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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:7,9-dihydro-1H-purine-2,6,8(3H)-trione
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Accession:CHEBI:17775 term browser browse the term
Definition:An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Synonyms:related_synonym: 2,6,8-trioxopurine;   2,6,8-trioxypurine;   Formula=C5H4N4O3;   InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12);   InChIKey=LEHOTFFKMJEONL-UHFFFAOYSA-N;   SMILES=O=c1[nH]c2[nH]c(=O)[nH]c(=O)c2[nH]1;   URIC ACID;   Urate;   purine-2,6,8(1H,3H,9H)-trione
 alt_id: CHEBI:46455;   CHEBI:9885
 xref: Beilstein:156158;   CAS:69-93-2;   DrugBank:DB01696;   Gmelin:241332;   HMDB:HMDB0000289;   KEGG:C00366;   KNApSAcK:C00007301
 xref_mesh: MESH:D014527
 xref: MetaCyc:URATE;   PDBeChem:URC;   PMID:22770225;   Reaxys:156158;   Wikipedia:Uric_acid
 cyclic_relationship: is_tautomer_of CHEBI:46811;   is_tautomer_of CHEBI:46814;   is_tautomer_of CHEBI:46817;   is_tautomer_of CHEBI:46823;   is_tautomer_of CHEBI:49051


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7,9-dihydro-1H-purine-2,6,8(3H)-trione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A1cf APOBEC1 complementation factor affects abundance ISO A1CF gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 1:250,426,027...250,514,245
Ensembl chr 1:250,426,158...250,514,866
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects export
multiple interactions
ISO ABCC4 protein affects the export of Uric Acid
Uric Acid inhibits the reaction [ABCC4 protein affects the transport of Methotrexate]
CTD PMID:15454390 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Ace angiotensin I converting enzyme multiple interactions
increases expression
ISO APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of ACE mRNA] CTD PMID:30710622 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Agt angiotensinogen multiple interactions
increases expression
ISO resveratrol inhibits the reaction [Uric Acid results in increased expression of AGT mRNA]; resveratrol inhibits the reaction [Uric Acid results in increased expression of AGT protein]
Uric Acid results in increased expression of AGT mRNA; Uric Acid results in increased expression of AGT protein modified form
APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGT mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGT protein modified form]
CTD PMID:25493383, PMID:30710622 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
increases expression
ISO APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGTR1A mRNA] CTD PMID:30710622 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression
multiple interactions
ISO Uric Acid results in increased expression of AGTR2 mRNA
APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGTR2 mRNA]
CTD PMID:30710622 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases expression
multiple interactions
ISO Uric Acid results in increased expression of AKR1B3 mRNA
acetovanillone inhibits the reaction [Uric Acid results in increased expression of AKR1B3 mRNA]
CTD PMID:30651350 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions ISO Uric Acid affects the reaction [ALAD polymorphism affects the susceptibility to Lead] CTD PMID:16263504 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Aldh16a1 aldehyde dehydrogenase 16 family, member A1 affects abundance ISO ALDH16A1 gene SNP affects the abundance of Uric Acid CTD PMID:21983786 NCBI chr 1:101,138,237...101,151,320
Ensembl chr 1:101,138,248...101,151,320
JBrowse link
G Alpk1 alpha-kinase 1 increases expression
multiple interactions
increases response to substance
ISO Uric Acid results in increased expression of ALPK1 mRNA
ALPK1 protein promotes the reaction [Uric Acid results in increased secretion of TGFB1 protein]
ALPK1 protein results in increased susceptibility to Uric Acid
CTD PMID:27542954 NCBI chr 2:231,997,360...232,117,471
Ensembl chr 2:231,996,088...232,117,134
JBrowse link
G Apln apelin multiple interactions ISO APLN protein modified form inhibits the reaction [Uric Acid results in decreased activity of CAT protein]; APLN protein modified form inhibits the reaction [Uric Acid results in decreased expression of APLNR mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of ACE mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGT mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGT protein modified form]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGTR1A mRNA]; APLN protein modified form inhibits the reaction [Uric Acid results in increased expression of AGTR2 mRNA] CTD PMID:30710622 NCBI chr  X:134,856,719...134,866,210
Ensembl chr  X:134,856,726...134,866,210
JBrowse link
G Aplnr apelin receptor multiple interactions
decreases expression
ISO APLN protein modified form inhibits the reaction [Uric Acid results in decreased expression of APLNR mRNA] CTD PMID:30710622 NCBI chr 3:72,540,538...72,544,183
Ensembl chr 3:72,540,538...72,544,182
JBrowse link
G Aqp1 aquaporin 1 multiple interactions ISO AQP1 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:21051542 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp9 aquaporin 9 multiple interactions ISO AQP9 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:21051542 NCBI chr 8:77,559,621...77,599,781
Ensembl chr 8:77,559,624...77,599,781
