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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:calycosin
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Accession:CHEBI:17793 term browser browse the term
Definition:A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at the 3' position and a methoxy group at the 4' position.
Synonyms:exact_synonym: 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one
 related_synonym: 3'-hydroxy-formononetin;   7,3'-dihydroxy-4'-methoxyisoflavone;   7-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)chromen-4-one;   7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one;   Formula=C16H12O5;   InChI=1S/C16H12O5/c1-20-14-5-2-9(6-13(14)18)12-8-21-15-7-10(17)3-4-11(15)16(12)19/h2-8,17-18H,1H3;   InChIKey=ZZAJQOPSWWVMBI-UHFFFAOYSA-N;   SMILES=COc1ccc(cc1O)-c1coc2cc(O)ccc2c1=O
 alt_id: CHEBI:13938;   CHEBI:22989;   CHEBI:3334;   MESH:C121707
 xref: CAS:20575-57-9;   KEGG:C01562;   KNApSAcK:C00009389;   LIPID_MAPS_instance:LMPK12050056
 xref_mesh: MESH:C121707
 xref: PMID:11025148;   PMID:16286304;   PMID:16441066;   PMID:17253088;   Patent:CN102030735;   Patent:KR20080079237;   Patent:WO2009129260;   Reaxys:1292488;   Wikipedia:Calycosin
 cyclic_relationship: is_conjugate_acid_of CHEBI:77992


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calycosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd14b abhydrolase domain containing 14b increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of ABHD14B protein CTD PMID:24455688 NCBI chr 8:107,087,157...107,092,122
Ensembl chr 8:107,088,069...107,092,119 		JBrowse link
G Ache acetylcholinesterase increases expression
multiple interactions		 EXP 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of ACHE mRNA
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of and results in increased activity of ACHE protein		 CTD PMID:27019979 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased expression of AGER protein] CTD PMID:36195188 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased expression of APP protein] CTD PMID:36195188 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression
multiple interactions		 EXP
ISO		 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of ATP5F1A mRNA
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A protein]
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]]		 CTD PMID:36436616 NCBI chr18:73,567,537...73,575,473
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Bace1 beta-secretase 1 multiple interactions EXP 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased expression of BACE1 protein] CTD PMID:36195188 NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Blvrb biliverdin reductase B increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of BLVRB protein CTD PMID:24455688 NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased expression of CASP3 protein] CTD PMID:36195188 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnb1 cyclin B1 increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of CCNB1 mRNA CTD PMID:24455688 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of CCND3 mRNA CTD PMID:24455688 NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccng1 cyclin G1 increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of CCNG1 mRNA CTD PMID:24455688 NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,176,234...25,181,641 		JBrowse link
G Cdk7 cyclin-dependent kinase 7 increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of CDK7 mRNA CTD PMID:24455688 NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of CDKN1A mRNA CTD PMID:24455688 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C decreases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of CDKN1C mRNA CTD PMID:24455688 NCBI chr 1:208,084,801...208,087,680
Ensembl chr 1:198,655,407...198,658,048 		JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D decreases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of CDKN2D mRNA CTD PMID:24455688 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674 		JBrowse link
G Epo erythropoietin increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of EPO mRNA CTD PMID:21309574 PMID:37348668 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of ERP29 protein CTD PMID:24455688 NCBI chr12:40,750,177...40,756,607
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in decreased phosphorylation of GSK3B protein] CTD PMID:36195188 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression		 ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in decreased degradation of and results in increased expression of HIF1A protein modified form; 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of and results in decreased degradation of HIF1A protein
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of HIF1A mRNA; 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of HIF1A protein		 CTD PMID:21309574 PMID:37348668 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmgb1 high mobility group box 1 decreases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of HMGB1 protein CTD PMID:24455688 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL1B protein] CTD PMID:31726037 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 multiple interactions EXP 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL1RL1 mRNA] CTD PMID:31726037 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:42,697,192...42,727,256 		JBrowse link
G Il33 interleukin 33 multiple interactions EXP 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL33 mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL33 protein] CTD PMID:31726037 NCBI chr 1:237,115,478...237,149,897
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 protein] CTD PMID:31726037 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Krt1 keratin 1 increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of KRT1 protein CTD PMID:24455688 NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844 		JBrowse link
G Lasp1 LIM and SH3 protein 1 increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of LASP1 protein CTD PMID:24455688 NCBI chr10:83,290,820...83,331,989
