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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ferroheme b
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Accession:CHEBI:17627 term browser browse the term
Definition:Heme b in which the iron has oxidation state +2.
Synonyms:exact_synonym: (protoporphyrinato)iron(II)
 related_synonym: Fe(ppIX);   Formula=C34H32FeN4O4;   Haem;   Heme;   InChI=1S/C34H34N4O4.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);/q;+2/p-2/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;   InChIKey=KABFMIBPWCXCRK-RGGAHWMASA-L;   Protoheme;   SMILES=CC1=C(CCC(O)=O)C2=[N+]3C1=Cc1c(C)c(C=C)c4C=C5C(C)=C(C=C)C6=[N+]5[Fe--]3(n14)n1c(=C6)c(C)c(CCC(O)=O)c1=C2;   [3,7,12,17-tetramethyl-8,13-divinylporphyrin-2,18-dipropanoato(2-)]iron(II);   ferroprotoheme;   ferroprotoporphyrin IX;   ferrous protoheme;   ferrous protoheme IX;   iron(II) protoporphyrin IX;   protoferroheme
 alt_id: CHEBI:14957;   CHEBI:5651
 xref: Beilstein:953574;   CAS:14875-96-8;   Gmelin:95291;   KEGG:C00032
 xref_mesh: MESH:D006418
 xref: PDB:3KS0;   PDBeChem:HEM;   PMID:20546754;   YMDB:YMDB00041
 cyclic_relationship: is_conjugate_acid_of CHEBI:60344



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ferroheme b term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb6 ATP binding cassette subfamily B member 6 increases expression ISO Heme results in increased expression of ABCB6 mRNA; Heme results in increased expression of ABCB6 protein CTD PMID:17006453 NCBI chr 9:84,117,222...84,125,939
Ensembl chr 9:84,117,220...84,125,526
JBrowse link
G Adra1a adrenoceptor alpha 1A increases expression ISO Heme metabolite results in increased expression of ADRA1A mRNA CTD PMID:19191707 NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 decreases expression
multiple interactions
ISO Heme results in decreased expression of ALAS1 protein
MG 262 inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; Protease Inhibitors inhibits the reaction [Heme results in decreased expression of ALAS1 protein]; succinylacetone inhibits the reaction [Heme results in decreased expression of ALAS1 protein]
CTD PMID:21659532 NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:115,755,238...115,768,642
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 decreases expression ISO Heme metabolite results in decreased expression of ALAS2 mRNA CTD PMID:19191707 NCBI chr  X:22,890,650...22,914,046
Ensembl chr  X:22,890,689...22,914,043
JBrowse link
G Alb albumin affects binding
multiple interactions
ISO Heme binds to ALB protein
abacavir inhibits the reaction [Heme binds to ALB protein]; Heme inhibits the reaction [abacavir binds to ALB protein]
CTD PMID:16336266 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor increases expression ISO Heme results in increased expression of AMBP mRNA CTD PMID:22096585 NCBI chr 5:81,583,621...81,593,938
Ensembl chr 5:81,583,622...81,593,850
JBrowse link
G App amyloid beta precursor protein affects binding
multiple interactions
ISO APP protein modified form binds to Heme
[Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme]; Hydrogen Peroxide promotes the reaction [APP protein modified form binds to Heme]
CTD PMID:25211009 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
JBrowse link
G Arhgap31 Rho GTPase activating protein 31 decreases expression ISO Heme metabolite results in decreased expression of ARHGAP31 mRNA CTD PMID:19191707 NCBI chr11:75,544,176...75,657,087
Ensembl chr11:75,544,040...75,661,076
JBrowse link
G Asb1 ankyrin repeat and SOCS box-containing 1 increases expression ISO Heme metabolite results in increased expression of ASB1 mRNA CTD PMID:19191707 NCBI chr 9:99,566,852...99,588,321
Ensembl chr 9:99,567,867...99,583,907
JBrowse link
G Asxl2 ASXL transcriptional regulator 2 decreases expression ISO Heme metabolite results in decreased expression of ASXL2 mRNA CTD PMID:19191707 NCBI chr 6:32,090,497...32,234,487
Ensembl chr 6:32,145,607...32,227,851
JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO ATP7B gene mutant form promotes the reaction [Copper results in decreased abundance of Heme] CTD PMID:19888908 NCBI chr16:76,654,725...76,726,092
Ensembl chr16:76,653,660...76,728,801
JBrowse link
G Bcar3 BCAR3 adaptor protein, NSP family member increases expression ISO Heme metabolite results in increased expression of BCAR3 mRNA CTD PMID:19191707 NCBI chr 2:213,209,907...213,323,305
Ensembl chr 2:213,209,893...213,323,302
JBrowse link