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO Uric Acid inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 mRNA] CTD PMID:21703327 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions
increases phosphorylation
ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of ATR protein] CTD PMID:23619996 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Atxn2 ataxin 2 affects abundance ISO ATXN2 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr12:40,264,601...40,335,637
Ensembl chr12:40,266,662...40,332,612
JBrowse link
G B3gnt4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 affects abundance ISO B3GNT4 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr12:38,503,361...38,506,793
Ensembl chr12:38,503,361...38,504,774
JBrowse link
G Baz1b bromodomain adjacent to zinc finger domain, 1B affects abundance ISO BAZ1B gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr12:24,478,882...24,536,851
Ensembl chr12:24,478,898...24,537,313
JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions
decreases expression
ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of BRCA1 mRNA] CTD PMID:23619996 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Casp1 caspase 1 multiple interactions
increases phosphorylation
increases expression
increases cleavage
ISO [Lipopolysaccharides co-treated with Uric Acid] results in increased activity of CASP1 protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein; CASP1 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; Silicon Dioxide analog inhibits the reaction [Uric Acid results in increased cleavage of CASP1 protein]
Uric Acid results in increased phosphorylation of CASP1 protein
Uric Acid results in increased expression of CASP1 protein modified form
[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein; Apigenin inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of CASP1 protein modified form]; CASP1 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]
CTD PMID:18403674, PMID:18604214, PMID:23430110, PMID:23619996, PMID:29960001, PMID:30842373 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Cat catalase increases expression
multiple interactions
decreases activity
ISO Uric Acid results in increased expression of CAT protein
APLN protein modified form inhibits the reaction [Uric Acid results in decreased activity of CAT protein]
CTD PMID:23619996, PMID:30710622 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
increases secretion
ISO
EXP
[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein; Allopurinol inhibits the reaction [[Fructose co-treated with Uric Acid] results in increased secretion of CCL2 protein]
Probenecid inhibits the reaction [Uric Acid results in increased expression of CCL2 protein]
Uric Acid results in increased secretion of CCL2 protein
CTD PMID:16113518, PMID:19158351 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnb1 cyclin B1 decreases expression
multiple interactions
ISO Uric Acid results in decreased expression of CCNB1 mRNA
NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of CCNB1 mRNA]
CTD PMID:23619996 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of CCND1 mRNA] CTD PMID:23619996 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid] CTD PMID:24709313 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997
JBrowse link
G Cp ceruloplasmin affects activity ISO Uric Acid affects the activity of CP protein CTD PMID:10949969 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Ctsb cathepsin B multiple interactions ISO [Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of CTSB protein CTD PMID:18604214 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions ISO CYBA protein affects the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:18403674 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Uric Acid inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of DDIT3 mRNA] CTD PMID:21703327 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Edn1 endothelin 1 multiple interactions
increases expression
ISO resveratrol inhibits the reaction [Uric Acid results in increased expression of EDN1 mRNA]; resveratrol inhibits the reaction [Uric Acid results in increased expression of EDN1 protein]
Uric Acid results in increased expression of EDN1 mRNA; Uric Acid results in increased expression of EDN1 protein
CTD PMID:25493383 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Gnai2 G protein subunit alpha i2 multiple interactions EXP Uric Acid inhibits the reaction [Glucose results in decreased expression of GNAI2 protein]; Uric Acid inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI2 protein]; Uric Acid inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI2 protein] CTD PMID:16962941, PMID:18055527, PMID:18441196 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Gnai3 G protein subunit alpha i3 multiple interactions EXP Uric Acid inhibits the reaction [Glucose results in decreased expression of GNAI3 protein]; Uric Acid inhibits the reaction [Peroxynitrous Acid results in decreased expression of GNAI3 protein]; Uric Acid inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein] CTD PMID:16962941, PMID:18055527, PMID:18441196 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749
JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects abundance ISO GSTT1 protein polymorphism affects the abundance of Uric Acid CTD PMID:23747713 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
multiple interactions
