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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:7,9-dihydro-1H-purine-2,6,8(3H)-trione
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Accession:CHEBI:17775 term browser browse the term
Definition:An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Synonyms:related_synonym: 2,6,8-trioxopurine;   2,6,8-trioxypurine;   Formula=C5H4N4O3;   InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12);   InChIKey=LEHOTFFKMJEONL-UHFFFAOYSA-N;   SMILES=O=c1[nH]c2[nH]c(=O)[nH]c(=O)c2[nH]1;   URIC ACID;   Urate;   purine-2,6,8(1H,3H,9H)-trione
 alt_id: CHEBI:46455;   CHEBI:9885
 xref: Beilstein:156158;   CAS:69-93-2;   DrugBank:DB01696;   Gmelin:241332;   HMDB:HMDB0000289;   KEGG:C00366;   KNApSAcK:C00007301
 xref_mesh: MESH:D014527
 xref: MetaCyc:URATE;   PDBeChem:URC;   PMID:22770225;   Reaxys:156158;   Wikipedia:Uric_acid
 cyclic_relationship: is_tautomer_of CHEBI:46811;   is_tautomer_of CHEBI:46814;   is_tautomer_of CHEBI:46817;   is_tautomer_of CHEBI:46823;   is_tautomer_of CHEBI:49051


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7,9-dihydro-1H-purine-2,6,8(3H)-trione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP6V0D1 ATPase H+ transporting V0 subunit d1 increases expression EXP Uric Acid results in increased expression of ATP6V0D1 protein CTD PMID:32991862 NCBI chr 5:81,926,589...81,965,959
Ensembl chr 5:81,926,612...81,965,526 		JBrowse link
G DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 increases expression EXP Uric Acid results in increased expression of DNAJC3 protein CTD PMID:32991862 NCBI chr22:46,323,263...46,402,240
Ensembl chr22:46,307,905...46,398,625 		JBrowse link
G EEF2 eukaryotic translation elongation factor 2 decreases expression EXP Uric Acid results in decreased expression of EEF2 protein CTD PMID:32991862 NCBI chr20:55,577,413...55,586,422
Ensembl chr20:55,522,213...55,586,126 		JBrowse link
G EZR ezrin increases expression EXP Uric Acid results in increased expression of EZR protein CTD PMID:32991862 NCBI chr 1:48,160,206...48,210,036
Ensembl chr 1:48,160,206...48,210,036 		JBrowse link
G HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 increases expression EXP Uric Acid results in increased expression of HNRNPA2B1 protein CTD PMID:32991862 NCBI chr14:39,498,805...39,509,034
Ensembl chr14:39,500,897...39,508,952 		JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 increases expression EXP Uric Acid results in increased expression of HSP90AA1 protein CTD PMID:32991862 NCBI chr 8:70,091,203...70,096,107
Ensembl chr 8:70,092,217...70,095,243 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Uric Acid results in increased expression of HSPA5 protein CTD PMID:32991862 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257 		JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 decreases expression EXP Uric Acid results in decreased expression of HSPD1 protein CTD PMID:32991862 NCBI chr37:7,010,421...7,025,912 JBrowse link
G IMMT inner membrane mitochondrial protein increases expression EXP Uric Acid results in increased expression of IMMT protein CTD PMID:32991862 NCBI chr17:38,927,508...38,964,522
Ensembl chr17:38,927,531...38,967,004 		JBrowse link
G LOC102151342 ATP synthase subunit d, mitochondrial-like increases expression EXP Uric Acid results in increased expression of ATP5PD protein CTD PMID:32991862 NCBI chr 7:66,856,651...66,857,162 JBrowse link
G MDH2 malate dehydrogenase 2 decreases expression EXP Uric Acid results in decreased expression of MDH2 protein CTD PMID:32991862 NCBI chr 6:7,389,266...7,405,311 JBrowse link
G NAPA NSF attachment protein alpha decreases expression EXP Uric Acid results in decreased expression of NAPA protein CTD PMID:32991862 NCBI chr 1:108,510,920...108,533,317
Ensembl chr 1:108,510,931...108,532,881 		JBrowse link
G OAT ornithine aminotransferase increases expression EXP Uric Acid results in increased expression of OAT protein CTD PMID:32991862 NCBI chr28:33,763,661...33,788,817
Ensembl chr28:33,758,473...33,788,759 		JBrowse link
G PC pyruvate carboxylase decreases expression EXP Uric Acid results in decreased expression of PC protein CTD PMID:32991862 NCBI chr18:50,406,994...50,507,677
Ensembl chr18:50,412,272...50,507,669 		JBrowse link
G RAB11A RAB11A, member RAS oncogene family decreases expression EXP Uric Acid results in decreased expression of RAB11A protein CTD PMID:32991862 NCBI chr30:30,200,831...30,218,412
Ensembl chr30:30,200,831...30,218,411 		JBrowse link
G SAE1 SUMO1 activating enzyme subunit 1 decreases expression EXP Uric Acid results in decreased expression of SAE1 protein CTD PMID:32991862 NCBI chr 1:108,757,543...108,864,763
Ensembl chr 1:108,749,061...108,859,797 		JBrowse link
G SLC25A12 solute carrier family 25 member 12 decreases expression EXP Uric Acid results in decreased expression of SLC25A12 protein CTD PMID:32991862 NCBI chr36:16,185,011...16,391,080
Ensembl chr36:16,185,649...16,483,016 		JBrowse link
G SLC2A9 solute carrier family 2 member 9 increases transport EXP SLC2A9 protein results in increased transport of Uric Acid CTD PMID:18989453 NCBI chr 3:69,394,304...69,588,462
Ensembl chr 3:69,394,152...69,595,802 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 494
    role 501
      biological role 494
        biochemical role 454
          metabolite 445
            prokaryotic metabolite 396
              bacterial metabolite 391
                Escherichia coli metabolite 379
                  7,9-dihydro-1H-purine-2,6,8(3H)-trione 18
                    1,3,7,9-tetramethyluric acid 0
                    1,3-dimethyluric acid 0
                    1,7-dimethyluric acid 0
                    1-methyluric acid 0
                    3,7-dimethyluric acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 494
    subatomic particle 494
      composite particle 494
        hadron 501
          baryon 494
            nucleon 494
              atomic nucleus 494
                atom 494
                  main group element atom 487
                    p-block element atom 487
                      carbon group element atom 476
                        carbon atom 482
                          organic molecular entity 475
                            organic molecule 466
                              organic cyclic compound 449
                                organic heterocyclic compound 419
                                  organic heteropolycyclic compound 96
                                    organic heterobicyclic compound 44
                                      imidazopyrimidine 21
                                        purines 21
                                          oxopurine 20
                                            uric acid 18
                                              7,9-dihydro-1H-purine-2,6,8(3H)-trione 18
                                                1,3,7,9-tetramethyluric acid 0
                                                1,3-dimethyluric acid 0
                                                1,7-dimethyluric acid 0
                                                1-methyluric acid 0
                                                3,7-dimethyluric acid 0
paths to the root