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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:serine
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Accession:CHEBI:17822 term browser browse the term
Definition:An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.
Synonyms:related_synonym: 2-Amino-3-hydroxypropionic acid;   2-amino-3-hydroxypropanoic acid;   3-Hydroxyalanine;   Formula=C3H7NO3;   InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7);   InChIKey=MTCFGRXMJLQNBG-UHFFFAOYSA-N;   SMILES=NC(CO)C(O)=O;   Serin
 alt_id: CHEBI:15081;   CHEBI:26648;   CHEBI:9116
 xref: Beilstein:1721402;   CAS:302-84-1;   Gmelin:26429;   KEGG:C00716;   KNApSAcK:C00001393;   Reaxys:1721402;   Wikipedia:Serine
 cyclic_relationship: is_conjugate_acid_of CHEBI:32845;   is_conjugate_base_of CHEBI:32846;   is_tautomer_of CHEBI:35243



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D-cycloserine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Cycloserine inhibits the reaction [resveratrol results in increased expression of DDIT3 protein] CTD PMID:24264887 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Egr1 early growth response 1 increases expression EXP Cycloserine results in increased expression of EGR1 protein CTD PMID:19144966 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Cycloserine promotes the reaction [Clozapine results in increased expression of FOS mRNA] CTD PMID:12464447 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions EXP Cycloserine inhibits the reaction [Clozapine results in increased expression of HOMER1 mRNA]; Cycloserine inhibits the reaction [Haloperidol results in increased expression of HOMER1 mRNA] CTD PMID:12464447 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Cycloserine inhibits the reaction [Dronabinol results in increased activity of MAPK1 protein] CTD PMID:11903061 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Cycloserine inhibits the reaction [Dronabinol results in increased activity of MAPK3 protein] CTD PMID:11903061 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Cycloserine inhibits the reaction [resveratrol results in increased cleavage of PARP1 protein] CTD PMID:24264887 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
L-serine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt1 angiopoietin 1 multiple interactions EXP [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine affects the localization of TARDBP protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in decreased expression of SLC1A2 protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of APP protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of IL6 protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of MAP1LC3B protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased phosphorylation of MAPT protein] CTD PMID:30476904 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of APP protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of APP protein] CTD PMID:30476904 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Serine results in increased expression of ATF4 mRNA CTD PMID:29098664 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Serine results in increased expression of ATF6 mRNA CTD PMID:29098664 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atf6b activating transcription factor 6 beta increases expression ISO Serine results in increased expression of ATF6B mRNA CTD PMID:29098664 NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894
JBrowse link
G Atxn3 ataxin 3 increases expression ISO Serine results in increased expression of ATXN3 mRNA CTD PMID:29098664 NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Serine results in increased expression of BAX mRNA CTD PMID:29098664 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Calr calreticulin increases expression ISO Serine results in increased expression of CALR mRNA CTD PMID:29098664 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Canx calnexin increases expression ISO Serine results in increased expression of CANX mRNA CTD PMID:29098664 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
JBrowse link
G Cct4 chaperonin containing TCP1 subunit 4 increases expression ISO Serine results in increased expression of CCT4 mRNA CTD PMID:29098664 NCBI chr14:96,991,853...97,004,732
Ensembl chr14:96,991,859...97,005,267
JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 increases expression ISO Serine results in increased expression of CCT7 mRNA CTD PMID:29098664 NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO Serine results in decreased expression of CEBPB mRNA CTD PMID:29098664 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Derl2 derlin 2 increases expression ISO Serine results in increased expression of DERL2 mRNA CTD PMID:29098664 NCBI chr10:55,727,764...55,739,462
Ensembl chr10:55,727,643...55,739,518
JBrowse link
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 increases expression ISO Serine results in increased expression of DNAJB2 mRNA CTD PMID:29098664 NCBI chr 9:76,731,060...76,739,278
Ensembl chr 9:76,731,065...76,739,277
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO Serine results in increased expression of DNAJB9 mRNA CTD PMID:29098664 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO Serine results in increased expression of DNAJC3 mRNA CTD PMID:29098664 NCBI chr15:96,025,729...96,065,114
Ensembl chr15:96,025,624...96,065,181
JBrowse link
G Dnajc4 DnaJ heat shock protein family (Hsp40) member C4 increases expression ISO Serine results in increased expression of DNAJC4 mRNA CTD PMID:29098664 NCBI chr 1:204,178,189...204,182,412
Ensembl chr 1:204,178,191...204,182,387
JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression ISO Serine results in increased expression of EDEM1 mRNA CTD PMID:29098664 NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases expression ISO Serine results in increased expression of EIF2A mRNA CTD PMID:29098664 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
