CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 3-oxo-5beta-cholanic acid
Accession: CHEBI:17639
browse the term
Definition: An oxo-5beta-cholanic acid that has formula 374.55672.
Synonyms: exact_synonym: 3-oxo-5beta-cholan-24-oic acid
related_synonym: 3-Oxo-5beta-cholanate; 3-ketolithocholic acid; 3-oxocholan-24-oic acid; Formula=C24H38O3; InChI=1S/C24H38O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-16,18-21H,4-14H2,1-3H3,(H,26,27)/t15-,16-,18+,19-,20+,21+,23+,24-/m1/s1; InChIKey=KIQFUORWRVZTHT-OPTMKGCMSA-N; SMILES=[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@]([H])(CC[C@@]34[H])[C@H](C)CCC(O)=O)[C@@]1(C)CCC(=O)C2
alt_id: CHEBI:1623; CHEBI:20151; CHEBI:20152
xref: Beilstein:3218542; CAS:1553-56-6; KEGG:C03070; LIPID_MAPS_instance:LMST04010127
xref_mesh: MESH:C046230
cyclic_relationship: is_conjugate_acid_of CHEBI:11867
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
multiple interactions
EXP
[CYP2C11 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of 3-oxocholan-24-oic acid
CTD
PMID:18039809
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
EXP
[CYP3A2 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of 3-oxocholan-24-oic acid
CTD
PMID:18039809
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
multiple interactions
EXP
[CYP3A23-3A1 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of 3-oxocholan-24-oic acid
CTD
PMID:18039809
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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Dhrs11
dehydrogenase/reductase 11
increases reduction
ISO
DHRS11 protein results in increased reduction of 3-oxocholan-24-oic acid
CTD
PMID:30926317
NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
3-oxocholan-24-oic acid results in increased activity of NR1I2 protein
CTD
PMID:15708356
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Vdr
vitamin D receptor
increases activity
ISO
3-oxocholan-24-oic acid results in increased activity of VDR protein
CTD
PMID:15708356
NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
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