G Blvra biliverdin reductase A increases expression ISO Heme metabolite results in increased expression of BLVRA mRNA CTD PMID:19191707 NCBI chr 3:134,793,397...134,819,367
Ensembl chr 3:134,794,203...134,819,785
JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression ISO Heme metabolite results in decreased expression of BOK mRNA CTD PMID:19191707 NCBI chr 9:101,670,729...101,681,834
Ensembl chr 9:101,670,625...101,681,833
JBrowse link
G Ca1 carbonic anhydrase 1 multiple interactions
increases expression
EXP [Heme co-treated with Calcium, Dietary] results in increased expression of CAR1 mRNA
Heme results in increased expression of CAR1 mRNA
CTD PMID:15539406 NCBI chr 2:88,550,681...88,593,454
Ensembl chr 2:88,495,475...88,593,454
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta decreases expression ISO Heme metabolite results in decreased expression of CAMK2B mRNA CTD PMID:19191707 NCBI chr14:85,059,166...85,148,121
Ensembl chr14:85,059,191...85,148,485
JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma decreases expression ISO Heme metabolite results in decreased expression of CAMK2G mRNA CTD PMID:19191707 NCBI chr15:3,553,238...3,612,310
Ensembl chr15:3,553,294...3,612,310
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Heme metabolite results in increased expression of CCL2 mRNA CTD PMID:19191707 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion ISO Heme analog results in increased secretion of CCL3 protein CTD PMID:23355332 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439
JBrowse link
G Ccl9 C-C motif chemokine ligand 9 increases expression ISO Heme metabolite results in increased expression of CCL6 mRNA CTD PMID:19191707 NCBI chr10:68,863,994...68,868,928
Ensembl chr10:68,863,995...68,868,877
JBrowse link
G Ccs copper chaperone for superoxide dismutase multiple interactions ISO [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein] CTD PMID:19039664 NCBI chr 1:211,543,192...211,564,354
Ensembl chr 1:211,542,701...211,564,260
JBrowse link
G Cd2 Cd2 molecule increases expression ISO Heme metabolite results in increased expression of CD2 mRNA CTD PMID:19191707 NCBI chr 2:191,399,510...191,412,659
Ensembl chr 2:191,399,510...191,413,665
JBrowse link
G Cel carboxyl ester lipase decreases expression
multiple interactions
EXP Heme results in decreased expression of CEL mRNA
[Heme co-treated with Calcium, Dietary] results in decreased expression of CEL mRNA
CTD PMID:15539406 NCBI chr 3:32,281,518...32,289,019
Ensembl chr 3:32,281,518...32,289,019
JBrowse link
G Clca1 chloride channel accessory 1 decreases expression EXP Heme results in decreased expression of CLCA1 mRNA CTD PMID:15539406 NCBI chr 2:236,599,022...236,624,714
Ensembl chr 2:236,599,022...236,624,714
JBrowse link
G Cnot9 CCR4-NOT transcription complex subunit 9 increases expression ISO Heme metabolite results in increased expression of CNOT9 mRNA CTD PMID:19191707 NCBI chr 9:83,533,369...83,558,207
Ensembl chr 9:83,533,369...83,558,197
JBrowse link
G Cops5 COP9 signalosome subunit 5 increases expression ISO Heme metabolite results in increased expression of COPS5 mRNA CTD PMID:19191707 NCBI chr 5:13,975,198...13,993,391
Ensembl chr 5:13,975,052...13,993,387
JBrowse link
G Cpox coproporphyrinogen oxidase increases chemical synthesis ISO CPOX protein results in increased chemical synthesis of Heme CTD PMID:11248690 NCBI chr11:55,405,778...55,415,761
Ensembl chr11:55,405,784...55,415,761
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO Heme metabolite results in decreased expression of CSF2 mRNA CTD PMID:19191707 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO Heme metabolite results in increased expression of CXCL2 mRNA CTD PMID:19191707 NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255
JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr18:80,487,923...80,520,544
Ensembl chr18:14,453,966...14,455,094
Ensembl chr18:14,453,966...14,455,094
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Dgcr8 DGCR8 microprocessor complex subunit affects binding ISO DGCR8 protein binds to Heme; DGCR8 protein mutant form binds to Heme CTD PMID:21454614 NCBI chr11:96,208,959...96,241,560
Ensembl chr11:96,209,038...96,241,551
JBrowse link
G Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 decreases expression EXP Heme results in decreased expression of DNAJC7 mRNA CTD PMID:15539406 NCBI chr10:86,018,977...86,055,419
Ensembl chr10:86,018,961...86,055,489
JBrowse link