ISO Uric Acid results in increased phosphorylation of H2AX protein
CASP1 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein]
CTD PMID:23619996 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hlf HLF transcription factor, PAR bZIP family member affects abundance ISO HLF gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr10:77,836,352...77,918,656
Ensembl chr10:77,840,568...77,918,191
JBrowse link
G Hnf4g hepatocyte nuclear factor 4, gamma affects abundance ISO HNF4G gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 2:100,225,880...100,372,710
Ensembl chr 2:100,225,888...100,372,252
JBrowse link
G Igf1r insulin-like growth factor 1 receptor affects abundance ISO IGF1R gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
increases secretion
EXP
ISO
Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased expression of IL1B mRNA]; Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased expression of IL1B protein]
Uric Acid results in increased expression of IL1B mRNA; Uric Acid results in increased expression of IL1B protein
Uric Acid results in increased secretion of IL1B protein
[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of and results in increased activity of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; CYBA protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]; NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]; PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; TXN protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; UOX protein inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]
[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with Uric Acid] results in increased expression of IL1B protein; Acetylcysteine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Ammonium Chloride inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Apigenin inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein]; AQP1 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein]; AQP9 mRNA affects the reaction [Uric Acid results in increased secretion of IL1B protein]; CASP1 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein]; Cytochalasin D inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; diphenyleneiodonium inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; flavone analog inhibits the reaction [Uric Acid results in increased cleavage of and results in increased secretion of IL1B protein]; latrunculin A inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Mercuric Chloride inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine inhibits the reaction [Uric Acid results in increased cleavage of and results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; Phloretin inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [Uric Acid results in increased cleavage of and results in increased secretion of IL1B protein]; Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein
CTD PMID:18403674, PMID:18604214, PMID:19655406, PMID:21051542, PMID:23430110, PMID:24158569, PMID:26296894, PMID:27542954, PMID:29960001 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Inhbb inhibin subunit beta B affects abundance ISO INHBB gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr13:35,436,532...35,442,222
Ensembl chr13:35,436,532...35,442,222
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO Uric Acid inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein] CTD PMID:17241155 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
JBrowse link
G Khk ketohexokinase increases expression EXP
ISO
Uric Acid results in increased expression of KHK protein CTD PMID:30651350 NCBI chr 6:26,810,577...26,821,013
Ensembl chr 6:26,810,579...26,820,959
JBrowse link
G Maf MAF bZIP transcription factor affects abundance ISO MAF gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Uric Acid inhibits the reaction [Ammonium Chloride results in increased phosphorylation of MAPK1 protein] CTD PMID:11923223 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Uric Acid inhibits the reaction [Ammonium Chloride results in increased phosphorylation of MAPK3 protein] CTD PMID:11923223 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 affects abundance
affects localization
ISO NFAT5 gene SNP affects the abundance of Uric Acid
Uric Acid affects the localization of NFAT5 protein
CTD PMID:23263486, PMID:30651350 NCBI chr19:38,446,059...38,533,735
Ensembl chr19:38,446,059...38,533,735
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
decreases response to substance
ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of BRCA1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of CCNB1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of CCND1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of OGG1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of POLB mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of PRIM1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RAD51 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RFC3 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RFC4 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TTK mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TYMS mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of XRCC1 mRNA]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of ATR protein]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]; NLRP3 protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]
