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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3-Methoxynobiletin
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Accession:CHEBI:176100 term browser browse the term
Synonyms:exact_synonym: 2-(3,4-dimethoxyphenyl)-3,5,6,7,8-pentamethoxychromen-4-one
 related_synonym: Formula=C22H24O9;   InChI=1S/C22H24O9/c1-24-12-9-8-11(10-13(12)25-2)16-19(27-4)15(23)14-17(26-3)20(28-5)22(30-7)21(29-6)18(14)31-16/h8-10H,1-7H3;   InChIKey=SSXJHQZOHUYEGD-UHFFFAOYSA-N;   SMILES=O1C2=C(C(OC)=C(OC)C(OC)=C2OC)C(=O)C(OC)=C1C3=CC(OC)=C(OC)C=C3
 xref: CAS:1178-24-1;   Chemspider:132996;   HMDB:HMDB0037689;   LIPID_MAPS_instance:LMPK12113345
 xref_mesh: MESH:C059294


show annotations for term's descendants           Sort by:
3-Methoxynobiletin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor increases expression
multiple interactions		 EXP 3,3',4',5,6,7,8-heptamethoxyflavone results in increased expression of BDNF protein
U 0126 inhibits the reaction [3,3',4',5,6,7,8-heptamethoxyflavone results in increased expression of BDNF protein]		 CTD PMID:31195342 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions		 EXP 3,3',4',5,6,7,8-heptamethoxyflavone results in increased phosphorylation of CREB1 protein
U 0126 inhibits the reaction [3,3',4',5,6,7,8-heptamethoxyflavone results in increased phosphorylation of CREB1 protein]		 CTD PMID:31195342 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects phosphorylation ISO 3,3',4',5,6,7,8-heptamethoxyflavone affects the phosphorylation of FOS protein CTD PMID:29470423 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit affects phosphorylation ISO 3,3',4',5,6,7,8-heptamethoxyflavone affects the phosphorylation of JUN protein CTD PMID:29470423 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
affects phosphorylation		 EXP
ISO		 U 0126 inhibits the reaction [3,3',4',5,6,7,8-heptamethoxyflavone results in increased phosphorylation of MAPK1 protein]
3,3',4',5,6,7,8-heptamethoxyflavone affects the phosphorylation of MAPK1 protein		 CTD PMID:29470423 PMID:31195342 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects phosphorylation ISO 3,3',4',5,6,7,8-heptamethoxyflavone affects the phosphorylation of MAPK3 protein CTD PMID:29470423 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 affects phosphorylation ISO 3,3',4',5,6,7,8-heptamethoxyflavone affects the phosphorylation of MAPK8 protein CTD PMID:29470423 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mmp1 matrix metallopeptidase 1 affects expression ISO 3,3',4',5,6,7,8-heptamethoxyflavone affects the expression of MMP1 protein CTD PMID:29470423 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Pde4a phosphodiesterase 4A decreases activity EXP 3,3',4',5,6,7,8-heptamethoxyflavone results in decreased activity of PDE4A protein CTD PMID:31195342 NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961 		JBrowse link
G Smad3 SMAD family member 3 affects phosphorylation ISO 3,3',4',5,6,7,8-heptamethoxyflavone affects the phosphorylation of SMAD3 protein CTD PMID:29470423 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smad7 SMAD family member 7 affects phosphorylation ISO 3,3',4',5,6,7,8-heptamethoxyflavone affects the phosphorylation of SMAD7 protein CTD PMID:29470423 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      atom 19897
        nonmetal atom 19819
          carbon atom 19772
            organic molecular entity 19772
              flavonoids 11636
                3-Methoxynobiletin 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19532
                              organochalcogen compound 19293
                                organooxygen compound 19209
                                  ether 17328
                                    3-Methoxynobiletin 11
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