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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lactose
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Accession:CHEBI:17716 term browser browse the term
Definition:A glycosylglucose disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form.
Synonyms:related_synonym: (Gal)1 (Glc)1;   1-beta-D-Galactopyranosyl-4-D-glucopyranose;   4-(beta-D-galactosido)-D-glucose;   4-O-beta-D-galactopyranosyl-D-glucose;   D-lactose;   Formula=C12H22O11;   Galbeta1-4Glc;   InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1;   InChIKey=GUBGYTABKSRVRQ-QKKXKWKRSA-N;   Lac;   Laktobiose;   Laktose;   Milchzucker;   SMILES=OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O;   WURCS=2.0/2,2,1/[a2122h-1x_1-5][a2112h-1b_1-5]/1-2/a4-b1;   beta-D-Gal-(1->4)-D-Glc;   beta-D-Galp-(1->4)-D-Glcp;   beta-Gal1,4-Glc;   lactobiose;   milk sugar
 alt_id: CHEBI:10296;   CHEBI:10380;   CHEBI:14497;   CHEBI:22460;   CHEBI:22760;   CHEBI:25005;   CHEBI:27755;   CHEBI:613009
 xref: Beilstein:1292745;   CAS:63-42-3;   GlyGen:G74621DY;   GlyTouCan:G74621DY;   Gmelin:882872;   KEGG:C00243;   KEGG:D00046;   KEGG:G10504;   KNApSAcK:C00001136
 xref_mesh: MESH:D007785
 xref: PMID:1292745;   PMID:17329833;   PMID:18300214;   PMID:19053747;   PMID:19846069;   PMID:19913595;   PMID:20094999;   PMID:20503067;   PMID:20699559;   PMID:20873837;   PMID:20961532;   PMID:21403918;   PMID:2432147;   PMID:2456994;   PMID:28690131;   PMID:28807538;   PMID:6194884;   PMID:7574700;   Reaxys:1292745



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lactose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity EXP Lactose results in decreased activity of CAT protein CTD PMID:2539851 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Lgals3 galectin 3 affects binding ISO Lactose binds to LGALS3 protein CTD PMID:17385862 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Sod1 superoxide dismutase 1 decreases activity EXP Lactose results in decreased activity of SOD1 protein CTD PMID:2539851 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20083
    role 20034
      biological role 20033
        biochemical role 19660
          metabolite 19642
            eukaryotic metabolite 19345
              animal metabolite 19191
                mammalian metabolite 19191
                  human metabolite 18645
                    lactose 3
                      2'-fucosyllactose + 0
                      3-(hexadecylsulfonyl)-2-[(hexadecylsulfonyl)methyl]propyl beta-D-galactosyl-(1->4)-beta-D-glucoside 0
                      3-fucosyllactose + 0
                      D-Galp-(1->3)-beta-D-Galp-(1->4)-D-Glcp 0
                      D-Galp-(1->6)-beta-D-Galp-(1->4)-D-Glcp 0
                      alpha-L-Fucp-(1->4)-beta-D-Galp-(1->4)-D-Glcp 0
                      alpha-lactose + 0
                      beta-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-Glcp 0
                      beta-D-Galp-(1->4)-[alpha-D-Glcp-(1->2)]-D-Glcp 0
                      beta-D-Galp-(1->6)-beta-D-Galp-(1->4)-D-Glcp 0
                      beta-D-Galp6S-(1->4)-D-Glcp 0
                      beta-D-GlcpNAc-(1->4)-beta-D-Galp-(1->4)-D-Glcp 0
                      beta-D-GlcpNAc-(1->6)-beta-D-Galp-(1->4)-D-Glcp 0
                      beta-L-Fucp-(1->4)-beta-D-Galp-(1->4)-D-Glcp 0
                      beta-lactose + 0
                      lactobionic acid + 0
                      lactose 6'-phosphate 0
                      lactose phosphate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20083
    subatomic particle 20081
      composite particle 20081
        hadron 20081
          baryon 20081
            nucleon 20081
              atomic nucleus 20081
                atom 20081
                  main group element atom 19982
                    p-block element atom 19982
                      carbon group element atom 19909
                        carbon atom 19902
                          organic molecular entity 19902
                            heteroorganic entity 19585
                              organochalcogen compound 19294
                                organooxygen compound 19267
                                  carbohydrates and carbohydrate derivatives 13944
                                    carbohydrate 13944
                                      oligosaccharide 581
                                        disaccharide 490
                                          glycosylglucose 196
                                            lactose 3
                                              2'-fucosyllactose + 0
                                              3-(hexadecylsulfonyl)-2-[(hexadecylsulfonyl)methyl]propyl beta-D-galactosyl-(1->4)-beta-D-glucoside 0
                                              3-fucosyllactose + 0
                                              D-Galp-(1->3)-beta-D-Galp-(1->4)-D-Glcp 0
                                              D-Galp-(1->6)-beta-D-Galp-(1->4)-D-Glcp 0
                                              alpha-L-Fucp-(1->4)-beta-D-Galp-(1->4)-D-Glcp 0
                                              alpha-lactose + 0
                                              beta-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-Glcp 0
                                              beta-D-Galp-(1->4)-[alpha-D-Glcp-(1->2)]-D-Glcp 0
                                              beta-D-Galp-(1->6)-beta-D-Galp-(1->4)-D-Glcp 0
                                              beta-D-Galp6S-(1->4)-D-Glcp 0
                                              beta-D-GlcpNAc-(1->4)-beta-D-Galp-(1->4)-D-Glcp 0
                                              beta-D-GlcpNAc-(1->6)-beta-D-Galp-(1->4)-D-Glcp 0
                                              beta-L-Fucp-(1->4)-beta-D-Galp-(1->4)-D-Glcp 0
                                              beta-lactose + 0
                                              lactobionic acid + 0
                                              lactose 6'-phosphate 0
                                              lactose phosphate + 0
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