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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-methylumbelliferyl acetate
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Accession:CHEBI:17763 term browser browse the term
Definition:An acetate ester consiting of umbelliferone carrying a 7-O-acetyl group.
Synonyms:exact_synonym: 4-methyl-2-oxo-2H-chromen-7-yl acetate
 related_synonym: 4-methyl-7-acetyloxy coumarin;   7-(Acetyloxy)-4-methyl-2-benzopyrone;   7-(acetyloxy)-4-methyl-2H-1-benzopyran-2-one;   7-Acetoxy-4-methylcoumarin;   7-acetoxy-4-methylchromen-2-one;   Formula=C12H10O4;   InChI=1S/C12H10O4/c1-7-5-12(14)16-11-6-9(15-8(2)13)3-4-10(7)11/h3-6H,1-2H3;   InChIKey=HXVZGASCDAGAPS-UHFFFAOYSA-N;   SMILES=CC(=O)Oc1ccc2c(C)cc(=O)oc2c1;   beta-Methylumbelliferyl acetate
 alt_id: CHEBI:110551;   CHEBI:12031;   CHEBI:1906;   CHEBI:20453
 xref: CAS:2747-05-9;   HMDB:HMDB0032989;   KEGG:C03837
 xref_mesh: MESH:C032078
 xref: MetaCyc:CPD-181;   PMID:11888210;   PMID:23245880;   Patent:US2008009544;   Patent:WO2007107846;   Reaxys:189667


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4-methylumbelliferyl acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALR calreticulin increases activity EXP 4-methylumbelliferyl acetate results in increased activity of CALR protein CTD PMID:20188080 NCBI chr19:12,938,609...12,944,489
Ensembl chr19:12,938,578...12,944,489 		JBrowse link
G CES1 carboxylesterase 1 multiple interactions
increases hydrolysis		 EXP Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; tropacocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] CTD PMID:9311626 NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337 		JBrowse link
G CES2 carboxylesterase 2 increases hydrolysis EXP CES2 protein results in increased hydrolysis of 4-methylumbelliferyl acetate CTD PMID:9169443 NCBI chr16:66,934,471...66,945,096
Ensembl chr16:66,934,444...66,945,096 		JBrowse link
G TXN thioredoxin increases activity EXP 4-methylumbelliferyl acetate results in increased activity of TXN protein CTD PMID:24103856 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507 		JBrowse link
G VEGFA vascular endothelial growth factor A increases expression EXP 4-methylumbelliferyl acetate results in increased expression of VEGFA protein CTD PMID:24103856 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      application 25179
        probe 530
          fluorescent probe 454
            umbelliferone 114
              4-methylumbelliferyl acetate 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            organic molecule 25228
                              organic cyclic compound 24281
                                organic heterocyclic compound 22324
                                  oxacycle 19999
                                    benzopyran 12753
                                      1-benzopyran 12488
                                        chromenes 4774
                                          chromenone 4726
                                            coumarins 4495
                                              hydroxycoumarin 363
                                                umbelliferone 114
                                                  4-methylumbelliferyl acetate 5
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