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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chloramphenicol
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Accession:CHEBI:17698 term browser browse the term
Definition:An organochlorine compound that is dichloro-substituted acetamide containing a nitrobenzene ring, an amide bond and two alcohol functions.
Synonyms:exact_synonym: 2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide
 related_synonym: Chloramex;   Chlorocid;   Chlorocol;   Chloromycetin;   D-(-)-2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenylethyl)acetamide;   D-(-)-threo-1-p-nitrophenyl-2-dichloroacetylamino-1,3-propanediol;   Fenicol;   Formula=C11H12Cl2N2O5;   Globenicol;   Halomycetin;   InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1;   InChIKey=WIIZWVCIJKGZOK-RKDXNWHRSA-N;   Oleomycetin;   SMILES=C1=C([C@H]([C@H](NC(C(Cl)Cl)=O)CO)O)C=CC(=C1)[N+]([O-])=O;   Sificetina;   chloramphenicolum;   chlornitromycin;   cloramfenicol;   laevomycetinum;   levomicetina;   levomycetin
 alt_id: CHEBI:13965;   CHEBI:23106;   CHEBI:23108;   CHEBI:3603;   CHEBI:47327
 xref: Beilstein:2225532;   CAS:56-75-7;   DrugBank:DB00446;   Drug_Central:589;   KEGG:C00918;   KEGG:D00104;   LINCS:LSM-5256
 xref_mesh: MESH:D002701
 xref: PDBeChem:CLM;   PMID:11468347;   PMID:12217690;   PMID:16659995;   PMID:16897441;   PMID:17217404;   PMID:17692887;   PMID:18559535;   PMID:18657290;   PMID:18794387;   PMID:23142491;   PMID:23317719;   PMID:23395526;   PMID:23494278;   PMID:23512826;   PMID:657786;   PMID:6653106;   Patent:GB795131;   Patent:GB796901;   Patent:US2483871;   Patent:US2483884;   Patent:US2483892;   Patent:US2839577;   VSDB:1835;   Wikipedia:Chloramphenicol


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chloramphenicol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alpl alkaline phosphatase, biomineralization associated increases expression ISO Chloramphenicol results in increased expression of ALPL mRNA CTD PMID:22083529 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Atg12 autophagy related 12 increases expression ISO Chloramphenicol results in increased expression of ATG12 mRNA CTD PMID:17457038 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Casp3 caspase 3 multiple interactions ISO CDKN1A mutant form inhibits the reaction [Chloramphenicol inhibits the reaction [Mitomycin results in increased activity of CASP3 protein]]; Chloramphenicol inhibits the reaction [Mitomycin results in increased activity of CASP3 protein] CTD PMID:15905168 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase increases expression ISO Chloramphenicol results in increased expression of CAT protein CTD PMID:18684218 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [enterotoxin B, staphylococcal co-treated with Chloramphenicol] results in increased expression of CCNB1 CTD PMID:18559535 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
decreases degradation
ISO CDKN1A mutant form inhibits the reaction [Chloramphenicol inhibits the reaction [Mitomycin results in increased activity of CASP3 protein]]; CDKN1A mutant form inhibits the reaction [Chloramphenicol inhibits the reaction [Mitomycin results in increased activity of PARP1 protein]]; Chloramphenicol results in increased expression of and affects the localization of CDKN1A protein
Chloramphenicol results in decreased degradation of CDKN1A mRNA
CTD PMID:15905168 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Chloramphenicol results in increased expression of CDKN2A protein CTD PMID:15905168 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Chloramphenicol results in increased expression of COL1A1 mRNA CTD PMID:22083529 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity
multiple interactions
ISO Chloramphenicol results in decreased activity of CYP2C19 protein
[Chloramphenicol results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole
CTD PMID:26599973 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Chloramphenicol results in increased expression of ESR1 mRNA CTD PMID:22083529 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Faslg Fas ligand decreases expression ISO Chloramphenicol results in decreased expression of FASLG CTD PMID:18559535 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Chloramphenicol results in increased phosphorylation of JUN protein]; Chloramphenicol results in increased phosphorylation of and affects the localization of JUN protein; pyrazolanthrone inhibits the reaction [Chloramphenicol results in increased phosphorylation of JUN protein] CTD PMID:20338993 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO Chloramphenicol results in decreased expression of MMP10 mRNA CTD PMID:20338993 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
increases secretion
increases expression
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA]; Curcumin inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA]; pyrazolanthrone inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA]
Chloramphenicol results in increased secretion of MMP13 protein
CTD PMID:20338993 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO Chloramphenicol results in increased expression of MMP3 mRNA CTD PMID:20338993 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression ISO Chloramphenicol results in decreased expression of COX1 protein CTD PMID:15905168 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II decreases expression ISO Chloramphenicol results in decreased expression of COX2 protein CTD PMID:31915244 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 multiple interactions
decreases expression
ISO Chloramphenicol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of ND1 mRNA]
Chloramphenicol results in decreased expression of ND1 mRNA
CTD PMID:21767162, PMID:22712077 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
JBrowse link
G Mtif2 mitochondrial translational initiation factor 2 decreases response to substance ISO MTIF2 protein results in decreased susceptibility to Chloramphenicol CTD PMID:31915244 NCBI chr14:113,946,084...113,965,574
Ensembl chr14:113,945,843...113,965,745
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO CDKN1A mutant form inhibits the reaction [Chloramphenicol inhibits the reaction [Mitomycin results in increased activity of PARP1 protein]]; Chloramphenicol inhibits the reaction [Mitomycin results in increased activity of PARP1 protein] CTD PMID:15905168 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Chloramphenicol results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Polg DNA polymerase gamma, catalytic subunit increases expression ISO Chloramphenicol results in increased expression of POLG mRNA CTD PMID:22712077 NCBI chr 1:141,172,117...141,188,893
Ensembl chr 1:141,172,531...141,188,031
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Chloramphenicol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of PTGS2 mRNA] CTD PMID:21767162 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO Chloramphenicol results in increased expression of RRM2B mRNA CTD PMID:21704725 NCBI chr 7:76,750,045...76,780,817
Ensembl chr 7:76,750,050...76,780,817
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Chloramphenicol inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline] CTD PMID:15901346 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Chloramphenicol affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Chloramphenicol affects the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Chloramphenicol results in increased expression of TFAM mRNA CTD PMID:22712077 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of Chloramphenicol CTD PMID:8302279 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
chloramphenicol palmitate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO chloramphenicol palmitate inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      biological role 19737
        antimicrobial agent 17329
          chloramphenicol 30
            O(3)-(2-L-lysino-2-oxoethyl)-O(1)-[4-(trifluoroacetamido)benzylcarbonyl]chloramphenicol 0
            O-(4-trifluoroacetamidobenzylphosphonyl)chloramphenicol 0
            chloramphenicol 3-acetate 0
            chloramphenicol palmitate 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18508
                              organic divalent group 18501
                                organodiyl group 18501
                                  carbonyl group 18404
                                    carbonyl compound 18404
                                      carboxylic acid 18079
                                        carboacyl group 17368
                                          univalent carboacyl group 17368
                                            carbamoyl group 17154
                                              carboxamide 17154
                                                chloramphenicol 30
                                                  O(3)-(2-L-lysino-2-oxoethyl)-O(1)-[4-(trifluoroacetamido)benzylcarbonyl]chloramphenicol 0
                                                  O-(4-trifluoroacetamidobenzylphosphonyl)chloramphenicol 0
                                                  chloramphenicol 3-acetate 0
                                                  chloramphenicol palmitate 1
paths to the root

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