Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:desmosterol
go back to main search page
Accession:CHEBI:17737 term browser browse the term
Definition:A cholestanoid that is cholesta-5,24-diene substituted by a beta-hydroxy group at position 3. It is an intermediate metabolite obtained during the synthesis of cholesterol.
Synonyms:related_synonym: 24-Dehydrocholesterol;   3beta-cholesta-5,24-dien-3-ol;   Cholesta-5,24-dien-3beta-ol;   Formula=C27H44O;   InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1;   InChIKey=AVSXSVCZWQODGV-DPAQBDIFSA-N;   SMILES=[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC=C(C)C
 alt_id: CHEBI:14130;   CHEBI:23646;   CHEBI:4451
 xref: CAS:313-04-2;   HMDB:HMDB0002719;   KEGG:C01802;   KNApSAcK:C00023743;   LIPID_MAPS_instance:LMST01010016
 xref_mesh: MESH:D003897
 xref: MetaCyc:DESMOSTEROL-CPD;   PMID:19115107;   PMID:23042211;   PMID:24095826;   PMID:24378747;   PMID:5432584;   Reaxys:2338693;   Wikipedia:Desmosterol



show annotations for term's descendants           Sort by:
 
desmosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Desmosterol results in increased expression of ABCA1 mRNA CTD PMID:19260826 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Clec4e C-type lectin domain family 4, member E increases activity ISO Desmosterol results in increased activity of CLEC4E protein CTD PMID:26296894 NCBI chr 4:156,606,927...156,612,911
Ensembl chr 4:156,607,614...156,612,767
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases metabolic processing ISO CYP27A1 protein results in increased metabolism of Desmosterol CTD PMID:14622972 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases metabolic processing
multiple interactions
ISO DHCR24 protein results in increased metabolism of Desmosterol
[DHCR24 protein results in increased metabolism of Desmosterol] which results in increased abundance of Cholesterol
CTD PMID:23042211 NCBI chr 5:121,344,637...121,368,853
Ensembl chr 5:121,344,575...121,371,137
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO Desmosterol results in decreased expression of HMGCR protein CTD PMID:19260826 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Desmosterol analog; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased abundance of Desmosterol analog CTD PMID:26820058 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Insig1 insulin induced gene 1 decreases expression ISO Desmosterol results in decreased expression of INSIG1 protein CTD PMID:19260826 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO Desmosterol results in decreased expression of LDLR protein CTD PMID:19260826 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Marchf6 membrane associated ring-CH-type finger 6 increases stability ISO Desmosterol results in increased stability of MARCHF6 protein CTD PMID:30545937 NCBI chr 2:82,455,686...82,532,917
Ensembl chr 2:82,455,689...82,532,910
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Desmosterol results in increased expression of SCD1 mRNA CTD PMID:19260826 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO Desmosterol results in increased expression of SREBF1 mRNA; Desmosterol results in increased expression of SREBF1 protein CTD PMID:19260826 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    chemical entity 20058
      atom 20056
        nonmetal atom 19944
          carbon atom 19873
            organic molecular entity 19873
              lipid 17624
                steroid 13379
                  C27-steroid 336
                    desmosterol 11
                      (24Z),26-hydroxydesmosterol 0
                      24(S),25-epoxycholesterol 0
                      7-dehydrodesmosterol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic molecule 19819
                              organic cyclic compound 19581
                                organic polycyclic compound 16968
                                  steroid 13379
                                    hydroxy steroid 13008
                                      3-hydroxy steroid 10395
                                        3beta-hydroxy steroid 2023
                                          3beta-hydroxy-Delta(5)-steroid 1854
                                            desmosterol 11
                                              (24Z),26-hydroxydesmosterol 0
                                              24(S),25-epoxycholesterol 0
                                              7-dehydrodesmosterol 0
paths to the root