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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cholesta-5,7-dien-3beta-ol
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Accession:CHEBI:17759 term browser browse the term
Definition:A 3beta-sterol that has formula C27H44O.
Synonyms:related_synonym: (3beta)-cholesta-5,7-dien-3-ol;   5,7-cholestadien-3-beta-ol;   5,7-cholestadien-3beta-ol;   7-Dehydrocholesterol;   Formula=C27H44O;   InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1;   InChIKey=UCTLRSWJYQTBFZ-DDPQNLDTSA-N;   Provitamin D3;   SMILES=[H][C@@]1(CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C
 alt_id: CHEBI:13981;   CHEBI:23181;   CHEBI:3658
 xref: Beilstein:2224615;   CAS:434-16-2;   Gmelin:893079;   KEGG:C01164;   KNApSAcK:C00023747;   LIPID_MAPS_instance:LMST01010069
 xref_mesh: MESH:C016705



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cholesta-5,7-dien-3beta-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases activity EXP 7-dehydrocholesterol results in decreased activity of CYP7A1 protein CTD PMID:1175606 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G Dhcr7 7-dehydrocholesterol reductase increases abundance
multiple interactions
increases reduction
ISO DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol
Simvastatin inhibits the reaction [DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol]
DHCR7 results in increased reduction of 7-dehydrocholesterol
[BM 15766 results in decreased activity of DHCR7 protein] which results in increased abundance of 7-dehydrocholesterol
CTD PMID:15896653 PMID:16365879 PMID:16446309 PMID:16824767 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    chemical entity 19823
      atom 19821
        nonmetal atom 19709
          carbon atom 19633
            organic molecular entity 19633
              lipid 17492
                steroid 13056
                  cholestanoid 344
                    cholesta-5,7-dien-3beta-ol 2
                      cholesta-5,7-dien-3beta,24S-diol 0
                      cholesta-5,7-dien-3beta,25-diol 0
                      cholesta-5,7-dien-3beta-ol benzoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic molecule 19572
                              organic cyclic compound 19366
                                organic polycyclic compound 16539
                                  steroid 13056
                                    hydroxy steroid 12658
                                      3-hydroxy steroid 10372
                                        sterol 439
                                          Delta(5),Delta(7)-sterol 2
                                            cholesta-5,7-dien-3beta-ol 2
                                              cholesta-5,7-dien-3beta,24S-diol 0
                                              cholesta-5,7-dien-3beta,25-diol 0
                                              cholesta-5,7-dien-3beta-ol benzoate 0
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