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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cystathionine
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Accession:CHEBI:17755 term browser browse the term
Definition:A modified amino acid generated by enzymic means from homocysteine and serine.
Synonyms:exact_synonym: 2-amino-4-[(2-amino-2-carboxyethyl)sulfanyl]butanoic acid;   S-(2-amino-2-carboxyethyl)homocysteine
 related_synonym: DL-Cystathionine;   Formula=C7H14N2O4S;   InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13);   InChIKey=ILRYLPWNYFXEMH-UHFFFAOYSA-N;   SMILES=NC(CCSCC(N)C(O)=O)C(O)=O;   cystathione
 alt_id: CHEBI:14059;   CHEBI:4048
 xref: CAS:535-34-2;   KEGG:C00542;   PMID:12907234;   PMID:15033753;   PMID:22212096;   PMID:22264337;   Reaxys:2416815



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L-cystathionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO BAX protein inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]]; BTSA1 compound inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine affects the localization of BAX protein]]; Cystathionine inhibits the reaction [Homocysteine affects the localization of BAX protein]; Cystathionine inhibits the reaction [Homocysteine results in increased expression of and affects the localization of BAX protein] CTD PMID:31885769 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Casp3 caspase 3 multiple interactions ISO BAX protein inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]]; BTSA1 compound inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased cleavage of CASP3 protein]]; Cystathionine inhibits the reaction [Homocysteine results in increased activity of and results in increased cleavage of CASP3 protein] CTD PMID:31885769 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO BTSA1 compound inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP9 protein]]; Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP9 protein] CTD PMID:31885769 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Cystathionine analog CTD PMID:26820058 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Kyat1 kynurenine aminotransferase 1 increases amination ISO KYAT1 protein results in increased amination of Cystathionine CTD PMID:22093698 NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Cystathionine inhibits the reaction [Formaldehyde results in increased expression of MMP1 protein] CTD PMID:27664576 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        biochemical role 19588
          metabolite 19574
            cystathionine 6
              L-cystathionine 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        amino acid 15961
                                          alpha-amino acid 13870
                                            non-proteinogenic alpha-amino acid 3801
                                              homocysteines 415
                                                cystathionines 6
                                                  cystathionine 6
                                                    L-cystathionine 6
paths to the root