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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide
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Accession:CHEBI:177298 term browser browse the term
Definition:A member of the class of indazoles that is 2H-indazole substituted by 4-(piperidin-3-yl)phenyl and aminocarbonyl groups at positions 2 and 7, respectively. It is a potent PARP1 inhibitor with IC50 of 3.2 nM.
Synonyms:related_synonym: Formula=C19H20N4O;   InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24);   InChIKey=PCHKPVIQAHNQLW-UHFFFAOYSA-N;   SMILES=NC(=O)C1=CC=CC2=CN(N=C12)C1=CC=C(C=C1)C1CCCNC1
 xref: PMID:25761096



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niraparib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G H2ax H2A.X variant histone increases expression
multiple interactions
ISO niraparib results in increased expression of H2AX protein
diphenyleneiodonium inhibits the reaction [niraparib results in increased expression of H2AX protein]
CTD PMID:34396909 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO niraparib binds to and results in decreased activity of PARP1 protein CTD PMID:28001384 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 multiple interactions ISO niraparib binds to and results in decreased activity of PARP2 protein CTD PMID:28001384 NCBI chr15:24,034,069...24,044,340
Ensembl chr15:24,034,106...24,044,338
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      application 19729
        pharmaceutical 19565
          drug 19565
            antineoplastic agent 17770
              2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide 3
                2-\{4-[(3R)-piperidin-3-yl]phenyl\}-2H-indazole-7-carboxamide 0
                niraparib 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        carboacyl group 17727
                                          univalent carboacyl group 17727
                                            carbamoyl group 17575
                                              carboxamide 17575
                                                primary carboxamide 5991
                                                  2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide 3
                                                    2-\{4-[(3R)-piperidin-3-yl]phenyl\}-2H-indazole-7-carboxamide 0
                                                    niraparib 3
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