JBrowse link
G Erp44 endoplasmic reticulum protein 44 increases expression ISO Serine results in increased expression of ERP44 mRNA CTD PMID:29098664 NCBI chr 5:62,516,550...62,610,762
Ensembl chr 5:62,516,551...62,610,761
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein] CTD PMID:30476904 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Serine results in increased expression of HERPUD1 mRNA CTD PMID:29098664 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424
JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Serine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B decreases expression ISO Serine results in decreased expression of HSPA1B mRNA CTD PMID:29098664 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like increases expression ISO Serine results in increased expression of HSPA1L mRNA CTD PMID:29098664 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
JBrowse link
G Htra4 HtrA serine peptidase 4 decreases expression ISO Serine results in decreased expression of HTRA4 mRNA CTD PMID:29098664 NCBI chr16:67,001,605...67,015,074
Ensembl chr16:67,001,605...67,015,074
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of IL6 protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of IL6 protein] CTD PMID:30476904 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lamc1 laminin subunit gamma 1 multiple interactions EXP [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine affects the localization of TARDBP protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in decreased expression of SLC1A2 protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of APP protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of IL6 protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of MAP1LC3B protein]; [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased phosphorylation of MAPT protein] CTD PMID:30476904 NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of MAP1LC3B protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of MAP1LC3B protein] CTD PMID:30476904 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mapk10 mitogen activated protein kinase 10 decreases expression ISO Serine results in decreased expression of MAPK10 mRNA CTD PMID:29098664 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased phosphorylation of MAPT protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine results in increased phosphorylation of MAPT protein] CTD PMID:30476904 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta increases expression ISO Serine results in increased expression of P4HB protein CTD PMID:28975502 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A decreases expression ISO Serine results in decreased expression of PPP1R15A mRNA CTD PMID:29098664 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions EXP [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in decreased expression of SLC1A2 protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine results in decreased expression of SLC1A2 protein] CTD PMID:30476904 NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO Serine results in decreased expression of SREBF1 mRNA CTD PMID:29098664 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Srr serine racemase multiple interactions EXP SRR protein results in increased abundance of and results in increased secretion of Serine analog CTD PMID:27387750 NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011
JBrowse link
G Tardbp TAR DNA binding protein multiple interactions EXP [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine affects the localization of TARDBP protein]; Serine inhibits the reaction [beta-N-methylamino-L-alanine affects the localization of TARDBP protein] CTD PMID:30476904 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 decreases expression ISO Serine results in decreased expression of UBE2G2 mRNA CTD PMID:29098664 NCBI chr20:10,983,734...11,005,468
Ensembl chr20:10,983,742...11,005,447
JBrowse link
G Vcp valosin-containing protein decreases expression ISO Serine results in decreased expression of VCP mRNA CTD PMID:29098664 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571
JBrowse link
Phe-Ser term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc15a1 solute carrier family 15 member 1 affects binding ISO phenylalanylserine analog binds to SLC15A1 protein CTD PMID:21147219 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      application 19492
        fuel 11113
          methanol 3865
            hydroxymethyl group 47
              serine 47
                3-oxoalanine + 0
                D-serine + 0
                L-serine + 40
                N-(2,4-dinitrophenyl)serine 0
                gougerotin 0
                serine derivative + 7
                serine residue + 0
                serino group + 0
                seryl group + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic group 18713
                              organic divalent group 18697
                                organodiyl group 18697
                                  carbonyl group 18646
                                    carbonyl compound 18646
                                      carboxylic acid 18341
                                        amino acid 14869
                                          polar amino acid 10735
                                            serine 47
                                              3-oxoalanine + 0
                                              D-serine + 0
                                              L-serine + 40
                                              N-(2,4-dinitrophenyl)serine 0
                                              gougerotin 0
                                              serine derivative + 7
                                              serine residue + 0
                                              serino group + 0
                                              seryl group + 0
paths to the root