructose results in increased secretion of INS1 protein]

NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914

G

insulin II

multiple interactions

Fenofibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]

NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118

G

insulin induced gene 1

decreases expression

Fenofibrate results in decreased expression of INSIG1 mRNA

NCBI chr 5:28,276,410...28,283,660
Ensembl chr 5:28,276,361...28,283,660

G

insulin induced gene 2

decreases expression

Fenofibrate results in decreased expression of INSIG2 mRNA

NCBI chr 1:121,232,082...121,260,391
Ensembl chr 1:121,232,082...121,260,318

G

interleukin-1 receptor-associated kinase 2

increases expression

Fenofibrate results in increased expression of IRAK2 mRNA

NCBI chr 6:113,615,428...113,671,987
Ensembl chr 6:113,615,428...113,671,987

G

interferon regulatory factor 7

increases expression

Fenofibrate results in increased expression of IRF7 mRNA

NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394

G

itchy, E3 ubiquitin protein ligase

multiple interactions
decreases expression

PPARA protein affects the reaction [Fenofibrate results in decreased expression of ITCH mRNA]

NCBI chr 2:154,975,401...155,068,775
Ensembl chr 2:154,975,429...155,068,775

G

integrin alpha FG-GAP repeat containing 2

increases expression

Fenofibrate results in increased expression of ITFG2 mRNA

NCBI chr 6:128,386,407...128,401,873
Ensembl chr 6:128,386,407...128,401,894

G

integrin beta 1 (fibronectin receptor beta)

decreases expression

Fenofibrate results in decreased expression of ITGB1 mRNA

NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681

G

integrin beta 3

affects expression

Fenofibrate affects the expression of ITGB3 mRNA

NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302

G

jun proto-oncogene

multiple interactions

Fenofibrate inhibits the reaction [Glucose results in increased expression of JUN protein]
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of JUN mRNA; Fenofibrate affects the reaction [[AHR protein affects the susceptibility to AGT protein] which affects the expression of JUN mRNA]

PMID:16600694 PMID:18978307 PMID:31016362

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

potassium channel, subfamily K, member 13

increases expression

Fenofibrate results in increased expression of KCNK13 mRNA

PMID:25572481 PMID:25596134

NCBI chr12:99,928,132...100,028,941
Ensembl chr12:99,930,758...100,028,941

G

kelch-like ECH-associated protein 1

multiple interactions

Fenofibrate inhibits the reaction [tyloxapol results in increased expression of KEAP1 protein]

NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657

G

kinesin family member 22

increases expression

Fenofibrate results in increased expression of KIF22 mRNA

NCBI chr 7:126,626,901...126,641,639
Ensembl chr 7:126,626,901...126,641,643

G

kinesin family member C1

increases expression

Fenofibrate results in increased expression of KIFC1 mRNA

NCBI chr17:34,094,640...34,109,607
Ensembl chr17:34,094,633...34,109,635

G

Kruppel-like transcription factor 10

decreases expression
increases expression

Fenofibrate results in decreased expression of KLF10 mRNA
Fenofibrate results in increased expression of KLF10 mRNA

PMID:11798191 PMID:25572481

NCBI chr15:38,291,702...38,300,950
Ensembl chr15:38,291,707...38,300,950

G

Kruppel-like transcription factor 11

increases expression

Fenofibrate results in increased expression of KLF11 mRNA

NCBI chr12:24,701,370...24,712,781
Ensembl chr12:24,701,273...24,712,788

G

keratin 18

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of KRT18 protein

NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462

G

keratin 23

increases expression

Fenofibrate results in increased expression of KRT23 mRNA

NCBI chr11:99,368,799...99,383,946
Ensembl chr11:99,368,800...99,383,963

G

keratin 8

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of KRT8 protein

NCBI chr15:101,905,146...101,912,777
Ensembl chr15:101,905,133...101,912,917

G

keratin associated protein 1-4

increases expression

Fenofibrate results in increased expression of KRTAP1-5 mRNA

NCBI chr11:99,473,375...99,474,503
Ensembl chr11:99,473,888...99,474,480

G

laminin, alpha 4

increases expression

Fenofibrate results in increased expression of LAMA4 mRNA

NCBI chr10:38,841,511...38,986,184
Ensembl chr10:38,841,511...38,986,184

G

leucyl-tRNA synthetase 1

increases expression
decreases expression

Fenofibrate results in increased expression of LARS1 mRNA
Fenofibrate results in decreased expression of LARS1 mRNA

NCBI chr18:42,335,363...42,395,302
Ensembl chr18:42,335,363...42,395,259

G

limb-bud and heart

increases expression

Fenofibrate results in increased expression of LBH mRNA

NCBI chr17:73,225,300...73,248,941
Ensembl chr17:73,225,300...73,248,942

G

lactate dehydrogenase B

increases expression

Fenofibrate results in increased expression of LDHB mRNA

NCBI chr 6:142,435,975...142,453,683
Ensembl chr 6:142,435,975...142,453,683

G

leptin

multiple interactions

[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of LEP mRNA]; Fenofibrate inhibits the reaction [Fructose results in increased expression of LEP mRNA]
Fenofibrate inhibits the reaction [Arsenic Trioxide results in decreased expression of and results in decreased secretion of LEP protein]

PMID:26973390 PMID:32929351

NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876

G

lectin, galactose binding, soluble 1

increases expression

Fenofibrate results in increased expression of LGALS1 mRNA

NCBI chr15:78,810,925...78,814,665
Ensembl chr15:78,810,925...78,814,665

G

LIF receptor alpha

decreases expression

Fenofibrate results in decreased expression of LIFR mRNA

NCBI chr15:7,120,091...7,226,970
Ensembl chr15:7,120,095...7,226,970

G

LIM and cysteine-rich domains 1

affects expression

Fenofibrate affects the expression of LMCD1 mRNA

NCBI chr 6:112,250,747...112,307,384
Ensembl chr 6:112,250,719...112,307,386

G

ligand of numb-protein X 1

multiple interactions
decreases expression

PPARA protein affects the reaction [Fenofibrate results in decreased expression of LNX1 mRNA]

NCBI chr 5:74,753,108...74,865,203
Ensembl chr 5:74,753,108...74,863,573

G

lysophosphatidylcholine acyltransferase 2

increases expression

Fenofibrate results in increased expression of LPCAT2 mRNA

NCBI chr 8:93,581,948...93,645,907
Ensembl chr 8:93,581,967...93,645,907

G

lysophosphatidylcholine acyltransferase 3

increases expression

Fenofibrate results in increased expression of LPCAT3 mRNA

NCBI chr 6:124,639,887...124,681,142
Ensembl chr 6:124,639,990...124,681,381

G

lipoprotein lipase

increases expression
multiple interactions
increases activity

Fenofibrate results in increased expression of LPL mRNA; Fenofibrate results in increased expression of LPL protein
PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LPL mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LPL protein]
PPARA protein promotes the reaction [Fenofibrate results in increased expression of LPL protein]
Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of LPL mRNA]
Fenofibrate results in increased activity of LPL protein

PMID:8593127 PMID:11798191 PMID:16595124 PMID:24752549 PMID:27071702

NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100

G

leucine rich repeat containing 31

increases expression

Fenofibrate results in increased expression of LRRC31 mRNA

NCBI chr 3:30,732,703...30,753,992
Ensembl chr 3:30,732,703...30,753,992

G

leucine rich repeat and sterile alpha motif containing 1

multiple interactions
decreases expression

PPARA protein affects the reaction [Fenofibrate results in decreased expression of LRSAM1 mRNA]

NCBI chr 2:32,815,227...32,851,666
Ensembl chr 2:32,815,228...32,851,626

G

lanosterol synthase

increases expression
multiple interactions

Fenofibrate results in increased expression of LSS mRNA
NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LSS mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LSS mRNA]

NCBI chr10:76,367,303...76,392,973
Ensembl chr10:76,367,422...76,392,972

G

listerin E3 ubiquitin protein ligase 1

decreases expression

Fenofibrate results in decreased expression of LTN1 mRNA

NCBI chr16:87,173,539...87,229,504
Ensembl chr16:87,173,539...87,229,500

G

lymphocyte antigen 6 family member D

increases expression

Fenofibrate results in increased expression of LY6D mRNA

NCBI chr15:74,633,905...74,635,416
Ensembl chr15:74,633,905...74,635,469

G

LYR motif containing 1

increases expression

Fenofibrate results in increased expression of LYRM1 mRNA

NCBI chr 7:119,495,038...119,515,979
Ensembl chr 7:119,495,084...119,556,186

G

lysozyme 2

decreases expression

Fenofibrate results in decreased expression of LYZ2 mRNA

NCBI chr10:117,113,446...117,118,177
Ensembl chr10:117,113,236...117,118,226

G

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)

decreases expression
increases expression

Fenofibrate results in decreased expression of MAFG mRNA
Fenofibrate results in increased expression of MAFG mRNA

NCBI chr11:120,515,943...120,525,771
Ensembl chr11:120,515,943...120,524,426

G

mannosidase 1, alpha

decreases expression

Fenofibrate results in decreased expression of MAN1A mRNA

NCBI chr10:53,780,881...53,952,712
Ensembl chr10:53,780,881...53,952,705

G

mannosidase, alpha, class 1A, member 2

decreases expression

Fenofibrate results in decreased expression of MAN1A2 mRNA

NCBI chr 3:100,469,519...100,592,789
Ensembl chr 3:100,469,524...100,592,819

G

monoamine oxidase B

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of MAOB mRNA

NCBI chr X:16,575,520...16,683,605
Ensembl chr X:16,575,521...16,683,605

G

microtubule-associated protein 1 light chain 3 alpha

increases expression
multiple interactions

Fenofibrate results in increased expression of MAP1LC3A mRNA
[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of MAP1LC3A mRNA

NCBI chr 2:155,118,284...155,119,993
Ensembl chr 2:155,118,217...155,119,993

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

Fenofibrate inhibits the reaction [tyloxapol results in increased lipidation of MAP1LC3B protein]

NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499

G

mitogen-activated protein kinase kinase kinase 13

increases expression

Fenofibrate results in increased expression of MAP3K13 mRNA

NCBI chr16:21,643,923...21,752,189
Ensembl chr16:21,613,096...21,752,189

G

methionine adenosyltransferase 2A

decreases expression

Fenofibrate results in decreased expression of MAT2A mRNA

NCBI chr 6:72,409,779...72,416,539
Ensembl chr 6:72,409,782...72,416,541

G

melanocortin 1 receptor

decreases expression
multiple interactions

Fenofibrate results in decreased expression of MC1R mRNA
[Fenofibrate results in decreased expression of MC1R mRNA] which results in decreased chemical synthesis of Melanins

NCBI chr 8:124,133,839...124,137,483
Ensembl chr 8:124,133,846...124,137,483

G

malate dehydrogenase 2, NAD (mitochondrial)

increases expression

Fenofibrate results in increased expression of MDH mRNA

NCBI chr 5:135,807,503...135,819,240
Ensembl chr 5:135,807,334...135,819,252

G

transformed mouse 3T3 cell double minute 2

decreases expression

Fenofibrate results in decreased expression of MDM2 mRNA

NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663

G

malic enzyme 1, NADP(+)-dependent, cytosolic

affects expression
increases expression
multiple interactions

Fenofibrate affects the expression of ME1 mRNA
Fenofibrate results in increased expression of ME1 mRNA
NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ME1 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ME1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ME1 mRNA]

PMID:20801182 PMID:23063693 PMID:25596134 PMID:27071702

NCBI chr 9:86,463,416...86,577,967
Ensembl chr 9:86,463,424...86,578,006

G

MER proto-oncogene tyrosine kinase

increases expression

Fenofibrate results in increased expression of MERTK mRNA

NCBI chr 2:128,540,836...128,645,082
Ensembl chr 2:128,540,876...128,644,814

G

mitofusin 2

multiple interactions

Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of MFN2 protein]

NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161

G

MFSD2 lysolipid transporter A, lysophospholipid

decreases expression

Fenofibrate results in decreased expression of MFSD2A mRNA

NCBI chr 4:122,840,643...122,855,844
Ensembl chr 4:122,840,643...122,854,981

G

monoglyceride lipase

increases expression

Fenofibrate results in increased expression of MGLL mRNA

PMID:11798191 PMID:17118139 PMID:27665778

NCBI chr 6:88,701,397...88,805,342
Ensembl chr 6:88,701,394...88,805,342

G

O-6-methylguanine-DNA methyltransferase

multiple interactions
increases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of MGMT mRNA
Fenofibrate results in increased expression of MGMT mRNA

PMID:17264098 PMID:18253720

NCBI chr 7:136,496,315...136,732,001
Ensembl chr 7:136,496,343...136,731,995

G

mahogunin, ring finger 1

increases expression
multiple interactions

Fenofibrate results in increased expression of MGRN1 mRNA
[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of MGRN1 mRNA

NCBI chr16:4,703,964...4,756,160
Ensembl chr16:4,704,113...4,756,160

G

microsomal glutathione S-transferase 3

increases expression

Fenofibrate results in increased expression of MGST3 mRNA

NCBI chr 1:167,199,535...167,221,410
Ensembl chr 1:167,199,535...167,221,410

G

melanogenesis associated transcription factor

decreases expression

Fenofibrate results in decreased expression of MITF mRNA; Fenofibrate results in decreased expression of MITF protein

NCBI chr 6:97,783,966...97,998,321
Ensembl chr 6:97,784,013...97,998,310

G

antigen identified by monoclonal antibody Ki 67

increases expression

Fenofibrate results in increased expression of MKI67 mRNA; Fenofibrate results in increased expression of MKI67 protein

PMID:17264098 PMID:32741897

NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090

G

mutL homolog 1

multiple interactions
increases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of MLH1 mRNA; [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of MLH1 mRNA
Fenofibrate results in increased expression of MLH1 mRNA

PMID:17264098 PMID:18253720 PMID:18775883

NCBI chr 9:111,057,296...111,100,854
Ensembl chr 9:111,057,296...111,100,859

G

malonyl-CoA decarboxylase

multiple interactions

[Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]; Fenofibrate inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]; Fenofibrate promotes the reaction [PPARA protein results in increased expression of MLYCD mRNA]

