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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3-oxo-5beta-cholanic acid
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Accession:CHEBI:17639 term browser browse the term
Definition:An oxo-5beta-cholanic acid that has formula 374.55672.
Synonyms:exact_synonym: 3-oxo-5beta-cholan-24-oic acid
 related_synonym: 3-Oxo-5beta-cholanate;   3-ketolithocholic acid;   3-oxocholan-24-oic acid;   Formula=C24H38O3;   InChI=1S/C24H38O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-16,18-21H,4-14H2,1-3H3,(H,26,27)/t15-,16-,18+,19-,20+,21+,23+,24-/m1/s1;   InChIKey=KIQFUORWRVZTHT-OPTMKGCMSA-N;   SMILES=[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@]([H])(CC[C@@]34[H])[C@H](C)CCC(O)=O)[C@@]1(C)CCC(=O)C2
 alt_id: CHEBI:1623;   CHEBI:20151;   CHEBI:20152
 xref: Beilstein:3218542;   CAS:1553-56-6;   KEGG:C03070;   LIPID_MAPS_instance:LMST04010127
 xref_mesh: MESH:C046230
 cyclic_relationship: is_conjugate_acid_of CHEBI:11867



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3-oxo-5beta-cholanic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP [CYP2C11 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of 3-oxocholan-24-oic acid CTD PMID:18039809 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP [CYP3A2 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of 3-oxocholan-24-oic acid CTD PMID:18039809 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP [CYP3A23-3A1 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of 3-oxocholan-24-oic acid CTD PMID:18039809 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of 3-oxocholan-24-oic acid CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO 3-oxocholan-24-oic acid results in increased activity of NR1I2 protein CTD PMID:15708356 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Vdr vitamin D receptor increases activity ISO 3-oxocholan-24-oic acid results in increased activity of VDR protein CTD PMID:15708356 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    chemical entity 19916
      atom 19916
        nonmetal atom 19852
          carbon atom 19806
            organic molecular entity 19806
              lipid 17957
                steroid 14707
                  5beta steroid 1124
                    5beta-cholanic acids 987
                      oxo-5beta-cholanic acid 7
                        3-oxo-5beta-cholanic acid 6
                          3-oxocholan-24-oyl-CoA 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic molecule 19758
                              organic cyclic compound 19565
                                organic polycyclic compound 17279
                                  steroid 14707
                                    steroid fundamental parent 14503
                                      cholane 1003
                                        cholanoid 1003
                                          cholanic acids 987
                                            cholanic acid 987
                                              5beta-cholanic acid 987
                                                oxo-5beta-cholanic acid 7
                                                  3-oxo-5beta-cholanic acid 6
                                                    3-oxocholan-24-oyl-CoA 0
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