G Dner delta/notch-like EGF repeat containing decreases expression ISO Heme metabolite results in decreased expression of DNER mRNA CTD PMID:19191707 NCBI chr 9:93,035,108...93,350,568
Ensembl chr 9:93,035,108...93,350,568
JBrowse link
G Dusp14 dual specificity phosphatase 14 increases expression ISO Heme metabolite results in increased expression of DUSP14 mRNA CTD PMID:19191707 NCBI chr10:69,433,949...69,463,863
Ensembl chr10:69,426,730...69,462,837
JBrowse link
G Dusp2 dual specificity phosphatase 2 decreases expression ISO Heme metabolite results in decreased expression of DUSP2 mRNA CTD PMID:19191707 NCBI chr 3:135,009,636...135,011,821
Ensembl chr 3:135,009,590...135,011,809
JBrowse link
G Eif2s3 eukaryotic translation initiation factor 2 subunit gamma decreases expression ISO Heme metabolite results in decreased expression of EIF2S3X mRNA CTD PMID:19191707 NCBI chr  X:62,910,292...62,933,936
Ensembl chr  X:62,910,293...62,934,489
JBrowse link
G Eno2 enolase 2 increases expression ISO Heme metabolite results in increased expression of ENO2 mRNA CTD PMID:19191707 NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220
JBrowse link
G Ereg epiregulin increases expression ISO Heme metabolite results in increased expression of EREG mRNA CTD PMID:19191707 NCBI chr14:17,311,485...17,325,260
Ensembl chr14:17,311,485...17,325,260
JBrowse link
G Esrra estrogen related receptor, alpha decreases expression ISO Heme metabolite results in decreased expression of ESRRA mRNA CTD PMID:19191707 NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:213,533,310...213,543,811
JBrowse link
G F10 coagulation factor X increases expression ISO Heme metabolite results in increased expression of F10 mRNA CTD PMID:19191707 NCBI chr16:83,170,973...83,190,280
Ensembl chr16:83,170,977...83,190,280
JBrowse link
G F3 coagulation factor III, tissue factor increases expression
multiple interactions
ISO Heme results in increased expression of F3 mRNA
Curcumin inhibits the reaction [Heme results in increased expression of F3 mRNA]; Heme results in increased expression of and results in increased activity of F3 protein; Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA]
CTD PMID:18983524 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369
JBrowse link
G Fabp2 fatty acid binding protein 2 multiple interactions
increases expression
EXP [Heme co-treated with Calcium, Dietary] results in increased expression of FABP2 mRNA
Heme results in increased expression of FABP2 mRNA
CTD PMID:15539406 NCBI chr 2:213,724,629...213,728,686
Ensembl chr 2:213,724,629...213,728,686
JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression ISO Heme metabolite results in increased expression of FABP3 mRNA CTD PMID:19191707 NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:147,936,119...147,942,881
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Heme metabolite results in decreased expression of FOS mRNA CTD PMID:19191707 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
JBrowse link
G Fxyd4 FXYD domain-containing ion transport regulator 4 decreases expression EXP Heme results in decreased expression of FXYD4 mRNA CTD PMID:15539406 NCBI chr 4:152,782,181...152,786,118
Ensembl chr 4:152,782,181...152,786,039
JBrowse link
G Gfod1 Gfo/Idh/MocA-like oxidoreductase domain containing 1 decreases expression ISO Heme metabolite results in decreased expression of GFOD1 mRNA CTD PMID:19191707 NCBI chr17:21,606,090...21,710,922
Ensembl chr17:21,605,415...21,710,920
JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 increases expression ISO Heme metabolite results in increased expression of GIPC1 mRNA CTD PMID:19191707 NCBI chr19:41,380,125...41,392,078
Ensembl chr19:41,380,125...41,391,725
JBrowse link
G Gpr176 G protein-coupled receptor 176 increases expression ISO Heme metabolite results in increased expression of GPR176 mRNA CTD PMID:19191707 NCBI chr 3:125,690,750...125,791,172
Ensembl chr 3:125,690,751...125,791,172
JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A increases expression ISO Heme metabolite results in increased expression of GPRC5A mRNA CTD PMID:19191707 NCBI chr 4:169,634,896...169,653,627
Ensembl chr 4:169,634,748...169,653,625
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Heme metabolite results in increased expression of GPT mRNA CTD PMID:19191707 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions EXP 5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]] CTD PMID:19466990 NCBI chr 2:169,716,684...169,780,360
Ensembl chr 2:169,716,709...169,779,737
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions ISO