[Uric Acid co-treated with Lipopolysaccharides] results in increased activity of NLRP3 protein; NLRP3 protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]
NLRP3 gene mutant form results in decreased susceptibility to Uric Acid
CTD PMID:18403674, PMID:18604214, PMID:23619996 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos3 nitric oxide synthase 3 increases abundance ISO NOS3 gene mutant form results in increased abundance of Uric Acid CTD PMID:12947532 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase decreases expression
multiple interactions
ISO Uric Acid results in decreased expression of OGG1 mRNA
NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of OGG1 mRNA]
CTD PMID:23619996 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Pawr pro-apoptotic WT1 regulator multiple interactions EXP Uric Acid inhibits the reaction [Nerve Growth Factors deficiency results in increased expression of PAWR mRNA]; Uric Acid inhibits the reaction [Nerve Growth Factors deficiency results in increased expression of PAWR protein] CTD PMID:10428045 NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
JBrowse link
G Pml PML nuclear body scaffold multiple interactions ISO PML protein promotes the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of IL1B protein]; PML protein promotes the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of IL1B protein]; Uric Acid promotes the reaction [Lipopolysaccharides results in increased expression of PML protein] CTD PMID:23430110 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Polb DNA polymerase beta multiple interactions
decreases expression
ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of POLB mRNA] CTD PMID:23619996 NCBI chr16:74,237,001...74,260,272
Ensembl chr16:74,237,001...74,260,271
JBrowse link
G Pon1 paraoxonase 1 affects abundance ISO PON1 protein polymorphism affects the abundance of Uric Acid CTD PMID:23747713 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO Uric Acid results in increased expression of PRDX1 protein CTD PMID:23619996 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prim1 DNA primase subunit 1 multiple interactions
decreases expression
ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of PRIM1 mRNA] CTD PMID:23619996 NCBI chr 7:2,435,524...2,451,169
Ensembl chr 7:2,435,553...2,451,165
JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 affects abundance ISO PRKAG2 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 4:6,559,153...6,799,888
Ensembl chr 4:6,559,545...6,799,632
JBrowse link
G Prkg2 protein kinase cGMP-dependent 2 decreases expression ISO Uric Acid results in decreased expression of PRKG2 mRNA CTD PMID:27542954 NCBI chr14:12,217,121...12,313,616
Ensembl chr14:12,218,553...12,315,229
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions
increases phosphorylation
ISO Apigenin inhibits the reaction [Uric Acid results in increased phosphorylation of PTK2B protein] CTD PMID:29960001 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased secretion of and results in increased cleavage of IL1B protein]; PYCARD protein affects the reaction [Uric Acid results in increased cleavage of CASP1 protein]; PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]
Apigenin inhibits the reaction [Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]]; kaempferol inhibits the reaction [Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]]; PYCARD protein affects the reaction [Uric Acid results in increased secretion of IL1B protein]; Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]
CTD PMID:18403674, PMID:18604214, PMID:29960001 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Rad51 RAD51 recombinase multiple interactions
decreases expression
ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RAD51 mRNA] CTD PMID:23619996 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased localization of and results in increased activity of RELA protein]; Uric Acid results in increased localization of and results in increased activity of RELA protein CTD PMID:19655406 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rfc3 replication factor C subunit 3 multiple interactions
decreases expression
ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RFC3 mRNA] CTD PMID:23619996 NCBI chr12:1,460,581...1,471,344
Ensembl chr12:1,460,538...1,471,357
JBrowse link
G Rfc4 replication factor C subunit 4 multiple interactions
decreases expression
ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of RFC4 mRNA] CTD PMID:23619996 NCBI chr11:81,358,592...81,373,044
Ensembl chr11:81,358,592...81,373,043
JBrowse link
G Sfmbt1 Scm-like with four mbt domains 1 affects abundance ISO SFMBT1 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr16:6,775,648...6,896,155
Ensembl chr16:6,779,281...6,895,299
JBrowse link
G Slc12a2 solute carrier family 12 member 2 multiple interactions EXP Uric Acid inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; Uric Acid inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein] CTD PMID:25817889 NCBI chr18:52,917,124...52,985,281
Ensembl chr18:52,917,124...52,985,261
JBrowse link
G Slc17a3 solute carrier family 17 member 3 affects transport ISO SLC17A3 gene SNP affects the transport of Uric Acid CTD PMID:21282933 NCBI chr17:43,518,760...43,545,160
Ensembl chr17:43,518,655...43,543,185
JBrowse link
G Slc22a12 solute carrier family 22 member 12 increases import
increases uptake
affects transport
multiple interactions