PMID:14641110 PMID:26973390

NCBI chr 8:120,121,591...120,148,577
Ensembl chr 8:120,121,617...120,137,841

G

monocyte to macrophage differentiation-associated

increases expression

Fenofibrate results in increased expression of MMD mRNA

NCBI chr11:90,078,513...90,169,399
Ensembl chr11:90,140,282...90,169,415

G

matrix metallopeptidase 19

increases expression

Fenofibrate results in increased expression of MMP19 mRNA

NCBI chr10:128,626,779...128,636,696
Ensembl chr10:128,626,779...128,636,693

G

matrix metallopeptidase 1b (interstitial collagenase)

decreases expression

Fenofibrate results in decreased expression of MMP1 protein

NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047

G

matrix metallopeptidase 2

decreases expression

Fenofibrate results in decreased expression of MMP2 protein

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 7

decreases expression

Fenofibrate results in decreased expression of MMP7 protein

NCBI chr 9:7,692,095...7,699,587
Ensembl chr 9:7,692,091...7,699,586

G

matrix metallopeptidase 9

multiple interactions
decreases expression

Fenofibrate inhibits the reaction [Dinoprostone results in increased expression of MMP9 mRNA]; Fenofibrate inhibits the reaction [Dinoprostone results in increased secretion of MMP9 protein]; Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP9 protein]
Fenofibrate results in decreased expression of MMP9 protein

PMID:19880272 PMID:21075133 PMID:25545733

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

melanocortin 2 receptor accessory protein

increases expression

Fenofibrate results in increased expression of MRAP mRNA

NCBI chr16:90,535,095...90,546,673
Ensembl chr16:90,535,095...90,546,673

G

membrane-spanning 4-domains, subfamily A, member 10

decreases expression

Fenofibrate results in decreased expression of MS4A10 mRNA

NCBI chr19:10,939,653...10,952,088
Ensembl chr19:10,939,657...10,952,034

G

musculin

decreases expression

Fenofibrate results in decreased expression of MSC mRNA

NCBI chr 1:14,823,570...14,826,216
Ensembl chr 1:14,823,570...14,826,216

G

methylsterol monoxygenase 1

affects expression

Fenofibrate affects the expression of MSMO1 mRNA

NCBI chr 8:65,171,157...65,186,822
Ensembl chr 8:65,171,173...65,186,826

G

microsomal triglyceride transfer protein

increases expression

Fenofibrate results in increased expression of MTTP mRNA

NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729

G

myelocytomatosis oncogene

multiple interactions
increases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of MYC mRNA
Fenofibrate results in increased expression of MYC mRNA

PMID:18978307 PMID:32741897

NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223

G

myosin, light polypeptide kinase

decreases expression

Fenofibrate results in decreased expression of MYLK mRNA

NCBI chr16:34,565,569...34,822,806
Ensembl chr16:34,565,580...34,822,790

G

NEDD4 binding protein 2-like 1

increases expression

Fenofibrate results in increased expression of N4BP2L1 mRNA

NCBI chr 5:150,495,108...150,518,288
Ensembl chr 5:150,495,109...150,520,653

G

nucleus accumbens associated 1, BEN and BTB (POZ) domain containing

increases expression

Fenofibrate results in increased expression of NACC1 mRNA

NCBI chr 8:85,397,106...85,414,528
Ensembl chr 8:85,397,108...85,414,531

G

nicotinamide phosphoribosyltransferase

increases expression

Fenofibrate results in increased expression of NAMPT mRNA

NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348

G

asparaginyl-tRNA synthetase 1

affects expression

Fenofibrate affects the expression of NARS1 mRNA

NCBI chr18:64,632,726...64,649,586
Ensembl chr18:64,632,718...64,649,723

G

N-acetyltransferase 8 (GCN5-related) family member 3

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of NAT8F3 mRNA

NCBI chr 6:85,737,613...85,742,726
Ensembl chr 6:85,709,495...85,742,736

G

nibrin

multiple interactions
increases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of NBN mRNA
Fenofibrate results in increased expression of NBN mRNA

PMID:17264098 PMID:18253720 PMID:18775883

NCBI chr 4:15,955,388...15,992,589
Ensembl chr 4:15,957,925...15,992,589

G

neutral cholesterol ester hydrolase 1

increases expression

Fenofibrate results in increased expression of NCEH1 mRNA

NCBI chr 3:27,237,153...27,299,112
Ensembl chr 3:27,237,114...27,338,757

G

NADH:ubiquinone oxidoreductase subunit AB1

increases expression

Fenofibrate results in increased expression of NDUFAB1 mRNA

NCBI chr 7:121,686,038...121,701,071
Ensembl chr 7:121,684,626...121,701,109

G

nuclear paraspeckle assembly transcript 1 (non-protein coding)

increases expression

Fenofibrate results in increased expression of NEAT1 mRNA; Fenofibrate results in increased expression of NEAT1 mRNA alternative form

NCBI chr19:5,874,736...5,895,508
Ensembl chr19:5,874,736...5,895,898

G

neural precursor cell expressed, developmentally down-regulated 4

increases expression
multiple interactions

Fenofibrate results in increased expression of NEDD4 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of NEDD4 mRNA]

NCBI chr 9:72,569,613...72,657,133
Ensembl chr 9:72,569,628...72,657,134

G

neural precursor cell expressed, developmentally down-regulated gene 9

decreases expression

Fenofibrate results in decreased expression of NEDD9 mRNA

NCBI chr13:41,463,392...41,640,836
Ensembl chr13:41,463,057...41,640,838

G

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4

multiple interactions

EDN1 protein promotes the reaction [Fenofibrate promotes the reaction [NFATC4 protein binds to PPARA protein]]; Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]; Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to NPPB promoter]]; Fenofibrate promotes the reaction [NFATC4 protein binds to PPARA protein]; PPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]]

NCBI chr14:56,062,252...56,071,400
Ensembl chr14:56,060,601...56,071,400

G

nuclear factor, erythroid derived 2, like 2

multiple interactions
increases activity
decreases expression
affects activity

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of NFE2L2 protein
Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of NFE2L2 protein]
Fenofibrate inhibits the reaction [triptolide results in increased expression of NFE2L2 mRNA]; Fenofibrate inhibits the reaction [triptolide results in increased expression of NFE2L2 protein]
Fenofibrate results in increased activity of NFE2L2 protein
Fenofibrate results in decreased expression of NFE2L2 mRNA
Fenofibrate affects the activity of NFE2L2 protein

PMID:18775883 PMID:25596134 PMID:30114225 PMID:30203046 PMID:31241159 More...

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

multiple interactions
affects localization

Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of NFKB1 protein]
Fenofibrate affects the localization of NFKB1 protein

PMID:20580385 PMID:25545733

NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

multiple interactions
decreases expression

Fenofibrate inhibits the reaction [ALB protein modified form results in increased degradation of NFKBIA protein]
Fenofibrate results in decreased expression of NFKBIA protein modified form

PMID:20580385 PMID:25545733

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of NFKBIB mRNA; [Fenofibrate co-treated with Sodium Glutamate] results in increased expression of NFKBIB mRNA

PMID:18253720 PMID:21999347

NCBI chr 7:28,457,676...28,466,069
Ensembl chr 7:28,457,676...28,466,937

G

NIM1 serine/threonine protein kinase

increases expression

Fenofibrate results in increased expression of NIM1K mRNA

NCBI chr13:120,171,630...120,217,418
Ensembl chr13:120,171,630...120,217,418

G

ninjurin 1

affects expression

Fenofibrate affects the expression of NINJ1 mRNA

NCBI chr13:49,341,005...49,349,727
Ensembl chr13:49,340,961...49,349,720

G

neuromedin U receptor 1

decreases expression

Fenofibrate results in decreased expression of NMUR1 mRNA

NCBI chr 1:86,313,964...86,317,083
Ensembl chr 1:86,314,025...86,353,950

G

nicotinamide N-methyltransferase

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of NNMT mRNA

NCBI chr 9:48,448,905...48,518,958
Ensembl chr 9:48,503,177...48,516,453

G

nitric oxide synthase 2, inducible

multiple interactions

Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
[Fenofibrate co-treated with Sodium Glutamate] results in increased expression of NOS2 mRNA; [Fenofibrate co-treated with Sodium Glutamate] results in increased expression of NOS2 protein

PMID:21300114 PMID:21999347

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nitric oxide synthase 3, endothelial cell

multiple interactions
increases phosphorylation
increases activity

dorsomorphin inhibits the reaction [Fenofibrate results in increased activity of NOS3 protein]; Fenofibrate inhibits the reaction [Wortmannin results in decreased phosphorylation of NOS3 protein]; PRKAA1 protein affects the reaction [Fenofibrate results in increased activity of NOS3 protein]
Fenofibrate results in increased phosphorylation of NOS3 protein

PMID:16442496 PMID:20580385

NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472

G

notch 1

multiple interactions

Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH1 mRNA]

NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675

G

notch 3

multiple interactions

Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH3 mRNA]; Fenofibrate inhibits the reaction [triptolide results in increased expression of NOTCH3 protein]

NCBI chr17:32,339,794...32,385,869
Ensembl chr17:32,339,794...32,385,826

G

natriuretic peptide type A

multiple interactions

Fenofibrate inhibits the reaction [Doxorubicin results in decreased expression of NPPA mRNA]

NCBI chr 4:148,085,179...148,086,531
Ensembl chr 4:148,085,179...148,086,536

G

natriuretic peptide type B

multiple interactions

Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to NPPB promoter]]; Fenofibrate inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; PPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]]

NCBI chr 4:148,070,264...148,071,662
Ensembl chr 4:148,070,245...148,071,662

G

nuclear receptor subfamily 0, group B, member 2

multiple interactions
increases expression

Dactinomycin inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA]; dorsomorphin inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [NR4A1 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]]; pyrazolanthrone inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA]
[Methionine deficiency co-treated with Choline deficiency co-treated with Fenofibrate] results in increased expression of NR0B2 mRNA; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of IL6 mRNA]]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA]]; NR0B2 protein promotes the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Fenofibrate] results in increased expression of CYP4A14 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of FAS mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of IL6 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TIMP1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]]
Fenofibrate results in increased expression of NR0B2 mRNA; Fenofibrate results in increased expression of NR0B2 protein

NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847

G

nuclear receptor subfamily 1, group H, member 2

increases expression
multiple interactions

Fenofibrate results in increased expression of NR1H2 mRNA
NR1H2 gene mutant form affects the reaction [Fenofibrate results in increased expression of ACACB mRNA]; NR1H2 gene mutant form affects the reaction [Fenofibrate results in increased expression of SCD1 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACACA mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A10 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A14 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ELOVL6 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FASN mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FDFT1 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of HMGCR mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LSS mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ME1 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of PPARA mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SCD2 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SQLE mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SREBF1 mRNA]

PMID:19201410 PMID:23063693

NCBI chr 7:44,199,040...44,204,928
Ensembl chr 7:44,199,040...44,203,375

G

nuclear receptor subfamily 1, group H, member 3

increases expression
multiple interactions
affects response to substance

Fenofibrate results in increased expression of NR1H3 mRNA
NR1H3 gene mutant form affects the reaction [Fenofibrate results in increased expression of ACACB mRNA]; NR1H3 gene mutant form affects the reaction [Fenofibrate results in increased expression of SCD1 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACACA mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A10 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A14 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ELOVL6 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FASN mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FDFT1 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of HMGCR mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LSS mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ME1 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of PPARA mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SCD2 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SQLE mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SREBF1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of NR1H3 mRNA]
NR1H3 protein affects the susceptibility to Fenofibrate
[Oleic Acid co-treated with Fenofibrate] affects the expression of NR1H3 mRNA; NR1H3 protein affects the reaction [Fenofibrate results in increased expression of PPARA mRNA]

PMID:19201410 PMID:23063693 PMID:24534255 PMID:25949234

NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions
increases expression

[Oleic Acid co-treated with Fenofibrate] results in decreased expression of NR1H4 mRNA
fenofibrate increases expression of Nr1h4 mRNA in steatotic liver

CTD
RGD

PMID:24534255 PMID:30257410

NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

Fenofibrate binds to and results in increased activity of NR1I2 protein

NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186

G

nuclear receptor subfamily 1, group I, member 3

affects localization
increases activity
multiple interactions
increases expression

Fenofibrate affects the localization of NR1I3 protein
Fenofibrate results in increased activity of NR1I3 protein
[Oleic Acid co-treated with Fenofibrate] results in increased expression of NR1I3 mRNA; Fenofibrate binds to and results in increased activity of NR1I3 protein alternative form
Fenofibrate results in increased expression of NR1I3 mRNA

PMID:17962186 PMID:19118567 PMID:24534255 PMID:30203046 PMID:31312845 More...

NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270

G

nuclear receptor subfamily 4, group A, member 1

multiple interactions

Fenofibrate inhibits the reaction [NR4A1 protein results in increased expression of SERPINE1 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [NR4A1 protein results in increased expression of SERPINE1 mRNA]]

NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676

G

neuronal regeneration related protein

decreases expression

Fenofibrate results in decreased expression of NREP mRNA

NCBI chr18:33,570,072...33,597,444
Ensembl chr18:33,570,072...33,597,082

G

NAD(P) dependent steroid dehydrogenase-like

increases expression

Fenofibrate results in increased expression of NSDHL mRNA

NCBI chr X:71,962,127...72,002,134
Ensembl chr X:71,962,163...72,002,120

G

nucleoside-triphosphatase, cancer-related

affects expression

Fenofibrate affects the expression of NTPCR mRNA

NCBI chr 8:126,456,724...126,474,974
Ensembl chr 8:126,456,702...126,474,974

G

NUAK family, SNF1-like kinase, 1

decreases expression

Fenofibrate results in decreased expression of NUAK1 mRNA

NCBI chr10:84,206,764...84,282,028
Ensembl chr10:84,206,769...84,276,461

G

2'-5' oligoadenylate synthetase-like 1

increases expression

Fenofibrate results in increased expression of OASL mRNA

NCBI chr 5:115,061,236...115,075,970
Ensembl chr 5:115,061,299...115,075,974

G

OPA1, mitochondrial dynamin like GTPase

multiple interactions

Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of OPA1 protein]

NCBI chr16:29,398,099...29,481,924
Ensembl chr16:29,398,152...29,473,702

G

ORAI calcium release-activated calcium modulator 3

decreases expression

Fenofibrate results in decreased expression of ORAI3 mRNA

NCBI chr 7:127,368,987...127,374,322
Ensembl chr 7:127,368,987...127,374,322

G

orosomucoid 2

decreases expression

Fenofibrate results in decreased expression of ORM2 mRNA

NCBI chr 4:63,280,543...63,284,114
Ensembl chr 4:63,280,686...63,284,115

G

oxidative stress induced growth inhibitor 1

decreases expression

Fenofibrate results in decreased expression of OSGIN1 mRNA

NCBI chr 8:120,160,874...120,172,996
Ensembl chr 8:120,160,863...120,172,995

G

procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide

affects expression

Fenofibrate affects the expression of P4HA1 mRNA

NCBI chr10:59,159,019...59,209,126
Ensembl chr10:59,159,118...59,209,126

G

prolyl 4-hydroxylase, beta polypeptide

affects expression

Fenofibrate affects the expression of P4HB mRNA

NCBI chr11:120,451,124...120,464,079
Ensembl chr11:120,451,124...120,464,079

G

pantothenate kinase 1

increases expression

Fenofibrate results in increased expression of PANK1 mRNA

PMID:16707586 PMID:25572481 PMID:25596134

NCBI chr19:34,784,335...34,862,420
Ensembl chr19:34,784,340...34,856,855

G

PDZ binding kinase

increases expression

Fenofibrate results in increased expression of PBK mRNA

NCBI chr14:66,043,337...66,055,271
Ensembl chr14:66,043,286...66,055,271

G

phosphoenolpyruvate carboxykinase 1, cytosolic

increases expression

Fenofibrate results in increased expression of PCK1 mRNA

NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066

G

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

increases expression

Fenofibrate results in increased expression of PCK2 mRNA

PMID:16569247 PMID:24752549

NCBI chr14:55,777,721...55,787,477
Ensembl chr14:55,777,723...55,788,699

G

proliferating cell nuclear antigen

multiple interactions
increases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of PCNA protein
Fenofibrate results in increased expression of PCNA protein
ESR1 protein inhibits the reaction [Fenofibrate results in increased expression of PCNA protein]; Estradiol inhibits the reaction [Fenofibrate results in increased expression of PCNA protein]

PMID:18978307 PMID:29134746

NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234

G

proprotein convertase subtilisin/kexin type 9

increases expression

Fenofibrate results in increased expression of PCSK9 protein

NCBI chr 4:106,299,531...106,321,522
Ensembl chr 4:106,299,526...106,321,526

G

protein disulfide isomerase associated 5

decreases expression

Fenofibrate results in decreased expression of PDIA5 mRNA

NCBI chr16:35,217,678...35,311,289
Ensembl chr16:35,217,682...35,311,243

G

pyruvate dehydrogenase kinase, isoenzyme 1

decreases expression

Fenofibrate results in decreased expression of PDK1 mRNA

NCBI chr 2:71,703,398...71,734,202
Ensembl chr 2:71,703,568...71,734,202

G

pyruvate dehydrogenase kinase, isoenzyme 4

increases expression

Fenofibrate results in increased expression of PDK4 mRNA

PMID:17118139 PMID:19395589 PMID:25572481 PMID:25596134 PMID:27665778 More...

NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309

G

PDZ and LIM domain 1 (elfin)

decreases expression

Fenofibrate results in decreased expression of PDLIM1 mRNA

NCBI chr19:40,210,683...40,260,060
Ensembl chr19:40,209,617...40,260,286

G

p53 and DNA damage regulated 1

multiple interactions
decreases expression

PPARA protein affects the reaction [Fenofibrate results in decreased expression of PDRG1 mRNA]

NCBI chr 2:152,850,810...152,857,939
Ensembl chr 2:152,850,810...152,857,347

G

phosphatidylethanolamine N-methyltransferase

increases expression

Fenofibrate results in increased expression of PEMT mRNA

NCBI chr11:59,861,440...59,937,394
Ensembl chr11:59,861,440...59,937,315

G

peroxisomal biogenesis factor 11 alpha

affects expression
increases expression

Fenofibrate affects the expression of PEX11A mRNA
Fenofibrate results in increased expression of PEX11A mRNA

PMID:20801182 PMID:25572481 PMID:27665778 PMID:32741897

NCBI chr 7:79,385,705...79,392,879
Ensembl chr 7:79,385,705...79,392,879

G

phosphoglucomutase 1

increases expression

Fenofibrate results in increased expression of PGM1 mRNA

NCBI chr 4:99,786,648...99,844,491
Ensembl chr 4:99,786,611...99,844,491

G

3-phosphoglycerate dehydrogenase

increases expression

Fenofibrate results in increased expression of PHGDH mRNA

NCBI chr 3:98,220,487...98,247,285
Ensembl chr 3:98,220,486...98,247,306

G

pleckstrin homology like domain, family A, member 1

decreases expression

Fenofibrate results in decreased expression of PHLDA1 mRNA

NCBI chr10:111,342,147...111,344,510
Ensembl chr10:111,342,147...111,344,506

G

pleckstrin homology like domain, family A, member 3

affects expression

Fenofibrate affects the expression of PHLDA3 mRNA

NCBI chr 1:135,693,823...135,696,872
Ensembl chr 1:135,693,857...135,696,874

G

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma

decreases expression

Fenofibrate results in decreased expression of PIK3C2G mRNA

NCBI chr 6:139,591,070...139,915,010
Ensembl chr 6:139,564,219...139,915,010

G

pirin

decreases expression

Fenofibrate results in decreased expression of PIR mRNA

NCBI chr X:163,052,427...163,156,009
Ensembl chr X:163,052,367...163,156,007

G

praja ring finger ubiquitin ligase 2

increases expression
multiple interactions

Fenofibrate results in increased expression of PJA2 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of PJA2 mRNA]

NCBI chr17:64,588,001...64,638,878
Ensembl chr17:64,588,000...64,638,911

G

protein kinase inhibitor beta, cAMP dependent, testis specific

increases expression

Fenofibrate results in increased expression of PKIB mRNA

NCBI chr10:57,508,077...57,617,208
Ensembl chr10:57,508,077...57,617,208

G

pyruvate kinase liver and red blood cell

decreases expression

Fenofibrate results in decreased expression of PKLR mRNA

NCBI chr 3:89,043,429...89,054,122
Ensembl chr 3:89,043,449...89,054,091

G

phospholipase A1 member A

increases expression

Fenofibrate results in increased expression of PLA1A mRNA

NCBI chr16:38,214,245...38,253,553
Ensembl chr16:38,216,479...38,253,507

G

phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)

decreases activity
multiple interactions

Fenofibrate results in decreased activity of PLA2G7 protein
[orlistat co-treated with Fenofibrate] results in decreased activity of PLA2G7 protein

NCBI chr17:43,879,009...43,923,093
Ensembl chr17:43,878,989...43,923,092

G

phosphatidylinositol-specific phospholipase C, X domain containing 3

decreases expression

Fenofibrate results in decreased expression of PLCXD3 mRNA

NCBI chr15:4,404,973...4,605,067
Ensembl chr15:4,404,973...4,605,035

G

perilipin 1

increases expression

Fenofibrate results in increased expression of PLIN1 mRNA

NCBI chr 7:79,370,912...79,382,652
Ensembl chr 7:79,369,966...79,382,651

G

perilipin 2

increases expression
multiple interactions

Fenofibrate results in increased expression of PLIN2 mRNA
Fenofibrate promotes the reaction [Oleic Acid results in increased expression of PLIN2 mRNA]

PMID:24534255 PMID:25572481 PMID:25596134 PMID:27665778

NCBI chr 4:86,545,147...86,588,518
Ensembl chr 4:86,566,623...86,588,297

G

perilipin 4

increases expression

Fenofibrate results in increased expression of PLIN4 mRNA

NCBI chr17:56,407,587...56,416,947
Ensembl chr17:56,407,591...56,416,803

G

perilipin 5

increases expression

Fenofibrate results in increased expression of PLIN5 mRNA

NCBI chr17:56,418,601...56,424,606
Ensembl chr17:56,418,601...56,424,596

G

phospholipid transfer protein

increases expression

Fenofibrate results in increased expression of PLTP mRNA

NCBI chr 2:164,681,441...164,699,564
Ensembl chr 2:164,681,438...164,699,631

G

prostate transmembrane protein, androgen induced 1

decreases expression

Fenofibrate results in decreased expression of PMEPA1 mRNA

NCBI chr 2:173,066,251...173,118,329
Ensembl chr 2:173,066,251...173,118,326

G

promyelocytic leukemia

multiple interactions

Fenofibrate promotes the reaction [Arsenic Trioxide results in decreased expression of PML protein mutant form]

NCBI chr 9:58,125,359...58,157,077
Ensembl chr 9:58,125,359...58,157,069

G

podocalyxin-like

decreases expression

Fenofibrate results in decreased expression of PODXL mRNA

NCBI chr 6:31,496,428...31,540,872
Ensembl chr 6:31,496,423...31,540,916

G

paraoxonase 1

increases expression

Fenofibrate results in increased expression of PON1 protein

NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946

G

cytochrome p450 oxidoreductase

increases expression

Fenofibrate results in increased expression of POR mRNA

PMID:16707586 PMID:25572481

NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180

G

peter pan homolog

affects expression

Fenofibrate affects the expression of PPAN mRNA

NCBI chr 9:20,799,471...20,803,475
Ensembl chr 9:20,799,471...20,803,474

G

peroxisome proliferator activated receptor alpha

decreases expression
multiple interactions
increases response to substance
decreases response to substance
increases activity
increases expression
affects response to substance

Fenofibrate results in decreased expression of PPARA mRNA
fenofibrate co-treated with fructose diet decreases expression of ppara mRNA in liver
PPARA protein results in increased susceptibility to Fenofibrate
PPARA gene mutant form results in decreased susceptibility to Fenofibrate
Fenofibrate results in increased activity of PPARA protein
[Fenofibrate co-treated with Fatty Acids, Nonesterified] results in increased expression of PPARA mRNA; ESR1 protein inhibits the reaction [Estradiol inhibits the reaction [Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]]]; ESR1 protein inhibits the reaction [Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]]; Estradiol inhibits the reaction [ESR1 protein inhibits the reaction [Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]]]; Estradiol inhibits the reaction [Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]]; Fenofibrate binds to and results in increased activity of PPARA protein; Fenofibrate inhibits the reaction [ESR1 protein binds to PPARA protein]; Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of PPARA mRNA]; Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of PPARA protein]; NR1H3 protein affects the reaction [Fenofibrate results in increased expression of PPARA mRNA]; PPARA protein inhibits the reaction [Fenofibrate results in decreased expression of APOA1 mRNA]; PPARA protein promotes the reaction [Fenofibrate results in increased expression of ACOX1 protein]; PPARA protein promotes the reaction [Fenofibrate results in increased expression of ACSL1 protein]; PPARA protein promotes the reaction [Fenofibrate results in increased expression of LPL protein]; PPARA protein promotes the reaction [Fenofibrate results in increased expression of SLC27A4 protein]; PPARA protein promotes the reaction [Fenofibrate results in increased expression of UCP2 protein]
[Fenofibrate binds to and results in increased activity of PPARA protein] which affects the abundance of Fatty Acids, Nonesterified; [Fenofibrate binds to and results in increased activity of PPARA protein] which affects the abundance of Triglycerides; [Fenofibrate results in increased activity of PPARA protein] which results in decreased abundance of Adenosine Triphosphate; [Fenofibrate results in increased activity of PPARA protein] which results in increased expression of TRIB3 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of ASB6 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of BRCC3 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of DNAJC14 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of DNAJC19 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of DNAJC2 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of FKBP15 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of HECTD1 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of HSPB8 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of MAP1LC3A mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of MGRN1 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of PRKAB2 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of SEC63 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of SMPD3 mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of TOPORS mRNA; [PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of UBR2 mRNA; Fenofibrate binds to and results in increased activity of PPARA protein; Fenofibrate inhibits the reaction [Zoledronic Acid results in decreased expression of PPARA mRNA]; Fenofibrate promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Fenofibrate results in increased expression of and results in increased activity of PPARA protein; Lipopolysaccharides inhibits the reaction [Fenofibrate results in increased expression of PPARA mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of PPARA mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of PPARA mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACACA mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACACB mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACLY mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 protein]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACSL1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACSL1 protein]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A10 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A14 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ELOVL6 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FASN mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LPL mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LPL protein]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ME1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of NR1H3 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SCD1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SCD2 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SLC27A4 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SLC27A4 protein]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of UCP2 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of UCP2 protein]; PPARA promotes the reaction [Fenofibrate results in decreased expression of FGA mRNA]; PPARA protein affects the reaction [Fenofibrate affects the expression of BRAP mRNA]; PPARA protein affects the reaction [Fenofibrate promotes the reaction [APOA1 protein results in increased secretion of Lipids]]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of ANAPC11 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of CISH mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of CYLD mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of DNAJB4 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of HSPA13 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of ITCH mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of LNX1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of LRSAM1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of PDRG1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of PPP3CA mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of PRKAB1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of RBJ mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of RNF144B mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of UBE2R2 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of URM1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of USP36 mRNA]; PPARA protein affects the reaction [Fenofibrate results in decreased expression of WSB1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of ACADM mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of ARIH1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of ATE1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of ATG12 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of ATG7 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of CANX mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of CBLB mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of CNOT4 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of DNAJA2 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of DNAJB6 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of DNAJC3 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of DNAJC5 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of ENC1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of FBXO3 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of FBXO30 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of FBXO32 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of FOXO1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of GRPEL2 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of HSP90AA1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of HSP90AB1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPA4L mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPA8 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPA9 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPB1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of HSPH1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of NEDD4 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of PJA2 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of PPP1R15B mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of PSMB2 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of PSMC6 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of PSMD4 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of RABGEF1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of RNF14 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of SENP2 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of SOCS6 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of SPOP mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of TOR1B mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of TOR3A mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of TRIM63 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of TRIP12 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of UBE2Q2 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of UBE3A mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of URI1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of USP1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of USP10 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of USP22 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of USP38 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of USP7 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of USP9X mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of USPL1 mRNA]; PPARA protein affects the reaction [Fenofibrate results in increased expression of VCPIP1 mRNA]
Fenofibrate results in increased expression of PPARA mRNA; Fenofibrate results in increased expression of PPARA protein
PPARA protein results in increased susceptibility to Fenofibrate; PPARA results in increased susceptibility to Fenofibrate
[Fenofibrate binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA; EDN1 protein promotes the reaction [Fenofibrate promotes the reaction [NFATC4 protein binds to PPARA protein]]; Fenofibrate binds to and results in increased activity of PPARA protein; Fenofibrate inhibits the reaction [Fructose results in decreased expression of and results in decreased activity of PPARA protein]; Fenofibrate inhibits the reaction [Pyrazinamide results in decreased expression of PPARA mRNA]; Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PPARA mRNA]; Fenofibrate inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of PPARA protein]; Fenofibrate promotes the reaction [NFATC4 protein binds to PPARA protein]; Fenofibrate promotes the reaction [PPARA protein results in increased expression of MLYCD mRNA]; PPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]]; PPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]]

CTD
RGD

PMID:7983038 PMID:10216095 PMID:11341955 PMID:11798191 PMID:11934685 More...

NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020

G

peroxisome proliferator activator receptor delta

increases expression

Fenofibrate results in increased expression of PPARD mRNA

NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448

G

peroxisome proliferator activated receptor gamma

increases expression
affects activity
multiple interactions

Fenofibrate results in increased expression of PPARG mRNA
Fenofibrate affects the activity of PPARG protein
[Oleic Acid co-treated with Fenofibrate] results in increased expression of PPARG mRNA

PMID:19201410 PMID:24534255 PMID:25596134 PMID:28034800

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

multiple interactions

Fenofibrate inhibits the reaction [zoledronic acid results in decreased expression of PPARGC1A mRNA]
Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of PPARGC1A protein]

PMID:28871336 PMID:32730863

NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068

G

phosphopantothenoylcysteine synthetase

increases expression

Fenofibrate results in increased expression of PPCS mRNA

NCBI chr 4:119,275,724...119,279,673
Ensembl chr 4:119,275,727...119,279,617

G

protein phosphatase 1D magnesium-dependent, delta isoform

decreases expression

Fenofibrate results in decreased expression of PPM1D mRNA

NCBI chr11:85,202,080...85,237,897
Ensembl chr11:85,202,070...85,237,892

G

protein phosphatase 1, regulatory subunit 15A

increases expression
decreases expression

Fenofibrate results in increased expression of PPP1R15A mRNA
Fenofibrate results in decreased expression of PPP1R15A mRNA

NCBI chr 7:45,172,341...45,175,692
Ensembl chr 7:45,172,340...45,175,692

G

protein phosphatase 1, regulatory subunit 15B

increases expression
multiple interactions

Fenofibrate results in increased expression of PPP1R15B mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of PPP1R15B mRNA]

NCBI chr 1:133,058,904...133,067,538
Ensembl chr 1:133,058,881...133,067,521

G

protein phosphatase 3, catalytic subunit, alpha isoform

multiple interactions
decreases expression

PPARA protein affects the reaction [Fenofibrate results in decreased expression of PPP3CA mRNA]

NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488

G

protein kinase, AMP-activated, alpha 1 catalytic subunit

multiple interactions
decreases response to substance

PRKAA1 protein affects the reaction [Fenofibrate results in decreased susceptibility to ALB protein modified form]; PRKAA1 protein affects the reaction [Fenofibrate results in increased abundance of Nitric Oxide]; PRKAA1 protein affects the reaction [Fenofibrate results in increased activity of NOS3 protein]
PRKAA1 gene mutant form results in decreased susceptibility to Fenofibrate

PMID:20580385 PMID:25545733

NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380

G

protein kinase, AMP-activated, beta 1 non-catalytic subunit

decreases expression
increases phosphorylation
multiple interactions

Fenofibrate results in decreased expression of PRKAB1 mRNA
Fenofibrate results in increased phosphorylation of PRKAB1 protein
PPARA protein affects the reaction [Fenofibrate results in decreased expression of PRKAB1 mRNA]

PMID:21318169 PMID:25545733

NCBI chr 5:116,151,654...116,162,449
Ensembl chr 5:116,151,645...116,162,567

G

protein kinase, AMP-activated, beta 2 non-catalytic subunit

increases expression
multiple interactions

Fenofibrate results in increased expression of PRKAB2 mRNA
[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of PRKAB2 mRNA

NCBI chr 3:97,565,527...97,581,128
Ensembl chr 3:97,565,509...97,581,128

G

protein kinase, AMP-activated, gamma 1 non-catalytic subunit

increases expression

Fenofibrate results in increased expression of PRKAG1 protein

NCBI chr15:98,710,678...98,729,354
Ensembl chr15:98,710,678...98,729,402

G

proline dehydrogenase

decreases expression

Fenofibrate results in decreased expression of PRODH mRNA

NCBI chr16:17,889,593...17,907,147
Ensembl chr16:17,878,221...17,908,067

G

proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)

increases expression

Fenofibrate results in increased expression of PRRG4 mRNA

NCBI chr 2:104,657,374...104,680,216
Ensembl chr 2:104,661,086...104,680,221

G

presenilin 1

multiple interactions

Fenofibrate affects the reaction [PSEN1 protein affects the cleavage of APP protein]

NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973

G

proteasome (prosome, macropain) subunit, beta type 2

increases expression
multiple interactions

Fenofibrate results in increased expression of PSMB2 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of PSMB2 mRNA]

NCBI chr 4:126,571,460...126,603,503
Ensembl chr 4:126,571,423...126,603,507

G

proteasome (prosome, macropain) 26S subunit, ATPase, 6

increases expression
multiple interactions

Fenofibrate results in increased expression of PSMC6 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of PSMC6 mRNA]

NCBI chr14:45,567,285...45,587,150
Ensembl chr14:45,567,245...45,587,162

G

proteasome (prosome, macropain) 26S subunit, non-ATPase, 4

increases expression
multiple interactions

Fenofibrate results in increased expression of PSMD4 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of PSMD4 mRNA]

NCBI chr 3:94,939,999...94,949,880
Ensembl chr 3:94,940,005...94,949,925

G

prostaglandin-endoperoxide synthase 1

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of PTGS1 mRNA

NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

protein tyrosine phosphatase receptor type F

affects expression

Fenofibrate affects the expression of PTPRF mRNA

NCBI chr 4:118,065,410...118,148,602
Ensembl chr 4:118,065,410...118,148,602

G

protein tyrosine phosphatase receptor type Q

decreases expression

Fenofibrate results in decreased expression of PTPRQ mRNA

NCBI chr10:107,350,224...107,555,939
Ensembl chr10:107,352,910...107,555,912

G

liver glycogen phosphorylase

increases expression

Fenofibrate results in increased expression of PYGL mRNA

NCBI chr12:70,237,589...70,274,457
Ensembl chr12:70,237,585...70,278,262

G

glutaminyl-peptide cyclotransferase (glutaminyl cyclase)

increases expression

Fenofibrate results in increased expression of QPCT mRNA

PMID:27665778 PMID:32741897

NCBI chr17:79,359,335...79,397,807
Ensembl chr17:79,359,335...79,397,807

G

RAB30, member RAS oncogene family

increases expression

Fenofibrate results in increased expression of RAB30 mRNA

NCBI chr 7:92,390,845...92,493,743
Ensembl chr 7:92,390,811...92,493,743

G

RAB31, member RAS oncogene family

decreases expression

Fenofibrate results in decreased expression of RAB31 mRNA

NCBI chr17:65,958,721...66,079,747
Ensembl chr17:65,958,724...66,079,747

G

RAB guanine nucleotide exchange factor (GEF) 1

increases expression
multiple interactions

Fenofibrate results in increased expression of RABGEF1 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of RABGEF1 mRNA]

NCBI chr 5:130,200,644...130,243,178
Ensembl chr 5:130,200,639...130,243,183

G

RAD50 double strand break repair protein

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of RAD50 mRNA

NCBI chr11:53,540,346...53,598,146
Ensembl chr11:53,540,346...53,598,146

G

RAD51 paralog B

increases expression

Fenofibrate results in increased expression of RAD51B mRNA

NCBI chr12:79,344,032...79,895,034
Ensembl chr12:79,344,056...79,861,464

G

retinoic acid early transcript 1E

increases expression

Fenofibrate results in increased expression of RAET1E mRNA

NCBI chr10:22,034,441...22,059,820
Ensembl chr10:22,034,468...22,250,038

G

receptor (calcitonin) activity modifying protein 2

decreases expression

Fenofibrate results in decreased expression of RAMP2 mRNA

NCBI chr11:101,137,160...101,139,076
Ensembl chr11:101,136,854...101,150,372

G

retinoic acid receptor, alpha

multiple interactions
decreases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of RARA mRNA
Fenofibrate results in decreased expression of RARA mRNA

PMID:18253720 PMID:25596134

NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768

G

retinoic acid receptor, beta

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of RARB mRNA

NCBI chr14:5,387,365...6,038,924
Ensembl chr14:5,650,540...6,038,924

G

retinol binding protein 2, cellular

increases expression

Fenofibrate results in increased expression of RBP2 mRNA

NCBI chr 9:98,372,590...98,391,824
Ensembl chr 9:98,368,168...98,391,834

G

ring-box 1

decreases expression

Fenofibrate results in decreased expression of RBX1 mRNA

NCBI chr15:81,350,517...81,360,570
Ensembl chr15:81,350,497...81,360,570

G

retinol dehydrogenase 16

increases expression

Fenofibrate results in increased expression of RDH16 mRNA

NCBI chr10:127,636,959...127,651,715
Ensembl chr10:127,637,021...127,682,434

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

Fenofibrate affects the localization of and results in decreased activity of RELA protein; Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of RELA protein]; Fenofibrate inhibits the reaction [Glucose results in increased expression of RELA protein]; Fenofibrate results in decreased localization of and results in decreased activity of RELA protein
[Fenofibrate co-treated with Sodium Glutamate] results in increased expression of RELA protein; Fenofibrate inhibits the reaction [Dietary Fats results in increased expression of RELA protein]; Fenofibrate inhibits the reaction [Doxorubicin results in increased expression of RELA protein]; Fenofibrate promotes the reaction [Pioglitazone inhibits the reaction [Doxorubicin results in increased expression of RELA protein]]; Pioglitazone promotes the reaction [Fenofibrate inhibits the reaction [Doxorubicin results in increased expression of RELA protein]]

PMID:16600694 PMID:20520642 PMID:20580385 PMID:21999347 PMID:25545733 More...

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

resistin

multiple interactions

Fenofibrate inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased secretion of RETN protein]

NCBI chr 8:3,705,770...3,709,818
Ensembl chr 8:3,705,770...3,710,110

G

retinol saturase (all trans retinol 13,14 reductase)

increases expression

Fenofibrate results in increased expression of RETSAT mRNA

NCBI chr 6:72,575,585...72,584,471
Ensembl chr 6:72,575,458...72,585,408

G

regulator of G-protein signaling 16

increases expression

Fenofibrate results in increased expression of RGS16 mRNA

NCBI chr 1:153,616,099...153,621,212
Ensembl chr 1:153,616,095...153,621,214

G

ras homolog family member F (in filopodia)

increases expression

Fenofibrate results in increased expression of RHOF mRNA

NCBI chr 5:123,256,243...123,270,692
Ensembl chr 5:123,241,107...123,270,755

G

rearranged L-myc fusion sequence

increases expression

Fenofibrate results in increased expression of RLF mRNA

NCBI chr 4:121,003,080...121,072,318
Ensembl chr 4:121,002,570...121,072,281

G

Rho family GTPase 1

decreases expression

Fenofibrate results in decreased expression of RND1 mRNA

NCBI chr15:98,567,086...98,575,342
Ensembl chr15:98,561,302...98,575,342

G

Rho family GTPase 3

decreases expression

Fenofibrate results in decreased expression of RND3 mRNA

NCBI chr 2:51,020,451...51,039,123
Ensembl chr 2:51,020,450...51,039,123

G

ring finger protein 125

increases expression

Fenofibrate results in increased expression of RNF125 mRNA

NCBI chr18:21,077,672...21,120,416
Ensembl chr18:21,077,682...21,116,919

G

ring finger protein 14

increases expression
multiple interactions

Fenofibrate results in increased expression of RNF14 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of RNF14 mRNA]

NCBI chr18:38,410,513...38,450,905
Ensembl chr18:38,417,590...38,450,902

G

ring finger protein 144B

decreases expression
multiple interactions

Fenofibrate results in decreased expression of RNF144B mRNA
PPARA protein affects the reaction [Fenofibrate results in decreased expression of RNF144B mRNA]

NCBI chr13:47,276,196...47,401,470
Ensembl chr13:47,276,132...47,401,467

G

ring finger protein 19A

increases expression

Fenofibrate results in increased expression of RNF19A mRNA

NCBI chr15:36,240,080...36,283,293
Ensembl chr15:36,240,079...36,283,293

G

Ro60, Y RNA binding protein

decreases expression

Fenofibrate results in decreased expression of RO60 mRNA

NCBI chr 1:143,626,528...143,652,794
Ensembl chr 1:143,626,528...143,652,806

G

arginine/serine-rich coiled-coil 2

decreases expression

Fenofibrate results in decreased expression of RSRC2 mRNA

NCBI chr 5:123,866,489...123,887,522
Ensembl chr 5:123,866,489...123,887,477

G

retinoid X receptor alpha

decreases expression
affects expression

Fenofibrate results in decreased expression of RXRA mRNA
Fenofibrate affects the expression of RXRA mRNA

NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969

G

S100 calcium binding protein A10 (calpactin)

increases expression

Fenofibrate results in increased expression of S100A10 mRNA

NCBI chr 3:93,462,424...93,471,952
Ensembl chr 3:93,462,387...93,471,950

G

serum amyloid A 1

decreases expression

Fenofibrate results in decreased expression of SAA1 mRNA

NCBI chr 7:46,389,921...46,392,404
Ensembl chr 7:46,389,921...46,392,404

G

serum amyloid A 2

decreases expression

Fenofibrate results in decreased expression of SAA2 mRNA

NCBI chr 7:46,401,257...46,403,737
Ensembl chr 7:46,401,214...46,403,737

G

serum amyloid A 3

decreases expression

Fenofibrate results in decreased expression of SAA3 mRNA

NCBI chr 7:46,361,422...46,365,100
Ensembl chr 7:46,361,422...46,365,124

G

seryl-tRNA synthetase 1

increases expression

Fenofibrate results in increased expression of SARS1 mRNA

NCBI chr 3:108,332,180...108,352,575
Ensembl chr 3:108,332,181...108,352,525

G

spermidine/spermine N1-acetyl transferase 1

increases expression

Fenofibrate results in increased expression of SAT1 mRNA

NCBI chr X:153,996,128...153,999,345
Ensembl chr X:153,996,128...153,999,445

G

secretory carrier membrane protein 1

decreases expression

Fenofibrate results in decreased expression of SCAMP1 mRNA

NCBI chr13:94,337,818...94,422,339
Ensembl chr13:94,337,818...94,422,365

G

scavenger receptor class B, member 1

multiple interactions
decreases activity
increases expression

[Aspirin co-treated with Fenofibrate] results in increased expression of SCARB1 protein
Fenofibrate results in decreased activity of SCARB1 protein
Fenofibrate inhibits the reaction [SCARB1 protein results in increased export of Cholesterol, HDL]; Fenofibrate inhibits the reaction [SCARB1 protein results in increased uptake of cholesteryl oleyl ether]
Fenofibrate results in increased expression of SCARB1 protein