EXP
Polysorbates inhibits the reaction [Heme binds to GUCY1B1 protein]
5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]; zinc protoporphyrin inhibits the reaction [BAY 58-2667 inhibits the reaction [Heme deficiency results in decreased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]]
CTD PMID:19466990 PMID:22171090 NCBI chr 2:169,646,897...169,697,060
Ensembl chr 2:169,646,898...169,696,987
JBrowse link
G Hectd3 HECT domain E3 ubiquitin protein ligase 3 decreases expression ISO Heme metabolite results in decreased expression of HECTD3 mRNA CTD PMID:19191707 NCBI chr 5:135,706,437...135,715,173
Ensembl chr 5:135,706,473...135,714,421
JBrowse link
G Hk3 hexokinase 3 increases expression ISO Heme metabolite results in increased expression of HK3 mRNA CTD PMID:19191707 NCBI chr17:9,602,119...9,620,038
Ensembl chr17:9,605,016...9,620,037
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases degradation
increases expression
decreases abundance
decreases expression
increases metabolic processing
ISO
EXP
[HMOX1 protein results in increased degradation of Heme] which results in increased abundance of Iron; NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA]; SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
[stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Heme; Heme promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of HMOX1 protein]
Heme metabolite results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 mRNA
Heme analog results in increased expression of HMOX1 protein; Heme results in increased expression of HMOX1 mRNA; Heme results in increased expression of HMOX1 protein
HMOX1 protein results in decreased abundance of Heme
[Heme binds to HPX protein] which results in increased expression of HMOX1 protein; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; HMOX1 enhancer affects the reaction [Heme results in increased expression of HMOX1 mRNA]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]
Heme results in decreased expression of HMOX1 mRNA
HMOX1 protein results in increased metabolism of Heme
CTD PMID:7538129 PMID:8630002 PMID:9224953 PMID:10874044 PMID:12783778 More... NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Hpx hemopexin multiple interactions
affects binding
ISO [Heme binds to HPX protein] inhibits the reaction [Triethylenephosphoramide results in increased expression of CCS protein]; [Heme binds to HPX protein] which results in increased degradation of CCS protein; [Heme binds to HPX protein] which results in increased expression of HMOX1 protein; [Heme co-treated with HPX protein] affects the activity of MT1 promoter; [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein]; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; Copper inhibits the reaction [Heme binds to HPX protein]; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]] CTD PMID:11213479 PMID:19039664 NCBI chr 1:169,344,647...169,352,155
Ensembl chr 1:169,344,583...169,352,156
JBrowse link
G Ifng interferon gamma multiple interactions ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]] CTD PMID:11076874 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Heme metabolite results in increased expression of IL1A mRNA CTD PMID:19191707 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of IL1B protein
CTD PMID:11076874 PMID:23355332 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 decreases expression ISO Heme metabolite results in decreased expression of IL1RL1 mRNA CTD PMID:19191707 NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:50,204,551...50,222,891
JBrowse link
G Il20 interleukin 20 increases expression ISO Heme metabolite results in increased expression of IL20 mRNA CTD PMID:19191707 NCBI chr13:44,933,249...44,936,893
Ensembl chr13:44,933,249...44,936,893
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO Heme results in increased expression of IL6 mRNA; Heme results in increased expression of IL6 protein
LY96 protein promotes the reaction [Heme results in increased expression of IL6 mRNA]; LY96 protein promotes the reaction [Heme results in increased expression of IL6 protein]
CTD PMID:36115635 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Il7r interleukin 7 receptor increases expression ISO Heme metabolite results in increased expression of IL7R mRNA CTD PMID:19191707 NCBI chr 2:60,179,561...60,204,937
Ensembl chr 2:60,181,382...60,211,027
JBrowse link
