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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N,N-dimethylformamide
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Accession:CHEBI:17741 term browser browse the term
Definition:A member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups.
Synonyms:related_synonym: DMF;   Dimethylformamide;   Formula=C3H7NO;   InChI=1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3;   InChIKey=ZMXDDKWLCZADIW-UHFFFAOYSA-N;   N,N-Dimethylmethanamide;   N-Formyldimethylamine;   SMILES=[H]C(=O)N(C)C
 alt_id: CHEBI:12425;   CHEBI:21454;   CHEBI:42077;   CHEBI:7076
 xref: CAS:68-12-2;   DrugBank:DB01844;   HMDB:HMDB0001888;   KEGG:C03134
 xref_mesh: MESH:D004126
 xref: MetaCyc:CPD-581;   PDBeChem:DMF;   PMID:18666198;   PMID:19608215;   PMID:3824392;   Reaxys:605365;   Wikipedia:Dimethylformamide


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N,N-dimethylformamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B decreases expression EXP Dimethylformamide results in decreased expression of ABCB1B mRNA CTD PMID:12883083 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO Thiocarbamates analog inhibits the reaction [Dimethylformamide results in increased expression of BAX protein] CTD PMID:29984871 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
EXP
ISO
[Dimethylformamide co-treated with Carbon Tetrachloride] results in decreased expression of BCL2L1 protein
Dimethylformamide results in increased expression of BCL2L1 protein
Thiocarbamates analog inhibits the reaction [Dimethylformamide results in decreased expression of BCL2L1 protein]
CTD PMID:20097184 PMID:29984871 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
EXP
ISO
[Dimethylformamide co-treated with Carbon Tetrachloride] results in increased activity of CASP3 protein
Dimethylformamide results in increased expression of CASP3 protein modified form
CAT protein inhibits the reaction [Dimethylformamide results in increased expression of CASP3 protein modified form]; Thiocarbamates analog inhibits the reaction [Dimethylformamide results in increased expression of CASP3 protein modified form]
CTD PMID:20097184 PMID:29984871 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
ISO CAT protein inhibits the reaction [Dimethylformamide results in increased expression of CASP9 protein modified form]; Thiocarbamates analog inhibits the reaction [Dimethylformamide results in increased expression of CASP9 protein modified form] CTD PMID:29984871 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Dimethylformamide results in increased expression of CASP3 protein modified form]; CAT protein inhibits the reaction [Dimethylformamide results in increased expression of CASP9 protein modified form]; CAT protein inhibits the reaction [Dimethylformamide results in increased expression of TP53 protein] CTD PMID:29984871 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects metabolic processing
increases response to substance
increases abundance
multiple interactions
increases expression
increases oxidation
increases metabolic processing
ISO
EXP
CYP2E1 protein polymorphism affects the metabolism of Dimethylformamide
CYP2E1 protein results in increased susceptibility to Dimethylformamide
CYP2E1 polymorphism results in increased abundance of Dimethylformamide metabolite
CYP2E1 protein affects the reaction [Dimethylformamide results in increased activity of GPT protein]; CYP2E1 protein affects the reaction [Dimethylformamide results in increased expression of HSP90B1 protein]
Dimethylformamide results in increased expression of CYP2E1 protein
CYP2E1 protein results in increased oxidation of Dimethylformamide
CYP2E1 protein affects the metabolism of Dimethylformamide
CYP2E1 protein results in increased metabolism of Dimethylformamide
CTD PMID:9817075 PMID:10207612 PMID:11305777 PMID:15772367 PMID:29984871 PMID:31501917 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP [Dimethylformamide co-treated with Carbon Tetrachloride] results in increased expression of DDIT3 mRNA CTD PMID:20097184 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP [Dimethylformamide co-treated with Carbon Tetrachloride] results in increased expression of EIF2AK3 protein modified form CTD PMID:20097184 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases activity
ISO CYP2E1 protein affects the reaction [Dimethylformamide results in increased activity of GPT protein] CTD PMID:31501917 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsr glutathione-disulfide reductase decreases expression EXP Dimethylformamide results in decreased expression of GSR mRNA CTD PMID:12883083 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G H2ax H2A.X variant histone increases expression ISO Dimethylformamide results in increased expression of H2AX protein CTD PMID:26387567 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 multiple interactions
increases expression
EXP
ISO
[Dimethylformamide co-treated with Carbon Tetrachloride] results in increased expression of HSP90B1 protein
