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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Didymin
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Accession:CHEBI:176179 term browser browse the term
Synonyms:exact_synonym: (2S)-5-hydroxy-2-(4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one
 related_synonym: Formula=C28H34O14;   InChI=1S/C28H34O14/c1-11-21(31)23(33)25(35)27(39-11)38-10-19-22(32)24(34)26(36)28(42-19)40-14-7-15(29)20-16(30)9-17(41-18(20)8-14)12-3-5-13(37-2)6-4-12/h3-8,11,17,19,21-29,31-36H,9-10H2,1-2H3/t11-,17-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1;   InChIKey=RMCRQBAILCLJGU-HIBKWJPLSA-N;   SMILES=O1[C@@H]([C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC=2C=C3O[C@@H](CC(=O)C3=C(O)C2)C4=CC=C(OC)C=C4)CO[C@@H]5O[C@H]([C@H](O)[C@@H](O)[C@H]5O)C
 xref: CAS:14259-47-3;   Chemspider:16498764
 xref_mesh: MESH:C552234



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Didymin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO didymin inhibits the reaction [INS protein results in decreased phosphorylation of AKT1 protein]; didymin results in decreased expression of and results in decreased phosphorylation of AKT1 protein; locostatin inhibits the reaction [didymin results in decreased expression of and results in decreased phosphorylation of AKT1 protein] CTD PMID:27899290 PMID:30928401 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO didymin inhibits the reaction [APP protein alternative form results in increased expression of BACE1 protein] CTD PMID:31194956 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bace1 beta-secretase 1 decreases activity
multiple interactions
ISO didymin results in decreased activity of BACE1 protein
didymin inhibits the reaction [APP protein alternative form results in increased expression of BACE1 protein]
CTD PMID:31194956 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO locostatin inhibits the reaction [didymin results in increased expression of BAX protein] CTD PMID:27899290 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO didymin results in decreased expression of BCL2 protein
locostatin inhibits the reaction [didymin results in decreased expression of BCL2 protein]
CTD PMID:27899290 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO locostatin inhibits the reaction [didymin results in increased activity of CASP3 protein] CTD PMID:27899290 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO didymin results in increased activity of CASP9 protein
locostatin inhibits the reaction [didymin results in increased activity of CASP9 protein]
CTD PMID:27899290 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression
ISO locostatin inhibits the reaction [didymin results in decreased expression of CCNB1 protein] CTD PMID:27899290 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO didymin results in decreased expression of CCND1 protein
locostatin inhibits the reaction [didymin results in decreased expression of CCND1 protein]
CTD PMID:27899290 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression
multiple interactions
ISO didymin results in decreased expression of CDK4 protein
locostatin inhibits the reaction [didymin results in decreased expression of CDK4 protein]
CTD PMID:27899290 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO didymin inhibits the reaction [INS protein results in decreased phosphorylation of GSK3B protein] CTD PMID:30928401 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Ins2 insulin 2 multiple interactions ISO didymin inhibits the reaction [INS protein results in decreased phosphorylation of AKT1 protein]; didymin inhibits the reaction [INS protein results in decreased phosphorylation of GSK3B protein]; didymin inhibits the reaction [INS protein results in decreased phosphorylation of IRS1 protein]; didymin inhibits the reaction [INS protein results in increased expression of PTPN1 protein] CTD PMID:30928401 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO didymin inhibits the reaction [INS protein results in decreased phosphorylation of IRS1 protein] CTD PMID:30928401 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO locostatin inhibits the reaction [didymin results in decreased phosphorylation of MAPK1 protein] CTD PMID:27899290 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO didymin results in decreased phosphorylation of MAPK3 protein
locostatin inhibits the reaction [didymin results in decreased phosphorylation of MAPK3 protein]
CTD PMID:27899290 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 multiple interactions
increases expression
ISO locostatin inhibits the reaction [didymin results in increased expression of PEBP1 protein] CTD PMID:27899290 NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions
decreases activity
ISO didymin inhibits the reaction [INS protein results in increased expression of PTPN1 protein]
didymin results in decreased activity of PTPN1 protein
CTD PMID:30928401 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    chemical entity 20055
      atom 20054
        nonmetal atom 19945
          oxygen atom 19666
            oxygen molecular entity 19666
              flavonoids 11186
                Didymin 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            heteroorganic entity 19561
                              organochalcogen compound 19310
                                organooxygen compound 19243
                                  carbohydrates and carbohydrate derivatives 13928
                                    carbohydrate 13928
                                      carbohydrate derivative 13657
                                        glycosyl compound 12913
                                          glycoside 11726
                                            Didymin 17
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