Ensembl chr10:82,795,137...82,943,292 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased phosphorylation of MAPK1 protein CTD PMID:20686605 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased phosphorylation of MAPK3 protein CTD PMID:20686605 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased phosphorylation of MAPT protein] CTD PMID:36195188 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mcm5 minichromosome maintenance complex component 5 decreases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of MCM5 mRNA CTD PMID:24455688 NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389 		JBrowse link
G Mcm6 minichromosome maintenance complex component 6 increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of MCM6 mRNA CTD PMID:24455688 NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960 		JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 multiple interactions EXP
ISO		 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 protein]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]] CTD PMID:36436616 NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:243,408,619...243,413,817 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of NFE2L2 protein] CTD PMID:31726037 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nme1 NME/NM23 nucleoside diphosphate kinase 1 increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of NME1 protein CTD PMID:24455688 NCBI chr10:79,403,939...79,426,620
Ensembl chr10:78,906,083...78,916,408 		JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions EXP 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of and affects the localization of NRF1 protein]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NRF1 mRNA]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of ATP5F1A protein]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NDUFB8 protein]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB protein]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of NRF1 mRNA]] CTD PMID:36436616 NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:58,664,957...58,825,328 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PEBP1 protein CTD PMID:24455688 NCBI chr12:44,946,307...44,967,890
Ensembl chr12:39,302,840...39,307,862 		JBrowse link
G Pgam1 phosphoglycerate mutase 1 increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PGAM1 protein CTD PMID:24455688 NCBI chr 1:250,673,152...250,680,762
Ensembl chr 1:240,723,920...240,738,452 		JBrowse link
G Pnpo pyridoxamine 5'-phosphate oxidase increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PNPO protein CTD PMID:24455688 NCBI chr10:82,421,027...82,427,288
Ensembl chr10:81,924,569...81,930,871 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in decreased expression of PPARGC1A protein]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in increased acetylation of and affects the localization of PPARGC1A protein]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in increased acetylation of PPARGC1A protein]] CTD PMID:36195188 PMID:36436616 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PRDX1 protein CTD PMID:24455688 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Prdx2 peroxiredoxin 2 decreases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of PRDX2 protein CTD PMID:24455688 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194 		JBrowse link
G Prima1 proline rich membrane anchor 1 increases expression EXP 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of PRIMA1 mRNA CTD PMID:27019979 NCBI chr 6:122,338,365...122,390,955
Ensembl chr 6:122,338,370...122,389,921 		JBrowse link
G Ptgr1 prostaglandin reductase 1 increases expression ISO [Calycosin cotreated with gallic acid] increases expression of PTGR1 mRNA in hepatocellular carcinoma cells RGD PMID:26265982 RGD:401959214 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666 		JBrowse link
G Rad9a RAD9 checkpoint clamp component A decreases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of RAD9A mRNA CTD PMID:24455688 NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608 		JBrowse link
G Rbx1 ring-box 1 increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of RBX1 mRNA CTD PMID:24455688 NCBI chr 7:114,870,893...114,881,194
Ensembl chr 7:112,990,835...113,001,051 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of RELA protein] CTD PMID:31726037 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B multiple interactions ISO
EXP		 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB protein]
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB mRNA]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB protein]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB mRNA]]; SR18292 inhibits the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SDHB protein]]		 CTD PMID:36436616 NCBI chr 5:158,547,775...158,568,589
Ensembl chr 5:153,264,899...153,314,293 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of SIRT1 protein] CTD PMID:36436616 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Skp1 S-phase kinase-associated protein 1 increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of SKP1 mRNA CTD PMID:24455688 NCBI chr10:36,401,987...36,417,066
Ensembl chr10:36,402,153...36,417,388 		JBrowse link
G Skp2 S-phase kinase associated protein 2 decreases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of SKP2 mRNA CTD PMID:24455688 NCBI chr 2:59,888,406...59,916,471
Ensembl chr 2:58,161,229...58,189,338 		JBrowse link
G Stip1 stress-induced phosphoprotein 1 increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of STIP1 protein CTD PMID:24455688 NCBI chr 1:213,638,641...213,657,654
Ensembl chr 1:204,178,932...204,228,476 		JBrowse link
G Tagln2 transgelin 2 increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of TAGLN2 protein CTD PMID:24455688 NCBI chr13:84,966,980...84,973,973