Dimethylformamide results in increased expression of HSP90B1 protein
CYP2E1 protein affects the reaction [Dimethylformamide results in increased expression of HSP90B1 protein]
CTD PMID:20097184 PMID:31501917 NCBI chr 7:27,226,570...27,240,533
Ensembl chr 7:27,226,569...27,240,533
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP [Dimethylformamide co-treated with Carbon Tetrachloride] results in increased expression of HSPA5 mRNA; [Dimethylformamide co-treated with Carbon Tetrachloride] results in increased expression of HSPA5 protein CTD PMID:20097184 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ltf lactotransferrin increases expression ISO Dimethylformamide results in increased expression of LTF mRNA CTD PMID:18063697 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Mpo myeloperoxidase increases expression ISO Dimethylformamide results in increased expression of MPO mRNA CTD PMID:18063697 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease increases expression ISO Dimethylformamide results in increased expression of MRE11 mRNA; Dimethylformamide results in increased expression of MRE11 protein CTD PMID:26387567 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 increases expression ISO Dimethylformamide results in increased expression of NCF1 mRNA CTD PMID:18063697 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nefh neurofilament heavy affects expression EXP Dimethylformamide affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP [Dimethylformamide co-treated with Carbon Tetrachloride] results in increased cleavage of PARP1 protein CTD PMID:20097184 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rad50 RAD50 double strand break repair protein increases expression ISO Dimethylformamide results in increased expression of RAD50 mRNA; Dimethylformamide results in increased expression of RAD50 protein CTD PMID:26387567 NCBI chr10:39,002,130...39,054,042
Ensembl chr10:39,001,498...39,054,142
JBrowse link
G Rad51 RAD51 recombinase increases expression ISO Dimethylformamide results in increased expression of RAD51 mRNA; Dimethylformamide results in increased expression of RAD51 protein CTD PMID:26387567 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO Dimethylformamide inhibits the reaction [SULT1A1 protein results in increased sulfation of 1-hydroxypyrene]; Dimethylformamide inhibits the reaction [SULT1A1 protein results in increased sulfation of 4-nitrophenol] CTD PMID:14570759 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions ISO Dimethylformamide inhibits the reaction [SULT2A1 protein results in increased sulfation of 1-hydroxypyrene] CTD PMID:14570759 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO Dimethylformamide results in increased expression of TNFSF10 mRNA; Dimethylformamide results in increased expression of TNFSF10 protein CTD PMID:18063697 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO CAT protein inhibits the reaction [Dimethylformamide results in increased expression of TP53 protein]; Thiocarbamates analog inhibits the reaction [Dimethylformamide results in increased expression of TP53 protein]
Dimethylformamide results in increased expression of TP53 protein modified form
CTD PMID:29984871 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Xrcc2 X-ray repair cross complementing 2 increases expression
affects expression
ISO Dimethylformamide results in increased expression of XRCC2 protein
Dimethylformamide affects the expression of XRCC2 mRNA
CTD PMID:26387567 NCBI chr 4:5,842,013...5,860,516
Ensembl chr 4:5,841,998...5,860,527
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 increases expression ISO Dimethylformamide results in increased expression of XRCC3 mRNA; Dimethylformamide results in increased expression of XRCC3 protein CTD PMID:26387567 NCBI chr 6:136,366,917...136,380,751
Ensembl chr 6:136,371,555...136,379,348
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      application 19494
        solvent 16571
          formamide 129
            N,N-dimethylformamide 28
              N,N-dimethylformamide dimethyl acetal 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic group 18569
                              organic divalent group 18560
                                organodiyl group 18560
                                  carbonyl group 18468
                                    carbonyl compound 18468
                                      carboxylic acid 18142
                                        carboacyl group 17404
                                          univalent carboacyl group 17404
                                            carbamoyl group 17189
                                              carboxamide 17189
                                                formamides 1353
                                                  formamide 129
                                                    N,N-dimethylformamide 28
                                                      N,N-dimethylformamide dimethyl acetal 0
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