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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cholesta-5,7-dien-3beta-ol
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Accession:CHEBI:17759 term browser browse the term
Definition:A 3beta-sterol that has formula C27H44O.
Synonyms:related_synonym: (3beta)-cholesta-5,7-dien-3-ol;   5,7-cholestadien-3-beta-ol;   5,7-cholestadien-3beta-ol;   7-Dehydrocholesterol;   Formula=C27H44O;   InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1;   InChIKey=UCTLRSWJYQTBFZ-DDPQNLDTSA-N;   Provitamin D3;   SMILES=[H][C@@]1(CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C
 alt_id: CHEBI:13981;   CHEBI:23181;   CHEBI:3658
 xref: Beilstein:2224615;   CAS:434-16-2;   Gmelin:893079;   KEGG:C01164;   KNApSAcK:C00023747;   LIPID_MAPS_instance:LMST01010069
 xref_mesh: MESH:C016705



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cholesta-5,7-dien-3beta-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases activity EXP 7-dehydrocholesterol results in decreased activity of CYP7A1 protein CTD PMID:1175606 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G Dhcr7 7-dehydrocholesterol reductase increases abundance
multiple interactions
increases reduction
ISO DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol
Simvastatin inhibits the reaction [DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol]
DHCR7 results in increased reduction of 7-dehydrocholesterol
[BM 15766 results in decreased activity of DHCR7 protein] which results in increased abundance of 7-dehydrocholesterol
CTD PMID:15896653 PMID:16365879 PMID:16446309 PMID:16824767 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19848
    chemical entity 19846
      atom 19846
        nonmetal atom 19784
          carbon atom 19737
            organic molecular entity 19737
              lipid 17978
                steroid 14689
                  cholestanoid 365
                    cholesta-5,7-dien-3beta-ol 2
                      cholesta-5,7-dien-3beta,24S-diol 0
                      cholesta-5,7-dien-3beta,25-diol 0
                      cholesta-5,7-dien-3beta-ol benzoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19848
    subatomic particle 19846
      composite particle 19846
        hadron 19846
          baryon 19846
            nucleon 19846
              atomic nucleus 19846
                atom 19846
                  main group element atom 19796
                    p-block element atom 19796
                      carbon group element atom 19741
                        carbon atom 19737
                          organic molecular entity 19737
                            organic molecule 19690
                              organic cyclic compound 19501
                                organic polycyclic compound 17247
                                  steroid 14689
                                    hydroxy steroid 14435
                                      3-hydroxy steroid 12772
                                        sterol 465
                                          Delta(5),Delta(7)-sterol 2
                                            cholesta-5,7-dien-3beta-ol 2
                                              cholesta-5,7-dien-3beta,24S-diol 0
                                              cholesta-5,7-dien-3beta,25-diol 0
                                              cholesta-5,7-dien-3beta-ol benzoate 0
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