increases export
ISO
EXP
SLC22A12 protein results in increased import of Uric Acid
SLC22A12 protein results in increased uptake of Uric Acid
SLC22A12 protein affects the transport of Uric Acid
Benzbromarone inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]; Chlorides affects the reaction [SLC22A12 protein affects the transport of Uric Acid]; Lactic Acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]; pyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]
SLC22A12 protein results in increased export of Uric Acid
Benzbromarone inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]; gluconic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]; Lactic Acid affects the reaction [SLC22A12 protein affects the transport of Uric Acid]; Probenecid inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]; pyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid]
6-hydroxybenzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; [Chlorine co-treated with perfluoro-n-heptanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Chlorine co-treated with perfluoro-n-nonanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Chlorine co-treated with perfluorodecanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Chlorine co-treated with perfluorooctanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Losartan results in decreased activity of SLC22A12 protein] which results in decreased abundance of Uric Acid; benzarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Benzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Chlorine inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; E 3040 inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Enalapril inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Indomethacin inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Phenylbutazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Probenecid inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Salicylates inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Sulfinpyrazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]; Uric Acid inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol]
CTD PMID:14694169, PMID:14747372, PMID:15284287, PMID:16135657, PMID:18670416, PMID:20639259, PMID:21074513, PMID:21272127, PMID:21449597 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
JBrowse link
G Slc22a20 solute carrier family 22 member 20 multiple interactions ISO Uric Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate] CTD PMID:16478971 NCBI chr 1:221,327,608...221,344,367
Ensembl chr 1:221,328,711...221,343,889
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
affects secretion
increases uptake
ISO
EXP
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; Benzbromarone inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; gluconic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; Glutarates promotes the reaction [SLC22A6 protein results in increased uptake of Uric Acid]; Ketoglutaric Acids inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of Uric Acid]; Probenecid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; pyrazinoic acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; Salicylates inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]
SLC22A6 protein affects the secretion of Uric Acid
[Oxonic Acid co-treated with Uric Acid] results in decreased expression of SLC22A6 protein
CTD PMID:12472777, PMID:19605544 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a8 solute carrier family 22 member 8 affects transport
multiple interactions
ISO
EXP
SLC22A8 protein affects the transport of Uric Acid
[Oxonic Acid co-treated with Uric Acid] results in decreased expression of SLC22A8 protein
CTD PMID:11306713, PMID:19605544 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions
affects abundance
affects transport
increases transport
decreases secretion
ISO Benzbromarone inhibits the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]; Fructose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]; Glucose promotes the reaction [SLC2A9 protein alternative form results in increased transport of Uric Acid]
SLC2A9 gene polymorphism affects the abundance of Uric Acid; SLC2A9 intron SNP affects the abundance of Uric Acid
SLC2A9 protein affects the transport of Uric Acid
Benzbromarone inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]; Losartan inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]; Phloretin inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid]
SLC2A9 protein alternative form affects the transport of Uric Acid
SLC2A9 protein results in decreased secretion of Uric Acid
CTD PMID:18327256, PMID:18327257, PMID:18842065, PMID:19587147, PMID:22132990 NCBI chr14:77,067,537...77,192,702
Ensembl chr14:77,067,503...77,192,702
JBrowse link
G Sod1 superoxide dismutase 1 affects activity ISO Uric Acid affects the activity of SOD1 protein CTD PMID:10949969 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Uric Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SOD2 protein] CTD PMID:21767162 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sord sorbitol dehydrogenase increases expression ISO Uric Acid results in increased expression of SORD protein CTD PMID:30651350 NCBI chr 3:114,176,127...114,207,368
Ensembl chr 3:114,176,309...114,207,366
JBrowse link
G Stc1 stanniocalcin 1 affects abundance ISO STC1 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr15:50,891,137...50,901,791