PMID:16816107 PMID:17533223

NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158

G

stearoyl-Coenzyme A desaturase 1

multiple interactions
affects expression
increases expression

NR1H2 gene mutant form affects the reaction [Fenofibrate results in increased expression of SCD1 mRNA]; NR1H3 gene mutant form affects the reaction [Fenofibrate results in increased expression of SCD1 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SCD1 mRNA]
Fenofibrate affects the expression of SCD mRNA

PMID:23063693 PMID:27665778

NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318

G

stearoyl-Coenzyme A desaturase 2

increases expression
multiple interactions

Fenofibrate results in increased expression of SCD mRNA; Fenofibrate results in increased expression of SCD2 mRNA
[Oleic Acid co-treated with Fenofibrate] results in increased expression of SCD1 mRNA
NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SCD2 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SCD2 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SCD2 mRNA]

PMID:17118139 PMID:23063693 PMID:24534255

NCBI chr19:44,282,115...44,295,303
Ensembl chr19:44,282,113...44,295,303

G

selenocysteine lyase

affects expression

Fenofibrate affects the expression of SCLY mRNA

NCBI chr 1:91,226,017...91,248,797
Ensembl chr 1:91,226,060...91,248,797

G

succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

increases expression

Fenofibrate results in increased expression of SDHB protein

NCBI chr 4:140,688,582...140,706,509
Ensembl chr 4:140,688,514...140,706,504

G

SEC63 homolog, protein translocation regulator

increases expression
multiple interactions

Fenofibrate results in increased expression of SEC63 mRNA
[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of SEC63 mRNA

NCBI chr10:42,637,492...42,708,510
Ensembl chr10:42,637,492...42,708,510

G

selectin, endothelial cell

multiple interactions

dorsomorphin inhibits the reaction [Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of SELE mRNA]]; Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of SELE mRNA]

NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246

G

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B

multiple interactions
decreases expression

alitretinoin promotes the reaction [Fenofibrate results in decreased expression of SEMA6B mRNA]; alitretinoin promotes the reaction [Fenofibrate results in decreased expression of SEMA6B protein]
Fenofibrate results in decreased expression of SEMA6B mRNA; Fenofibrate results in decreased expression of SEMA6B protein

NCBI chr17:56,430,085...56,447,343
Ensembl chr17:56,430,085...56,447,343

G

SUMO/sentrin specific peptidase 2

increases expression
multiple interactions

Fenofibrate results in increased expression of SENP2 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of SENP2 mRNA]

NCBI chr16:21,828,182...21,868,019
Ensembl chr16:21,828,234...21,868,019

G

serine (or cysteine) peptidase inhibitor, clade A, member 3K

decreases expression

Fenofibrate results in decreased expression of SERPINA3K mRNA

NCBI chr12:104,304,745...104,311,998
Ensembl chr12:104,304,745...104,312,403

G

serine (or cysteine) peptidase inhibitor, clade A, member 3N

affects expression

Fenofibrate affects the expression of SERPINA3N mRNA

NCBI chr12:104,372,967...104,380,588
Ensembl chr12:104,372,988...104,380,588

G

serine (or cysteine) peptidase inhibitor, clade E, member 1

multiple interactions
affects expression

Fenofibrate inhibits the reaction [NR4A1 protein results in increased expression of SERPINE1 mRNA]; Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]; Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; Fenofibrate inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [NR4A1 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]]
[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of SERPINE1 mRNA
Fenofibrate affects the expression of SERPINE1 mRNA
Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]]

PMID:18253720 PMID:19593819 PMID:20801182

NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122

G

SERTA domain containing 1

decreases expression

Fenofibrate results in decreased expression of SERTAD1 mRNA

NCBI chr 7:27,186,378...27,189,741
Ensembl chr 7:27,186,335...27,189,741

G

sestrin 1

decreases expression

Fenofibrate results in decreased expression of SESN1 mRNA

NCBI chr10:41,686,570...41,784,432
Ensembl chr10:41,685,931...41,784,420

G

serum/glucocorticoid regulated kinase 2

increases expression

Fenofibrate results in increased expression of SGK2 mRNA

NCBI chr 2:162,829,249...162,856,059
Ensembl chr 2:162,829,250...162,856,047

G

SH3 domain binding glutamic acid-rich protein like 2

increases expression

Fenofibrate results in increased expression of SH3BGRL2 mRNA

NCBI chr 9:83,430,391...83,482,345
Ensembl chr 9:83,430,380...83,520,854

G

SH3 domain and tetratricopeptide repeats 1

increases expression

Fenofibrate results in increased expression of SH3TC1 mRNA

NCBI chr 5:35,854,524...35,897,331
Ensembl chr 5:35,854,524...35,897,331

G

siah E3 ubiquitin protein ligase 2

affects expression

Fenofibrate affects the expression of SIAH2 mRNA

NCBI chr 3:58,582,370...58,599,857
Ensembl chr 3:58,582,359...58,599,821

G

salt inducible kinase 1

increases expression
decreases expression

Fenofibrate results in increased expression of SIK1 mRNA
Fenofibrate results in decreased expression of SIK1 mRNA

NCBI chr17:32,063,222...32,074,808
Ensembl chr17:32,063,224...32,074,778

G

sirtuin 1

multiple interactions
increases expression

dorsomorphin inhibits the reaction [Fenofibrate results in increased expression of SIRT1 protein]; Fenofibrate inhibits the reaction [[Fructose co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein]; zinc protoporphyrin inhibits the reaction [Fenofibrate results in increased expression of SIRT1 protein]

PMID:32730863 PMID:34520103

NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483

G

SIVA1, apoptosis-inducing factor

decreases expression

Fenofibrate results in decreased expression of SIVA1 mRNA

NCBI chr12:112,611,262...112,615,586
Ensembl chr12:112,611,113...112,615,583

G

solute carrier family 10 (sodium/bile acid cotransporter family), member 1

decreases expression

Fenofibrate results in decreased expression of SLC10A1 mRNA

PMID:25572481 PMID:27765674

NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479

G

solute carrier family 16 (monocarboxylic acid transporters), member 13

increases expression

Fenofibrate results in increased expression of SLC16A13 mRNA

NCBI chr11:70,107,615...70,113,638
Ensembl chr11:70,107,615...70,111,890

G

solute carrier family 16 (monocarboxylic acid transporters), member 6

increases expression

Fenofibrate results in increased expression of SLC16A6 mRNA

NCBI chr11:109,341,681...109,366,428
Ensembl chr11:109,341,681...109,364,424

G

solute carrier family 1 (glutamate transporter), member 7

increases expression

Fenofibrate results in increased expression of SLC1A7 mRNA

NCBI chr 4:107,825,603...107,870,726
Ensembl chr 4:107,825,529...107,870,729

G

solute carrier family 22 (organic cation transporter), member 5

increases expression

Fenofibrate results in increased expression of SLC22A5 mRNA

PMID:27665778 PMID:32741897

NCBI chr11:53,755,368...53,782,609
Ensembl chr11:53,755,368...53,782,486

G

solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20

increases expression

Fenofibrate results in increased expression of SLC25A20 mRNA

PMID:16707586 PMID:25572481 PMID:25596134

NCBI chr 9:108,539,335...108,561,841
Ensembl chr 9:108,539,287...108,561,840

G

solute carrier family 25, member 30

increases expression

Fenofibrate results in increased expression of SLC25A30 mRNA

NCBI chr14:75,994,986...76,024,477
Ensembl chr14:75,997,557...76,024,477

G

solute carrier family 25, member 34

increases expression

Fenofibrate results in increased expression of SLC25A34 mRNA

NCBI chr 4:141,346,130...141,351,202
Ensembl chr 4:141,346,135...141,351,132

G

solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4

decreases expression

Fenofibrate results in decreased expression of SLC25A4 protein

NCBI chr 8:46,660,205...46,664,099
Ensembl chr 8:46,659,834...46,664,321

G

solute carrier family 27 (fatty acid transporter), member 1

increases expression

Fenofibrate results in increased expression of SLC27A1 mRNA

NCBI chr 8:72,021,372...72,039,951
Ensembl chr 8:72,021,526...72,039,946

G

solute carrier family 27 (fatty acid transporter), member 2

increases expression

Fenofibrate results in increased expression of SLC27A2 mRNA

PMID:17118139 PMID:25572481 PMID:27665778 PMID:32741897 PMID:32741898

NCBI chr 2:126,394,944...126,430,163
Ensembl chr 2:126,394,327...126,430,163

G

solute carrier family 27 (fatty acid transporter), member 4

increases expression
multiple interactions

Fenofibrate results in increased expression of SLC27A4 mRNA; Fenofibrate results in increased expression of SLC27A4 protein
PPARA protein promotes the reaction [Fenofibrate results in increased expression of SLC27A4 protein]
PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SLC27A4 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SLC27A4 protein]

NCBI chr 2:29,692,646...29,707,534
Ensembl chr 2:29,692,646...29,707,534

G

solute carrier family 34 (sodium phosphate), member 2

increases expression

Fenofibrate results in increased expression of SLC34A2 mRNA

NCBI chr 5:53,206,695...53,229,006
Ensembl chr 5:53,195,423...53,229,006

G

solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2

increases expression

Fenofibrate results in increased expression of SLC3A2 mRNA

NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733

G

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

decreases expression
increases expression

Fenofibrate results in decreased expression of SLC6A9 mRNA
Fenofibrate results in increased expression of SLC6A9 mRNA

NCBI chr 4:117,692,240...117,726,502
Ensembl chr 4:117,691,703...117,732,395

G

solute carrier family 7 (cationic amino acid transporter, y+ system), member 1

increases expression

Fenofibrate results in increased expression of SLC7A1 mRNA

NCBI chr 5:148,264,220...148,336,714
Ensembl chr 5:148,264,220...148,336,714

G

solute carrier family 7 (cationic amino acid transporter, y+ system), member 5

increases expression

Fenofibrate results in increased expression of SLC7A5 mRNA

NCBI chr 8:122,607,885...122,634,425
Ensembl chr 8:122,607,889...122,634,433

G

solute carrier organic anion transporter family, member 2b1

decreases expression

Fenofibrate results in decreased expression of SLCO2B1 mRNA

NCBI chr 7:99,307,011...99,360,547
Ensembl chr 7:99,307,011...99,360,547

G

SMAD family member 3

multiple interactions

Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD3 protein results in increased expression of SERPINE1 mRNA]]

NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276

G

SMAD family member 4

multiple interactions

Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [SMAD4 protein results in increased expression of SERPINE1 mRNA]]

NCBI chr18:73,767,861...73,836,862
Ensembl chr18:73,772,080...73,836,851

G

sphingomyelin phosphodiesterase 2, neutral

multiple interactions

Fenofibrate promotes the reaction [Dextran Sulfate results in decreased expression of SMPD2 mRNA]

NCBI chr10:41,363,168...41,366,410
Ensembl chr10:41,361,638...41,366,365

G

sphingomyelin phosphodiesterase 3, neutral

increases expression
multiple interactions

Fenofibrate results in increased expression of SMPD3 mRNA
[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of SMPD3 mRNA

NCBI chr 8:106,979,180...107,064,597
Ensembl chr 8:106,979,180...107,064,620

G

sphingomyelin phosphodiesterase 4

multiple interactions

Fenofibrate promotes the reaction [Dextran Sulfate results in decreased expression of SMPD4 mRNA]

NCBI chr16:17,437,218...17,462,694
Ensembl chr16:17,437,218...17,462,692

G

suppressor of cytokine signaling 3

multiple interactions

[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]; Fenofibrate inhibits the reaction [Fructose results in increased expression of SOCS3 mRNA]

NCBI chr11:117,856,905...117,860,192
Ensembl chr11:117,856,905...117,860,873

G

suppressor of cytokine signaling 6

increases expression
multiple interactions

Fenofibrate results in increased expression of SOCS6 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of SOCS6 mRNA]

NCBI chr18:88,883,293...88,912,623
Ensembl chr18:88,683,348...88,945,605

G

suppressor of cytokine signaling 7

decreases expression

Fenofibrate results in decreased expression of SOCS7 mRNA

NCBI chr11:97,253,044...97,289,368
Ensembl chr11:97,253,261...97,289,368

G

superoxide dismutase 2, mitochondrial

increases expression

Fenofibrate results in increased expression of SOD2 mRNA

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

Son DNA binding protein

decreases expression

Fenofibrate results in decreased expression of SON mRNA

NCBI chr16:91,444,712...91,476,080
Ensembl chr16:91,444,394...91,476,109

G

sortilin-related receptor, LDLR class A repeats-containing

increases expression
decreases expression

Fenofibrate results in increased expression of SORL1 mRNA
Fenofibrate results in decreased expression of SORL1 mRNA

NCBI chr 9:41,876,005...42,035,593
Ensembl chr 9:41,876,016...42,035,593

G

sortilin 1

increases expression

Fenofibrate results in increased expression of SORT1 mRNA

NCBI chr 3:108,191,272...108,268,835
Ensembl chr 3:108,191,398...108,268,827

G

sperm microtubule inner protein 11

increases expression

Fenofibrate results in increased expression of SPMIP11 mRNA

NCBI chr15:98,468,885...98,487,469
Ensembl chr15:98,468,885...98,487,461

G

SPNS lysolipid transporter 2, sphingosine-1-phosphate

increases expression

Fenofibrate results in increased expression of SPNS2 mRNA

NCBI chr11:72,342,464...72,380,797
Ensembl chr11:72,342,464...72,380,730

G

speckle-type BTB/POZ protein

increases expression
multiple interactions

Fenofibrate results in increased expression of SPOP mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of SPOP mRNA]

NCBI chr11:95,304,909...95,384,236
Ensembl chr11:95,304,906...95,384,232

G

splA/ryanodine receptor domain and SOCS box containing 1

increases expression

Fenofibrate results in increased expression of SPSB1 mRNA

NCBI chr 4:149,980,740...150,039,494
Ensembl chr 4:149,980,740...150,039,500

G

squalene epoxidase

increases expression
multiple interactions

Fenofibrate results in increased expression of SQLE mRNA
NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SQLE mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SQLE mRNA]