Ensembl chr13:84,967,009...84,973,972 		JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions EXP 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in decreased expression of TFAM protein]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of TFAM mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of TFAM protein] CTD PMID:36195188 PMID:36436616 NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein] CTD PMID:31726037 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TNF protein] CTD PMID:31726037 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions ISO 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in increased expression of TNNI3 protein] CTD PMID:36436616 NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
G Ube3a ubiquitin protein ligase E3A increases expression ISO 7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of UBE3A mRNA CTD PMID:24455688 NCBI chr 1:110,070,260...110,161,675
Ensembl chr 1:110,070,480...110,157,250 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone CTD PMID:25044472 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone CTD PMID:25044472 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone CTD PMID:25044472 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of 7,3'-dihydroxy-4'-methoxyisoflavone CTD PMID:25044472 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 multiple interactions
increases expression		 ISO
EXP		 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 protein]
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 protein]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 mRNA]]; NRF1 protein affects the reaction [7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [triptolide results in decreased expression of UQCRC2 protein]]
7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of UQCRC2 mRNA		 CTD PMID:36436616 NCBI chr 1:184,599,240...184,629,804
Ensembl chr 1:175,167,894...175,199,453 		JBrowse link
calycosin-7-O-beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of BAX mRNA]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of BAX protein]
calycosin-7-O-beta-D-glucoside results in increased expression of BAX mRNA; calycosin-7-O-beta-D-glucoside results in increased expression of BAX protein		 CTD PMID:36812960 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 mRNA]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 protein]
calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 mRNA; calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 protein		 CTD PMID:36812960 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases cleavage
increases expression
multiple interactions		 ISO calycosin-7-O-beta-D-glucoside results in increased cleavage of CASP3 protein
calycosin-7-O-beta-D-glucoside results in increased expression of CASP3 mRNA
TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased cleavage of CASP3 protein]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of CASP3 mRNA]		 CTD PMID:36812960 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases expression ISO calycosin-7-O-beta-D-glucoside results in decreased expression of CAT protein CTD PMID:36812960 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Epo erythropoietin increases expression ISO calycosin-7-O-beta-D-glucoside results in increased expression of EPO mRNA CTD PMID:21309574 PMID:37348668 NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Gpt glutamic--pyruvic transaminase decreases expression ISO calycosin-7-O-beta-D-glucoside results in decreased expression of GPT protein CTD PMID:36812960 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression		 ISO calycosin-7-O-beta-D-glucoside results in decreased degradation of and results in increased expression of HIF1A protein modified form; calycosin-7-O-beta-D-glucoside results in increased expression of and results in decreased degradation of HIF1A protein
calycosin-7-O-beta-D-glucoside results in increased expression of HIF1A mRNA; calycosin-7-O-beta-D-glucoside results in increased expression of HIF1A protein		 CTD PMID:21309574 PMID:37348668 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions
decreases expression		 ISO TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 mRNA]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in decreased expression of BCL2 protein]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased cleavage of CASP3 protein]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of BAX mRNA]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of BAX protein]; TXN protein affects the reaction [calycosin-7-O-beta-D-glucoside results in increased expression of CASP3 mRNA]
calycosin-7-O-beta-D-glucoside results in decreased expression of TXN mRNA; calycosin-7-O-beta-D-glucoside results in decreased expression of TXN protein		 CTD PMID:36812960 NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19904
    role 19875
      chemical role 19504
        antioxidant 16191
          calycosin 67
            calycosin-7-O-beta-D-glucoside 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19904
    subatomic particle 19902
      composite particle 19902
        hadron 19902
          baryon 19902
            nucleon 19902
              atomic nucleus 19902
                atom 19902
                  main group element atom 19841
                    p-block element atom 19841
                      carbon group element atom 19779
                        carbon atom 19776
                          organic molecular entity 19776
                            organic molecule 19730
                              organic cyclic compound 19522
                                organic heterocyclic compound 18896
                                  oxacycle 17926
                                    benzopyran 11985
                                      1-benzopyran 11739
                                        isoflavonoid 3837
                                          isoflavones 3818
                                            methoxyisoflavone 312
                                              4'-methoxyisoflavones 206
                                                calycosin 67
                                                  calycosin-7-O-beta-D-glucoside 8
paths to the root