Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:niraparib
go back to main search page
Accession:CHEBI:176844 term browser browse the term
Definition:A 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC50 of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy.
Synonyms:exact_synonym: 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide
 related_synonym: 2-[4-(3S)-3-piperidinylphenyl]-2H-indazole-7-carboxamide;   2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide;   Formula=C19H20N4O;   InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1;   InChIKey=PCHKPVIQAHNQLW-CQSZACIVSA-N;   MK-4827;   MK4827;   SMILES=[H][C@]1(CCCNC1)C1=CC=C(C=C1)N1C=C2C=CC=C(C(N)=O)C2=N1;   Zejula;   niraparibum
 xref: CAS:1038915-60-4;   Chemspider:24531930;   DrugBank:DB11793;   Drug_Central:5222;   KEGG:D10140
 xref_mesh: MESH:C545685
 xref: PDBeChem:3JD;   PMID:19873981;   PMID:23482742;   PMID:24970803;   PMID:28001384;   PMID:29081841;   PMID:29214031;   PMID:29856239;   PMID:30096696;   PMID:31857852;   PMID:32073931;   PMID:32679152;   PMID:32753559;   PMID:32863940;   PMID:33361107;   PMID:33407715;   PMID:33470063;   PMID:33545804;   PMID:33559417;   PMID:33621324;   PMID:33641880;   PMID:33691564;   PMID:33774805;   PMID:33905671;   PMID:33915252;   PMID:33920140;   PMID:33993885;   PMID:34073147;   PMID:34164503;   PMID:34241562;   PMID:34307148;   PMID:34324028;   PMID:34327724;   Patent:KR20100114021;   Wikipedia:Niraparib



show annotations for term's descendants           Sort by:
 
niraparib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO niraparib binds to and results in decreased activity of PARP1 protein CTD PMID:28001384 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 multiple interactions ISO niraparib binds to and results in decreased activity of PARP2 protein CTD PMID:28001384 NCBI chr15:24,034,069...24,044,340
Ensembl chr15:24,034,106...24,044,338
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19715
    role 19690
      biological role 19688
        biochemical role 19395
          apoptosis inducer 13443
            niraparib 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19715
    subatomic particle 19713
      composite particle 19713
        hadron 19713
          baryon 19713
            nucleon 19713
              atomic nucleus 19713
                atom 19713
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19606
                        carbon atom 19603
                          organic molecular entity 19603
                            organic group 18792
                              organic divalent group 18777
                                organodiyl group 18777
                                  carbonyl group 18743
                                    carbonyl compound 18743
                                      carboxylic acid 18443
                                        carboacyl group 17599
                                          univalent carboacyl group 17599
                                            carbamoyl group 17435
                                              carboxamide 17435
                                                primary carboxamide 5913
                                                  2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide 2
                                                    niraparib 2
paths to the root