Ensembl chr15:50,891,127...50,903,162
JBrowse link
G Syk spleen associated tyrosine kinase multiple interactions
increases phosphorylation
ISO Apigenin inhibits the reaction [Uric Acid results in increased phosphorylation of SYK protein]; N4-(2,2-dimethyl-3-oxo-4H-pyrid(1,4)oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine inhibits the reaction [Uric Acid results in increased phosphorylation of SYK protein] CTD PMID:29960001 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases secretion
multiple interactions
increases expression
ISO Uric Acid results in increased secretion of TGFB1 protein
ALPK1 protein promotes the reaction [Uric Acid results in increased secretion of TGFB1 protein]
Uric Acid results in increased expression of TGFB1 mRNA
CTD PMID:27542954 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tmem171 transmembrane protein 171 affects abundance ISO TMEM171 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 2:28,791,831...28,802,135
Ensembl chr 2:28,791,875...28,801,223
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased expression of TNF mRNA]; Drugs, Chinese Herbal inhibits the reaction [Uric Acid results in increased expression of TNF protein]
Uric Acid results in increased expression of TNF mRNA; Uric Acid results in increased expression of TNF protein
CTD PMID:19655406 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases phosphorylation ISO Uric Acid results in increased phosphorylation of TRP53 protein CTD PMID:23619996 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trim46 tripartite motif-containing 46 affects abundance ISO TRIM46 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 2:188,548,608...188,561,617
Ensembl chr 2:188,548,644...188,561,360
JBrowse link
G Ttk Ttk protein kinase multiple interactions
decreases expression
ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TTK mRNA] CTD PMID:23619996 NCBI chr 8:91,368,065...91,405,995
Ensembl chr 8:91,368,111...91,405,993
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO TXN protein affects the reaction [Uric Acid results in increased secretion of IL1B protein] CTD PMID:18403674 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Tyms thymidylate synthetase multiple interactions
decreases expression
ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of TYMS mRNA] CTD PMID:23619996 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
G Ube2q2 ubiquitin conjugating enzyme E2 Q2 affects abundance ISO UBE2Q2 gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 8:59,709,972...59,754,102
Ensembl chr 8:59,711,549...59,766,889
JBrowse link
G Vegfa vascular endothelial growth factor A affects abundance ISO VEGFA gene SNP affects the abundance of Uric Acid CTD PMID:23263486 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions
increases chemical synthesis
increases abundance
ISO
EXP
Fructose promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]
[bisphenol A results in increased activity of XDH protein] which results in increased chemical synthesis of Uric Acid; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]]; Tetradecanoylphorbol Acetate promotes the reaction [XDH protein results in increased chemical synthesis of Uric Acid]
[2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased activity of XDH protein] which results in decreased abundance of Uric Acid
XDH protein results in increased abundance of Uric Acid
CTD PMID:17439425, PMID:19158351, PMID:21920950, PMID:22036979, PMID:31574244 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions
decreases expression
ISO NLRP3 gene mutant form inhibits the reaction [Uric Acid results in decreased expression of XRCC1 mRNA] CTD PMID:23619996 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link
1-methyluric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Xdh xanthine dehydrogenase multiple interactions ISO [XDH protein alternative form results in increased metabolism of 1-methylxanthine] which results in increased chemical synthesis of 1-methyluric acid CTD PMID:19215233 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            prokaryotic metabolite 18402
              bacterial metabolite 18402
                Escherichia coli metabolite 18283
                  7,9-dihydro-1H-purine-2,6,8(3H)-trione 88
                    1,3,7,9-tetramethyluric acid 0
                    1,3-dimethyluric acid 0
                    1,7-dimethyluric acid 0
                    1-methyluric acid 1
                    3,7-dimethyluric acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organic heteropolycyclic compound 17844
                                    organic heterobicyclic compound 16765
                                      imidazopyrimidine 5443
                                        purines 5441
                                          oxopurine 4026
                                            uric acid 88
                                              7,9-dihydro-1H-purine-2,6,8(3H)-trione 88
                                                1,3,7,9-tetramethyluric acid 0
                                                1,3-dimethyluric acid 0
                                                1,7-dimethyluric acid 0
                                                1-methyluric acid 1
                                                3,7-dimethyluric acid 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.