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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:kanamycin A
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Accession:CHEBI:17630 term browser browse the term
Definition:A kanamycin that has formula C18H36N4O11.
Synonyms:exact_synonym: (1S,2R,3R,4S,6R)-4,6-diamino-3-(6-amino-6-deoxy-alpha-D-glucopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
 related_synonym: 4,6-diamino-2-hydroxy-1,3-cyclohexane 3,6'diamino-3,6'-dideoxydi-alpha-D-glucoside;   4,6-diamino-2-hydroxy-1,3-cyclohexylene 3,6'-diamino-3,6'-dideoxydi-D-glucopyranoside;   Formula=C18H36N4O11;   InChI=1S/C18H36N4O11/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17/h4-18,23-29H,1-3,19-22H2/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-/m1/s1;   InChIKey=SBUJHOSQTJFQJX-NOAMYHISSA-N;   O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4))-2-deoxy-D-streptamine;   SMILES=NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
 alt_id: CHEBI:14487;   CHEBI:24945;   CHEBI:24947;   CHEBI:43482;   CHEBI:6106
 xref: Beilstein:61647;   CAS:59-01-8;   DrugBank:DB01172;   Drug_Central:1519;   Gmelin:2044856;   KEGG:C01822;   LINCS:LSM-5261
 xref_mesh: MESH:D007612
 xref: PDBeChem:KAN;   PMID:22907688;   PMID:24336356;   PMID:24566637;   VSDB:1921;   Wikipedia:Kanamycin
 cyclic_relationship: is_conjugate_base_of CHEBI:58214


show annotations for term's descendants           Sort by:
kanamycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 decreases activity ISO Kanamycin results in decreased activity of ABCC4 protein CTD PMID:39023798 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Cd86 CD86 molecule increases expression ISO Kanamycin results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Diaph1 diaphanous-related formin 1 multiple interactions
decreases expression 		ISO Kanamycin inhibits the reaction [DIAPH1 binds to RHOA]
Kanamycin results in decreased expression of DIAPH1 protein 		CTD PMID:16521128 NCBI chr18:29,669,659...29,769,070
Ensembl chr18:29,669,659...29,769,172 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation EXP Kanamycin results in increased phosphorylation of JUN protein CTD PMID:17570507 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation EXP Kanamycin results in increased phosphorylation of MAPK8 protein CTD PMID:17570507 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO Kanamycin promotes the reaction [RAC1 binds to NCF2] CTD PMID:16521128 NCBI chr13:67,505,492...67,536,015
Ensembl chr13:64,955,503...64,986,277 		JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions
increases expression 		ISO 2,3-dihydroxybenzoic acid promotes the reaction [Kanamycin results in increased expression of PRDX3 protein]
Kanamycin results in increased expression of PRDX3 mRNA; Kanamycin results in increased expression of PRDX3 protein 		CTD PMID:23626763 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Kanamycin promotes the reaction [RAC1 binds to NCF2] CTD PMID:16521128 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rhoa ras homolog family member A multiple interactions
increases expression
decreases expression 		ISO Kanamycin inhibits the reaction [DIAPH1 binds to RHOA]
Kanamycin results in increased expression of RHOA protein
Kanamycin results in decreased expression of RHOA protein 		CTD PMID:16521128 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Slc1a3 solute carrier family 1 member 3 affects response to substance ISO SLC1A3 affects the susceptibility to Kanamycin CTD PMID:15862894 NCBI chr 2:59,482,707...59,557,808
Ensembl chr 2:57,755,497...57,830,605 		JBrowse link
amikacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression EXP Amikacin results in decreased expression of ABCC3 mRNA CTD PMID:27765674 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression EXP Amikacin results in decreased expression of ABCC4 mRNA CTD PMID:27765674 NCBI chr15:101,948,387...102,182,912
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Casr calcium-sensing receptor increases activity ISO Amikacin results in increased activity of CASR protein CTD PMID:19884751 NCBI chr11:77,738,398...77,813,639
Ensembl chr11:64,235,251...64,304,811 		JBrowse link
G Cat catalase decreases activity
multiple interactions 		ISO Amikacin results in decreased activity of CAT protein
cefepime inhibits the reaction [Amikacin results in decreased activity of CAT protein] 		CTD PMID:18781908 PMID:23416261 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Amikacin results in decreased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Amikacin results in decreased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il24 interleukin 24 decreases expression ISO Amikacin results in decreased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:44,905,362...44,910,760
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Amikacin results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:159,561,271...159,742,778 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Amikacin results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Amikacin results in decreased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Amikacin results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Amikacin results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Tyr tyrosinase decreases activity ISO Amikacin results in decreased activity of TYR protein CTD PMID:23416261 NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    role 20816
      biological role 20814
        antimicrobial agent 18575
          carbohydrate-containing antibiotic 7612
            aminoglycoside antibiotic 7600
              kanamycins 31
                kanamycin A 22
                  2'-oxokanamycin 0
                  3'',6'-di-N-acetylkanamycin A 0
                  4'-adenylkanamycin A 0
                  6''-O-carbamoylkanamycin A 0
                  amikacin 13
                  kanamycin 0
                  kanamycin A 3'-phosphate 0
                  kanamycin A sulfate 0
                  kanamycin D + 0
                  kanamycin X + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbohydrates and carbohydrate derivatives 15436
                                    carbohydrate 15436
                                      carbohydrate derivative 14453
                                        glycosyl compound 13161
                                          glycoside 11929
                                            aminoglycoside 11344
                                              aminoglycoside antibiotic 7600
                                                kanamycins 31
                                                  kanamycin A 22
                                                    2'-oxokanamycin 0
                                                    3'',6'-di-N-acetylkanamycin A 0
                                                    4'-adenylkanamycin A 0
                                                    6''-O-carbamoylkanamycin A 0
                                                    amikacin 13
                                                    kanamycin 0
                                                    kanamycin A 3'-phosphate 0
                                                    kanamycin A sulfate 0
                                                    kanamycin D + 0
                                                    kanamycin X + 0
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