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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Didymin
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Accession:CHEBI:176179 term browser browse the term
Synonyms:exact_synonym: (2S)-5-hydroxy-2-(4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one
 related_synonym: Formula=C28H34O14;   InChI=1S/C28H34O14/c1-11-21(31)23(33)25(35)27(39-11)38-10-19-22(32)24(34)26(36)28(42-19)40-14-7-15(29)20-16(30)9-17(41-18(20)8-14)12-3-5-13(37-2)6-4-12/h3-8,11,17,19,21-29,31-36H,9-10H2,1-2H3/t11-,17-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1;   InChIKey=RMCRQBAILCLJGU-HIBKWJPLSA-N;   Isosakuranetin-7-O-rutinoside;   SMILES=O1[C@@H]([C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC=2C=C3O[C@@H](CC(=O)C3=C(O)C2)C4=CC=C(OC)C=C4)CO[C@@H]5O[C@H]([C@H](O)[C@@H](O)[C@H]5O)C
 xref: CAS:14259-47-3;   Chemspider:16498764
 xref_mesh: MESH:C552234


show annotations for term's descendants           Sort by:
Didymin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO didymin inhibits the reaction [INS protein results in decreased phosphorylation of AKT1 protein]; didymin results in decreased expression of and results in decreased phosphorylation of AKT1 protein; locostatin inhibits the reaction [didymin results in decreased expression of and results in decreased phosphorylation of AKT1 protein] CTD PMID:27899290 PMID:30928401 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO didymin inhibits the reaction [APP protein alternative form results in increased expression of BACE1 protein] CTD PMID:31194956 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bace1 beta-secretase 1 decreases activity
multiple interactions		 ISO didymin results in decreased activity of BACE1 protein
didymin inhibits the reaction [APP protein alternative form results in increased expression of BACE1 protein]		 CTD PMID:31194956 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO locostatin inhibits the reaction [didymin results in increased expression of BAX protein] CTD PMID:27899290 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO didymin results in decreased expression of BCL2 protein
locostatin inhibits the reaction [didymin results in decreased expression of BCL2 protein]		 CTD PMID:27899290 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO locostatin inhibits the reaction [didymin results in increased activity of CASP3 protein] CTD PMID:27899290 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 ISO didymin results in increased activity of CASP9 protein
locostatin inhibits the reaction [didymin results in increased activity of CASP9 protein]		 CTD PMID:27899290 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions
decreases expression		 ISO locostatin inhibits the reaction [didymin results in decreased expression of CCNB1 protein] CTD PMID:27899290 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO didymin results in decreased expression of CCND1 protein
locostatin inhibits the reaction [didymin results in decreased expression of CCND1 protein]		 CTD PMID:27899290 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression
multiple interactions		 ISO didymin results in decreased expression of CDK4 protein
locostatin inhibits the reaction [didymin results in decreased expression of CDK4 protein]		 CTD PMID:27899290 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO didymin inhibits the reaction [INS protein results in decreased phosphorylation of GSK3B protein] CTD PMID:30928401 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO didymin inhibits the reaction [INS protein results in decreased phosphorylation of AKT1 protein]; didymin inhibits the reaction [INS protein results in decreased phosphorylation of GSK3B protein]; didymin inhibits the reaction [INS protein results in decreased phosphorylation of IRS1 protein]; didymin inhibits the reaction [INS protein results in increased expression of PTPN1 protein] CTD PMID:30928401 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO didymin inhibits the reaction [INS protein results in decreased phosphorylation of IRS1 protein] CTD PMID:30928401 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO locostatin inhibits the reaction [didymin results in decreased phosphorylation of MAPK1 protein] CTD PMID:27899290 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions		 ISO didymin results in decreased phosphorylation of MAPK3 protein
locostatin inhibits the reaction [didymin results in decreased phosphorylation of MAPK3 protein]		 CTD PMID:27899290 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 multiple interactions
increases expression		 ISO locostatin inhibits the reaction [didymin results in increased expression of PEBP1 protein] CTD PMID:27899290 NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions
decreases activity		 ISO didymin inhibits the reaction [INS protein results in increased expression of PTPN1 protein]
didymin results in decreased activity of PTPN1 protein		 CTD PMID:30928401 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    chemical entity 19829
      atom 19829
        nonmetal atom 19767
          oxygen atom 19509
            oxygen molecular entity 19509
              flavonoids 11609
                Didymin 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  carbohydrates and carbohydrate derivatives 15289
                                    carbohydrate 15289
                                      carbohydrate derivative 14294
                                        glycosyl compound 13051
                                          glycoside 11832
                                            Didymin 17
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