G Irf3 interferon regulatory factor 3 decreases expression ISO Heme metabolite results in decreased expression of IRF3 mRNA CTD PMID:19191707 NCBI chr 1:104,616,608...104,621,402
Ensembl chr 1:104,616,469...104,621,401
JBrowse link
G Irf4 interferon regulatory factor 4 increases expression ISO Heme metabolite results in increased expression of IRF4 mRNA CTD PMID:19191707 NCBI chr17:33,930,460...33,948,842
Ensembl chr17:33,930,471...33,948,730
JBrowse link
G Itln1 intelectin 1 decreases expression EXP Heme results in decreased expression of ITLN1 mRNA CTD PMID:15539406 NCBI chr13:86,464,641...86,490,655
Ensembl chr13:86,464,669...86,490,651
JBrowse link
G Krt20 keratin 20 increases expression EXP Heme results in increased expression of KRT20 mRNA CTD PMID:15539406 NCBI chr10:84,880,952...84,890,285
Ensembl chr10:84,880,952...84,890,285
JBrowse link
G Ly96 lymphocyte antigen 96 affects binding
multiple interactions
ISO Heme binds to LY96 protein
ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Heme promotes the reaction [TLR4 protein binds to LY96 protein]]; Heme promotes the reaction [TLR4 protein binds to LY96 protein]; LY96 protein promotes the reaction [Heme results in decreased localization of NFKBIA protein]; LY96 protein promotes the reaction [Heme results in increased expression of IL6 mRNA]; LY96 protein promotes the reaction [Heme results in increased expression of IL6 protein]; LY96 protein promotes the reaction [Heme results in increased expression of TNF mRNA]; LY96 protein promotes the reaction [Heme results in increased expression of TNF protein]; LY96 protein promotes the reaction [Heme results in increased localization of RELA protein]; LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK1 protein]; LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK3 protein]; LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK8 protein]
CTD PMID:36115635 NCBI chr 5:7,365,536...7,397,864
Ensembl chr 5:7,365,557...7,395,816
JBrowse link
G Lyz2 lysozyme 2 multiple interactions
increases secretion
ISO SB 203580 inhibits the reaction [Heme analog results in increased secretion of LYZ protein] CTD PMID:23355332 NCBI chr 7:54,792,715...54,798,060
Ensembl chr 7:54,792,716...54,798,011
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Heme results in increased phosphorylation of MAPK1 protein
LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK1 protein]
CTD PMID:36115635 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Heme results in increased phosphorylation of MAPK3 protein
LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK3 protein]
CTD PMID:36115635 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
ISO Heme results in increased phosphorylation of MAPK8 protein
LY96 protein promotes the reaction [Heme results in increased phosphorylation of MAPK8 protein]
CTD PMID:36115635 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Heme inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:17292349 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
JBrowse link
G Mptx1 mucosal pentraxin 1 decreases expression
multiple interactions
EXP Heme results in decreased expression of MPTX1 mRNA
Calcium, Dietary inhibits the reaction [Heme results in decreased expression of MPTX1 mRNA]
CTD PMID:15539406 NCBI chr13:88,260,335...88,263,869
Ensembl chr13:88,260,335...88,263,869
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease decreases expression ISO Heme metabolite results in decreased expression of MRE11A mRNA CTD PMID:19191707 NCBI chr 8:19,900,211...19,961,906
Ensembl chr 8:19,913,772...19,961,904
JBrowse link
G Mt1a metallothionein 1A decreases response to substance
multiple interactions
ISO MT1A protein results in decreased susceptibility to Heme
[Heme co-treated with HPX protein] affects the activity of MT1 promoter
CTD PMID:11213479 PMID:11878821 NCBI chr19:10,831,959...10,832,975
Ensembl chr17:79,695,809...79,696,200
Ensembl chr  X:79,695,809...79,696,200
Ensembl chr19:79,695,809...79,696,200
JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions ISO [Heme co-treated with HPX protein] affects the localization of MTF1 protein; bathocuproine sulfonate inhibits the reaction [[Heme co-treated with HPX protein] affects the localization of MTF1 protein] CTD PMID:11213479 NCBI chr 5:142,347,024...142,391,810
Ensembl chr 5:142,347,054...142,391,810
JBrowse link
G Mtmr10 myotubularin related protein 10 increases expression ISO Heme metabolite results in increased expression of MTMR10 mRNA CTD PMID:19191707 NCBI chr 1:127,271,139...127,322,621
Ensembl chr 1:127,270,870...127,322,621
