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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lonapalene
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Accession:CHEBI:177429 term browser browse the term
Synonyms:exact_synonym: (4-acetyloxy-6-chloro-2,3-dimethoxynaphthalen-1-yl) acetate
 related_synonym: Formula=C16H15ClO6;   InChI=1S/C16H15ClO6/c1-8(18)22-13-11-6-5-10(17)7-12(11)14(23-9(2)19)16(21-4)15(13)20-3/h5-7H,1-4H3;   InChIKey=IFWMVQUGSGWCRP-UHFFFAOYSA-N;   SMILES=ClC1=CC2=C(C(OC(=O)C)=C(OC)C(OC)=C2OC(=O)C)C=C1
 xref: CAS:91431-42-4;   Chemspider:50751;   KEGG:D04770
 xref_mesh: MESH:C045954



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lonapalene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase multiple interactions
decreases activity
ISO [RS 43179 results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [RS 43179 results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid CTD PMID:2849922 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      molecular entity 19799
        polyatomic entity 19721
          heteroatomic molecular entity 19662
            halide 18156
              organohalogen compound 17938
                organochlorine compound 17755
                  lonapalene 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                carbocyclic compound 18316
                                  carbopolycyclic compound 17029
                                    carbobicyclic compound 5822
                                      naphthalenes 3766
                                        lonapalene 1
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