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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:177387 term browser browse the term
Definition:A quinolinemonocarboxylic acid that is quinoline substituted by 2'-fluoro[1,1'-biphenyl]-4-yl, methyl, carboxy and fluoro groups at positions 2, 3, 4, and 6, respectively. It is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. The compound exhibits antineoplastic and antiviral properties.
Synonyms:exact_synonym: 6-fluoro-2-(2'-fluoro[biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid
 related_synonym: 6-fluoro-2-(2'-fluoro-1,1'-biphenyl-4-yl)-3-methylquinoline-4-carboxylic acid;   6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid;   6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-quinoline-4-carboxylic acid;   6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid;   Formula=C23H15F2NO2;   InChI=1S/C23H15F2NO2/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25/h2-12H,1H3,(H,27,28);   InChIKey=PHEZJEYUWHETKO-UHFFFAOYSA-N;   SMILES=CC1=C(C(O)=O)C2=C(C=CC(F)=C2)N=C1C1=CC=C(C=C1)C1=CC=CC=C1F;   biphenquinate;   brequinarum
 alt_id: CHEBI:41224
 xref: CAS:96187-53-0;   Chemspider:51422;   DrugBank:DB03523;   LINCS:LSM-45952
 xref_mesh: MESH:C046943
 xref: PDBeChem:BRF;   PMID:20606073;   PMID:21840180;   PMID:24013224;   PMID:28833638;   PMID:30663496;   PMID:31146110;   PMID:31557612;   PMID:31635418;   PMID:33007394;   PMID:33080984;   PMID:33344900;   PMID:33437396;   PMID:33584854;   PMID:4053030;   PMID:8132203;   Patent:WO9742953;   Reaxys:8354757;   Wikipedia:Brequinar
 cyclic_relationship: is_conjugate_acid_of CHEBI:177870

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brequinar term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhodh dihydroorotate dehydrogenase (quinone) multiple interactions
decreases activity
brequinar inhibits the reaction [DHODH protein results in increased metabolism of 4,5-dihydroorotic acid]; brequinar inhibits the reaction [DHODH protein results in increased metabolism of Quinones]; brequinar inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]
brequinar results in decreased activity of DHODH protein
CTD PMID:9776318 PMID:9802339 PMID:10658902 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
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Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19659
    role 19634
      biological role 19633
        antimicrobial agent 17784
          antiviral agent 10531
            brequinar 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    p-block element atom 19607
                      carbon group element atom 19550
                        carbon atom 19547
                          organic molecular entity 19588
                            organic group 18752
                              organic divalent group 18771
                                organodiyl group 18737
                                  carbonyl group 18704
                                    carbonyl compound 18738
                                      carboxylic acid 18409
                                        aromatic carboxylic acid 11765
                                          quinolinemonocarboxylic acid 103
                                            brequinar 1
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