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Heme promotes the reaction [TLR4 protein binds to MYD88 protein]]; Heme promotes the reaction [TLR4 protein binds to MYD88 protein] CTD PMID:36115635 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 mutant form inhibits the reaction [Heme results in increased expression of HMOX1 mRNA] CTD PMID:10874044 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects localization ISO Heme analog affects the localization of NFKB1 protein CTD PMID:23355332 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases localization
ISO Heme analog results in increased phosphorylation of and results in increased degradation of NFKBIA protein
Heme results in decreased localization of NFKBIA protein
LY96 protein promotes the reaction [Heme results in decreased localization of NFKBIA protein]
CTD PMID:23355332 PMID:36115635 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Ngb neuroglobin affects binding ISO Carbon Dioxide binds to [Heme binds to NGB protein]; Heme binds to NGB protein CTD PMID:16684569 NCBI chr 6:112,475,332...112,480,786
Ensembl chr 6:112,475,332...112,480,786
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]] CTD PMID:11076874 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Pars2 prolyl-tRNA synthetase 2, mitochondrial decreases expression ISO Heme metabolite results in decreased expression of PARS2 mRNA CTD PMID:19191707 NCBI chr 5:126,662,882...126,667,981
Ensembl chr 5:126,657,700...126,676,455
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 increases expression ISO Heme metabolite results in increased expression of PCSK2 mRNA CTD PMID:19191707 NCBI chr 3:151,333,938...151,636,628
Ensembl chr 3:151,333,234...151,638,849
JBrowse link
G Pdgfb platelet derived growth factor subunit B decreases expression ISO Heme metabolite results in decreased expression of PDGFB mRNA CTD PMID:19191707 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343
JBrowse link
G Pgap2 post-GPI attachment to proteins 2 decreases expression ISO Heme metabolite results in decreased expression of PGAP2 mRNA CTD PMID:19191707 NCBI chr 1:166,003,593...166,030,088
Ensembl chr 1:166,003,523...166,030,088
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 decreases expression ISO Heme metabolite results in decreased expression of PHLDA1 mRNA CTD PMID:19191707 NCBI chr 7:48,853,690...48,855,894
Ensembl chr 7:48,853,260...48,857,542
JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 decreases expression ISO Heme metabolite results in decreased expression of PJA2 mRNA CTD PMID:19191707 NCBI chr 9:111,403,624...111,453,703
Ensembl chr 9:111,403,624...111,453,703
JBrowse link
G Plekhm1 pleckstrin homology and RUN domain containing M1 increases expression ISO Heme metabolite results in increased expression of PLEKHM1 mRNA CTD PMID:19191707 NCBI chr10:88,814,699...88,876,570
Ensembl chr10:88,814,699...88,862,544
JBrowse link
G Plekho1 pleckstrin homology domain containing O1 increases expression ISO Heme metabolite results in increased expression of PLEKHO1 mRNA CTD PMID:19191707 NCBI chr 2:186,233,435...186,242,114
Ensembl chr 2:186,233,452...186,241,354
JBrowse link
G Plk2 polo-like kinase 2 increases expression ISO Heme metabolite results in increased expression of PLK2 mRNA CTD PMID:19191707 NCBI chr 2:43,702,536...43,708,305
Ensembl chr 2:43,701,865...43,708,296
JBrowse link
G Plxna2 plexin A2 increases expression ISO Heme metabolite results in increased expression of PLXNA2 mRNA CTD PMID:19191707 NCBI chr13:108,683,155...108,888,336
Ensembl chr13:108,691,530...108,887,453
JBrowse link
G Pomt1 protein-O-mannosyltransferase 1 decreases expression ISO Heme metabolite results in decreased expression of POMT1 mRNA CTD PMID:19191707 NCBI chr 3:35,918,370...35,936,330
Ensembl chr 3:35,918,188...35,936,364
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine]; [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809
JBrowse link
G Ppie peptidylprolyl isomerase E increases expression ISO Heme metabolite results in increased expression of PPIE mRNA CTD PMID:19191707 NCBI chr 5:140,691,285...140,704,347
Ensembl chr 5:140,683,801...140,740,767
JBrowse link
G Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 increases expression ISO Heme metabolite results in increased expression of PSTPIP2 mRNA CTD PMID:19191707 NCBI chr18:73,585,729...73,671,868
Ensembl chr18:73,585,993...73,671,871
JBrowse link