NCBI chr15:59,186,941...59,203,042
Ensembl chr15:59,186,926...59,203,041

G

sequestosome 1

increases expression
multiple interactions

Fenofibrate results in increased expression of SQSTM1 mRNA
Fenofibrate inhibits the reaction [tyloxapol results in increased expression of SQSTM1 protein]

PMID:25596134 PMID:36905866

NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654

G

steroid 5 alpha-reductase 3

decreases expression

Fenofibrate results in decreased expression of SRD5A3 mRNA

NCBI chr 5:76,285,296...76,303,350
Ensembl chr 5:76,288,118...76,303,351

G

sterol regulatory element binding transcription factor 1

multiple interactions
increases expression

Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]; Fenofibrate inhibits the reaction [tyloxapol results in increased expression of SREBF1 protein]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SREBF1 mRNA]; NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SREBF1 mRNA]
Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 mRNA]; Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 protein]
[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]

PMID:19593819 PMID:23063693 PMID:24735863 PMID:26973390 PMID:36905866

NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407

G

sulfiredoxin 1 homolog (S. cerevisiae)

increases expression

Fenofibrate results in increased expression of SRXN1 mRNA

NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 4

decreases expression

Fenofibrate results in decreased expression of ST3GAL4 mRNA

NCBI chr 9:34,957,872...35,028,160
Ensembl chr 9:34,957,872...35,030,564

G

signal transducer and activator of transcription 5B

decreases activity

Fenofibrate results in decreased activity of STAT5B protein

NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550

G

serine/threonine kinase 11

multiple interactions

Fenofibrate results in increased expression of and results in increased phosphorylation of STK11 protein

NCBI chr10:79,951,602...79,966,513
Ensembl chr10:79,951,637...79,966,516

G

spermatid perinuclear RNA binding protein

increases expression

Fenofibrate results in increased expression of STRBP mRNA

NCBI chr 2:37,459,880...37,593,890
Ensembl chr 2:37,373,240...37,593,871

G

succinate-CoA ligase, GDP-forming, alpha subunit

affects expression
increases expression

Fenofibrate affects the expression of SUCLG1 mRNA
Fenofibrate results in increased expression of SUCLG1 protein
Fenofibrate results in increased expression of SUCLG1 mRNA

PMID:16707586 PMID:20801182 PMID:24752549

NCBI chr 6:73,225,488...73,253,890
Ensembl chr 6:73,225,365...73,253,894

G

sulfatase 2

decreases expression

Fenofibrate results in decreased expression of SULF2 mRNA

NCBI chr 2:165,915,819...165,997,603
Ensembl chr 2:165,915,009...165,997,583

G

sulfotransferase family, cytosolic, 1C, member 2

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of SULT1C2 mRNA

NCBI chr17:54,136,665...54,152,986
Ensembl chr17:54,136,665...54,153,367

G

sulfotransferase family 1E, member 1

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of SULT1E1 mRNA

NCBI chr 5:87,723,827...87,739,470
Ensembl chr 5:87,723,828...87,739,453

G

sulfotransferase family 4A, member 1

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of SULT4A1 mRNA

NCBI chr15:83,960,298...83,989,955
Ensembl chr15:83,960,298...83,989,955

G

transaldolase 1

decreases expression

Fenofibrate results in decreased expression of TALDO1 mRNA

NCBI chr 7:140,972,073...140,982,889
Ensembl chr 7:140,972,112...140,982,881

G

threonyl-tRNA synthetase 1

decreases expression

Fenofibrate results in decreased expression of TARS1 mRNA

NCBI chr15:11,383,749...11,399,744
Ensembl chr15:11,382,387...11,399,751

G

t-complex protein 1

multiple interactions

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of TCP1 mRNA

NCBI chr17:13,135,216...13,143,954
Ensembl chr17:13,134,588...13,143,954

G

tryptophan 2,3-dioxygenase

increases expression

Fenofibrate results in increased expression of TDO2 mRNA

NCBI chr 3:81,865,719...81,883,035
Ensembl chr 3:81,864,397...81,883,509

G

transcription factor E3

affects expression
increases expression

Fenofibrate affects the expression of TFE3 mRNA
Fenofibrate results in increased expression of TFE3 mRNA

NCBI chr X:7,628,769...7,641,441
Ensembl chr X:7,628,799...7,641,441

G

transforming growth factor, beta 1

multiple interactions

Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]
[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of TGFB1 mRNA]; Fenofibrate inhibits the reaction [Fructose results in increased expression of TGFB1 mRNA]
Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in decreased expression of TRIB3 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of IL6 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of IL6 mRNA]]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TGFB1 mRNA]]

PMID:19593819 PMID:26973390 PMID:32613381

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

thyroid hormone responsive

multiple interactions
decreases expression

Fenofibrate promotes the reaction [Oleic Acid results in decreased expression of THRSP mRNA]
Fenofibrate results in decreased expression of THRSP mRNA

PMID:24534255 PMID:25572481

NCBI chr 7:97,062,140...97,066,757
Ensembl chr 7:97,062,145...97,066,937

G

tissue inhibitor of metalloproteinase 1

multiple interactions

Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TIMP1 mRNA]; Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA]; Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of TIMP1 mRNA]; NR0B2 protein inhibits the reaction [Fenofibrate inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 mRNA]]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TIMP1 mRNA]]

PMID:19593819 PMID:28871336

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

tissue inhibitor of metalloproteinase 2

multiple interactions

Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of TIMP2 mRNA]

NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566

G

TCDD-inducible poly(ADP-ribose) polymerase

increases expression

Fenofibrate results in increased expression of TIPARP mRNA

NCBI chr 3:65,435,868...65,462,939
Ensembl chr 3:65,435,831...65,462,939

G

transmembrane protein 120A

decreases expression
increases expression

Fenofibrate results in decreased expression of TMEM120A mRNA
Fenofibrate results in increased expression of TMEM120A mRNA

PMID:25572481 PMID:32741897

NCBI chr 5:135,764,344...135,773,026
Ensembl chr 5:135,764,339...135,773,302

G

tumor necrosis factor

multiple interactions
decreases expression
decreases response to substance

Fenofibrate affects the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] affects the expression of CPT1A mRNA]; Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of CD36 mRNA]; Fenofibrate inhibits the reaction [[osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in increased secretion of CCL2 protein]; Fenofibrate inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Fenofibrate inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Fenofibrate inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]]
[Fenofibrate co-treated with Resveratrol] inhibits the reaction [Fructose results in increased expression of and results in increased secretion of TNF protein]; [Fenofibrate co-treated with Sodium Glutamate] results in increased expression of TNF protein; Fenofibrate inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Fenofibrate inhibits the reaction [Fructose results in increased expression of and results in increased secretion of TNF protein]; Fenofibrate promotes the reaction [Pioglitazone inhibits the reaction [Doxorubicin results in increased expression of TNF protein]]; Pioglitazone promotes the reaction [Fenofibrate inhibits the reaction [Doxorubicin results in increased expression of TNF protein]]
Fenofibrate results in decreased expression of TNF mRNA; Fenofibrate results in decreased expression of TNF protein
[Fenofibrate co-treated with Alitretinoin] inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Fenofibrate inhibits the reaction [triptolide results in increased expression of TNF mRNA]; Fenofibrate promotes the reaction [Dextran Sulfate results in increased expression of TNF protein]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]]
Fenofibrate results in decreased susceptibility to TNF protein; TNF protein results in decreased susceptibility to Fenofibrate

PMID:12586603 PMID:15968640 PMID:18356826 PMID:19593819 PMID:20520642 More...

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

decreases expression

Fenofibrate results in decreased expression of TNFRSF11B mRNA

NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880

G

tumor necrosis factor receptor superfamily, member 21

increases expression

Fenofibrate results in increased expression of TNFRSF21 mRNA

PMID:25572481 PMID:25596134

NCBI chr17:43,327,446...43,400,079
Ensembl chr17:43,327,446...43,400,080

G

topoisomerase (DNA) I

multiple interactions
increases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of TOP1 mRNA
Fenofibrate results in increased expression of TOP1 mRNA

PMID:18253720 PMID:25596134

NCBI chr 2:160,487,901...160,564,684
Ensembl chr 2:160,487,808...160,564,684

G

topoisomerase (DNA) II alpha

increases expression

Fenofibrate results in increased expression of TOP2A mRNA

NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015

G

topoisomerase I binding, arginine/serine-rich

increases expression
multiple interactions

Fenofibrate results in increased expression of TOPORS mRNA
[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of TOPORS mRNA

NCBI chr 4:40,259,606...40,269,841
Ensembl chr 4:40,259,601...40,269,850

G

torsin family 1, member B

increases expression
multiple interactions

Fenofibrate results in increased expression of TOR1B mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of TOR1B mRNA]

NCBI chr 2:30,842,951...30,854,085
Ensembl chr 2:30,842,971...30,849,027

G

torsin family 3, member A

increases expression
multiple interactions

Fenofibrate results in increased expression of TOR3A mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of TOR3A mRNA]

NCBI chr 1:156,481,187...156,501,909
Ensembl chr 1:156,481,187...156,501,926

G

TRAF type zinc finger domain containing 1

decreases expression

Fenofibrate results in decreased expression of TRAFD1 mRNA

NCBI chr 5:121,509,788...121,524,543
Ensembl chr 5:121,509,788...121,523,695

G

TP53 regulated inhibitor of apoptosis 1

decreases expression

Fenofibrate results in decreased expression of TRIAP1 mRNA

NCBI chr 5:115,479,290...115,481,612
Ensembl chr 5:115,479,284...115,481,628

G

tribbles pseudokinase 3

multiple interactions
decreases expression

[Fenofibrate results in increased activity of PPARA protein] which results in increased expression of TRIB3 mRNA; Fenofibrate inhibits the reaction [TGFB1 protein results in decreased expression of TRIB3 mRNA]
Fenofibrate results in decreased expression of TRIB3 mRNA
Fenofibrate inhibits the reaction [Arsenic Trioxide results in increased expression of TRIB3 mRNA]; Fenofibrate inhibits the reaction [Arsenic Trioxide results in increased expression of TRIB3 protein]

PMID:19593819 PMID:32929351

NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952

G

tripartite motif-containing 24

increases expression

Fenofibrate results in increased expression of TRIM24 mRNA

NCBI chr 6:37,846,816...37,945,380
Ensembl chr 6:37,847,746...37,943,231

G

tripartite motif-containing 63

multiple interactions
increases expression

Lovastatin promotes the reaction [Fenofibrate results in increased expression of TRIM63 protein]; PPARA protein affects the reaction [Fenofibrate results in increased expression of TRIM63 mRNA]
Fenofibrate results in increased expression of TRIM63 mRNA; Fenofibrate results in increased expression of TRIM63 protein

NCBI chr 4:134,042,431...134,056,940
Ensembl chr 4:134,042,431...134,056,940

G

thyroid hormone receptor interactor 12

increases expression
multiple interactions

Fenofibrate results in increased expression of TRIP12 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of TRIP12 mRNA]

NCBI chr 1:84,698,910...84,818,285
Ensembl chr 1:84,698,910...84,818,237

G

transformation related protein 53

increases expression
affects activity

Fenofibrate results in increased expression of TP53 mRNA
Fenofibrate affects the activity of TP53 protein

PMID:17264098 PMID:25596134

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

transformation related protein 53 inducible nuclear protein 1

increases expression
affects expression
decreases expression

Fenofibrate results in increased expression of TRP53INP1 mRNA
Fenofibrate affects the expression of TP53INP1 mRNA
Fenofibrate results in decreased expression of TP53INP1 mRNA

PMID:17264098 PMID:25596134

NCBI chr 4:11,156,441...11,174,379
Ensembl chr 4:11,156,431...11,174,379

G

thioredoxin interacting protein

increases expression

Fenofibrate results in increased expression of TXNIP mRNA

PMID:17264098 PMID:25572481

NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199

G

thioredoxin reductase 1

increases expression

Fenofibrate results in increased expression of TXNRD1 mRNA

NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546

G

tyrosinase

multiple interactions
decreases expression

[Fenofibrate results in decreased chemical synthesis of Melanins] which results in decreased expression of TYR; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Fenofibrate results in decreased expression of TYR protein]; Fenofibrate results in decreased expression of and results in decreased activity of TYR protein
Fenofibrate results in decreased expression of TYR mRNA

NCBI chr 7:87,073,979...87,142,637
Ensembl chr 7:87,073,979...87,142,720

G

ubiquitin-like modifier activating enzyme 5

decreases expression

Fenofibrate results in decreased expression of UBA5 mRNA

NCBI chr 9:103,923,786...103,940,767
Ensembl chr 9:103,923,798...103,940,333

G

ubiquitin-conjugating enzyme E2G 2

affects expression

Fenofibrate affects the expression of UBE2G2 mRNA

NCBI chr10:77,458,155...77,481,824
Ensembl chr10:77,458,109...77,481,827

G

ubiquitin-conjugating enzyme E2Q family member 2

increases expression
multiple interactions

Fenofibrate results in increased expression of UBE2Q2 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of UBE2Q2 mRNA]

NCBI chr 9:55,056,602...55,114,813
Ensembl chr 9:55,056,138...55,114,813

G

ubiquitin-conjugating enzyme E2R 2

decreases expression
multiple interactions

Fenofibrate results in decreased expression of UBE2R2 mRNA
PPARA protein affects the reaction [Fenofibrate results in decreased expression of UBE2R2 mRNA]

NCBI chr 4:41,136,021...41,193,370
Ensembl chr 4:41,135,743...41,193,380

G

ubiquitin-conjugating enzyme E2W (putative)

increases expression

Fenofibrate results in increased expression of UBE2W mRNA

NCBI chr 1:16,611,012...16,689,676
Ensembl chr 1:16,611,014...16,689,713

G

ubiquitin protein ligase E3A

increases expression
multiple interactions

Fenofibrate results in increased expression of UBE3A mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of UBE3A mRNA]

NCBI chr 7:58,871,891...58,960,585
Ensembl chr 7:58,878,498...58,961,284

G

ubiquitin protein ligase E3 component n-recognin 2

multiple interactions
increases expression

[PPARA protein affects the susceptibility to Fenofibrate] which affects the expression of UBR2 mRNA
Fenofibrate results in increased expression of UBR2 mRNA

NCBI chr17:47,239,217...47,321,812
Ensembl chr17:47,239,221...47,321,482

G

uncoupling protein 2 (mitochondrial, proton carrier)

multiple interactions
increases expression

[Fenofibrate binds to and results in increased activity of PPARA protein] which results in increased expression of UCP2 mRNA; [Fenofibrate co-treated with Sodium Glutamate] results in increased expression of UCP2 mRNA
PPARA protein promotes the reaction [Fenofibrate results in increased expression of UCP2 protein]
PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of UCP2 mRNA]; PPARA gene mutant form inhibits the reaction [Fenofibrate results in increased expression of UCP2 protein]
Fenofibrate results in increased expression of UCP2 mRNA; Fenofibrate results in increased expression of UCP2 protein

