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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:desmosterol
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Accession:CHEBI:17737 term browser browse the term
Definition:A cholestanoid that is cholesta-5,24-diene substituted by a beta-hydroxy group at position 3. It is an intermediate metabolite obtained during the synthesis of cholesterol.
Synonyms:related_synonym: 24-Dehydrocholesterol;   3beta-cholesta-5,24-dien-3-ol;   Cholesta-5,24-dien-3beta-ol;   Formula=C27H44O;   InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1;   InChIKey=AVSXSVCZWQODGV-DPAQBDIFSA-N;   SMILES=[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCC=C(C)C
 alt_id: CHEBI:14130;   CHEBI:23646;   CHEBI:4451
 xref: CAS:313-04-2;   HMDB:HMDB0002719;   KEGG:C01802;   KNApSAcK:C00023743;   LIPID_MAPS_instance:LMST01010016
 xref_mesh: MESH:D003897
 xref: MetaCyc:DESMOSTEROL-CPD;   PMID:19115107;   PMID:23042211;   PMID:24095826;   PMID:24378747;   PMID:5432584;   Reaxys:2338693;   Wikipedia:Desmosterol


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desmosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Desmosterol results in increased expression of ABCA1 mRNA CTD PMID:19260826 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Clec4e C-type lectin domain family 4, member E increases activity ISO Desmosterol results in increased activity of CLEC4E protein CTD PMID:26296894 NCBI chr 4:156,271,087...156,276,243
Ensembl chr 4:156,270,920...156,276,304
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases metabolic processing ISO CYP27A1 protein results in increased metabolism of Desmosterol CTD PMID:14622972 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases metabolic processing
multiple interactions
ISO DHCR24 protein results in increased metabolism of Desmosterol
[DHCR24 protein results in increased metabolism of Desmosterol] which results in increased abundance of Cholesterol
CTD PMID:23042211 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression ISO Desmosterol results in decreased expression of HMGCR protein CTD PMID:19260826 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [1-Methyl-3-isobutylxanthine co-treated with butylbenzyl phthalate co-treated with INS protein] results in increased abundance of Desmosterol analog; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased abundance of Desmosterol analog CTD PMID:26820058 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insig1 insulin induced gene 1 decreases expression ISO Desmosterol results in decreased expression of INSIG1 protein CTD PMID:19260826 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO Desmosterol results in decreased expression of LDLR protein CTD PMID:19260826 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Marchf6 membrane associated ring-CH-type finger 6 increases stability ISO Desmosterol results in increased stability of MARCHF6 protein CTD PMID:30545937 NCBI chr 2:84,533,546...84,608,743
Ensembl chr 2:84,536,669...84,608,712
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Desmosterol results in increased expression of SCD1 mRNA CTD PMID:19260826 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO Desmosterol results in increased expression of SREBF1 mRNA; Desmosterol results in increased expression of SREBF1 protein CTD PMID:19260826 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19767
    chemical entity 19767
      atom 19766
        nonmetal atom 19645
          carbon atom 19563
            organic molecular entity 19563
              lipid 17489
                steroid 13054
                  C27-steroid 318
                    desmosterol 11
                      (24Z),26-hydroxydesmosterol 0
                      24(S),25-epoxycholesterol 0
                      7-dehydrodesmosterol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    p-block element atom 19657
                      carbon group element atom 19573
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19496
                              organic cyclic compound 19322
                                organic polycyclic compound 16514
                                  steroid 13054
                                    hydroxy steroid 12652
                                      3-hydroxy steroid 10360
                                        3beta-hydroxy steroid 2007
                                          3beta-hydroxy-Delta(5)-steroid 1839
                                            desmosterol 11
                                              (24Z),26-hydroxydesmosterol 0
                                              24(S),25-epoxycholesterol 0
                                              7-dehydrodesmosterol 0
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