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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cholesta-5,7-dien-3beta-ol
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Accession:CHEBI:17759 term browser browse the term
Definition:A 3beta-sterol that has formula C27H44O.
Synonyms:related_synonym: (3beta)-cholesta-5,7-dien-3-ol;   5,7-cholestadien-3-beta-ol;   5,7-cholestadien-3beta-ol;   7-Dehydrocholesterol;   Formula=C27H44O;   InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1;   InChIKey=UCTLRSWJYQTBFZ-DDPQNLDTSA-N;   Provitamin D3;   SMILES=[H][C@@]1(CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C
 alt_id: CHEBI:13981;   CHEBI:23181;   CHEBI:3658
 xref: Beilstein:2224615;   CAS:434-16-2;   Gmelin:893079;   KEGG:C01164;   KNApSAcK:C00023747;   LIPID_MAPS_instance:LMST01010069
 xref_mesh: MESH:C016705


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cholesta-5,7-dien-3beta-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases activity EXP 7-dehydrocholesterol results in decreased activity of CYP7A1 protein CTD PMID:1175606 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase increases abundance
multiple interactions
increases reduction		 ISO DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol
Simvastatin inhibits the reaction [DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol]
DHCR7 results in increased reduction of 7-dehydrocholesterol
[BM 15766 results in decreased activity of DHCR7 protein] which results in increased abundance of 7-dehydrocholesterol		 CTD PMID:15896653 PMID:16365879 PMID:16446309 PMID:16824767 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    chemical entity 19816
      atom 19816
        nonmetal atom 19749
          carbon atom 19698
            organic molecular entity 19698
              lipid 17843
                steroid 14409
                  cholestanoid 356
                    cholesta-5,7-dien-3beta-ol 2
                      cholesta-5,7-dien-3beta,24S-diol 0
                      cholesta-5,7-dien-3beta,25-diol 0
                      cholesta-5,7-dien-3beta-ol benzoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic molecule 19656
                              organic cyclic compound 19461
                                organic polycyclic compound 17202
                                  steroid 14409
                                    hydroxy steroid 14128
                                      3-hydroxy steroid 12206
                                        sterol 460
                                          Delta(5),Delta(7)-sterol 2
                                            cholesta-5,7-dien-3beta-ol 2
                                              cholesta-5,7-dien-3beta,24S-diol 0
                                              cholesta-5,7-dien-3beta,25-diol 0
                                              cholesta-5,7-dien-3beta-ol benzoate 0
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