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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lactose
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Accession:CHEBI:17716 term browser browse the term
Definition:A glycosylglucose disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form.
Synonyms:related_synonym: (Gal)1 (Glc)1;   1-beta-D-Galactopyranosyl-4-D-glucopyranose;   4-(beta-D-galactosido)-D-glucose;   4-O-beta-D-galactopyranosyl-D-glucose;   D-lactose;   Formula=C12H22O11;   Galbeta1-4Glc;   InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1;   InChIKey=GUBGYTABKSRVRQ-QKKXKWKRSA-N;   Lac;   Laktobiose;   Laktose;   Milchzucker;   SMILES=OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O;   WURCS=2.0/2,2,1/[a2122h-1x_1-5][a2112h-1b_1-5]/1-2/a4-b1;   beta-D-Gal-(1->4)-D-Glc;   beta-D-Galp-(1->4)-D-Glcp;   beta-Gal1,4-Glc;   lactobiose;   milk sugar
 alt_id: CHEBI:10296;   CHEBI:10380;   CHEBI:14497;   CHEBI:22460;   CHEBI:22760;   CHEBI:25005;   CHEBI:27755;   CHEBI:613009
 xref: Beilstein:1292745;   CAS:63-42-3;   GlyGen:G74621DY;   GlyTouCan:G74621DY;   Gmelin:882872;   KEGG:C00243;   KEGG:D00046;   KEGG:G10504;   KNApSAcK:C00001136
 xref_mesh: MESH:D007785
 xref: PMID:1292745;   PMID:17329833;   PMID:18300214;   PMID:19053747;   PMID:19846069;   PMID:19913595;   PMID:20094999;   PMID:20503067;   PMID:20699559;   PMID:20873837;   PMID:20961532;   PMID:21403918;   PMID:2432147;   PMID:2456994;   PMID:28690131;   PMID:28807538;   PMID:6194884;   PMID:7574700;   Reaxys:1292745


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lactose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity EXP Lactose results in decreased activity of CAT protein CTD PMID:2539851 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Lgals3 galectin 3 affects binding ISO Lactose binds to LGALS3 protein CTD PMID:17385862 NCBI chr15:24,153,602...24,165,537
Ensembl chr15:24,141,651...24,165,537
JBrowse link
G Sod1 superoxide dismutase 1 decreases activity EXP Lactose results in decreased activity of SOD1 protein CTD PMID:2539851 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      biological role 19716
        biochemical role 19304
          metabolite 19286
            eukaryotic metabolite 18957
              animal metabolite 18786
                mammalian metabolite 18785
                  human metabolite 18293
                    lactose 3
                      2'-fucosyllactose + 0
                      3-(hexadecylsulfonyl)-2-[(hexadecylsulfonyl)methyl]propyl beta-D-galactosyl-(1->4)-beta-D-glucoside 0
                      3-fucosyllactose + 0
                      D-Galp-(1->3)-beta-D-Galp-(1->4)-D-Glcp 0
                      D-Galp-(1->6)-beta-D-Galp-(1->4)-D-Glcp 0
                      alpha-L-Fucp-(1->4)-beta-D-Galp-(1->4)-D-Glcp 0
                      alpha-lactose + 0
                      beta-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-Glcp 0
                      beta-D-Galp-(1->4)-[alpha-D-Glcp-(1->2)]-D-Glcp 0
                      beta-D-Galp-(1->6)-beta-D-Galp-(1->4)-D-Glcp 0
                      beta-D-Galp6S-(1->4)-D-Glcp 0
                      beta-D-GlcpNAc-(1->4)-beta-D-Galp-(1->4)-D-Glcp 0
                      beta-D-GlcpNAc-(1->6)-beta-D-Galp-(1->4)-D-Glcp 0
                      beta-L-Fucp-(1->4)-beta-D-Galp-(1->4)-D-Glcp 0
                      beta-lactose + 0
                      lactobionic acid + 0
                      lactose 6'-phosphate 0
                      lactose phosphate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            heteroorganic entity 19199
                              organochalcogen compound 18946
                                organooxygen compound 18873
                                  carbohydrates and carbohydrate derivatives 12285
                                    carbohydrate 12285
                                      oligosaccharide 553
                                        disaccharide 460
                                          glycosylglucose 186
                                            lactose 3
                                              2'-fucosyllactose + 0
                                              3-(hexadecylsulfonyl)-2-[(hexadecylsulfonyl)methyl]propyl beta-D-galactosyl-(1->4)-beta-D-glucoside 0
                                              3-fucosyllactose + 0
                                              D-Galp-(1->3)-beta-D-Galp-(1->4)-D-Glcp 0
                                              D-Galp-(1->6)-beta-D-Galp-(1->4)-D-Glcp 0
                                              alpha-L-Fucp-(1->4)-beta-D-Galp-(1->4)-D-Glcp 0
                                              alpha-lactose + 0
                                              beta-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-Glcp 0
                                              beta-D-Galp-(1->4)-[alpha-D-Glcp-(1->2)]-D-Glcp 0
                                              beta-D-Galp-(1->6)-beta-D-Galp-(1->4)-D-Glcp 0
                                              beta-D-Galp6S-(1->4)-D-Glcp 0
                                              beta-D-GlcpNAc-(1->4)-beta-D-Galp-(1->4)-D-Glcp 0
                                              beta-D-GlcpNAc-(1->6)-beta-D-Galp-(1->4)-D-Glcp 0
                                              beta-L-Fucp-(1->4)-beta-D-Galp-(1->4)-D-Glcp 0
                                              beta-lactose + 0
                                              lactobionic acid + 0
                                              lactose 6'-phosphate 0
                                              lactose phosphate + 0
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