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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oncrasin-1
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Accession:CHEBI:178196 term browser browse the term
Definition:A member of the class of indoles that is 1H-indole substituted by 4-chlorobenzyl and formyl groups at positions 1 and 3, respectively. It is an anti-cancer agent that is active against lung cancer cells with K-Ras mutations.
Synonyms:exact_synonym: 1-(4-chlorobenzyl)-1H-indole-3-carbaldehyde
 related_synonym: 1-(p-chlorobenzyl)-1H-indole-3-carbaldehyde;   1-[(4-chlorophenyl)methyl]-1H-indole-3-carbaldehyde;   Formula=C16H12ClNO;   InChI=1S/C16H12ClNO/c17-14-7-5-12(6-8-14)9-18-10-13(11-19)15-3-1-2-4-16(15)18/h1-8,10-11H,9H2;   InChIKey=ZDRQMXCSSAPUMM-UHFFFAOYSA-N;   ONC-1;   SMILES=[H]C(=O)C1=CN(CC2=CC=C(Cl)C=C2)C2=CC=CC=C12
 xref: CAS:75629-57-1;   Chemspider:761753
 xref_mesh: MESH:C532252
 xref: PMID:18794128;   PMID:19208825;   PMID:21443218;   PMID:22174819;   PMID:25874341;   PMID:32019870;   PMID:32727562;   PMID:33169204;   Patent:US2009286847



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oncrasin-1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kras KRAS proto-oncogene, GTPase increases response to substance ISO KRAS protein mutant form results in increased susceptibility to oncrasin-1 CTD PMID:21443218 NCBI chr 4:178,185,418...178,218,484 JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        biochemical role 19640
          apoptosis inducer 13408
            oncrasin-1 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        carboacyl group 17706
                                          univalent carboacyl group 17706
                                            formyl group 8800
                                              aldehyde 8800
                                                arenecarbaldehyde 135
                                                  oncrasin-1 1
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