G Rab33a RAB33A, member RAS oncogene family increases expression ISO Heme metabolite results in increased expression of RAB33A mRNA CTD PMID:19191707 NCBI chr  X:132,572,133...132,584,255
Ensembl chr  X:132,572,148...132,584,254
JBrowse link
G Rab3a RAB3A, member RAS oncogene family decreases expression ISO Heme metabolite results in decreased expression of RAB3A mRNA CTD PMID:19191707 NCBI chr16:18,718,164...18,722,273
Ensembl chr16:18,718,167...18,721,842
JBrowse link
G Rbm39 RNA binding motif protein 39 increases expression ISO Heme metabolite results in increased expression of RBM39 mRNA CTD PMID:19191707 NCBI chr 3:165,123,087...165,156,453
Ensembl chr 3:165,123,095...165,149,397
JBrowse link
G Rbx1 ring-box 1 increases expression ISO Heme metabolite results in increased expression of RBX1 mRNA CTD PMID:19191707 NCBI chr 7:114,870,893...114,881,194
Ensembl chr 7:114,870,972...114,881,191
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
increases localization
ISO Heme analog affects the localization of RELA protein
LY96 protein promotes the reaction [Heme results in increased localization of RELA protein]
CTD PMID:23355332 PMID:36115635 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Rhebl1 RHEB like 1 increases expression ISO Heme metabolite results in increased expression of RHEBL1 mRNA CTD PMID:19191707 NCBI chr 7:131,905,207...131,910,088
Ensembl chr 7:131,905,207...131,909,199
JBrowse link
G Rpap1 RNA polymerase II associated protein 1 decreases expression ISO Heme metabolite results in decreased expression of RPAP1 mRNA CTD PMID:19191707 NCBI chr 3:127,200,450...127,221,985
Ensembl chr 3:127,110,550...127,221,952
JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 increases expression ISO Heme metabolite results in increased expression of RPS6KA2 mRNA CTD PMID:19191707 NCBI chr 1:55,178,988...55,454,271
Ensembl chr 1:55,179,319...55,454,338
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 increases expression ISO Heme metabolite results in increased expression of H2-T23 mRNA CTD PMID:19191707 NCBI chr20:4,872,720...4,876,425 JBrowse link
G RT1-Bb RT1 class II, locus Bb decreases expression ISO Heme metabolite results in decreased expression of H2-AB1 mRNA CTD PMID:19191707 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118
JBrowse link
G RT1-CE16 RT1 class I, locus CE16 decreases expression ISO Heme metabolite results in decreased expression of H2-Q1 mRNA CTD PMID:19191707 NCBI chr20:3,261,656...3,265,548 JBrowse link
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 decreases expression ISO Heme metabolite results in decreased expression of SETDB1 mRNA CTD PMID:19191707 NCBI chr 2:185,587,722...185,619,084
Ensembl chr 2:185,587,722...185,618,982
JBrowse link
G Slamf7 SLAM family member 7 increases expression ISO Heme metabolite results in increased expression of SLAMF7 mRNA CTD PMID:19191707 NCBI chr13:86,668,060...86,688,222
Ensembl chr13:86,668,060...86,686,341
JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions
increases uptake
ISO SLC46A1 protein promotes the reaction [Heme results in increased expression of HMOX1 mRNA]
SLC46A1 protein results in increased uptake of Heme
CTD PMID:17156779 NCBI chr10:63,859,551...63,865,987
Ensembl chr10:63,859,504...63,866,869
JBrowse link
G Smarcb1 SWI/SNF related BAF chromatin remodeling complex subunit B1 decreases expression ISO Heme metabolite results in decreased expression of SMARCB1 mRNA CTD PMID:19191707 NCBI chr20:12,740,105...12,763,054
Ensembl chr20:12,740,943...12,763,055
JBrowse link
G Smc4 structural maintenance of chromosomes 4 decreases expression ISO Heme metabolite results in decreased expression of SMC4 mRNA CTD PMID:19191707 NCBI chr 2:155,550,262...155,578,695
Ensembl chr 2:155,550,262...155,581,937
JBrowse link
G Srp9 signal recognition particle 9 increases expression ISO Heme metabolite results in increased expression of SRP9 mRNA CTD PMID:19191707 NCBI chr13:96,364,253...96,372,393
Ensembl chr13:96,364,298...96,373,257
JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 increases expression ISO Heme metabolite results in increased expression of STARD4 mRNA CTD PMID:19191707 NCBI chr18:25,088,831...25,104,172
Ensembl chr18:25,091,255...25,104,172
JBrowse link
G Taf7 TATA-box binding protein associated factor 7 increases expression ISO Heme metabolite results in increased expression of TAF7 mRNA CTD PMID:19191707 NCBI chr18:29,704,182...29,713,382
Ensembl chr18:29,705,920...29,712,712
