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ONTOLOGY REPORT - ANNOTATIONS


Term:calcitriol
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Accession:CHEBI:17823 term browser browse the term
Definition:A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Synonyms:related_synonym: (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol;   (1alpha,3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol;   (5Z,7E)-(1S,3R)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol;   1,25-DHCC;   1-alpha-25-Dihydroxyvitamin D3;   1alpha,25(OH)2D3;   1alpha,25-dihydroxycholecalciferol;   1alpha,25-dihydroxyvitamin D3;   5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL;   Calcijex;   Decostriol;   Formula=C27H44O3;   InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1;   InChIKey=GMRQFYUYWCNGIN-NKMMMXOESA-N;   Rocaltrol;   SMILES=[H][C@@]1(CC[C@@]2([H])\\C(CCC[C@]12C)=C\\C=C1\\C[C@@H](O)C[C@H](O)C1=C)[C@H](C)CCCC(C)(C)O;   calcitriolum
 alt_id: CHEBI:13932;   CHEBI:19209;   CHEBI:3307;   CHEBI:46435
 xref: Beilstein:2227647 "Beilstein";   CAS:32222-06-3 "ChemIDplus";   CAS:32222-06-3 "KEGG COMPOUND";   DrugBank:DB00136;   Drug_Central:466 "DrugCentral";   KEGG:C01673;   KEGG:D00129;   LIPID_MAPS_instance:LMST03020258 "LIPID MAPS"
 xref_mesh: MESH:D002117
 xref: MetaCyc:CALCITRIOL;   PDBeChem:VDX;   PMID:10217585 "Europe PMC";   PMID:15928596 "Europe PMC";   PMID:19429426 "Europe PMC";   PMID:20599255 "Europe PMC";   PMID:22905919 "Europe PMC";   PMID:23103122 "Europe PMC";   PMID:23144765 "Europe PMC";   PMID:6687801 "Europe PMC";   Reaxys:2227647 "Reaxys";   Wikipedia:Calcitriol


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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20971
    role 20952
      biological role 20950
        immunomodulator 13975
          calcitriol 2417
            18-acetoxy-1alpha,25-dihydroxyvitamin D3 0
            1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 0
            1alpha,25-dihydroxy-2beta-(4-hydroxybutoxy)vitamin D3 0
            AMCR277A 0
            AMCR277B 0
            calcitriol 25-O-(beta-D-glucuronate) 0
            calcitriol 25-O-(beta-D-glucuronide) 0
            calcitriol 26,23-lactone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20971
    subatomic particle 20965
      composite particle 20965
        hadron 20965
          baryon 20965
            nucleon 20965
              atomic nucleus 20965
                atom 20965
                  main group element atom 20803
                    p-block element atom 20803
                      carbon group element atom 20543
                        carbon atom 20519
                          organic molecular entity 20519
                            organic molecule 20371
                              organic cyclic compound 20047
                                organic polycyclic compound 16869
                                  steroid 13008
                                    hydroxy steroid 12576
                                      hydroxy seco-steroid 2668
                                        vitamin D 2664
                                          D3 vitamins 2614
                                            calciol 2614
                                              hydroxycalciol 2471
                                                calcitriol 2417
                                                  18-acetoxy-1alpha,25-dihydroxyvitamin D3 0
                                                  1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 0
                                                  1alpha,25-dihydroxy-2beta-(4-hydroxybutoxy)vitamin D3 0
                                                  AMCR277A 0
                                                  AMCR277B 0
                                                  calcitriol 25-O-(beta-D-glucuronate) 0
                                                  calcitriol 25-O-(beta-D-glucuronide) 0
                                                  calcitriol 26,23-lactone 0
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