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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cholesta-5,7-dien-3beta-ol
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Accession:CHEBI:17759 term browser browse the term
Definition:A 3beta-sterol that has formula C27H44O.
Synonyms:related_synonym: (3beta)-cholesta-5,7-dien-3-ol;   5,7-cholestadien-3-beta-ol;   5,7-cholestadien-3beta-ol;   7-Dehydrocholesterol;   Formula=C27H44O;   InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1;   InChIKey=UCTLRSWJYQTBFZ-DDPQNLDTSA-N;   Provitamin D3;   SMILES=[H][C@@]1(CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)C
 alt_id: CHEBI:13981;   CHEBI:23181;   CHEBI:3658
 xref: Beilstein:2224615;   CAS:434-16-2;   Gmelin:893079;   KEGG:C01164;   KNApSAcK:C00023747;   LIPID_MAPS_instance:LMST01010069
 xref_mesh: MESH:C016705


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cholesta-5,7-dien-3beta-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases activity EXP 7-dehydrocholesterol results in decreased activity of CYP7A1 protein CTD PMID:1175606 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
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G Dhcr7 7-dehydrocholesterol reductase increases abundance
multiple interactions
increases reduction
ISO DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol
Simvastatin inhibits the reaction [DHCR7 mutant form results in increased abundance of 7-dehydrocholesterol]
DHCR7 results in increased reduction of 7-dehydrocholesterol
[BM 15766 results in decreased activity of DHCR7 protein] which results in increased abundance of 7-dehydrocholesterol
CTD PMID:15896653, PMID:16365879, PMID:16446309, PMID:16824767 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      atom 19782
        nonmetal atom 19657
          carbon atom 19561
            organic molecular entity 19561
              lipid 16976
                steroid 12788
                  cholestanoid 327
                    cholesta-5,7-dien-3beta-ol 2
                      cholesta-5,7-dien-3beta,24S-diol 0
                      cholesta-5,7-dien-3beta,25-diol 0
                      cholesta-5,7-dien-3beta-ol benzoate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic polycyclic compound 16384
                                  steroid 12788
                                    hydroxy steroid 12371
                                      3-hydroxy steroid 9999
                                        sterol 417
                                          Delta(5),Delta(7)-sterol 2
                                            cholesta-5,7-dien-3beta-ol 2
                                              cholesta-5,7-dien-3beta,24S-diol 0
                                              cholesta-5,7-dien-3beta,25-diol 0
                                              cholesta-5,7-dien-3beta-ol benzoate 0
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