PMID:11341955 PMID:16595124 PMID:21999347 PMID:24752549 PMID:32741897

NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227

G

uncoupling protein 3 (mitochondrial, proton carrier)

increases expression
multiple interactions

Fenofibrate results in increased expression of UCP3 mRNA
fenofibrate co-treated with fructose increases expression of Ucp3 mRNA in liver and muscle
fenofibrate increases expression of Ucp3 mRNA in muscle

CTD
RGD

PMID:16595124 PMID:11934685 PMID:11934685

RGD:628329, RGD:628329

NCBI chr 7:100,122,198...100,135,639
Ensembl chr 7:100,122,197...100,135,639

G

UDP glucuronosyltransferase 1 family, polypeptide A1

increases expression

Fenofibrate results in increased expression of UGT1A1 mRNA

NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases expression

Fenofibrate results in increased expression of UGT1A3 mRNA

NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719

G

UDP glucuronosyltransferase 1 family, polypeptide A6B

multiple interactions
increases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA
Fenofibrate results in increased expression of UGT1A6 mRNA

PMID:18253720 PMID:18775883

NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725

G

ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5) decarboxylase

increases expression

Fenofibrate results in increased expression of URAD mRNA

NCBI chr 5:147,251,794...147,259,250
Ensembl chr 5:147,251,794...147,259,250

G

URI1, prefoldin-like chaperone

increases expression
multiple interactions

Fenofibrate results in increased expression of URI1 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of URI1 mRNA]

NCBI chr 7:37,659,417...37,722,989
Ensembl chr 7:37,659,417...37,722,976

G

ubiquitin related modifier 1

decreases expression
multiple interactions

Fenofibrate results in decreased expression of URM1 mRNA
PPARA protein affects the reaction [Fenofibrate results in decreased expression of URM1 mRNA]

NCBI chr 2:29,717,401...29,735,008
Ensembl chr 2:29,710,087...29,735,014

G

ubiquitin specific peptidase 1

increases expression
multiple interactions

Fenofibrate results in increased expression of USP1 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of USP1 mRNA]

NCBI chr 4:98,812,047...98,823,780
Ensembl chr 4:98,812,047...98,823,780

G

ubiquitin specific peptidase 10

increases expression
multiple interactions

Fenofibrate results in increased expression of USP10 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of USP10 mRNA]

NCBI chr 8:120,637,099...120,684,299
Ensembl chr 8:120,637,099...120,684,299

G

ubiquitin specific peptidase 22

increases expression
multiple interactions

Fenofibrate results in increased expression of USP22 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of USP22 mRNA]

NCBI chr11:61,042,607...61,065,885
Ensembl chr11:61,042,611...61,065,881

G

ubiquitin specific peptidase 3

increases expression

Fenofibrate results in increased expression of USP3 mRNA

NCBI chr 9:66,421,573...66,501,996
Ensembl chr 9:66,421,919...66,500,424

G

ubiquitin specific peptidase 36

decreases expression
multiple interactions

Fenofibrate results in decreased expression of USP36 mRNA
PPARA protein affects the reaction [Fenofibrate results in decreased expression of USP36 mRNA]

NCBI chr11:118,150,477...118,181,086
Ensembl chr11:118,150,477...118,181,070

G

ubiquitin specific peptidase 38

increases expression
multiple interactions

Fenofibrate results in increased expression of USP38 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of USP38 mRNA]

NCBI chr 8:81,707,353...81,741,631
Ensembl chr 8:81,707,362...81,741,557

G

ubiquitin specific peptidase 4 (proto-oncogene)

increases expression

Fenofibrate results in increased expression of USP4 mRNA

NCBI chr 9:108,223,763...108,269,744
Ensembl chr 9:108,225,052...108,269,744

G

ubiquitin specific peptidase 7

increases expression
multiple interactions

Fenofibrate results in increased expression of USP7 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of USP7 mRNA]

NCBI chr16:8,506,586...8,574,931
Ensembl chr16:8,507,459...8,610,172

G

ubiquitin specific peptidase 9, X chromosome

increases expression
multiple interactions

Fenofibrate results in increased expression of USP9X mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of USP9X mRNA]

NCBI chr X:12,937,221...13,039,567
Ensembl chr X:12,937,737...13,039,567

G

ubiquitin specific peptidase like 1

increases expression
multiple interactions

Fenofibrate results in increased expression of USPL1 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of USPL1 mRNA]

NCBI chr 5:149,121,338...149,152,246
Ensembl chr 5:149,121,160...149,152,244

G

valyl-tRNA synthetase 1

increases expression

Fenofibrate results in increased expression of VARS1 mRNA

NCBI chr17:35,219,895...35,235,304
Ensembl chr17:35,219,963...35,235,298

G

vascular cell adhesion molecule 1

multiple interactions

Fenofibrate inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]
dorsomorphin inhibits the reaction [Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of VCAM1 mRNA]]; Fenofibrate inhibits the reaction [ALB protein modified form results in increased expression of VCAM1 mRNA]

PMID:20580385 PMID:21300114

NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337

G

valosin containing protein (p97)/p47 complex interacting protein 1

increases expression
multiple interactions

Fenofibrate results in increased expression of VCPIP1 mRNA
PPARA protein affects the reaction [Fenofibrate results in increased expression of VCPIP1 mRNA]

NCBI chr 1:9,788,847...9,818,607
Ensembl chr 1:9,788,847...9,818,607

G

vascular endothelial growth factor A

multiple interactions

Fenofibrate inhibits the reaction [AHR protein affects the reaction [AGT protein results in increased expression of VEGFA protein]]

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

vascular endothelial growth factor B

increases expression

Fenofibrate results in increased expression of VEGFB mRNA

PMID:17264098 PMID:25596134

NCBI chr19:6,959,840...6,965,019
Ensembl chr19:6,959,841...6,965,019

G

vanin 1

increases expression

Fenofibrate results in increased expression of VNN1 mRNA

PMID:11798191 PMID:25572481 PMID:27665778 PMID:32741897

NCBI chr10:23,770,586...23,781,242
Ensembl chr10:23,770,586...23,781,241

G

V-set immunoregulatory receptor

decreases expression

Fenofibrate results in decreased expression of VSIR mRNA

NCBI chr10:60,182,630...60,266,073
Ensembl chr10:60,182,630...60,208,463

G

von Willebrand factor A domain containing 8

increases expression

Fenofibrate results in increased expression of VWA8 mRNA

NCBI chr14:79,086,489...79,439,750
Ensembl chr14:79,086,492...79,439,750

G

WD repeat and SOCS box-containing 1

decreases expression
multiple interactions

Fenofibrate results in decreased expression of WSB1 mRNA
PPARA protein affects the reaction [Fenofibrate results in decreased expression of WSB1 mRNA]

NCBI chr11:79,130,208...79,145,521
Ensembl chr11:79,130,198...79,145,497

G

WD repeat and SOCS box-containing 2

increases expression

Fenofibrate results in increased expression of WSB2 mRNA

NCBI chr 5:117,495,370...117,516,666
Ensembl chr 5:117,495,369...117,516,666

G

WW, C2 and coiled-coil domain containing 2

decreases expression

Fenofibrate results in decreased expression of WWC2 mRNA

NCBI chr 8:48,279,117...48,443,579
Ensembl chr 8:48,276,994...48,443,959

G

X-box binding protein 1

affects activity
decreases expression

Fenofibrate affects the activity of XBP1 protein
Fenofibrate results in decreased expression of XBP1 mRNA

NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893

G

xeroderma pigmentosum, complementation group C

decreases expression

Fenofibrate results in decreased expression of XPC mRNA

NCBI chr 6:91,466,287...91,492,870
Ensembl chr 6:91,466,287...91,492,870

G

X-ray repair complementing defective repair in Chinese hamster cells 5

multiple interactions
increases expression

[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of XRCC5 mRNA
Fenofibrate results in increased expression of XRCC5 mRNA

PMID:17264098 PMID:18253720 PMID:18775883

NCBI chr 1:72,346,576...72,434,112
Ensembl chr 1:72,346,586...72,434,111

G

tyrosyl-tRNA synthetase 1

increases expression

Fenofibrate results in increased expression of YARS1 mRNA

NCBI chr 4:129,083,595...129,113,033
Ensembl chr 4:129,083,553...129,113,400

isocarbophos

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity

isocarbophos metabolite results in decreased activity of ACHE protein
isocarbophos results in decreased activity of ACHE protein

PMID:24752505 PMID:26818681 PMID:33844597

NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728

G

BCL2-associated X protein

increases expression

isocarbophos analog results in increased expression of BAX protein

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

decreases expression

isocarbophos analog results in decreased expression of BCL2 protein

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

caspase 3

increases cleavage

isocarbophos results in increased cleavage of CASP3 protein

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

CYP1A2 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

G

cytochrome P450, family 2, subfamily c, polypeptide 38

multiple interactions

CYP2C19 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos

NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519

G

cytochrome P450, family 2, subfamily c, polypeptide 65

multiple interactions

CYP2C9 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos

NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388

G

cytochrome P450, family 2, subfamily d, polypeptide 22

multiple interactions

CYP2D6 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos

NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461

G

gap junction protein, alpha 1

increases expression

isocarbophos results in increased expression of GJA1 protein

NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609

G

intercellular adhesion molecule 1

increases expression

isocarbophos results in increased expression of ICAM1 protein

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

mitogen-activated protein kinase 1

increases phosphorylation
multiple interactions

isocarbophos analog results in increased phosphorylation of MAPK1 protein
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [isocarbophos analog results in increased phosphorylation of MAPK1 protein]

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

increases phosphorylation
multiple interactions

isocarbophos analog results in increased phosphorylation of MAPK3 protein
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [isocarbophos analog results in increased phosphorylation of MAPK3 protein]

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

transformation related protein 53

affects activity

isocarbophos affects the activity of TP53 protein; isocarbophos metabolite affects the activity of TP53 protein

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

vascular cell adhesion molecule 1

increases expression

isocarbophos results in increased expression of VCAM1 protein

NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337

isofenphos

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

androgen receptor

multiple interactions

Dihydrotestosterone inhibits the reaction [isofenphos results in increased activity of AR protein]

NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821

G

estrogen receptor 1 (alpha)

increases activity

isofenphos results in increased activity of ESR1 protein

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

isofenphos binds to and results in increased activity of NR1I2 protein; isofenphos metabolite binds to and results in increased activity of NR1I2 protein

NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186

G

nuclear receptor subfamily 1, group I, member 3

increases activity

isofenphos results in increased activity of NR1I3 protein

NCBI chr 1:171,041,503...171,046,414
Ensembl chr 1:171,041,539...171,048,270

G

transformation related protein 53

affects activity

isofenphos metabolite affects the activity of TP53 protein

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

isopropyl palmitate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

insulin II

multiple interactions

[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased abundance of isopropyl palmitate analog

NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118

isoprothiolane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

estrogen receptor 1 (alpha)

multiple interactions
decreases expression

isoprothiolane binds to and results in increased activity of ESR1 protein
isoprothiolane results in decreased expression of ESR1 protein

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

isoprothiolane binds to and results in increased activity of NR1I2 protein

NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186

G

progesterone receptor

increases expression

isoprothiolane results in increased expression of PGR mRNA

NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612

G

trefoil factor 1

increases expression

isoprothiolane results in increased expression of TFF1 mRNA

NCBI chr17:31,380,369...31,384,034
Ensembl chr17:31,380,369...31,384,251

Isradipine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B member 11

decreases activity
multiple interactions

Isradipine results in decreased activity of ABCB11 protein
Isradipine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]

NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958

G

aryl-hydrocarbon receptor

increases activity

Isradipine results in increased activity of AHR protein

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

calcium channel, voltage-dependent, R type, alpha 1E subunit

multiple interactions

Isradipine inhibits the reaction [CACNA1E protein results in increased transport of Barium]; omega-conotoxin-MVIIC promotes the reaction [Isradipine inhibits the reaction [CACNA1E protein results in increased transport of Barium]]

NCBI chr 1:154,266,552...154,760,374
Ensembl chr 1:154,266,477...154,760,247

G

calcium channel, voltage-dependent, alpha 1F subunit

multiple interactions

Isradipine inhibits the reaction [CACNA1F protein results in increased transport of Barium]

NCBI chr X:7,473,342...7,501,435
Ensembl chr X:7,473,322...7,501,435

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
decreases activity

Isradipine results in increased expression of CYP1A1 mRNA
Isradipine results in decreased activity of CYP1A1 protein

PMID:27732883 PMID:33814510

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

Isradipine results in increased expression of CYP1A2 mRNA

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Isradipine results in decreased activity of CYP1B1 protein

NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490

G

cytochrome P450, family 2, subfamily a, polypeptide 5

increases expression

Isradipine results in increased expression of CYP2A6 mRNA; Isradipine results in increased expression of CYP2A6 protein

NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973

G

cytochrome P450, family 2, subfamily b, polypeptide 10

increases expression

Isradipine results in increased expression of CYP2B6 mRNA; Isradipine results in increased expression of CYP2B6 protein

NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049

G

cytochrome P450, family 2, subfamily c, polypeptide 65

decreases activity

Isradipine results in decreased activity of CYP2C9 protein

NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388

G

fibroblast growth factor 2

increases secretion

Isradipine results in increased secretion of FGF2 protein

NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257

G

nuclear receptor coactivator 2

multiple interactions

Isradipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]

NCBI chr 1:13,209,329...13,444,451
Ensembl chr 1:13,209,329...13,444,307

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

Isradipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]

NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447

G

nuclear receptor subfamily 1, group I, member 2

increases activity

Isradipine results in increased activity of NR1I2 protein

NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186

G

preproenkephalin

multiple interactions

Isradipine inhibits the reaction [Oxidopamine results in increased expression of PENK mRNA]

NCBI chr 4:4,133,536...4,138,815
Ensembl chr 4:4,133,531...4,138,819

G

renin 1 structural

increases activity

Isradipine results in increased activity of REN protein

NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063

G

steroidogenic acute regulatory protein

multiple interactions

Isradipine promotes the reaction [Cyclic AMP results in increased expression of STAR protein]

NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010

latanoprost

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B member 11

decreases activity

latanoprost results in decreased activity of ABCB11 protein

NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958

Malotilate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome b5 type A (microsomal)

increases expression
multiple interactions

diisopropyl 1,3-dithiol-2-ylidenemalonate results in increased expression of CYB5A protein
diisopropyl 1,3-dithiol-2-ylidenemalonate results in increased expression of [CYB5A protein results in increased metabolism of Halothane]

NCBI chr18:84,869,463...84,897,996
Ensembl chr18:84,856,829...84,897,996

G

glutamic pyruvic transaminase, soluble

multiple interactions

diisopropyl 1,3-dithiol-2-ylidenemalonate inhibits the reaction [allyl alcohol results in increased activity of GPT protein]; diisopropyl 1,3-dithiol-2-ylidenemalonate inhibits the reaction [bromobenzene results in increased activity of GPT protein]; diisopropyl 1,3-dithiol-2-ylidenemalonate inhibits the reaction [Chloroform results in increased activity of GPT protein]; diisopropyl 1,3-dithiol-2-ylidenemalonate inhibits the reaction [Dimethylnitrosamine results in increased activity of GPT protein]; diisopropyl 1,3-dithiol-2-ylidenemalonate inhibits the reaction [Thioacetamide results in increased activity of GPT protein]

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

methoprene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

retinoid X receptor alpha

multiple interactions

Methoprene binds to and results in increased activity of RXRA protein

NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969

G

retinoid X receptor beta

multiple interactions

Methoprene binds to and results in increased activity of RXRB protein

NCBI chr17:34,250,786...34,257,377
Ensembl chr17:34,250,786...34,257,373

G

uncoupling protein 1 (mitochondrial, proton carrier)

increases expression

Methoprene results in increased expression of UCP1 mRNA

NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081

Nilvadipine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B member 1A

multiple interactions

nilvadipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]

NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575

G

cytochrome P450, family 2, subfamily j, polypeptide 9

decreases activity

nilvadipine results in decreased activity of CYP2J2 protein

NCBI chr 4:96,456,661...96,480,748
Ensembl chr 4:96,456,666...96,479,815

G

FMS-like tyrosine kinase 1

multiple interactions

nilvadipine inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA]

NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821

G

neurofilament, light polypeptide

multiple interactions

nilvadipine inhibits the reaction [Rotenone results in decreased expression of NEFL mRNA]

NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544

G

renin 1 structural

multiple interactions

nilvadipine inhibits the reaction [Tacrolimus results in increased expression of REN protein]

NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063

nimodipine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

anoctamin 1, calcium activated chloride channel

decreases activity

Nimodipine results in decreased activity of ANO1 protein

NCBI chr 7:144,142,286...144,305,762
Ensembl chr 7:144,142,286...144,305,711

G

amyloid beta precursor protein

multiple interactions

Nimodipine inhibits the reaction [APP protein results in increased uptake of Calcium]

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

androgen receptor

decreases activity

Nimodipine results in decreased activity of AR protein

NCBI chr X:97,192,363...97,366,824
Ensembl chr X:97,192,375...97,366,821

G

BCL2-associated X protein

increases expression
multiple interactions

Nimodipine results in increased expression of BAX protein
Nimodipine inhibits the reaction [Sevoflurane results in increased expression of BAX protein]

PMID:17490525 PMID:33171207

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

decreases expression
multiple interactions

Nimodipine results in decreased expression of BCL2 protein
Nimodipine inhibits the reaction [Sevoflurane results in decreased expression of BCL2 protein]

PMID:17490525 PMID:33171207

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

brain derived neurotrophic factor

multiple interactions

[alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in decreased expression of BDNF protein]

NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352

G

baculoviral IAP repeat-containing 5

multiple interactions

Nimodipine inhibits the reaction [Dibutyl Phthalate results in decreased expression of BIRC5 protein]

NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569

G

calcium channel, voltage-dependent, L type, alpha 1C subunit

multiple interactions

Nimodipine inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein]

NCBI chr 6:118,564,201...119,174,345
Ensembl chr 6:118,564,201...119,173,851

G

calcitonin/calcitonin-related polypeptide, alpha

multiple interactions

Nimodipine inhibits the reaction [Potassium results in increased secretion of CALCA protein]

NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592

G

caspase 3

multiple interactions
increases activity

Palmitic Acid promotes the reaction [Nimodipine results in increased activity of CASP3 protein]
[alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]; Nimodipine inhibits the reaction [Dibutyl Phthalate results in increased expression of CASP3 protein]
Nimodipine inhibits the reaction [Sevoflurane results in increased expression of CASP3 protein modified form]

PMID:22700542 PMID:30776390 PMID:33171207 PMID:33336902

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 7

multiple interactions
increases activity

Palmitic Acid promotes the reaction [Nimodipine results in increased activity of CASP7 protein]

NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776

G

caspase 9

multiple interactions

Nimodipine inhibits the reaction [Sevoflurane results in increased expression of CASP9 protein modified form]

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

multiple interactions

Nimodipine inhibits the reaction [Pilocarpine results in increased expression of CAT protein]

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

cystic fibrosis transmembrane conductance regulator

increases activity
multiple interactions

Nimodipine results in increased activity of CFTR protein
3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [Nimodipine results in increased activity of CFTR protein]; Colforsin promotes the reaction [Nimodipine results in increased activity of CFTR protein]

NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767

G

glycoprotein hormones, alpha subunit

multiple interactions

Nimodipine inhibits the reaction [cypermethrin results in increased expression of CGA mRNA]

NCBI chr 4:34,893,779...34,907,374
Ensembl chr 4:34,893,779...34,907,370

G

clusterin

multiple interactions

Nimodipine inhibits the reaction [Cadmium results in increased expression of CLU protein]; Nimodipine inhibits the reaction [Zinc results in increased expression of CLU protein]

NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996

G

collagen, type I, alpha 1

multiple interactions

Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of COL1A1 protein]

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

cAMP responsive element binding protein 1

multiple interactions

[alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in decreased phosphorylation of CREB1 protein]; Nimodipine inhibits the reaction [Dibutyl Phthalate results in decreased phosphorylation of CREB1 protein]

NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707

G

cytochrome c, somatic

multiple interactions

Nimodipine inhibits the reaction [Sevoflurane results in increased expression of CYCS protein]

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions

Nimodipine inhibits the reaction [cypermethrin results in increased expression of CYP11A1 mRNA]

PMID:28731686 PMID:35931855

NCBI chr 9:57,905,307...57,934,314
Ensembl chr 9:57,913,694...57,934,306

G

dopamine beta hydroxylase

multiple interactions

Nimodipine inhibits the reaction [Dichlorvos results in increased activity of DBH protein]

NCBI chr 2:27,055,519...27,073,216
Ensembl chr 2:27,055,245...27,073,212

G

dopamine receptor D2

multiple interactions

Nimodipine inhibits the reaction [Dichlorvos results in decreased activity of DRD2 protein]

NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477

G

early growth response 1

multiple interactions

Nimodipine inhibits the reaction [Zinc results in increased expression of EGR1 protein]

NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037

G

FBJ osteosarcoma oncogene

multiple interactions
increases expression

Nimodipine affects the reaction [Haloperidol results in increased expression of FOS protein]
Nimodipine results in increased expression of FOS mRNA

PMID:12730611 PMID:17913375

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

follicle stimulating hormone beta

multiple interactions

Nimodipine inhibits the reaction [cypermethrin results in increased expression of FSHB mRNA]; Nimodipine inhibits the reaction [cypermethrin results in increased secretion of FSHB protein]

NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001

G

ferritin heavy polypeptide 1

multiple interactions

Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein]

NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462

G

gap junction protein, alpha 1

multiple interactions

Nimodipine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of GJA1 protein]

NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609

G

hepcidin antimicrobial peptide

multiple interactions

Nimodipine promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA]

NCBI chr 7:30,641,793...30,643,454
Ensembl chr 7:30,641,793...30,643,457

G

jun proto-oncogene

multiple interactions

Nimodipine inhibits the reaction [4-OH-2',3,3',4',5'-pentachlorobiphenyl results in increased expression of JUN protein]

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

potassium voltage-gated channel, subfamily H (eag-related), member 2

multiple interactions

Nimodipine inhibits the reaction [KCNH2 protein affects the abundance of Calcium]

NCBI chr 5:24,524,583...24,556,671
Ensembl chr 5:24,524,587...24,556,602

G

luteinizing hormone beta

multiple interactions

Nimodipine inhibits the reaction [cypermethrin results in increased expression of LHB mRNA]; Nimodipine inhibits the reaction [cypermethrin results in increased secretion of LHB protein]

NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321

G

microtubule-associated protein 2

multiple interactions

Nimodipine inhibits the reaction [Dichlorvos results in increased phosphorylation of MAP2 protein]

NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742

G

mitogen-activated protein kinase 1

multiple interactions

[Nimodipine co-treated with alpha-Tocopherol] inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK1 protein]; Nimodipine inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Nimodipine inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK1 protein]

PMID:29149324 PMID:30776390 PMID:33336902

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

multiple interactions

[Nimodipine co-treated with alpha-Tocopherol] inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK3 protein]; Nimodipine inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Nimodipine inhibits the reaction [Dibutyl Phthalate results in increased expression of and results in increased phosphorylation of MAPK3 protein]

PMID:29149324 PMID:30776390 PMID:33336902

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

matrix metallopeptidase 13

multiple interactions

Nimodipine promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]

NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331

G

nuclear receptor coactivator 2

multiple interactions

Nimodipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]

NCBI chr 1:13,209,329...13,444,451
Ensembl chr 1:13,209,329...13,444,307

G

natriuretic peptide type C

multiple interactions

Nimodipine inhibits the reaction [NPPC protein results in increased uptake of Calcium]

NCBI chr 1:86,594,015...86,598,295
Ensembl chr 1:86,594,013...86,598,293

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions
increases activity
decreases activity

Nimodipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; Nimodipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
Nimodipine results in increased activity of NR1H4 protein
Nimodipine results in decreased activity of NR1H4 protein

PMID:25257666 PMID:27773686

NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447

G

nuclear receptor subfamily 1, group I, member 2

increases activity

Nimodipine results in increased activity of NR1I2 protein

PMID:21068194 PMID:25455453

NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186

G

protein kinase C, alpha

multiple interactions

Nimodipine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of and results in decreased phosphorylation of PRKCA protein]

NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754

G

v-raf-leukemia viral oncogene 1

multiple interactions

Nimodipine inhibits the reaction [cypermethrin results in increased phosphorylation of and results in increased activity of RAF1 protein]

NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596

G

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

multiple interactions

Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein]

NCBI chr15:100,285,779...100,322,090
Ensembl chr15:100,285,779...100,322,953

G

steroidogenic acute regulatory protein

multiple interactions

Nimodipine inhibits the reaction [cypermethrin results in increased expression of STAR mRNA]

PMID:28731686 PMID:35931855

NCBI chr 8:26,298,502...26,306,010
Ensembl chr 8:26,296,583...26,306,010

G

tyrosine hydroxylase

multiple interactions

Nimodipine inhibits the reaction [Dichlorvos results in increased activity of TH protein]

NCBI chr 7:142,446,516...142,453,732
Ensembl chr 7:142,446,489...142,484,865

G

tissue inhibitor of metalloproteinase 1

multiple interactions

Nimodipine inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein]

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

tumor necrosis factor

multiple interactions

[alpha-Tocopherol co-treated with Nimodipine] inhibits the reaction [Dibutyl Phthalate results in increased expression of TNF protein]

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

propetamphos

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

decreases activity
multiple interactions

propetamphos results in decreased activity of CAT protein
[cypermethrin co-treated with propetamphos] results in decreased activity of CAT protein
[propetamphos co-treated with cypermethrin] results in decreased activity of CAT protein

PMID:18214882 PMID:25926273

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

cytochrome c, somatic

multiple interactions
increases activity

[propetamphos co-treated with cypermethrin] results in increased activity of CYCS protein
propetamphos results in increased activity of CYCS protein

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
increases activity

[cypermethrin co-treated with propetamphos] results in increased activity of CYP2E1 protein
propetamphos results in increased activity of CYP2E1 protein

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

glucose-6-phosphate dehydrogenase X-linked

multiple interactions
decreases activity

[cypermethrin co-treated with propetamphos] results in decreased activity of G6PD protein
propetamphos results in decreased activity of G6PD protein

NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800

G

transformation related protein 53

affects activity

propetamphos metabolite affects the activity of TP53 protein

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

sofosbuvir

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

killer cell lectin-like receptor subfamily C, member 1

decreases expression

sofosbuvir co-treated with ledipasvir decreased expression of NCR1 protein in natural killer cells

RGD

NCBI chr 6:129,642,978...129,659,815
Ensembl chr 6:129,642,978...129,655,936

G

natural cytotoxicity triggering receptor 1

affects expression

sofosbuvir co-treated with ledipasvir affects expression of NCR1 protein in natural killer cells

RGD

NCBI chr 7:4,340,714...4,348,183
Ensembl chr 7:4,340,723...4,348,163

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22178
role	22194
chemical role	21407
donor	20266
Bronsted acid	20160
protic solvent	15299
propan-2-ol	791
(S)-1-(2,5-xylyloxy)-3-morpholinopropan-2-ol	0
1,1,1,3,3,3-hexafluoropropan-2-ol	0
O-propan-2-yl hexanethioate	0
isopropyl 3-hydroxybut-2-enoate +	5
isopropyl ester +	777
monoisopropyl phthalate	0
trimethyl(1-methylethoxy)silane	0
Path 2
Term	Annotations
CHEBI ontology	22178
subatomic particle	22170
composite particle	22170
hadron	22201
baryon	22170
nucleon	22170
atomic nucleus	22170
atom	22170
main group element atom	22104
p-block element atom	22104
carbon group element atom	21904
carbon atom	21859
organic molecular entity	21830
heteroorganic entity	21482
organochalcogen compound	20966
organooxygen compound	20806
carbon oxoacid	19593
carboxylic acid	19589
monocarboxylic acid	18952
fatty acid	17131
fatty acid derivative	8963
fatty alcohol	6054
secondary fatty alcohol	791
propan-2-ol	791
(S)-1-(2,5-xylyloxy)-3-morpholinopropan-2-ol	0
1,1,1,3,3,3-hexafluoropropan-2-ol	0
O-propan-2-yl hexanethioate	0
isopropyl 3-hydroxybut-2-enoate +	5
isopropyl ester +	777
monoisopropyl phthalate	0
trimethyl(1-methylethoxy)silane	0

paths to the root