CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: AL 8810
Accession: CHEBI:177643
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Synonyms: exact_synonym: (Z)-7-[(1R,2R,3S,5S)-2-[(E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxyprop-1-enyl]-3-luoro-5-hydroxycyclopentyl]hept-5-enoic acid
related_synonym: Formula=C24H31FO4; InChI=1S/C24H31FO4/c25-21-15-23(27)20(9-3-1-2-4-10-24(28)29)19(21)11-12-22(26)18-13-16-7-5-6-8-17(16)14-18/h1,3,5-8,11-12,18-23,26-27H,2,4,9-10,13-15H2,(H,28,29)/b3-1-,12-11+/t19-,20-,21+,22+,23+/m1/s1; InChIKey=WTYSXBKKVNOOIX-JTGCGUAKSA-N; SMILES=F[C@@H]1[C@@H]([C@H]([C@@H](O)C1)C/C=C\\CCCC(O)=O)/C=C/[C@H](O)C2CC=3C(C2)=CC=CC3
xref: CAS:246246-19-5; Chemspider:4470757
xref_mesh: MESH:C121227
G
Ereg
epiregulin
multiple interactions
ISO
[AL 8810 results in decreased activity of PTGFR protein] inhibits the reaction [[trans-10,cis-12-conjugated linoleic acid results in increased abundance of Dinoprost] which results in increased expression of EREG]
CTD
PMID:22583689
NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,027,287...17,041,062
G
Fabp4
fatty acid binding protein 4
increases expression
ISO
AL 8810 results in increased expression of FABP4 mRNA
CTD
PMID:21236357
NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:91,580,885...91,585,578
G
Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions
ISO
AL 8810 inhibits the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]]
CTD
PMID:33486071
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535
G
Hmox1
heme oxygenase 1
multiple interactions
ISO
AL 8810 inhibits the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]]
CTD
PMID:33486071
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
AL 8810 inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK1 protein]
CTD
PMID:33486071
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
AL 8810 inhibits the reaction [Oxidopamine results in increased phosphorylation of MAPK3 protein]
CTD
PMID:33486071
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO
AL 8810 inhibits the reaction [Oxidopamine affects the localization of NFE2L2 protein]
CTD
PMID:33486071
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
G
Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
ISO
AL 8810 inhibits the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]]
CTD
PMID:33486071
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
G
Pparg
peroxisome proliferator-activated receptor gamma
increases expression
ISO
AL 8810 results in increased expression of PPARG mRNA
CTD
PMID:21236357
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
G
Ptgfr
prostaglandin F receptor
multiple interactions
ISO
[AL 8810 results in decreased activity of PTGFR protein] inhibits the reaction [[trans-10,cis-12-conjugated linoleic acid results in increased abundance of Dinoprost] which results in increased expression of EREG]
CTD
PMID:22583689
NCBI chr 2:243,390,820...243,426,647
Ensembl chr 2:240,733,375...240,765,650
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