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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-methylumbelliferyl acetate
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Accession:CHEBI:17763 term browser browse the term
Definition:An acetate ester consiting of umbelliferone carrying a 7-O-acetyl group.
Synonyms:exact_synonym: 4-methyl-2-oxo-2H-chromen-7-yl acetate
 related_synonym: 4-methyl-7-acetyloxy coumarin;   7-(Acetyloxy)-4-methyl-2-benzopyrone;   7-(acetyloxy)-4-methyl-2H-1-benzopyran-2-one;   7-Acetoxy-4-methylcoumarin;   7-acetoxy-4-methylchromen-2-one;   Formula=C12H10O4;   InChI=1S/C12H10O4/c1-7-5-12(14)16-11-6-9(15-8(2)13)3-4-10(7)11/h3-6H,1-2H3;   InChIKey=HXVZGASCDAGAPS-UHFFFAOYSA-N;   SMILES=CC(=O)Oc1ccc2c(C)cc(=O)oc2c1;   beta-Methylumbelliferyl acetate
 alt_id: CHEBI:110551;   CHEBI:12031;   CHEBI:1906;   CHEBI:20453
 xref: CAS:2747-05-9;   HMDB:HMDB0032989;   KEGG:C03837
 xref_mesh: MESH:C032078
 xref: MetaCyc:CPD-181;   PMID:11888210;   PMID:23245880;   Patent:US2008009544;   Patent:WO2007107846;   Reaxys:189667



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4-methylumbelliferyl acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calr calreticulin increases activity ISO 4-methylumbelliferyl acetate results in increased activity of CALR protein CTD PMID:20188080 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
increases hydrolysis
ISO Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate]; tropacocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] CTD PMID:9311626 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of 4-methylumbelliferyl acetate CTD PMID:9169443 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Txn1 thioredoxin 1 increases activity ISO 4-methylumbelliferyl acetate results in increased activity of TXN protein CTD PMID:24103856 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO 4-methylumbelliferyl acetate results in increased expression of VEGFA protein CTD PMID:24103856 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      application 19781
        probe 500
          fluorescent probe 432
            umbelliferone 97
              4-methylumbelliferyl acetate 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic heterocyclic compound 18824
                                  oxacycle 17688
                                    benzopyran 11213
                                      1-benzopyran 10951
                                        chromenes 3028
                                          chromenone 2966
                                            coumarins 2720
                                              hydroxycoumarin 334
                                                umbelliferone 97
                                                  4-methylumbelliferyl acetate 5
paths to the root