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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:kanamycin A
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Accession:CHEBI:17630 term browser browse the term
Definition:A kanamycin that has formula C18H36N4O11.
Synonyms:exact_synonym: (1S,2R,3R,4S,6R)-4,6-diamino-3-(6-amino-6-deoxy-alpha-D-glucopyranosyloxy)-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
 related_synonym: 4,6-diamino-2-hydroxy-1,3-cyclohexane 3,6'diamino-3,6'-dideoxydi-alpha-D-glucoside;   4,6-diamino-2-hydroxy-1,3-cyclohexylene 3,6'-diamino-3,6'-dideoxydi-D-glucopyranoside;   Formula=C18H36N4O11;   InChI=1S/C18H36N4O11/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17/h4-18,23-29H,1-3,19-22H2/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-/m1/s1;   InChIKey=SBUJHOSQTJFQJX-NOAMYHISSA-N;   O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1->6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4))-2-deoxy-D-streptamine;   SMILES=NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
 alt_id: CHEBI:14487;   CHEBI:24945;   CHEBI:24947;   CHEBI:43482;   CHEBI:6106
 xref: Beilstein:61647;   CAS:59-01-8;   DrugBank:DB01172;   Drug_Central:1519;   Gmelin:2044856;   KEGG:C01822;   LINCS:LSM-5261
 xref_mesh: MESH:D007612
 xref: PDBeChem:KAN;   PMID:22907688;   PMID:24336356;   PMID:24566637;   VSDB:1921;   Wikipedia:Kanamycin
 cyclic_relationship: is_conjugate_base_of CHEBI:58214


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kanamycin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd86 CD86 molecule increases expression ISO Kanamycin results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Diaph1 diaphanous-related formin 1 multiple interactions
decreases expression
ISO Kanamycin inhibits the reaction [DIAPH1 binds to RHOA]
Kanamycin results in decreased expression of DIAPH1 protein
CTD PMID:16521128 NCBI chr18:30,972,907...31,071,371
Ensembl chr18:30,972,907...31,071,371
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation EXP Kanamycin results in increased phosphorylation of JUN protein CTD PMID:17570507 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation EXP Kanamycin results in increased phosphorylation of MAPK8 protein CTD PMID:17570507 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO Kanamycin promotes the reaction [RAC1 binds to NCF2] CTD PMID:16521128 NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576
JBrowse link
G Prdx3 peroxiredoxin 3 multiple interactions
increases expression
ISO 2,3-dihydroxybenzoic acid promotes the reaction [Kanamycin results in increased expression of PRDX3 protein]
Kanamycin results in increased expression of PRDX3 mRNA; Kanamycin results in increased expression of PRDX3 protein
CTD PMID:23626763 NCBI chr 1:282,238,774...282,251,193
Ensembl chr 1:282,238,773...282,251,257
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Kanamycin promotes the reaction [RAC1 binds to NCF2] CTD PMID:16521128 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rhoa ras homolog family member A multiple interactions
increases expression
decreases expression
ISO Kanamycin inhibits the reaction [DIAPH1 binds to RHOA]
Kanamycin results in increased expression of RHOA protein
Kanamycin results in decreased expression of RHOA protein
CTD PMID:16521128 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Slc1a3 solute carrier family 1 member 3 affects response to substance ISO SLC1A3 affects the susceptibility to Kanamycin CTD PMID:15862894 NCBI chr 2:57,860,881...57,935,363
Ensembl chr 2:57,860,834...57,935,363
JBrowse link
amikacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression EXP Amikacin results in decreased expression of ABCC3 mRNA CTD PMID:27765674 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression EXP Amikacin results in decreased expression of ABCC4 mRNA CTD PMID:27765674 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Casr calcium-sensing receptor increases activity ISO Amikacin results in increased activity of CASR protein CTD PMID:19884751 NCBI chr11:67,188,204...67,262,261
Ensembl chr11:67,188,630...67,258,771
JBrowse link
G Cat catalase decreases activity
multiple interactions
ISO Amikacin results in decreased activity of CAT protein
cefepime inhibits the reaction [Amikacin results in decreased activity of CAT protein]
CTD PMID:18781908, PMID:23416261 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Amikacin results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Tyr tyrosinase decreases activity ISO Amikacin results in decreased activity of TYR protein CTD PMID:23416261 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          carbohydrate-containing antibiotic 2547
            aminoglycoside antibiotic 2529
              kanamycins 24
                kanamycin A 15
                  2'-oxokanamycin 0
                  3'',6'-di-N-acetylkanamycin A 0
                  4'-adenylkanamycin A 0
                  6''-O-carbamoylkanamycin A 0
                  amikacin 6
                  kanamycin 0
                  kanamycin A 3'-phosphate 0
                  kanamycin A sulfate 0
                  kanamycin D + 0
                  kanamycin X + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            heteroorganic entity 19148
                              organochalcogen compound 18856
                                organooxygen compound 18778
                                  carbohydrates and carbohydrate derivatives 12180
                                    carbohydrate 12180
                                      carbohydrate derivative 11804
                                        glycosyl compound 10848
                                          glycoside 9204
                                            aminoglycoside 8416
                                              aminoglycoside antibiotic 2529
                                                kanamycins 24
                                                  kanamycin A 15
                                                    2'-oxokanamycin 0
                                                    3'',6'-di-N-acetylkanamycin A 0
                                                    4'-adenylkanamycin A 0
                                                    6''-O-carbamoylkanamycin A 0
                                                    amikacin 6
                                                    kanamycin 0
                                                    kanamycin A 3'-phosphate 0
                                                    kanamycin A sulfate 0
                                                    kanamycin D + 0
                                                    kanamycin X + 0
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