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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:kanamycin A
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Accession:CHEBI:17630 term browser browse the term
Definition:A kanamycin that has formula C18H36N4O11.
Synonyms:exact_synonym: (1S,2R,3R,4S,6R)-4,6-diamino-3-(6-amino-6-deoxy-alpha-D-glucopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
 related_synonym: 4,6-diamino-2-hydroxy-1,3-cyclohexane 3,6'diamino-3,6'-dideoxydi-alpha-D-glucoside;   4,6-diamino-2-hydroxy-1,3-cyclohexylene 3,6'-diamino-3,6'-dideoxydi-D-glucopyranoside;   Formula=C18H36N4O11;   InChI=1S/C18H36N4O11/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17/h4-18,23-29H,1-3,19-22H2/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-/m1/s1;   InChIKey=SBUJHOSQTJFQJX-NOAMYHISSA-N;   O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4))-2-deoxy-D-streptamine;   SMILES=NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
 alt_id: CHEBI:14487;   CHEBI:24945;   CHEBI:24947;   CHEBI:43482;   CHEBI:6106
 xref: Beilstein:61647;   CAS:59-01-8;   DrugBank:DB01172;   Drug_Central:1519;   Gmelin:2044856;   KEGG:C01822;   LINCS:LSM-5261
 xref_mesh: MESH:D007612
 xref: PDBeChem:KAN;   PMID:22907688;   PMID:24336356;   PMID:24566637;   VSDB:1921;   Wikipedia:Kanamycin
 cyclic_relationship: is_conjugate_base_of CHEBI:58214


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kanamycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd86 CD86 molecule increases expression ISO Kanamycin results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Diaph1 diaphanous-related formin 1 multiple interactions
decreases expression
ISO Kanamycin inhibits the reaction [DIAPH1 binds to RHOA]
Kanamycin results in decreased expression of DIAPH1 protein
CTD PMID:16521128 NCBI chr18:29,669,659...29,769,044
Ensembl chr18:29,669,659...29,769,172
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation EXP Kanamycin results in increased phosphorylation of JUN protein CTD PMID:17570507 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation EXP Kanamycin results in increased phosphorylation of MAPK8 protein CTD PMID:17570507 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO Kanamycin promotes the reaction [RAC1 binds to NCF2] CTD PMID:16521128 NCBI chr13:64,955,502...64,986,289
Ensembl chr13:64,955,503...64,986,277
JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions
increases expression
ISO 2,3-dihydroxybenzoic acid promotes the reaction [Kanamycin results in increased expression of PRDX3 protein]
Kanamycin results in increased expression of PRDX3 mRNA; Kanamycin results in increased expression of PRDX3 protein
CTD PMID:23626763 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Kanamycin promotes the reaction [RAC1 binds to NCF2] CTD PMID:16521128 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Rhoa ras homolog family member A multiple interactions
increases expression
decreases expression
ISO Kanamycin inhibits the reaction [DIAPH1 binds to RHOA]
Kanamycin results in increased expression of RHOA protein
Kanamycin results in decreased expression of RHOA protein
CTD PMID:16521128 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Slc1a3 solute carrier family 1 member 3 affects response to substance ISO SLC1A3 affects the susceptibility to Kanamycin CTD PMID:15862894 NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605
JBrowse link
amikacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression EXP Amikacin results in decreased expression of ABCC3 mRNA CTD PMID:27765674 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression EXP Amikacin results in decreased expression of ABCC4 mRNA CTD PMID:27765674 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Casr calcium-sensing receptor increases activity ISO Amikacin results in increased activity of CASR protein CTD PMID:19884751 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
JBrowse link
G Cat catalase decreases activity
multiple interactions
ISO Amikacin results in decreased activity of CAT protein
cefepime inhibits the reaction [Amikacin results in decreased activity of CAT protein]
CTD PMID:18781908 PMID:23416261 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Amikacin results in decreased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Amikacin results in decreased expression of IL1B mRNA CTD PMID:32816093 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il24 interleukin 24 decreases expression ISO Amikacin results in decreased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Amikacin results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 5:159,582,746...159,598,945 JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Amikacin results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Amikacin results in decreased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Amikacin results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Amikacin results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Tyr tyrosinase decreases activity ISO Amikacin results in decreased activity of TYR protein CTD PMID:23416261 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        antimicrobial agent 17400
          carbohydrate-containing antibiotic 2557
            aminoglycoside antibiotic 2539
              kanamycins 31
                kanamycin A 22
                  2'-oxokanamycin 0
                  3'',6'-di-N-acetylkanamycin A 0
                  4'-adenylkanamycin A 0
                  6''-O-carbamoylkanamycin A 0
                  amikacin 13
                  kanamycin 0
                  kanamycin A 3'-phosphate 0
                  kanamycin A sulfate 0
                  kanamycin D + 0
                  kanamycin X + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            heteroorganic entity 19283
                              organochalcogen compound 19054
                                organooxygen compound 19004
                                  carbohydrates and carbohydrate derivatives 12341
                                    carbohydrate 12341
                                      carbohydrate derivative 11945
                                        glycosyl compound 10978
                                          glycoside 9260
                                            aminoglycoside 8434
                                              aminoglycoside antibiotic 2539
                                                kanamycins 31
                                                  kanamycin A 22
                                                    2'-oxokanamycin 0
                                                    3'',6'-di-N-acetylkanamycin A 0
                                                    4'-adenylkanamycin A 0
                                                    6''-O-carbamoylkanamycin A 0
                                                    amikacin 13
                                                    kanamycin 0
                                                    kanamycin A 3'-phosphate 0
                                                    kanamycin A sulfate 0
                                                    kanamycin D + 0
                                                    kanamycin X + 0
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