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions EXP Heme promotes the reaction [pyridine results in increased activity of TDO2 protein] CTD PMID:10413312 NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:169,567,654...169,585,586
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
affects binding
ISO ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Heme promotes the reaction [TLR4 protein binds to LY96 protein]]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Heme promotes the reaction [TLR4 protein binds to MYD88 protein]]; Heme promotes the reaction [TLR4 protein binds to LY96 protein]; Heme promotes the reaction [TLR4 protein binds to MYD88 protein]
Heme binds to TLR4 protein
CTD PMID:36115635 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
increases expression
ISO Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; tin protoporphyrin IX inhibits the reaction [Heme inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased activity of NOS2 protein]]
Heme analog results in increased secretion of TNF protein
Heme results in increased expression of TNF mRNA; Heme results in increased expression of TNF protein
LY96 protein promotes the reaction [Heme results in increased expression of TNF mRNA]; LY96 protein promotes the reaction [Heme results in increased expression of TNF protein]
CTD PMID:11076874 PMID:23355332 PMID:36115635 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tnfsf13b TNF superfamily member 13b decreases expression ISO Heme metabolite results in decreased expression of TNFSF13B mRNA CTD PMID:19191707 NCBI chr16:86,164,377...86,195,072
Ensembl chr16:86,164,377...86,194,499
JBrowse link
G Tollip toll interacting protein increases expression ISO Heme metabolite results in increased expression of TOLLIP mRNA CTD PMID:19191707 NCBI chr 1:206,391,120...206,413,809
Ensembl chr 1:206,380,308...206,411,988
JBrowse link
G Tuba4a tubulin, alpha 4A increases expression ISO Heme metabolite results in increased expression of TUBA4A mRNA CTD PMID:19191707 NCBI chr 9:84,158,871...84,174,041
Ensembl chr 9:84,158,280...84,162,584
JBrowse link
G Ube2l3 ubiquitin-conjugating enzyme E2L 3 increases expression ISO Heme metabolite results in increased expression of UBE2L3 mRNA CTD PMID:19191707 NCBI chr11:97,300,584...97,343,084
Ensembl chr11:97,301,945...97,343,084
JBrowse link
G Ube2r2 ubiquitin-conjugating enzyme E2R 2 decreases expression ISO Heme metabolite results in decreased expression of UBE2R2 mRNA CTD PMID:19191707 NCBI chr 5:61,082,552...61,141,099
Ensembl chr 5:61,082,552...61,141,452
JBrowse link
G Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 decreases expression ISO Heme metabolite results in decreased expression of WFIKKN2 mRNA CTD PMID:19191707 NCBI chr10:79,682,459...79,688,553
Ensembl chr10:79,682,459...79,688,553
JBrowse link
G Yeats2 YEATS domain containing 2 decreases expression ISO Heme metabolite results in decreased expression of YEATS2 mRNA CTD PMID:19191707 NCBI chr11:94,247,538...94,333,652
Ensembl chr11:94,247,538...94,333,292
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20849
    role 20820
      biological role 20805
        biochemical role 20268
          cofactor 16929
            ferroheme b 128
              ferrocytochrome b + 0
              heme d cis-diol + 0
              heme d trans-diol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20849
    subatomic particle 20847
      composite particle 20860
        hadron 20847
          baryon 20860
            nucleon 20847
              atomic nucleus 20847
                atom 20860
                  main group element atom 20781
                    p-block element atom 20768
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20403
                                organic heterocyclic compound 19386
                                  organonitrogen heterocyclic compound 18530
                                    polypyrrole 711
                                      tetrapyrrole 599
                                        cyclic tetrapyrrole 471
                                          porphyrins 389
                                            metalloporphyrin 342
                                              heme 225
                                                heme b 225
                                                  ferroheme b 128
                                                    ferrocytochrome b + 0
                                                    heme d cis-diol + 0
                                                    heme d trans-diol 0
paths to the root